Article
Respiratory System
Patrick M. Wieruszewski, Heather P. May, Steve G. Peters, Ognjen Gajic, William J. Hogan, Ross A. Dierkhising, Hassan B. Alkhateeb, Hemang Yadav
Summary: PERDS is a common complication following autologous HCT, associated with higher mortality and healthcare utilization. Radiographic evidence of pulmonary involvement precedes hematopoietic recovery. Risk factors for PERDS include female sex, number of platelet transfusions, and more rapid engraftment.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Hematology
Viviane Gournay, Guillaume Dumas, Jean-Remi Lavillegrand, Geoffroy Hariri, Tomas Urbina, Jean-Luc Baudel, Hafid Ait-Oufella, Eric Maury, Eolia Brissot, Ollivier Legrand, Florent Malard, Mohamad Mohty, Bertrand Guidet, Remy Dulery, Naike Bige
Summary: The study found that haploidentical transplantation does not affect the prognosis of critically ill patients undergoing allogeneic hematopoietic stem cell transplant (alloHCT). However, patients receiving sequential conditioning and those requiring invasive mechanical ventilation (MV) had higher in-hospital mortality and decreased overall survival.
ANNALS OF HEMATOLOGY
(2021)
Article
Virology
Sebastien Barral, Aline Mamin, Carole Dantin, Stavroula Masouridi-Levrat, Yves Chalandon, Laurent Kaiser, Diem-Lan Vu
Summary: This retrospective observational study found that rhinovirus infections are the most common in allo-HSCT patients, including pre-transplant infections. However, the mortality rate due to pre-transplant RVIs is low.
Article
Oncology
Annabelle J. Anandappa, Gabriela S. Hobbs, Bimalangshu R. Dey, Areej El-Jawahri, Matthew J. Frigault, Steven L. McAfee, Paul V. O'Donnell, Thomas R. Spitzer, Yi-Bin Chen, Zachariah DeFilipp
Summary: Ruxolitinib, a selective inhibitor of Janus kinases 1 and 2, is increasingly used in allogeneic hematopoietic cell transplantation (HCT) recipients, with potential complications including acute hypoxemic respiratory failure upon discontinuation. However, systemic corticosteroids and reinitiation of ruxolitinib have shown to result in rapid clinical improvement in affected patients. Further research is necessary to characterize the biological and clinical effects of ruxolitinib discontinuation in this patient population.
Article
Biophysics
Catherina Lueck, Asterios Tzalavras, Philipp Wohlfarth, Elisabeth Meedt, Michael Kiehl, Amin T. Turki, Marius M. Hoeper, Matthias Eder, Julia Cserna, Nina Buchtele, Daniel Wolff, Peter Schellongowski, Gernot Beutel, Tobias Liebregts
Summary: Chronic graft-vs-host disease has a major impact on non-relapse mortality, but data on ICU outcomes are lacking. The study found that severe liver, intestinal, or pulmonary cGvHD is associated with worse outcomes.
BONE MARROW TRANSPLANTATION
(2023)
Article
Respiratory System
Svetlana Herasevich, Ryan D. Frank, Hong Bo, Hassan Alkhateeb, William J. Hogan, Ognjen Gajic, Hemang Yadav
Summary: The study identified several pretransplant risk factors for the development of ARDS after HCT, including decreased pulmonary function, abnormal laboratory indices, history of hospitalization, and specific drug exposure. This information could be valuable in predicting and preventing ARDS in HCT patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Oncology
Ludmila Stepanovna Zubarovskaya, Ivan Sergeevich Moiseev, Maria Dmidrievna Vladovskaya, Natalia Borisovna Mikhailova, Elena Vladislavovna Morozova, Tatyana Alexandrovna Bykova, Yulia Yurievna Vlasova, Olesya Vladimirovna Paina, Ilya Viktorovich Kazantsev, Olga Alexandrovna Slesarchuk, Anna Gennadyevna Smirnova, Anna Alekseevna Osipova, Liliya Vladimirovna Stelmakh, Alexey Yurievich Polushin, Oleg Valerievich Goloshchapov, Maxim Pavlovich Bogomolny, Maria Arkadievna Estrina, Marina Olegovna Popova, Maxim Anatolievich Kucher, Alisa Georgievna Volkova, Alexander Leonidovich Alyansky, Dmitrii Eduardovich Pevtcov, Natalia Evgenievna Ivanova, Elena Vitalievna Babenko, Nikolai Nikolaevich Mamaev, Tatiana Leonidovna Gindina, Alina Alexandrovna Vitrishchak, Alexei Borisovich Chukhlovin, Elena Vladimirovna Semenova, Sergei Nicolaevich Bondarenko, Alexander Dmitrievich Kulagin, Boris Vladimirovich Afanasyev, Yvonne A. Efebera
Summary: In this single-center analysis, trends in hematopoietic cell transplantations between 1990 and 2022 were evaluated. The study showed improved event-free survival after autologous hematopoietic cell transplantation due to reduced relapse incidence. Additionally, an improvement in event-free survival after allogeneic hematopoietic cell transplantation was observed due to reduced non-relapse mortality. Different diseases showed varying degrees of improvement in survival rates after different types of transplantation.
Article
Oncology
Tatsuya Suwabe, Kyoko Fuse, Kouji Katsura, Marie Soga, Takayuki Katagiri, Yasuhiko Shibasaki, Miwako Narita, Hirohito Sone, Masayoshi Masuko
Summary: Intensive oral care following allogeneic hematopoietic stem-cell transplantation can significantly reduce the incidence of post-engraftment bloodstream infection, particularly those caused by coagulase-negative staphylococci.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Infectious Diseases
Yan Jia, Ya Liu, Yi Liu, Kaitai Yang, Yanfeng Liu
Summary: This study investigated the clinical characteristics and prognosis of Burkholderia cepacia (BC) infection in hematopoietic stem cell transplantation (HSCT) patients. The results showed that BC infection increased the risk of death in patients, especially when combined with respiratory failure. Procalcitonin and septic shock were identified as independent risk factors for death.
BMC INFECTIOUS DISEASES
(2022)
Review
Cell Biology
Stefania Crippa, Ludovica Santi, Margherita Berti, Giada De Ponti, Maria Ester Bernardo
Summary: The human organism requires the production of approximately 1 trillion new blood cells per day through hematopoiesis in the bone marrow, regulated by the BM microenvironment and HSPCs. The BM niche, defined by interactions between HSPCs and non-hematopoietic cells, controls HSPC maintenance and orchestrates hematopoiesis according to the body's needs. Mesenchymal stromal cells (MSCs) play a key role in the BM niche by regulating HSPC homeostasis and impacting the outcome of hematopoietic stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Hematology
Tugba Barlas, Kamil Inci, Gulbin Aygencel, Melda Turkoglu, Ozlem Guzel Tunccan, Ferda Can, Lale Aydin Kaynar, Zubeyde Nur Ozkurt, Zeynep Arzu Yegin, Munci Yagci
Summary: This study investigated data of HSCT patients admitted to the Hematology ICU, finding sepsis and acute respiratory failure as common reasons for admission. The ICU mortality rate was 45.2% and APACHE II score was identified as an independent risk factor for mortality.
Article
Infectious Diseases
Wen Song, Xiaochao Song, Yinting Zhu, Yalu Ren, Jie Xu, Qiongfang Zhu
Summary: This retrospective cohort study analyzed the microbiological characteristics and 30-day all-cause mortality in patients with bloodstream infections after hematopoietic stem cell transplantation. Gram-negative bacteria were the most common pathogens, and showed high resistance rates to common antibiotics. Fungal infections and non-Hodgkin's lymphoma were associated with higher 30-day mortality.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Immunology
Yukun He, Jia Li, Wenyi Yu, Yali Zheng, Donghong Yang, Yu Xu, Lili Zhao, Xinqian Ma, Pihua Gong, Zhancheng Gao
Summary: The study found that the lower respiratory tract microbiome characteristics in patients with post-HSCT pneumonia are different from those with CAP and healthy controls, which may be associated with the patient's outcome. High abundance of Actinobacteria and low abundance of Bacteroidetes were observed in post-HSCT pneumonia samples. Pathogenic bacteria such as Pseudomonas, Acinetobacter, Burkholderia, and Mycobacterium were prominent in the pneumonia group after HSCT.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Respiratory System
Robert F. Tamburro, Kenneth R. Cooke, Stella M. Davies, Samuel Goldfarb, James S. Hagood, Ashok Srinivasan, Marie E. Steiner, Dennis Stokes, Nancy DiFronzo, Nahed El-Kassar, Nonniekaye Shelburne, Aruna Natarajan
Summary: Approximately 2,500 pediatric hematopoietic cell transplants, mostly allogeneic, are performed annually in the United States for life-threatening malignant and nonmalignant conditions. Post-HCT complications, with pulmonary dysfunction as the leading cause of nonrelapse mortality, limit successful outcomes. A multidisciplinary group of 33 experts convened to address knowledge gaps and research strategies to improve outcomes.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Hematology
Diego A. Pereira-Martins, Juan L. Coelho-Silva, Isabel Weinhauser, Pedro L. Franca-Neto, Douglas R. Silveira, Cesar Ortiz, Amanda Moreira-Aguiar, Marinus M. Lima, Luisa C. Koury, Raul A. de Melo, Ana B. Gloria, Evandro M. Fagundes, Bruno K. Lino, Katia Pagnano, Rosane Bittencourt, Elenaide Nunes, Fabiola Traina, Lorena Figueiredo-Pontes, Armand Keating, Martin S. Tallman, Raul C. Ribeiro, Richard Dilon, Arnold Ganser, Miguel A. Sanz, Nancy Berliner, Peter Valk, Bob Lowenberg, Tiziana Ottone, Nelida Noguera, Maria T. Voso, Francesca Paoloni, Paola Fazi, Emanuele Ammatuna, Gerwin Huls, Jan Jacob Schuringa, Eduardo M. Rego, Antonio R. Lucena-Araujo
Summary: A growing body of evidence indicates that higher-than-normal mitochondrial DNA content (mtDNAc) is associated with better prognosis in acute promyelocytic leukemia (APL) patients, regardless of tumor burden. This effect is more pronounced in low-risk patients. The multivariate Cox proportional hazard model reveals that high mtDNAc is independently associated with a decreased cumulative incidence of relapse. These findings highlight the potential role of mitochondrial metabolism in APL patients treated with ATRA.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Hendrik Eggers, Lea Haebel, Arnold Ganser, Viktor Gruenwald, Roland Merten, Athanasia Warnecke, Martin Durisin, Philipp Ivanyi
Summary: The application of cetuximab in palliative first-line therapy for R/M HNSCC patients can significantly improve overall survival, according to the study.
CANCER INVESTIGATION
(2023)
Article
Respiratory System
Marc Humbert, Gabor Kovacs, Marius M. Hoeper, Roberto Badagliacca, Rolf M. F. Berger, Margarita Brida, Jorn Carlsen, Andrew J. S. Coats, Pilar Escribano-Subias, Pisana Ferrari, Diogenes S. Ferreira, Hossein Ardeschir Ghofrani, George Giannakoulas, David G. Kiely, Eckhard Mayer, Gergely Meszaros, Blin Nagavci, Karen M. Olsson, Joanna Pepke-Zaba, Jennifer K. Quint, Goran Radegran, Gerald Simonneau, Olivier Sitbon, Thomy Tonia, Mark Toshner, Jean Luc Vachiery, Anton Vonk Noordegraaf, Marion Delcroix, Stephan Rosenkranz
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Hossein-Ardeschir Ghofrani, Pilar Escribano Subias, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Janethe de Oliveira Pena, David B. Badesch
Summary: In participants with pulmonary arterial hypertension, 24 weeks of sotatercept resulted in a significant reduction in pulmonary vascular resistance. This study reports the longer-term safety and efficacy of sotatercept in the PULSAR open-label extension, showing that sotatercept has good safety and efficacy in patients with pulmonary arterial hypertension.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Stephan Rosenkranz, Christine Pausch, John G. Coghlan, Doerte Huscher, David Pittrow, Ekkehard Gruenig, Gerd Staehler, Carmine Dario Vizza, Henning Gall, Oliver Distler, Marion Delcroix, Hossain A. Ghofrani, Ralf Ewert, Han -Joachim Kabitz, Dirk Skowasch, Juergen Behr, Katrin Milger, Michael Halank, Heinrike Wilkens, Hans-Juergen Seyfarth, Matthias Held, Laura Scelsi, Claus Neurohr, Anton Vonk-Noordegraaf, Silvia Ulrich, Hans Klose, Martin Claussen, Stephan Eisenmann, Kai-Helge Schmidt, Bjoern Andrew Remppis, Andris Skride, Elena Jureviciene, Lina Gumbiene, Skaidrius Miliauskas, Judith Loeffler-Ragg, Tobias J. Lange, Karen M. Olsson, Marius M. Hoeper, Christian Opitz
Summary: This study analyzed the response to PAH therapy in IPAH patients and compared the differences between patients without comorbidities, those with 1-2 comorbidities, and those with 3-4 comorbidities. The results showed that patients with comorbidities had smaller improvements in functional class, 6-minute walking distance, BNP/NT-pro-BNP, and mortality risk compared to patients without comorbidities. However, the 4-strata risk tool predicted the outcome in IPAH patients regardless of the presence of comorbidities.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Biophysics
Catherina Lueck, Asterios Tzalavras, Philipp Wohlfarth, Elisabeth Meedt, Michael Kiehl, Amin T. Turki, Marius M. Hoeper, Matthias Eder, Julia Cserna, Nina Buchtele, Daniel Wolff, Peter Schellongowski, Gernot Beutel, Tobias Liebregts
Summary: Chronic graft-vs-host disease has a major impact on non-relapse mortality, but data on ICU outcomes are lacking. The study found that severe liver, intestinal, or pulmonary cGvHD is associated with worse outcomes.
BONE MARROW TRANSPLANTATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Stephan Rosenkranz, Marion Delcroix, George Giannakoulas, Marius M. Hoeper, Gabor Kovacs, Marc Humbert
EUROPEAN HEART JOURNAL
(2023)
Article
Respiratory System
J. Gerry Coghlan, Sean Gaine, Richard Channick, Kelly M. Chin, Camille du Roure, J. Simon R. Gibbs, Marius M. Hoeper, Irene M. Lang, Stephen C. Mathai, Vallerie V. McLaughlin, Lada Mitchell, Gerald Simonneau, Olivier Sitbon, Victor F. Tapson, Nazzareno Galie
Summary: Further understanding of when to initiate therapies in pulmonary arterial hypertension (PAH) is important to improve long-term outcomes. Post hoc analyses of GRIPHON (NCT01106014) and exploratory analyses of TRITON (NCT02558231) suggested benefit of early selexipag initiation on long-term outcomes, despite no additional benefit versus initial double combination on haemodynamic and functional parameters in TRITON. These post hoc, pooled analyses build on previous insights, further supporting selexipag use within 6 months of diagnosis, including as part of triple therapy, to delay disease progression.
Article
Respiratory System
Hunter Gillies, Ralph Niven, Benjamin T. Dake, Murali M. Chakinala, Jeremy P. Feldman, Nicholas S. Hill, Marius M. Hoeper, Marc Humbert, Vallerie V. McLaughlin, Martin Kankam
Summary: AV-101, a dry powder inhaled formulation of imatinib, was well tolerated in healthy adults and significantly reduced the systemic exposure of imatinib compared with oral imatinib. An ongoing study will evaluate the safety, tolerability, and clinical benefit of AV-101 for pulmonary arterial hypertension.
Article
Medicine, General & Internal
Marius M. Hoeper, David B. Badesch, H. Ardeschir Ghofrani, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Vallerie V. McLaughlin, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Ekkehard Gruenig, Grzegorz Kopec, Gisela Meyer, Karen M. Olsson, Stephan Rosenkranz, Yayun Xu, Barry Miller, Marcie Fowler, John Butler, Joerg Koglin, Janethe de Oliveira Pena, Marc Humbert
Summary: This study confirms that in patients with stable background therapy, sotatercept can significantly improve the exercise capacity of patients with pulmonary arterial hypertension compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Respiratory System
Gerald Simonneau, Elie Fadel, Anton Vonk Noordegraaf, Mark Toshner, Irene M. Lang, Frederikus A. Klok, Micheal C. McInnis, Nicholas Screaton, Michael M. Madani, Guillermo Martinez, Kiran Salaunkey, David P. Jenkins, Hiromi Matsubara, Philippe Brenot, Marius M. Hoeper, Hossein A. Ghofrani, Xavier Jais, Christoph B. Wiedenroth, Stefan Guth, Nick H. Kim, Joanna Pepke-Zaba, Marion Delcroix, Eckhard Mayer
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism caused by persistent obstruction of the pulmonary arteries. It requires timely and accurate diagnosis through imaging and haemodynamic assessment. Optimal therapy should be determined by an experienced multidisciplinary CTEPH team. This report summarizes current knowledge and key messages from the International CTEPH Conference, covering various aspects of the disease.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Hematology
Peter Hokland, Isolda I. Fernandez, Sylvie D. Freeman, Bjorn T. Gjertsen, Jie Jin, Vidh Murthy, Masamitsu Yanada, Arnold Ganser
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Mardi Gomberg-Maitland, Vallerie V. Mclaughlin, David B. Badesch, Hossein-Ardeschir Ghofrani, Marius M. Hoeper, Marc Humbert, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Janethe de Oliveira Pena, Jonathan T. Lu, Solaiappan Manimaran, J. Simon R. Gibbs
JACC-HEART FAILURE
(2023)
Article
Oncology
Katrin Teich, Michael Stadler, Razif Gabdoulline, Jyoti Kandarp, Clara Wienecke, Bennet Heida, Piroska Klement, Konstantin Buttner, Letizia Venturini, Martin Wichmann, Wolfram Puppe, Christian Schultze-Florey, Christian Koenecke, Gernot Beutel, Matthias Eder, Arnold Ganser, Michael Heuser, Felicitas Thol
Summary: Donor lymphocyte infusions (DLIs) can be used to prevent or treat relapse in acute myeloid leukemia (AML) patients after allogeneic hematopoietic cell transplantation (alloHCT). Measurable residual disease (MRD) is a valuable biomarker for predicting the response and outcome of DLI treatment. This retrospective study showed that MRD status before and after DLI treatment is prognostic for event-free survival, overall survival, cumulative incidence of relapse, and relapse-free survival.
Correction
Cardiac & Cardiovascular Systems
[Anonymous]
EUROPEAN HEART JOURNAL
(2023)