Article
Multidisciplinary Sciences
Qing Ye, Chao Zhou, Sisi Li, Jingjing Wang, Fei Liu, Zhixia Liu, Jianhua Mao, Haidong Fu
Summary: This study analyzed the immune cell characteristics of patients with nephrotic syndrome, finding immune cell imbalances including T cells, B cells, Monocytes, and NK cells, confirming the involvement of immune factors in the pathogenesis of nephrotic syndrome.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Andrea Angeletti, Maurizio Bruschi, Xhuliana Kajana, Edoardo La Porta, Sonia Spinelli, Gianluca Caridi, Francesca Lugani, Enrico Eugenio Verrina, Gian Marco Ghiggeri
Summary: Nephrotic syndrome affects a small percentage of children each year, with steroids being the primary treatment option. However, there is a subset of patients who do not respond to steroids and are at risk for end stage kidney disease. Immune treatments have been explored as an alternative, but have shown limited effectiveness. A new hypothesis-driven treatment approach involving the combination of rituximab and daratumumab is proposed, aiming to target the entire B-cell subtypes pool.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Maximilian Webendoerfer, Linda Reinhard, Rolf A. K. Stahl, Thorsten Wiech, Hans-Willi Mittruecker, Sigrid Harendza, Elion Hoxha
Summary: This study found that rituximab can induce remission of proteinuria in patients with MCD even if circulating B cells are absent. CD20(+) T cells may play a role in the pathogenesis of MCD and might be a promising treatment target in patients with MCD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Transplantation
Cihan Heybeli, Stephen B. Erickson, Fernando C. Fervenza, Marie C. Hogan, Ladan Zand, Nelson Leung
Summary: Relapse is common in adults with MCD. Patients treated with RTX may be less likely to require a change in treatment and more likely to discontinue immunosuppressive drugs.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Urology & Nephrology
Cheng Xue, Bo Yang, Jing Xu, Chenchen Zhou, Liming Zhang, Xiang Gao, Bing Dai, Shengqiang Yu, Zhiguo Mao, Changlin Mei, Chenggang Xu
Summary: Rituximab (RTX) may be an effective and relatively safe alternative for the treatment of adult frequent-relapsing or steroid-dependent nephrotic syndrome patients. Patients with minimal change disease have a higher complete remission rate with RTX, while those with focal segmental glomerulosclerosis have a lower remission rate and further investigation is needed on long-term adverse events.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Urology & Nephrology
Lan Lan, Yuxin Lin, Binfeng Yu, Yin Wang, Hong Pan, Huijing Wang, Xiaowei Lou, Xiabing Lang, Qiankun Zhang, Lie Jin, Yi Yang, Liang Xiao, Jianghua Chen, Fei Han
Summary: Rituximab has been shown to be effective and safe in adult FR/SDNS patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), maintaining disease remission and minimizing corticosteroid exposure.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Federica Casiraghi, Marta Todeschini, Manuel Alfredo Podesta, Marilena Mister, Barbara Ruggiero, Matias Trillini, Camillo Carrara, Olimpia Diadei, Alessandro Villa, Ariela Benigni, Giuseppe Remuzzi
Summary: Immune dysregulation plays a key role in the pathogenesis of steroid-dependent/frequently relapsing nephrotic syndrome (SDNS/FRNS). However, no major B- or T-cell alterations have been described for adults, unlike in pediatric cases. This study found that patients with SDNS/FRNS have expansion of memory B cells and reduced memory Tregs. The levels of CD45RO(+) Tregs at baseline may help predict which patients will achieve sustained remission following rituximab infusion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Hongbo Xiao, Friedhelm Hildebrandt
Summary: By analyzing patients with SRNS using WES, we identified genetic mutations causing nephritic syndrome in these patients, providing strong evidence for the importance of clinical genetic testing in patients with proteinuria.
PEDIATRIC NEPHROLOGY
(2022)
Article
Pediatrics
Rasheed A. Gbadegesin, Loren P. Herrera Hernandez, Patrick D. Brophy
Summary: Minimal change disease is the most common cause of nephrotic syndrome worldwide, with corticosteroids being the main treatment, but high relapse rates and development of steroid resistance in some patients. A subset of patients initially sensitive to steroids may later become steroid resistant, with 80% of them developing disease recurrence post transplantation.
FRONTIERS IN PEDIATRICS
(2021)
Article
Rheumatology
Venkat R. Reddy, Ruth J. Pepper, Kavina Shah, Geraldine Cambridge, Scott R. Henderson, Christian Klein, Loren Kell, Samuel J. Taylor, David A. Isenberg, Mark S. Cragg, Maria J. Leandro
Summary: This study investigated the factors contributing to the variability of rituximab-mediated B cell depletion (BCD) in systemic lupus erythematosus (SLE). The results showed that BCD was less efficient in SLE compared to rheumatoid arthritis (RA). B cells were detectable in renal biopsy samples of SLE patients who had a poor response to rituximab. No significant relationships were found between peripheral BCD and patient demographics or B cell surface protein expression. Obinutuzumab was more efficient than rituximab at inducing BCD.
Article
Pharmacology & Pharmacy
Yewei Chen, Qian Shen, Min Dong, Ye Xiong, Hong Xu, Zhiping Li
Summary: The study aimed to investigate the pharmacokinetics of rituximab in pediatric patients with FRNS/SDNS, showing a significant increase in drug clearance in this patient population. It suggests that higher doses or more frequent regimens of rituximab may be needed for optimal therapeutic effects in patients with FRNS/SDNS, warranting further clinical studies with more patients to confirm this result.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Qing Ye, Yuzhou Li, Huihui Liu, Jianhua Mao, Hangjin Jiang
Summary: This study constructed a prediction model to accurately predict the responsiveness of nonhereditary SRNS patients to steroids. The model selected 26 clinical variables as predictive indicators and achieved an accuracy of 94.0%, which can help guide the selection of treatment methods for children with nonhereditary SRNS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Manuela Colucci, Andrea Angeletti, Federica Zotta, Rita Carsetti, Francesca Lugani, Lucilla Rava, Pietro Ravani, Francesco Emma, Gian Marco Ghiggeri, Marina Vivarelli
Summary: B-cell depleting anti-CD20 monoclonal antibodies have proven efficacy in children with frequently relapsing/steroid-dependent nephrotic syndrome. In this study, older age and lower levels of memory B cells at the time of anti-CD20 infusion were associated with a lower risk of relapse.
KIDNEY INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Farahnak Assadi, Mojgan Mazaheri, Simin Sadeghi-Bodj
Summary: This study indicates that maintenance therapy using mycophenolate mofetil (MMF) is more effective than cyclosporine (CYC) in children with initial steroid-resistant nephrotic syndrome, with fewer adverse events. Further high-quality randomized controlled trials with long-term follow-up are needed to identify potential long-term complications.
Article
Transplantation
Julie Oniszczuk, Asma Beldi-Ferchiou, Etienne Audureau, Imane Azzaoui, Valerie Molinier-Frenkel, Vincent Frontera, Alexandre Karras, Anissa Moktefi, Evangeline Pillebout, Mohamad Zaidan, Khalil El Karoui, Marie-Helene Delfau-Larue, Carole Henique, Mario Ollero, Dil Sahali, Matthieu Mahevas, Vincent Audard
Summary: In untreated adult patients with MCNS, an increase in the proportion of circulating plasmablasts seems to be a hallmark, and is significantly associated with proteinuria levels, albumin levels, and immunoglobulin levels. Further studies are needed to determine the phenotype and functions of these cells.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Jun Tsunezumi, Hidekazu Sugiura, Lalhaba Oinam, Aktar Ali, Bui Quoc Thang, Aiko Sada, Yoshito Yamashiro, Makoto Kuro-O, Hiromi Yanagisawa
Article
Otorhinolaryngology
Norio Kondo, Takahito Moriyama, Mayako Tachikawa, Erika Tomita, Ai Hattori, Yukie Yamamura, Manabu Nonaka
AURIS NASUS LARYNX
(2019)
Article
Urology & Nephrology
Takahiro Kamiyama, Takahito Moriyama, Saeko Kumon, Kazunori Karasawa, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Article
Urology & Nephrology
Marie Nakano, Kazunori Karasawa, Takahito Moriyama, Keiko Uchida, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Article
Medicine, General & Internal
Hiroshi Kataoka, Toshio Mochizuki, Taro Akihisa, Kentaro Kawasoe, Keiko Kawachi, Shiho Makabe, Anri Sawada, Shun Manabe, Masayo Sato, Nobuyuki Amemiya, Michihiro Mitobe, Takafumi Akanuma, Yasuko Ito, Takahiro Inoue, Tomo Suzuki, Katsuomi Matsui, Takahito Moriyama, Shigeru Horita, Mamiko Ohara, Kazuho Honda, Kosaku Nitta
Article
Urology & Nephrology
Takahito Moriyama
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Correction
Urology & Nephrology
Marie Nakano, Kazunori Karasawa, Takahito Moriyama, Keiko Uchida, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Article
Medicine, General & Internal
Kazunori Karasawa, Yuko Iwabuchi, Mizuki Kyoda, Taro Akihisa, Erika Yamaguchi, Shunji Suzuki, Shota Ogura, Tomo Takabe, Yoei Miyabe, Takahiro Kamiyama, Marie Nakano, Shun Manabe, Michiaki Kamiyama, Kenichi Akiyama, Masayo Sato, Keiko Uchida, Kosaku Nitta, Takahito Moriyama
Article
Urology & Nephrology
Yoei Miyabe, Kazunori Karasawa, Tomo Takabe, Shota Ogura, Naoko Sugiura, Mizuki Kyoda, Wataru Ono, Kenichi Akiyama, Nobue Tanaka, Takahito Moriyama, Norio Hanafusa, Keiko Uchida, Ken Tuchiya, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2020)
Article
Urology & Nephrology
Saeko Kumon, Takahito Moriyama, Takahiro Kamiyama, Kazunori Karasawa, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2020)
Letter
Immunology
Kazunori Karasawa, Shota Ogura, Yoei Miyabe, Kenichi Akiyama, Kosaku Nitta, Takahito Moriyama
CLINICAL IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Takahito Moriyama, Kazunori Karasawa, Yoei Miyabe, Kenichi Akiyama, Shota Ogura, Tomo Takabe, Naoko Sugiura, Momoko Seki, Yuko Iwabuchi, Keiko Uchida, Kosaku Nitta
SCIENTIFIC REPORTS
(2020)
Article
Urology & Nephrology
Takahito Moriyama, Hiroshi Kataoka, Kosaku Nitta, Keita Hirano, Keiichi Matsuzaki, Takashi Yasuda, Yoshinari Yasuda, Kentaro Koike, Shoichi Maruyama, Takashi Yokoo, Seiichi Matsuo, Tetsuya Kawamura, Yusuke Suzuki
Summary: This study suggests that the number of steroid pulses does not affect renal outcomes in IgA nephropathy patients with mild proteinuria and good renal function undergoing steroid pulse therapy with tonsillectomy. Treatment adaptation and protocols, such as the number of steroid pulses, should be tailored to individual patient backgrounds.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2021)
Article
Urology & Nephrology
Takahito Moriyama, Kazunori Karasawa, Fumio Hasegawa, Keiko Uchida, Kosaku Nitta
AMERICAN JOURNAL OF NEPHROLOGY
(2019)
Article
Physiology
Yoei Miyabe, Sachiko Sekiya, Naoko Sugiura, Masatoshi Oka, Kazunori Karasawa, Takahito Moriyama, Kosaku Nitta, Tatsuya Shimizu
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)