Article
Materials Science, Biomaterials
Zhiyu Li, Yichun Gao, Huinan Zhang, Fang Lan, Yao Wu
Summary: Alterations in plasma membrane glycoproteins have been identified as a hallmark of cancer. A bottom-up strategy using hydrophilic magnetic covalent triazine frameworks (CTFs) was reported to enrich PMGs of breast cancer cells, leading to the discovery of numerous N-glycopeptides and N-glycosites. Comparative analysis based on gene ontology was performed to verify breast cancer biomarkers and differential PMGs' function, suggesting great potential for illuminating the atlas of breast cancer PMGs and the causes of tumor metastasis.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Multidisciplinary
Wai Cheung Chan, Shabnam Sharifzadeh, Sara J. Buhrlage, Jarrod A. Marto
Summary: Covalent drugs are essential in modern medicine, and there has been a recent surge in interest in the development of covalent inhibitors, particularly utilizing mass spectrometry-based chemoproteomic methods. This review highlights the practical applications of these techniques in target identification, hit discovery, and lead characterization/optimization in covalent drug discovery, with case studies to demonstrate their real-world significance and future opportunities.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Food Science & Technology
Nikunj Naliyadhara, Aviral Kumar, Shailendra Kumar Gangwar, Thulsidharan Nair Devanarayanan, Mangala Hegde, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar Kunnumakara
Summary: The human gastrointestinal tract contains a diverse range of microbial species, which play a role in regulating gut barrier homeostasis, immune system stimulation, and neurological health benefits through the gut-brain axis. Dietary changes can significantly affect the gut microbial population, and positive changes can be made by changing dietary style. Dietary antioxidants, such as those found in food, have been found to have a positive impact on gut microbial populations, which can help alleviate gut microbial dysbiosis and contribute to the development of gut microbe-targeting therapeutics for various diseases. This review discusses the health benefits of major dietary antioxidant groups, and the interaction between gut microbiota and these antioxidants through pre-clinical and human dietary interventions.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Applied
Xiangju Liu, Qibin Song, Xin Li, Yunxi Chen, Chang Liu, Xiao Zhu, Jun Liu, Daniel Granato, Yijun Wang, Jinbao Huang
Summary: Conjugates of whey protein isolate (WPI) and four polyphenols were prepared through free-radical grafting in this study. The conjugation process significantly enhanced the antioxidant properties and thermal stabilities of polyphenols, while reducing the surface hydrophobicity of the complexes.
Review
Agriculture, Multidisciplinary
Martine Morzel, Francis Canon, Sylvain Guyot
Summary: This review discusses the effects of polyphenols-saliva interactions on the bioaccessibility or bioavailability of nutrients. It highlights the interactions between salivary proteins and polyphenols, and their impact on digestive processes, such as starch digestion and protein digestibility.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Applied
Yan-Jie Zhang, Na Zhang, Xin-Huai Zhao
Summary: The study revealed that kaempferol and quercetin caused fluorescence quenching in pure caseinate or crosslinked caseinate, while enzymatic crosslinking enhanced caseinate's affinity for these polyphenols. Different types of crosslinking impacted the driving forces, apparent binding constant, and thermodynamic indices of the caseinate-polyphenol interaction.
Review
Cell Biology
Zefeng Chen, Hang Luo, Amu Gubu, Sifan Yu, Huarui Zhang, Hong Dai, Yihao Zhang, Baoting Zhang, Yuan Ma, Aiping Lu, Ge Zhang
Summary: Nucleic acid aptamers are single-stranded DNA or RNA fragments that can specifically recognize targets. However, natural aptamers composed of 4 naturally occurring nucleosides often have inferior binding affinity compared to antibodies. To address this, various high-affinity modification strategies have been developed, such as nucleobase modifications, fluorine modifications, structural alteration modifications, phosphate modifications, and extended alphabets. These modifications enhance the non-covalent bonding between the modified aptamers and target proteins, resulting in significantly improved affinity. This review provides an overview of these high-affinity modification strategies and their effects on the pharmacodynamic properties of aptamers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Applied
Min Wang, Angeles Moron-Ortiz, Jianjun Zhou, Ana Benitez-Gonzalez, Paula Mapelli-Brahm, Antonio J. Melendez-Martinez, Francisco J. Barba
Summary: This study investigated the impact of pressurized liquid extraction (PLE) and DMSO concentration on the yield of antioxidants and minerals from Chlorella. The results showed that PLE increased the antioxidant yield, with 100% DMSO obtaining more polyphenols, chlorophylls, and carotenoids. PLE + 100% DMSO was found to be the most suitable method for the recovery of antioxidants and pigments from Chlorella. The extracts were also found to be a good source of minerals for different populations.
Article
Chemistry, Applied
Peiqing Yang, Wenxin Wang, Zhenzhen Xu, Lei Rao, Liang Zhao, Yongtao Wang, Xiaojun Liao
Summary: This study investigated the pH-dependence of anthocyanin-protein binding mechanisms using cyandin-3-O-glucoside (C3G) and bovine serum albumin (BSA). The results showed that the binding affinity between C3G and BSA was highest at pH 7, followed by pH 5 and pH 3. Molecular dynamics simulation revealed that electrostatic interactions played a crucial role in the binding mechanisms. Anionic quinoidal bases, the most common C3G forms at pH 7, had the highest binding affinity with BSA due to hydrogen bonding with surrounding amino acids.
FOOD HYDROCOLLOIDS
(2023)
Review
Microbiology
Ibrahim E. Sallam, Amr Abdelwareth, Heba Attia, Ramy K. Aziz, Masun Nabhan Homsi, Martin von Bergen, Mohamed A. Farag
Summary: Tannins, a diverse group of polyphenols found in various plant families, especially cereals, fruits, and vegetables, have beneficial pharmacological effects, including anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective properties. Microbiota-mediated hydrolysis of tannins generates highly bioaccessible metabolites, which contribute to the health effects associated with tannin consumption. Understanding the interactions between microbiota and tannins, as well as the metabolism and chemical motifs of tannin metabolites, is crucial for utilizing their biological effects for drug discovery and promoting health benefits.
Review
Food Science & Technology
Jun Li, Jinwei Li, Liuping Fan
Summary: Hyperuricemia is a global epidemic that researchers are focusing on improving through dietary sources. Flavonoids, especially, play a key role in the anti-hyperuricemia effects of dietary sources by inhibiting the production of uric acid.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Applied
Shuang Bi, Xin Pan, Wentao Zhang, Zhuo Ma, Fei Lao, Qun Shen, Jihong Wu
Summary: The molecular structures of flavor compounds have a strong influence on their binding affinity with pea protein. Different functional groups and chain lengths affect the binding abilities of the flavor compounds. Hydrophobic interactions play a dominant role in the binding between (E)-2-octenal/(Z)-2-penten-1-ol and pea protein, while hydrogen bonding is dominant in the binding between hexanal and pea protein.
Article
Food Science & Technology
Ratih W. Wisnuwardani, Stefaan De Henauw, Maria Forsner, Frederic Gottrand, Inge Huybrechts, Antonios G. Kafatos, Mathilde Kersting, Viktoria Knaze, Yannis Manios, Esther Nova, Denes Molnar, Joseph A. Rothwell, Augustin Scalbert, Stefania Sette, Kurt Widhalm, Luis A. Moreno, Nathalie Michels
Summary: European adolescents had low dietary polyphenol intake, and there was no linear association between dietary polyphenols and serum total antioxidant capacity. Future studies should use polyphenol biomarkers and additional antioxidant measures to confirm these findings.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Shirin Pourafshar, Mira Nicchitta, Crystal C. Tyson, Laura P. Svetkey, David L. Corcoran, James R. Bain, Michael J. Muehlbauer, Olga Ilkayeva, Thomas M. O'Connell, Pao-Hwa Lin, Julia J. Scialla
Summary: In a pilot feeding trial, researchers aimed to identify metabolites altered by the DASH diet in plasma and urine. Results showed that the DASH diet led to significant changes in various metabolites, particularly in urine where many phenolic acids and their microbial metabolites were higher. These findings provide insights into the mechanisms of benefit of the DASH diet.
Article
Food Science & Technology
Xiaoyun Fei, Yuzhong Yan, Langhong Wang, Zhaohua Huang, Deming Gong, Guowen Zhang
Summary: This study aimed to investigate the effects of gallic acid (GA)/protocatechuic acid (PA) on the structure and function of whey proteins (WP) through covalent binding. Covalent complexes of WP-PA and WP-GA were prepared at different concentrations using the alkaline method. The results showed that PA/GA was cross-linked to WP through covalent bonds, resulting in a slight loosening of the WP structure. The interaction with GA also increased the emulsion stability index and thermal stability of WP, as well as the antioxidant capacity of WP. These findings provide valuable information for enhancing the functional properties of WP and the application of PA/GA-WP covalent complexes in food emulsifiers.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Food Science & Technology
Paz Otero, M. Carpena, P. Garcia-Oliveira, J. Echave, A. Soria-Lopez, P. Garcia-Perez, M. Fraga-Corral, Hui Cao, Shaoping Nie, Jianbo Xiao, J. Simal-Gandara, M. A. Prieto
Summary: Consumers nowadays are increasingly aware of the relationship between diet and health, leading to a preference for natural products. Seaweeds have emerged as a potential source of bioactive carbohydrates, with numerous polysaccharides arousing the interest of the scientific community due to their biological activities. Environmentally friendly extraction technologies and chemical modification methods have been developed to improve the yield, quality, and applications of seaweed polysaccharides. This review aims to compile current information about seaweed polysaccharides, including extraction and modification methods, biological activities, and future trends for their industrial applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Yong Chen, Jing Wang, Liang Zou, Hui Cao, Xiaoling Ni, Jianbo Xiao
Summary: This review discusses the beneficial effects of dietary proanthocyanidins (PAC) on gastrointestinal functions. The findings suggest that PAC can directly act on the gastrointestinal tract through its antioxidant, antibacterial, anti-inflammatory, and anti-proliferative properties. PAC can also interact with carbohydrates, proteins, and lipids, reducing their digestion and absorption. Additionally, PAC has a prebiotic-like effect on the intestinal microbiota, which may contribute to the potential health benefits.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Zebin Weng, Yuanrong Chen, Tingting Liang, Yajuan Lin, Hui Cao, Haizhao Song, Ling Xiong, Fang Wang, Xinchun Shen, Jianbo Xiao
Summary: Wheat germ protein is a promising source of bioactive peptides with various biological functions. However, there are still scientific issues that need further exploration in the basic research and industrialization process of WGBPs.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Editorial Material
Plant Sciences
Huiyan Fan, Tong Zang, Jieqiong Sheng, Yang Zhou, Guoyin Kai
Review
Medicine, Research & Experimental
Nermeen Yosri, Sultan M. Alsharif, Jianbo Xiao, Syed G. Musharraf, Chao Zhao, Aamer Saeed, Ruichang Gao, Noha S. Said, Alessandro Di Minno, Maria Daglia, Zhiming Guo, Shaden A. M. Khalifa, Hesham R. El-Seedi
Summary: Arctium lappa, also known as burdock, is a medicinal edible plant that has been used in traditional Chinese medicine for centuries. It has demonstrated various pharmacological effects and has potential applications in nanomedicine.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Food Science & Technology
Yongbing Xu, Guilin Chen, Felix Wambua Muema, Jianbo Xiao, Mingquan Guo
Summary: Moringa oleifera Lam. (M. oleifera) is a fast-growing plant with high nutritional and medicinal values. It has been traditionally used to treat various health conditions. Phytochemical studies have revealed the presence of over 300 components in different parts of M. oleifera. Additionally, M. oleifera exhibits numerous pharmacological activities. This work aims to comprehensively review its nutritional components, chemical constituents, pharmacological activities, and applications in functional food products and medicines, providing valuable insights for future research.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Engineering, Chemical
Jiajia Su, Jun Qian, Weihuan Zeng, Yue Wang, Guoyin Kai
Summary: Salvianolic acids are separated from Danshen using a synthesized adsorbent PAPIM, which effectively captures salvianolic acid A (SAA), salvianolic acid B (SAB), and rosmarinic acid (RA). The adsorption follows a pseudo-second-order model and the maximum adsorption capacities are determined. The adsorption mechanism involves covalent bond, electrostatic interaction, hydrogen bond, and stacking interaction. The importance of boronic acid affinity and electrostatic interaction in selective adsorption is confirmed by density functional theory (DFT) calculations. Overall, this work highlights the promising potential of PAPIM in separating salvianolic acids and offers an alternative strategy for selectively separating compounds with multiple interactions.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomasz Baj, Grazyna Kowalska, Radoslaw Kowalski, Jolanta Szymanska, Guoyin Kai, Henrique Douglas Melo Coutinho, Elwira Sieniawska
Summary: Mixture design is a statistical tool that optimizes the composition of a mixture using a minimum number of experiments. In this study, a simplex-lattice mixture design method was used to optimize the composition of a mixture of essential oils from basil, citronella, cedarwood, and thyme. The optimized parameter was the antioxidant activity, and the test results showed a synergistic effect between the components of essential oils. The designed mixture with the highest antioxidant activity consisted of 54.4% citronella essential oil, 33.0% thyme essential oil, 9.2% cedarwood essential oil, and 3.4% basil essential oil.
Article
Agriculture, Multidisciplinary
Jiajia Su, Li Jin, Ruiwen Yang, Yi Liang, Shivraj Hariram Nile, Guoyin Kai
Summary: The polyphenolic constituents of twelve Chinese raspberries were analyzed, and B1 raspberry showed high content of phenolics, flavonoids, and anthocyanins. The ethanol extract of B1 raspberry exhibited strong antioxidant and cytotoxic effects. This suggests the potential therapeutic value of Chinese raspberry as a therapeutic agent, although further research is needed to identify the bioactive compound.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2023)
Review
Food Science & Technology
Huanqi Wu, Shangyuan Sang, Peifang Weng, Daodong Pan, Zufang Wu, Junsi Yang, Lingyi Liu, Mohamed A. Farag, Jianbo Xiao, Lianliang Liu
Summary: Starch-based materials have suitable structural characteristics for 3D food printing inks and possess viscoelasticity, viscous film-forming, dough pseudoplasticity, and rheological properties. 3D food printing technology has significant advantages in customizing personalized and precise nutrition, expanding the range of ingredients, designing unique food appearances, and simplifying the food supply chain.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Review
Food Science & Technology
Fan Zhang, Shengxiong Chen, Jianguo Zhang, Kiran Thakur, Maurizio Battino, Hui Cao, Mohamed A. Farag, Jianbo Xiao, Zhaojun Wei
Summary: Asparagus is a perennial herb with valuable functional ingredients, which has been used as medicine and food since ancient times. Among its main chemical constituents, saponins play a crucial role in various health benefits and biological activities. This review focuses on the preparation methods, structure, classification, biological functions, food and non-food applications of asparagus saponins, with a special emphasis on their anti-cancer effects. It also highlights the challenges and limitations in current research and serves as a bridge between bioactive components and human health, aiding research on functional and health-promoting foods and medicinal applications of asparagus saponins.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Yaqian Geng, Yingfeng Xie, Wei Li, Yao Mou, Fang Chen, Jianbo Xiao, Xiaojun Liao, Xiaosong Hu, Junfu Ji, Lingjun Ma
Summary: Myricitrin, a flavonol compound extracted from plant resources, has shown great potential for various biological activities such as anti-inflammatory and anti-cancer effects. However, its practical application is constrained by low production, high cost, and environmental damage caused by extraction. Fortunately, innovative and sustainable extraction techniques as well as biosynthesis based on synthetic biology are emerging as alternatives to conventional techniques, providing new perspectives for large-scale production of myricitrin.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Agricultural Engineering
Yinkai Yang, Chengyu Xiao, Yan Cai, Jingyi Wang, Qingyan Ruan, Miaomiao Sheng, Ling Li, Kexuan Tang, Guoyin Kai, Xiaolong Hao
Summary: This study revealed the synergistic effect of the phytohormone jasmonic acid (JA) and light on the biosynthesis of anti-malarial drug artemisinin in traditional Chinese medicinal plant Artemisia annua. A JA-responsive R2R3-MYB transcription factor, AaJRM1, was found to be highly expressed in trichomes and rapidly responded to JA treatment. Overexpression and suppression of AaJRM1 increased and decreased the accumulation of artemisinin, respectively. The study elucidated the molecular mechanism of JA-responsive AaJRM1 transcription factor regulating artemisinin biosynthesis.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Plant Sciences
Jiaxiong Yao, Junqiu Liu, Yining He, Lin Liu, Zonghui Xu, Xianming Lin, Na Liu, Guoyin Kai
Summary: This study investigated the protective effect and mechanism of Astragaloside IV (AS-IV) on macrophages and cyclophosphamide (CTX)-induced immunosuppressive mice. The results showed that AS-IV enhanced cell migration and phagocytosis, protected immune organs and bone tissues, and improved immune cell function. AS-IV activated the HIF-1 alpha/NF-kappa B signaling pathway to relieve immunosuppression caused by CTX and potentially enhance macrophage immune activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Weihuan Zeng, Jiajia Su, Yue Wang, Minyu Shou, Jun Qian, Guoyin Kai
Summary: This review summarizes the recent progress in the utilization of metal organic framework (MOF) nanocomposites in various biomedical applications, focusing on the properties and applications of Prussian blue (PB) and its analogues (PBA) in the biological field. The review provides a systematic introduction to the properties of PB and PBA, including their photothermal abilities, reactive oxygen species scavenging abilities, and adsorption abilities. It also discusses the various biomedical applications of PB and PBA, such as tumor therapy, anti-bacterial infection, biosensor, bioimaging, excretion, and ischemic stroke treatment. Additionally, the challenges, key factors, and prospects in the clinical transformation of PB and PBA are discussed. This review serves as a reference and guidance for the design and application of PB and PBA in the future.
