Review
Biochemistry & Molecular Biology
Nicolas Monnin, Anne Julie Fattet, Isabelle Koscinski
Summary: Endometriosis is caused by ectopic endometrial tissue, and its chronic inflammation is associated with pain and fertility problems. Endometriotic implants produce their own estrogen through aromatase and are dependent on estrogen receptor beta (ESR beta) while being resistant to progesterone. The transcription factor SF1 promotes aromatase synthesis and its expression, along with ESR beta, is enhanced by demethylation. Local estrogen concentrations play a role in implantation and development of endometriotic implants, as well as potentially promoting genital cancer. Certain microbiota components, prenatal exposure to endocrine disruptors, and phthalates are associated with increased estrogen levels, while the impact of dioxin and tobacco on endometriosis is less clear.
Article
Microbiology
Fabiola Avelino-Flores, Jorge Soria-Bustos, Zeus Saldana-Ahuactzi, Ygnacio Martinez-Laguna, Jorge A. Yanez-Santos, Maria L. Cedillo-Ramirez, Jorge A. Giron
Summary: The study investigated the influence of various environmental and nutritional signals on the expression of the flagellin gene in EPEC, finding that specific conditions can significantly enhance fliC transcription. When EPEC encounters certain signals in the intestinal niche, it may activate fliC expression to promote growth and colonization in the host.
Review
Environmental Sciences
Maja Srut
Summary: The effect of environmental pollutants on epigenetic changes, including DNA methylation, histone modifications, and non-coding RNAs, is a major concern in ecotoxicology. Earthworms have been widely used as models to study the impact of environmental stress on epigenetic mechanisms and to explore the possibility of epigenetic inheritance. However, there are still many knowledge gaps that need to be filled in.
Review
Biochemistry & Molecular Biology
Masanori Ono, Hitoshi Ando, Takiko Daikoku, Tomoko Fujiwara, Michihiro Mieda, Yasunari Mizumoto, Takashi Iizuka, Kyosuke Kagami, Takashi Hosono, Satoshi Nomura, Natsumi Toyoda, Naomi Sekizuka-Kagami, Yoshiko Maida, Naoaki Kuji, Hirotaka Nishi, Hiroshi Fujiwara
Summary: The circadian rhythm, controlled by clock genes, is crucial for reproduction. In the mouse uterus, the oscillation of circadian clock gene has been observed. CLOCK-BMAL1 heterodimer promotes the transcription of Per1/2 and Cry1/2 genes by binding to their promoters' E-box sequences. The endometrial clock plays an important role in pregnancy, and disruptions in the uterine clock can lead to complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Marta Gomez de Cedron, Rocio Moreno Palomares, Ana Ramirez de Molina
Summary: Epigenetic modifications are chemical modifications that can affect gene expression without changing DNA sequences. They occur on histone proteins, DNA, and RNA molecules. These modifications play important roles in developmental programs and functional plasticity, but imbalances can lead to diseases such as metabolic diseases, cancer, and aging.
FRONTIERS IN ONCOLOGY
(2023)
Review
Nutrition & Dietetics
Hanna Danielewicz
Summary: Breastfeeding is a natural mode of nutrition that has beneficial effects on both the neonatal period and lifelong health. However, there is limited data on its protective effect against allergies. This review explores various factors that can modify the impact of breastfeeding, such as exposure to cow milk, supplement use, introduction of solid foods, microbiota changes, and the epigenetic function of breastfeeding.
Review
Nutrition & Dietetics
Chiara Cencioni, Ilaria Trestini, Geny Piro, Emilio Bria, Giampaolo Tortora, Carmine Carbone, Francesco Spallotta
Summary: Nutritional habits have a significant impact on the health of the gastrointestinal tract and the progression of GI disorders, including cancer. Specific nutritional measures can be taken to prevent GI cancer and improve treatment outcomes. Nutritional counseling, nutrient delivery, supplementation, and timing are important factors in the management of these patients. The closure of nutritional gaps during cancer treatment is crucial for weight stabilization, treatment tolerability, and survival rate improvement. Recent studies have explored novel nutritional approaches targeting the connection between epigenetics and metabolism in GI cancer patients.
Article
Green & Sustainable Science & Technology
Stephanie Cap, Pieter Bots, Laura Scherer
Summary: This study used a multi-criteria decision analysis to assess the sustainability of 10 nuts and seeds, finding that walnuts and sunflower seeds performed the best while cashews performed poorly. Increasing consumption of more sustainable nuts can improve the overall environmental, nutritional, and social impacts of nut production and consumption.
SUSTAINABILITY SCIENCE
(2023)
Article
Computer Science, Interdisciplinary Applications
M. Mendiolar, J. A. Filar, W. -H. Yang, S. Leahy, A. J. Courtney
Summary: This study develops a family of weighted indices called IMPIT indices extracted from environmental signals, which are used to explain important response variables. A user-friendly software tool called IMPIT-a is developed to facilitate the construction and calibration of these indices. Examples of IMPIT indices extracted from the Southern Oscillation Index and sea surface temperature signals are provided, and their applications to two fished species in Queensland waters and wheat yield in New South Wales are illustrated.
ENVIRONMENTAL MODELLING & SOFTWARE
(2023)
Review
Biochemistry & Molecular Biology
Zhipeng Tao, Hiba Aslam, Jane Parke, Marcel Sanchez, Zhiyong Cheng
Summary: Autophagy is a crucial process for cellular remodeling and organelle quality control. It is regulated by various signaling pathways in response to changes in nutritional status. However, nutrient oversupply can disrupt autophagic regulation and is associated with chronic diseases in humans.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Plant Sciences
Yuri Gogolev, Sunny Ahmar, Bala Ani Akpinar, Hikmet Budak, Alexey S. Kiryushkin, Vladimir Y. Gorshkov, Goetz Hensel, Kirill N. Demchenko, Igor Kovalchuk, Freddy Mora-Poblete, Tugdem Muslu, Ivan D. Tsers, Narendra Singh Yadav, Viktor Korzun
Summary: The success of crop breeding and agricultural innovation in the last century led to the Green Revolution, but new challenges like rapid climate change require faster responses and innovative solutions. Utilizing high-throughput technologies and new tools to design new plant genomes will be crucial for increasing agricultural efficiency and facing these challenges.
Article
Biochemistry & Molecular Biology
Shelly A. Trigg, Yaamini R. Venkataraman, Mackenzie R. Gavery, Steven B. Roberts, Debashish Bhattacharya, Alan Downey-Wall, Jose M. Eirin-Lopez, Kevin M. Johnson, Katie E. Lotterhos, Jonathan B. Puritz, Hollie M. Putnam
Summary: This study compares three methods for quantifying DNA methylation and finds higher methylation in two coral species, primarily located in gene bodies and flanking regions. Each method has its advantages and disadvantages in detecting CpGs, and the relative genome size affects the number and location of CpGs detected by each method.
MOLECULAR ECOLOGY RESOURCES
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Emma Louise Robinson, Chukwuemeka George Anene-Nzelu, Manuel Rosa-Garrido, Roger S. Y. Foo
Summary: Epigenetic regulation is crucial for the homeostasis of every tissue and organ, especially in the cardiovascular system. Understanding the signaling from the cardiac epigenome is essential for unraveling the molecular underpinnings of cardiovascular disease and development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kaito Kikuchi, Leticia Galera-Laporta, Colleen Weatherwax, Jamie Y. Lam, Eun Chae Moon, Emmanuel A. Theodorakis, Jordi Garcia-Ojalvo, Gurol M. Suel
Summary: Despite their dormant state, bacterial spores are able to sense environmental signals through a preexisting electrochemical potential and integrate these signals over time, affecting their decision to exit dormancy.
Review
Plant Sciences
Boominathan Mohanasundaram, Sona Pandey
Summary: This article explores the phenotypic responses of mosses to environmental signals such as light, temperature, CO2, water, nutrients, and gravity, and compares them with the known responses in vascular plants. Hypotheses based on the contribution of anatomical and molecular factors to specific phenotypic responses are also outlined.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Eirini Pagkalidou, Athanasios Kordalis, Spyridon Deftereos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: Our network meta-analysis identified the most effective antiarrhythmics for pharmacologic cardioversion over different time settings, with intravenous vernakalant and flecainide showing the highest conversion rate within 4 hours. Flecainide, especially when compared to propafenone, demonstrated superiority for conversion rates within 12 hours, while amiodarone exhibited efficacy within 24 hours, particularly if ranolazine was added.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Gastroenterology & Hepatology
Corey J. Ketchem, Craig C. Reed, Zoe Stefanadis, Evan S. Dellon
Summary: The study evaluated the efficacy of a compounded fluticasone suspension for treating eosinophilic esophagitis, showing significant improvements in symptoms and endoscopic findings, with over a third of patients achieving histologic response.
DISEASES OF THE ESOPHAGUS
(2021)
Letter
Cardiac & Cardiovascular Systems
Dimitrios A. Vrachatis, George V. Giannopoulos, Sotiria G. Giotaki, Konstantinos Raisakis, Charalampos Kossyvakis, Konstantinos E. Iliodromitis, Bernhard Reimers, Dimitrios Tousoulis, Michael Cleman, Christodoulos Stefanadis, Alexandra Lansky, Spyridon G. Deftereos
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Review
Immunology
Joshua Adedeji Bolarin, Mercy Adaramodu Oluwatoyosi, Joshua Iseoluwa Orege, Emmanuel Ayodeji Ayeni, Yusuf Ajibola Ibrahim, Sherif Babatunde Adeyemi, Bashir Bolaji Tiamiyu, Lanre Anthony Gbadegesin, Toluwanimi Oluwadara Akinyemi, Chuks Kenneth Odoh, Happiness Ijeoma Umeobi, Adenike Bernice-Eloise Adeoye
Summary: This review outlines the usage of antiviral drugs, antibiotics, and immune-stimulants in managing SARS-CoV-2, as well as discussing potential drug interactions and monitoring methods.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Panagiota Pietri, Christodoulos Stefanadis
Summary: Cardiovascular aging and longevity are interconnected through various pathophysiological mechanisms, with factors like cardiometabolic disorders and genetic modulators playing significant roles. Understanding the genetic, molecular, and biochemical pathways of aging may lead to interventions that delay cardiovascular aging, potentially contributing to achieving longevity goals. Research on long-living populations helps translate these mechanisms into clinical data for further study.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
History & Philosophy Of Science
Matthew Adamson, Roberto Lalli
Summary: The contemporary scholarship on science diplomacy is turning to historical approaches to gain insights with the unique tools historians of science provide. Through historical studies, it is evident that science diplomacy has historically mediated the circulation of technoscientific knowledge and materials in both the Global South and North.
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)