Review
Immunology
Peishan Li, Qianmin Ou, Songtao Shi, Changshun Shao
Summary: Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and can be used for the treatment of autoimmune diseases and other chronic disorders. Dental stem cells (DSCs) have remarkable immunomodulatory properties and have therapeutic effects on systemic inflammatory diseases. MSCs derived from nondental tissues, such as the umbilical cord, also show benefits in the management of periodontitis in preclinical studies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Cell Biology
Yiming Zhao, Dingding Yu, Hongda Wang, Wang Jin, Xiang Li, Yonghao Hu, Yafei Qin, Dejun Kong, Guangming Li, Acheampong Ellen, Hao Wang
Summary: This study demonstrates that the high expression of Gal-9 on mesenchymal stem cells (MSCs) is closely associated with an optimized immunoregulatory effect, which can alleviate symptoms and organ damage caused by endotoxemia, promote macrophage polarization and Treg cell generation, and regulate inflammatory mediator levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Zhongqing Wang, Yuqiang Sun, Rou Shen, Xia Tang, Yingxin Xu, Ye Zhang, Yao Liu
Summary: This study investigated the global status and trends in the research of mesenchymal stem cell (MSC) immunomodulation. A total of 4,227 papers were analyzed, and it was found that the number of publications and research interests in this field have significantly increased worldwide. China had the highest number of related articles, while the US had the highest number of citations. The study identified four research hotspots in MSC immunomodulation and suggested that future research should focus on understanding the mechanisms and clinical applications of MSC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Bruna Roberta Oliveira Neves, Sumara de Freitas, Primavera Borelli, Marcelo Macedo Rogero, Ricardo Ambrosio Fock
Summary: This study investigated the effects of delphinidin on the immunomodulatory properties of mesenchymal stem cells (MSCs). The results showed that delphinidin can increase the production of the anti-inflammatory cytokine IL-10 by MSCs and reduce the expression of NF-[Kb].
Review
Cell Biology
Yufeng Shang, Haotong Guan, Fuling Zhou
Summary: Umbilical cord mesenchymal stem cells (UC-MSCs) have the characteristics of inhibiting tumor cell proliferation and migration, supporting hematopoietic microenvironment, and suppressing the immune system, showing great potential in the treatment of hematologic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lucero Lopez-Garcia, Marta E. Castro-Manrreza
Summary: Mesenchymal stem/stromal cells (MSCs) exhibit immunoregulatory abilities that are influenced by factors such as the microenvironment, cell-cell contact, and cytokines. Important factors include ICAM-1 and EVs, while guidelines for activation can aid in designing protocols for obtaining functional MSCs or EVs in various pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Ziwei Shen, Wei Huang, Jun Liu, Jie Tian, Shengjun Wang, Ke Rui
Summary: Research indicates that mesenchymal stem cell-derived exosomes (MSC-EXOs) have a significant inhibitory effect on effector cells involved in the immune response, and can be used to treat various autoimmune diseases, serving as a promising cell-free treatment strategy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Victor Adrian Cortes-Morales, Luis Chavez-Sanchez, Leticia Rocha-Zavaleta, Sandra Espindola-Garibay, Alberto Monroy-Garcia, Marta Elena Castro-Manrreza, Guadalupe Rosario Fajardo-Orduna, Teresa Apresa-Garcia, Marcos Gutierrez-de la Barrera, Hector Mayani, Juan Jose Montesinos
Summary: This study found that MSCs derived from cervical cancer (CeCa-MSCs) have the ability to promote M2 macrophage polarization, unlike MSCs derived from normal cervix (NCx-MSCs). CeCa-MSCs increase the production of anti-inflammatory molecules (IL-10 and IL-1RA) to regulate antitumor immune responses.
Article
Cell Biology
Yanping Xu, Jiaqi Zhu, Bing Feng, Feiyan Lin, Jiahang Zhou, Jingqi Liu, Xiaowei Shi, Xuan Lu, Qiaoling Pan, Jiong Yu, Ying Zhang, Lanjuan Li, Hongcui Cao
Summary: The study found that MSC transplantation significantly improved the survival rate of mice with ALI, alleviated lung damage, improved intestinal barrier integrity, and reduced inflammatory cytokines levels in both lung and gut. MSCs also inhibited the inflammatory response by decreasing CD8(+) T cells infiltration in the intestines, and altered gut bacterial community diversity.
CELL PROLIFERATION
(2021)
Review
Cell Biology
Stefania Crippa, Ludovica Santi, Margherita Berti, Giada De Ponti, Maria Ester Bernardo
Summary: The human organism requires the production of approximately 1 trillion new blood cells per day through hematopoiesis in the bone marrow, regulated by the BM microenvironment and HSPCs. The BM niche, defined by interactions between HSPCs and non-hematopoietic cells, controls HSPC maintenance and orchestrates hematopoiesis according to the body's needs. Mesenchymal stromal cells (MSCs) play a key role in the BM niche by regulating HSPC homeostasis and impacting the outcome of hematopoietic stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Zhou She, Min Xie, Marady Hun, Amin Sheikh Abdirahman, Cuifang Li, Feifeng Wu, Senlin Luo, Wuqing Wan, Chuan Wen, Jidong Tian
Summary: Mitochondria participate in immune regulation through various mechanisms, with recent studies showing the important effects of mitochondria from extracellular vesicles on immune regulation. Understanding the immunoregulatory effects of mitochondria from extracellular vesicles can shed light on underlying mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Cadenas-Martin, Francisco Arnalich-Montiel, Maria P. De Miguel
Summary: This study developed a protocol for deriving human limbal stem cells (LSCs) from adipose-derived mesenchymal stem cells (ADSCs) that is compatible with the standard carrier human amniotic membrane. The best protocol achieved optimal differentiation efficiency and will benefit patients with LSC deficiency, aiding in the restoration of vision.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiaoyun Cheng, Mao Jiang, Lingzhi Long, Jie Meng
Summary: COVID-19 is caused by SARS-CoV-2 and characterized by over activation of the immune system. Mesenchymal stem cells (MSCs) can regulate the immune system to prevent cytokine release syndrome and promote endogenous repair, making them a promising candidate for COVID-19 therapy.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wenya Zhu, Qianqian Chen, Yi Li, Jun Wan, Jia Li, Shuai Tang
Summary: A modified MSC transplantation with overexpression of HIF-1 alpha is an effective treatment for IBD. HIF-MSCs attenuate colitis and restore immune balance through regulating macrophage polarization via PI3K-gamma. The findings suggest that HIF-MSC transplantation is a potential precision therapy for IBD.
Article
Engineering, Biomedical
Cansu Gorgun, Davide Ceresa, Raphaelle Lesage, Federico Villa, Daniele Reverberi, Carolina Balbi, Sara Santamaria, Katia Cortese, Paolo Malatesta, Liesbet Geris, Rodolfo Quarto, Roberta Tasso
Summary: The research demonstrates that the MSC secretome is strongly modulated by concurrent stimulation with hypoxia and pro-inflammatory cytokines, which mimics the harsh environment at the injury site. The environmental variations strongly influence the angiogenic potential of different secretome fractions.
Review
Biology
Maria Chiara Ciferri, Rodolfo Quarto, Roberta Tasso
Summary: Extracellular vesicles (EVs) are membrane-bound vesicles released by all cell types, playing a crucial role in intercellular communication and serving as biomarkers for various diseases. EVs isolated from stem/progenitor cells exhibit innate immunosuppressive and anti-inflammatory properties, making them potential vehicles for drug delivery.
Article
Cell & Tissue Engineering
Cansu Gorgun, Maria Elisabetta Federica Palama, Daniele Reverberi, Maria Cristina Gagliani, Katia Cortese, Roberta Tasso, Chiara Gentili
Summary: The secretome of mesenchymal stromal cells (MSCs) derived from different tissue sources is considered an innovative therapeutic tool for regenerative medicine. The study compared middle- and small-sized extracellular vesicles (EVs) released by adipose tissue-derived MSCs (ADSCs) and bone marrow-derived MSCs (BMSCs), showing different protein content and functional effects, with ADSC-EVs overexpressing pro-angiogenic factors and BMSC-EVs containing a higher amount of pro-differentiation and chemotactic proteins. This study highlights the importance of selecting the appropriate cell source of EVs for targeted therapeutic applications.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Federico Villa, Silvia Bruno, Ambra Costa, Mingchuan Li, Michele Russo, James Cimino, Paola Altieri, Clarissa Ruggeri, Cansu Gorgun, Pierangela De Biasio, Dario Paladini, Domenico Coviello, Rodolfo Quarto, Pietro Ameri, Alessandra Ghigo, Silvia Ravera, Roberta Tasso, Sveva Bollini
Summary: This study evaluated and compared the cardioprotective effects of secretomes secreted by adult and fetal human stem cells, showing that both could protect against Dox-induced cardiac cell damage, reducing cardiotoxicity.
Editorial Material
Biotechnology & Applied Microbiology
Roberta Tasso, Susanne Graessel, Frank Zaucke
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Oncology
Barbara Cardinali, Roberta Tasso, Patrizia Piccioli, Maria Chiara Ciferri, Rodolfo Quarto, Lucia Del Mastro
Summary: This review discusses the potential application of circulating microRNAs (miRNAs) as diagnostic and monitoring biomarkers in breast cancer. It highlights the advantages and challenges that need to be addressed. Although further studies are needed to support their clinical utility, miRNAs could represent novel tools for breast cancer management.
Editorial Material
Oncology
Francesca Perut, Roberta Tasso, Bettina Mannerstroem
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Barbara Cardinali, Giuseppa De Luca, Roberta Tasso, Simona Coco, Anna Garuti, Giulia Buzzatti, Andrea Sciutto, Luca Arecco, Federico Villa, Franca Carli, Daniele Reverberi, Rodolfo Quarto, Mariella Dono, Lucia Del Mastro
Summary: This study investigates PIK3CA mutations in different circulating biomaterials and demonstrates the potential of these components to provide information on molecular targetable profiling. The consistent mutational profiles between extracellular vesicles and tumor cells suggest their association. This study also highlights the translational value of circulome in understanding the tumor heterogeneity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Cansu Gorgun, Chiara Africano, Maria Chiara Ciferri, Nadia Bertola, Daniele Reverberi, Rodolfo Quarto, Silvia Ravera, Roberta Tasso
Summary: This study demonstrates that EVs derived from MSCs preconditioned with hypoxia inflammatory cytokines can attenuate inflammaging and alleviate age-related inflammation and mitochondrial dysfunction.
Article
Cell Biology
Carlo Genova, Roberta Tasso, Alessandra Rosa, Giovanni Rossi, Daniele Reverberi, Vincenzo Fontana, Silvia Marconi, Michela Croce, Maria Giovanna Dal Bello, Chiara Dellepiane, Marco Tagliamento, Maria Chiara Ciferri, Lodovica Zullo, Alessandro Fedeli, Angela Alama, Katia Cortese, Chiara Gentili, Eugenia Cella, Giorgia Anselmi, Marco Mora, Giulia Barletta, Erika Rijavec, Francesco Grossi, Paolo Pronzato, Simona Coco
Summary: The advent of immune checkpoint inhibitors (ICIs) has dramatically changed the treatment of non-small cell lung cancer (NSCLC). However, their efficacy remains limited to a subset of patients. This study evaluated the prognostic role of soluble (s) immune checkpoints and immune checkpoints associated with extracellular vesicles (EVs) in NSCLC patients treated with ICIs. The results showed that high levels of sPD-L1, sB7-H3, and sB7-H4 were associated with different prognoses in advanced NSCLC patients treated with ICIs. The study also suggested potential involvement of EVs in the disease response to ICIs.
Review
Pharmacology & Pharmacy
Roberta Tasso, Silvia Marconi, Giovanni Rossi, Carlo Genova, Simona Coco
Summary: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death. Circulating elements such as platelets (PLTs) and their derived extracellular vesicles (P-EVs) have potential as diagnostic, prognostic, and predictive markers for NSCLC patient management. PLTs and P-EVs are both carriers of genetic materials and are involved in various pathological processes related to thrombosis, tumor progression, and metastasis.
DRUG DISCOVERY TODAY
(2023)
Article
Dermatology
Giulia Gasparini, Roberta Tasso, Maria Elisabetta Federica Palama, Maria Chiara Ciferri, Chiara Gentili, Giovanni Di Zenzo, Alessia Provini, Adele Salemme, Rodolfo Quarto, Aurora Parodi, Emanuele Cozzani
Summary: This study aimed to investigate the presence of BP targeted autoantigens in blister fluid-derived extracellular vesicles (EVs). EVs were isolated from blister fluid of BP patients and suction blister fluid of healthy donors, and EV characterization was performed. Western blot analysis revealed the presence of BP180 in EVs derived from blister fluid of 3 out of 6 BP patients, while no BP180 was detected in EVs from healthy donors. This discovery provides insights into the pathogenesis of BP.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Meeting Abstract
Cell & Tissue Engineering
Roberta Tasso, Cansu Gorgun, Davide Ceresa, Raphaelle Lesage, Federico Villa, Daniele Reverberi, Carolina Balbi, Sara Santamaria, Katia Cortese, Paolo Malatesta, Liesbet Geris, Rodolfo Quarto
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Federico Villa, Ambra Costa, Silvia Bruno, Mingchuan Li, Michele Russo, James Cimino, Clarissa Ruggeri, Rodolfo Quarto, Pietro Ameri, Alessandra Ghigo, Silvia Ravera, Bollini Sveva, Roberta Tasso
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Cansu Gorgun, Maria Elisabetta, Federica Palama, Daniele Reverberi, Roberta Tasso, Chiara Gentili
TISSUE ENGINEERING PART A
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
