The innate immune roles of host factors TRIM5α and Cyclophilin A on HIV-1 replication

Cyclophilin A (CypA) Interacts with NF-κB Subunit, p65/RelA, and Contributes to NF-κB Activation Signaling

(2014) Shan Sun et al.   PLoS One

The conserved sumoylation consensus site in TRIM5α modulates its immune activation functions

(2014) Marie-Édith Nepveu-Traversy et al.   VIRUS RESEARCH

Gene Therapy Strategies to Exploit TRIM Derived Restriction Factors against HIV-1

(2014) Emma Chan et al.   Viruses-Basel

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

Role of SUMO-1 and SUMO interacting motifs in rhesus TRIM5α-mediated restriction

(2013) Zana Lukic et al.   Retrovirology

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection

(2013) Sebla B. Kutluay et al.   PLoS Pathogens

Innate Immune Sensing of HIV-1 by Dendritic Cells

(2012) Jeremy Luban   Cell Host & Microbe

The TRIMCyp genotype in four species of macaques in China

(2012) Chang-Qing Yu et al.   IMMUNOGENETICS

TRIM Protein-Mediated Regulation of Inflammatory and Innate Immune Signaling and Its Association with Antiretroviral Activity

(2012) P. D. Uchil et al.   JOURNAL OF VIROLOGY

Diverse HIV viruses are targeted by a conformationally dynamic antiviral

(2012) Matthew E C Caines et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication

(2012) Hiroaki Takeuchi et al.   Retrovirology

Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5α

(2012) Alberto Brandariz-Nuñez et al.   VIROLOGY

TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling

(2012) Markus G Grütter et al.   Current Opinion in Virology

Trim5 TAKes on Pattern Recognition

(2011) Semih U. Tareen et al.   Cell Host & Microbe

Variable Prevalence and Functional Diversity of the Antiretroviral Restriction Factor TRIMCyp in Macaca fascicularis

(2011) E. A. Dietrich et al.   JOURNAL OF VIROLOGY

APOBEC3G/F as one possible driving force for co-receptor switch of the human immunodeficiency virus-1

(2011) Eva Heger et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

TRIM5 does double duty

(2011) Christopher Aiken et al.   NATURE

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Antiviral restriction factor transgenesis in the domestic cat

(2011) Pimprapar Wongsrikeao et al.   NATURE METHODS

Trafficking of some old world primate TRIM5α proteins through the nucleus

(2011) Felipe Diaz-Griffero et al.   Retrovirology

TRIM5 Acts as More Than a Retroviral Restriction Factor

(2011) Suresh De Silva et al.   Viruses-Basel

Innate signaling in HIV-1 infection of dendritic cells

(2011) Michiel van der Vlist et al.   Current Opinion in HIV and AIDS

SUMO-Interacting Motifs of Human TRIM5α are Important for Antiviral Activity

(2011) Gloria Arriagada et al.   PLoS Pathogens

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

(2010) Nicolas Manel et al.   NATURE

Human Trim5α has additional activities that are uncoupled from retroviral capsid recognition

(2010) Semih U. Tareen et al.   VIROLOGY

Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

(2010) Laura M. J. Ylinen et al.   PLoS Pathogens

Molecular evolution of the antiretroviral TRIM5 gene

(2009) Welkin E. Johnson et al.   IMMUNOGENETICS

Active site remodeling switches HIV specificity of antiretroviral TRIMCyp

(2009) Amanda J Price et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRIM5α and TRIMCyp form apparent hexamers and their multimeric state is not affected by exposure to restriction-sensitive viruses or by treatment with pharmacological inhibitors

(2009) Marie-Édith Nepveu-Traversy et al.   Retrovirology

Genotyping of TRIM5 locus in northern pig-tailed macaques (Macaca leonina), a primate species susceptible to Human Immunodeficiency Virus type 1 infection

(2009) Yi-Qun Kuang et al.   Retrovirology

An expanded clade of rodent Trim5 genes

(2009) Semih U. Tareen et al.   VIROLOGY

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

TRIM-ing down Tolls

(2008) Andrew G Bowie   NATURE IMMUNOLOGY

TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation

(2008) Mude Shi et al.   NATURE IMMUNOLOGY

TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis

(2008) G. Brennan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species

(2008) C. A. Virgen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Independent evolution of an antiviral TRIMCyp in rhesus macaques

(2008) S. J. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determinants of cyclophilin A-dependent TRIM5α restriction against HIV-1

(2008) Tsai-Yu Lin et al.   VIROLOGY

Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys

(2008) Ruchi M. Newman et al.   PLoS Pathogens