Editorial Material
Immunology
Alexandra I. Wells, Carolyn B. Coyne
Summary: This study found that the loss of NKG2A(+) uNK cells leads to deficient vascularization and restricted fetal growth, indicating the significant impact of NKG2A on vascular remodeling during pregnancy.
Article
Immunology
Wei Liu, Shuman Sheng, Chendi Zhu, Changzhong Li, Yonghui Zou, Chunrun Yang, Zi-Jiang Chen, Fei Wang, Xue Jiao
Summary: Immune dysregulation is associated with adenomyosis, with an increase in CD8+ T-cell number being the predominant alteration. Exhausted NKG2A+CD8+ T-cell subset is associated with the severity of adenomyosis and its number is increased in the eutopic endometrium and ectopic lesions. Increased expression of NKG2A ligand and interleukin-15 in glandular epithelial cells might contribute to CD8+ T-cell exhaustion in adenomyosis.
MUCOSAL IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaomeng Hu, Kathy White, Ari G. G. Olroyd, Rowena DeJesus, Antonia A. A. Dominguez, William E. E. Dowdle, Annabelle M. M. Friera, Chi Young, Frank Wells, Elaine Y. Y. Chu, Cade Ellis Ito, Harini Krishnapura, Surbhi Jain, Ramya Ankala, Trevor J. J. McGill, August Lin, Kyla Egenberger, Allison Gagnon, J. Michael Rukstalis, Nathaniel J. J. Hogrebe, Corie Gattis, Ron Basco, Jeffrey R. R. Millman, Paul Kievit, Mark M. M. Davis, Lewis L. L. Lanier, Andrew J. J. Connolly, Tobias Deuse, Sonja Schrepfer
Summary: Genetic engineering has been used to generate allogeneic cell therapeutics that can prevent rejection by the recipient's immune system. This breakthrough could eliminate the need for immunosuppressive drugs and enable large-scale manufacturing of off-the-shelf cell products.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Nicolas Huot, Philippe Rascle, Nicolas Tchitchek, Benedikt Wimmer, Caroline Passaes, Vanessa Contreras, Delphine Desjardins, Christiane Stahl-Hennig, Roger Le Grand, Asier Saez-Cirion, Beatrice Jacquelin, Michaela Mueller-Trutwin
Summary: The study showed that NKG2(a/c)(+)CD8(+) T cells increased in the blood and intestine of AGM in response to SIVagm infection, indicating a potential regulatory role in intestinal inflammation during SIV/HIV infections. The NKG2(a/c)(+)CD8(+) T cells expressed NK cell receptors and molecules with cytotoxic effector, gut homing, and immunoregulatory functions.
Article
Cell Biology
Seong Jin Choi, June-Young Koh, Min-Seok Rha, In-Ho Seo, Hoyoung Lee, Seongju Jeong, Su-Hyung Park, Eui-Cheol Shin
Summary: Subsets of human CD8+ T cells express inhibitory NK cell receptors, KIRs and NKG2A. These receptors are mutually exclusive in their expression and have distinct phenotypic and functional characteristics. KIR+CD8+ T cells are more differentiated, senescent, and responsive to IL2R8, while NKG2A+CD8+ T cells are more responsive to IL12R81, IL12R82, and IL18R8, and exhibit strong IFN-g production and NK-like cytotoxicity in response to IL-15.
Article
Oncology
Linda Borst, Marjolein Sluijter, Gregor Sturm, Pornpimol Charoentong, Saskia J. Santegoets, Mandy Gulijk, Marit J. van Elsas, Christianne Groeneveldt, Nadine van Montfoort, Francesca Finotello, Zlatko Trajanoski, Szymon M. Kielbasa, Sjoerd H. van der Burg, Thorbald van Hall
Summary: The study found that NKG2A is a late inhibitory receptor, expressed after repeated antigen stimulations, and its expression kinetics is similar to TIM-3 and CD39. NKG2A expression is associated with cell division and promoted by TGF-beta, potentially marking actively dividing tumor-specific TILs.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Nicholas G. Battaglia, Joseph D. Murphy, Taylor P. Uccello, Angela Hughson, Nicholas W. Gavras, Johnathan J. Caldon, Scott A. Gerber, Edith M. Lord
Summary: Radiotherapy is commonly used for treating solid tumors. Combining immune checkpoint blockade with radiotherapy can improve survival, but not all patients respond to this combination therapy. This study investigates the role of NKG2A and its ligand Qa-1(b) in regulating the response to radiotherapy, and suggests that blocking NKG2A in combination with immune checkpoint blockade may improve clinical response.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Berengere Salome, John P. Sfakianos, Daniel Ranti, Jorge Daza, Christine Bieber, Andrew Charap, Christian Hammer, Romain Banchereau, Adam M. Farkas, Dan Fu Ruan, Sudeh Izadmehr, Daniel Geanon, Geoffrey Kelly, Ronaldo M. de Real, Brian Lee, Kristin G. Beaumont, Sanjana Shroff, Yuanshuo A. Wang, Ying-chih Wang, Tin Htwe Thin, Monica Garcia-Barros, Everardo Hegewisch-Solloa, Emily M. Mace, Li Wang, Timothy O'Donnell, Diego Chowell, Ruben Fernandez-Rodriguez, Mihaela Skobe, Nicole Taylor, Seunghee Kim-Schulze, Robert P. Sebra, Doug Palmer, Eleanor Clancy-Thompson, Scott Hammond, Alice O. Kamphorst, Karl-Johan Malmberg, Emanuela Marcenaro, Pedro Romero, Rachel Brody, Mathias Viard, Yuko Yuki, Maureen Martin, Mary Carrington, Reza Mehrazin, Peter Wiklund, Ira Mellman, Sanjeev Mariathasan, Jun Zhu, Matthew D. Galsky, Nina Bhardwaj, Amir Horowitz
Summary: In bladder tumors, the expression of NKG2A on CD8(+) T cells is associated with improved survival and responsiveness to PD-L1 blockade immunotherapy. NKG2A(+) PD-1+ CD8(+) T cells exhibit innate-like mechanisms to react to HLA-I-deficient tumors, distinguishing them from exhausted T cells.
Article
Immunology
Heng Xu, Zhu Zhu, Jian Hu, Jiawei Sun, Yan Wo, Xianshu Wang, Hongzhi Zou, Bin Li, Yixin Zhang
Summary: This study found that downregulation of cytotoxic CD8(+) T cells is a specific signature of keloids. Additionally, the upregulation of the NKG2A/CD94 complex and high levels of soluble human leukocyte antigen-E (sHLA-E) were associated with keloid formation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Yawei Liu, Robert Bockermann, Mahdieh Hadi, Iman Safari, Belinda Carrion, Marie Kveiborg, Shohreh Issazadeh-Navikas
Summary: ADAM12 is identified as a costimulatory molecule in T cells that mimics CD28 signaling to activate and induce proliferation of Th1 cells. Lack of genomic ADAM12 in T cells diminishes T-bet and IFN gamma production in Th1 cells, providing a potential target for the treatment of Th1-mediated diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Anna Vyborova, Anke Janssen, Lucrezia Gatti, Froso Karaiskaki, Austin Yonika, Sanne van Dooremalen, Jasper Sanders, Dennis X. Beringer, Trudy Straetemans, Zsolt Sebestyen, Juergen Kuball
Summary: This study highlights the role of CDR3δ in modulating T-cell responses and identifies a CDR3δ bias in the NKR landscape of gamma 9 delta 2T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Joseph S. Dolina, Natalija Van Braeckel-Budimir, Graham D. Thomas, Shahram Salek-Ardakani
Summary: Recent research has revealed the heterogeneity within the exhausted CD8(+) T cell lineage, which consists of multiple interconnected subpopulations with distinct characteristics and locations. This understanding calls for a re-focusing of cancer immunotherapies on targeting the driver mechanisms underlying CD8(+) T(ex) development to stabilize functional subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lourdes Gimeno, Isabel Gonzalez-Lozano, Maria F. Soto-Ramirez, Maria V. Martinez-Sanchez, Pedro Lopez-Cubillana, Jose L. Fuster, Jeronimo Martinez-Garcia, Jorge Martinez-Escribano, Jose A. Campillo, Eduardo Pons-Fuster, Belen Ferri, Alicia Lopez-Abad, Manuel Muro, Alfredo Minguela
Summary: The study found that the M/T dimorphism at position -21 of the HLA-B leader peptide is associated with survival and CD226 expression in cancer patients, with higher expression in patients with more methionines. CD8(+) T lymphocytes from healthy donors with -21 M showed higher proliferation rates and lower expression of TIGIT after in vitro stimulation.
Article
Oncology
Kathleen Ducoin, Romain Oger, Linda Bilonda Mutala, Cecile Deleine, Nicolas Jouand, Juliette Desfrancois, Juliette Podevin, Emilie Duchalais, Jonathan Cruard, Houssem Benlalam, Nathalie Labarriere, Celine Bossard, Anne Jarry, Nadine Gervois-Segain
Summary: In colorectal cancer, the NKG2A(+) CD8(+) T lymphocyte subpopulation shows enrichment in tumors, terminal exhaustion status, co-expression of other immune checkpoints, high functional avidity, and inhibition of anti-tumor reactivity that can be overcome by blocking NKG2A.
Review
Immunology
Tamar Nizharadze, Nils B. Becker, Thomas Hoefer
Summary: This study uses mathematical inference to establish quantitatively testable models of mammalian CD8+ T cell memory development based on complex experimental data. Previous inference studies have shown that precursors of memory T cells develop early in the immune response. Recent work has validated a crucial prediction of this T cell diversification model and refined the model.
TRENDS IN IMMUNOLOGY
(2023)