Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Hye-Jin Song, In-Sook Jeon, Seung Ryul Kim, Kwan Sik Park, Jae-Won Soh, Kwang Youl Lee, Jae-Cheon Shin, Hak-Kyo Lee, Joong-Kook Choi
Summary: PKC interacts with and phosphorylates Stim1 to regulate cellular calcium dynamics. Phosphorylation of Stim1 at its C-terminal end is crucial for the regulation of SOCE activity in HEK293 and HeLa cells. PKC activators inhibit while PKC inhibitors activate SOCE activity in transient intracellular calcium mobilization assays.
Article
Biochemistry & Molecular Biology
Adriana Ariza, Cristobalina Mayorga, Gador Bogas, Francesco Gaeta, Maria Salas, Rocco L. Valluzzi, Marina Labella, Natalia Perez-Sanchez, Cristiano Caruso, Ana Molina, Tahia D. Fernandez, Maria Jose Torres, Antonino Romano
Summary: This study analyzed the utility of ImmunoCAP (R) for detecting sIgE to penicillin G (PG) and amoxicillin (AX) in patients with confirmed penicillin allergy. The results showed limitations of ImmunoCAP (R) in evaluating individuals with type I hypersensitivity reactions to penicillins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Kevin Plattner, Zahra Gharailoo, Simon Zinkhan, Paul Engeroff, Martin F. Bachmann, Monique Vogel
Summary: This study found that the glycosylation of IgE is crucial for initiating the anti-IgE IgG response, clearing serum IgE, and preventing systemic allergic reactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vanessza Emmert, Dominika Lendvai-Emmert, Kata Eklics, Viktoria Premusz, Gergely Peter Toth
Summary: Cow's milk protein allergy is a common pediatric food allergy that has a significant socioeconomic impact and affects the quality of life of individuals and their families. Various immunologic pathways contribute to the clinical symptoms, with some mechanisms well-known and others requiring further research. A comprehensive understanding of food allergy development and oral tolerance could lead to improved diagnostic tools and novel therapies for cow's milk protein allergy patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Paul Engeroff, Kevin Plattner, Federico Storni, Franziska Thoms, Kayluz Frias Boligan, Lukas Muerner, Alexander Eggel, Stephan von Gunten, Martin F. Bachmann, Monique Vogel
Summary: The study demonstrates that glycan-specific IgG anti-IgE autoantibodies can downregulate serum IgE levels and anaphylactic activity, providing potential therapeutic implications for allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Isabel J. Skypala, Samira Jeimy, Hannelore Brucker, Ajay P. Nayak, Ine I. Decuyper, Jonathan A. Bernstein, Lori Connors, Amin Kanani, Ludger Klimek, Shun Chi Ryan Lo, Kevin R. Murphy, Anil Nanda, Jill A. Poole, Jolanta Walusiak-Skorupa, Gordon Sussman, Joanna S. Zeiger, Richard E. Goodman, Anne K. Ellis, William S. Silvers, Didier G. Ebo
Summary: Cannabis is widely used as a recreational drug worldwide, but it can also cause allergic reactions and cross-reactivity with plant foods. Due to its illegal status in many countries, research and diagnosis face challenges, with limited management options and lack of education.
Article
Nutrition & Dietetics
Wenhua Yang, Wenjing Duan, Qiuhong Li, Dengle Duan, Qin Wang
Summary: This study investigated the effect of pulsed electric field (PEF) pretreatment combined with phosphorylation on the structure and immunoglobulin (Ig) G/IgE-binding ability of ovalbumin (OVA). The results showed that this treatment method significantly reduced the binding ability of OVA to IgG and IgE, and caused changes in the secondary and tertiary structure.
FRONTIERS IN NUTRITION
(2022)
Review
Allergy
Paul Engeroff, Monique Vogel
Summary: IgE can bind to two receptors, playing different roles on different cells, inducing allergic reactions on one hand and participating in IgE regulation and antigen presentation on the other. In inflammation and immune homeostasis, CD23 plays an important modulatory role.
Article
Biochemistry & Molecular Biology
Ksenja Riabova, Antonina Karsonova, Marianne van Hage, Ulrika Kack, Jon R. Konradsen, Hans Gronlund, Daria Fomina, Evgeny Beltyukov, Polina A. Glazkova, Dmitry Yu Semenov, Rudolf Valenta, Alexander Karaulov, Mirela Curin
Summary: Cat allergies are triggered by immunoglobulin E (IgE) sensitization and can result in respiratory reactions. This study investigated the associations between different cat allergen molecules and various phenotypes of cat allergy. The findings showed that in addition to the main cat allergen, rFel d 1, other allergen molecules such as rFel d 3, rFel d 4, and rFel d 7 are also important. Cumulative IgE levels specific to cat allergen molecules can serve as a biomarker for identifying patients with complex phenotypes of cat allergy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Raquel Freitas Zambonatto, Renata Nakata Teixeira, Sarah de Oliveira Poma, Eliane Borges da Silva, Mariana Mendes de Almeida, Gerson dos Santos Leite, Cesar Miguel Momesso dos Santos, Heloisa Helena de Oliveira Alves, Renata Gorjao, Tania Cristina Pithon-Curi, Celso R. F. Carvalho, Rui Curi, Adriana Cristina Levada-Pires
Summary: The study found that neutrophils from atopic elite runners exhibited lower responses to LPS stimulation compared to non-atopic runners. Both groups responded similarly to fMLP stimulation. Training hours and volume were not associated with neutrophil function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katie D. Hunter, Robert W. E. Crozier, Jessica L. Braun, Val A. Fajardo, Adam J. MacNeil
Summary: In this study, the role of SARCA in allergen-activated mast cells was characterized. Treatment with the SARCA activating compound, CDN1163, was found to attenuate early phase mast cell degranulation, reactive oxygen species (ROS) production, and secretion of IL-6, IL-13, and CCL3. These protective effects may be driven by the suppression of p38 MAPK signaling. These findings suggest that SARCA is an important regulator of the mast cell response to allergens and may have therapeutic potential in targeting allergic pathologies.
Article
Chemistry, Analytical
Maria Jose Juarez, Ethel Ibanez-Echevarria, Dolores Hernandez-Fernandez de Rojas, Angel Maquieira, Sergi Morais
Summary: The suspicion of beta-lactam allergy leads to non-compliant prescription of antibiotics, increasing antimicrobial resistance. In vitro quantification of specific IgE for allergy monitoring is challenging due to the lack of selective immunoreagents. An improved multiplex microimmunoassay for beta-lactam allergy testing standardization is reported in this study, showing reliable quantification and increased reproducibility, achieving accurate information for clinical diagnosis.
ANALYTICA CHIMICA ACTA
(2021)
Review
Allergy
Kensuke Miyake, Sho Shibata, Soichiro Yoshikawa, Hajime Karasuyama
Summary: Basophils are rare granulocytes that play crucial roles in allergic inflammation by releasing effector molecules to regulate immune responses and allergic disorders. They are recruited to inflamed tissues and activated in various ways, highlighting their versatile functions in the immune system.
Article
Allergy
Jeffrey A. SoRelle, Zhe Chen, Jianhui Wang, Tao Yue, Jin Huk Choi, Kuan-wen Wang, Xue Zhong, Sara Hildebrand, Jamie Russell, Lindsay Scott, Darui Xu, Xiaowei Zhan, Chun Hui Bu, Tao Wang, Mihwa Choi, Miao Tang, Sara Ludwig, Xiaoming Zhan, Xiaohong Li, Eva Marie Y. Moresco, Bruce Beutler
Summary: A genetic study in mice identified multiple genes associated with atopy, some of which are necessary for atopy development while others suppress it. It is estimated that up to 37% of individuals may carry at least one dominant atopy risk mutation as heterozygous carriers.
Article
Immunology
Satoshi Koga, Katsuto Hozumi, Ken-ichi Hirano, Masaki Yazawa, Tommy Terooatea, Aki Minoda, Takashi Nagasawa, Shigeo Koyasu, Kazuyo Moro
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Microbiology
Ho Namkoong, Makoto Ishii, Hideki Fujii, Kazuma Yagi, Takahiro Asami, Takanori Asakura, Shoji Suzuki, Ahmed E. Hegab, Hirofumi Kamata, Sadatomo Tasaka, Koji Atarashi, Nobuhiro Nakamoto, Satoshi Iwata, Kenya Honda, Takanori Kanai, Naoki Hasegawa, Shigeo Koyasu, Tomoko Betsuyaku
Review
Biochemistry & Molecular Biology
Eric Vivier, David Artis, Marco Colonna, Andreas Diefenbach, James P. Di Santo, Gerard Eberl, Shigeo Koyasu, Richard M. Locksley, Andrew N. J. McKenzie, Reina E. Mebius, Fiona Powrie, Hergen Spits
Review
Immunology
Hiroki Kabata, Kazuyo Moro, Shigeo Koyasu
IMMUNOLOGICAL REVIEWS
(2018)
Review
Immunology
Tobias Bald, Marek Wagner, Yulong Gao, Shigeo Koyasu, Mark J. Smyth
SEMINARS IN IMMUNOLOGY
(2019)
Review
Immunology
Marek Wagner, Shigeo Koyasu
TRENDS IN IMMUNOLOGY
(2019)
Article
Cell Biology
Takaharu Sasaki, Kazuyo Moro, Tetsuya Kubota, Naoto Kubota, Tamotsu Kato, Hiroshi Ohno, Susumu Nakae, Hirohisa Saito, Shigeo Koyasu
Article
Cell Biology
Marek Wagner, Kafi N. Ealey, Hiroe Tetsu, Tsuyoshi Kiniwa, Yasutaka Motomura, Kazuyo Moro, Shigeo Koyasu
Article
Multidisciplinary Sciences
Risa Nakamura, Akihiro Yoshizawa, Taeko Moriyasu, Sharmina Deloer, Masachika Senba, Mihoko Kikuchi, Shigeo Koyasu, Kazuyo Moro, Shinjiro Hamano
Article
Immunology
Mami Sumiyoshi, Yui Kotani, Yuki Ikuta, Kazutomo Suzue, Madoka Ozawa, Tomoya Katakai, Taketo Yamada, Takaya Abe, Kana Bando, Shigeo Koyasu, Yasunori Kanaho, Toshio Watanabe, Satoshi Matsuda
Summary: Arf family members Arf1 and Arf6 play crucial roles in T cell survival, while Arf1/6 deficiency contributes to alleviating autoimmune diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiroko Ishihama, Ken Ishii, Shigenori Nagai, Hiroaki Kakinuma, Aya Sasaki, Kenji Yoshioka, Tetsuya Kuramoto, Yuta Shiono, Haruki Funao, Norihiro Isogai, Takashi Tsuji, Yasunori Okada, Shigeo Koyasu, Yoshiaki Toyama, Masaya Nakamura, Mamoru Aizawa, Morio Matsumoto
Summary: In order to prevent infections associated with medical implants, a new antibacterial coating material with significant bactericidal activity has been developed, showing success in inhibiting bacterial biofilm formation by immobilizing ionic silver on hydroxyapatite film.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Hisashi Nomura, Naoko Wada, Hayato Takahashi, Yuko Kase, Jun Yamagami, Shohei Egami, Hisato Iriki, Miho Mukai, Aki Kamata, Hiromi Ito, Hideki Fujii, Tomoyuki Ishikura, Haruhiko Koseki, Takashi Watanabe, Taketo Yamada, Osamu Ohara, Shigeo Koyasu, Masayuki Amagai
Summary: The study reveals that Dsg3-specific B cells in mice do not undergo spontaneous pathogenic class switching in vivo and the induction of pemphigus phenotype is prevented under normal conditions.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Marek Wagner, Shigeo Koyasu
Summary: Innate lymphoid cells (ILCs), enriched in barrier tissues like skin, play a role in immune pathways despite lacking antigen receptors found on T and B cells. They are crucial in controlling melanoma and potentially benefiting patients with skin malignancies through their therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Takuma Misawa, Marek Wagner, Shigeo Koyasu
Summary: ILC2s are tissue-resident immune cells that exist not only in adipose tissue but also in various other tissues such as lung and skin. They can change their functions or distribution depending on the environment and circumstances. This review outlines the recent understanding of ILC2 biology and discusses future directions for ILC2 research, particularly in adipose tissue and metabolic homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Tadashi Takeuchi, Tetsuya Kubota, Yumiko Nakanishi, Hiroshi Tsugawa, Wataru Suda, Andrew Tae-Jun Kwon, Junshi Yazaki, Kazutaka Ikeda, Shino Nemoto, Yoshiki Mochizuki, Toshimori Kitami, Katsuyuki Yugi, Yoshiko Mizuno, Nobutake Yamamichi, Tsutomu Yamazaki, Iseki Takamoto, Naoto Kubota, Takashi Kadowaki, Erik Arner, Piero Carninci, Osamu Ohara, Makoto Arita, Masahira Hattori, Shigeo Koyasu, Hiroshi Ohno
Summary: Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes. Carbohydrate metabolism by gut microbiota plays a crucial role in insulin resistance, and an increase in host-accessible monosaccharides is associated with insulin resistance and host inflammation.