Article
Endocrinology & Metabolism
Turky H. Almigbal
Summary: This study found that patients with a higher knowledge level about hypoglycemia are less likely to experience hypoglycemia. Factors such as premixed insulin regimen, long duration of insulin treatment, use of oral hypoglycemic agents, and a high hypoglycemia knowledge score are associated with an increased risk of hypoglycemia. Early detection of hypoglycemic signs could ultimately improve the quality of life for patients with insulin-treated diabetes mellitus.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Cell Biology
Hitoshi Watanabe, Wen Du, Jinsook Son, Lina Sui, Shun-ichiro Asahara, Irwin J. Kurland, Taiyi Kuo, Takumi Kitamoto, Yasutaka Miyachi, Rafael de Cabo, Domenico Accili
Summary: Sulfonylureas are effective and affordable antidiabetic drugs, but chronic use leads to secondary failure. Cytochrome b5 reductase 3 (Cyb5r3) down-regulation is identified as a mechanism of secondary SU failure and can be successfully reversed. Cyb5r3 activators can rescue secondary SU failure and potentially rehabilitate SU use in diabetes.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jeremy F. Tuohy, Frank H. Bloomfield, Caroline A. Crowther, Jane E. Harding
Summary: Maternal hyperglycaemia is common following antenatal corticosteroid administration in women with diabetes, especially within 24 hours prior to birth, which is associated with increased risk of neonatal hypoglycaemia.
Article
Multidisciplinary Sciences
Jin-Ying Lu, Horng-Yih Ou, Chung-Ze Wu, Chwen-Yi Yang, Ju-Ying Jiang, Chieh-Hsiang Lu, Yi-Der Jiang, Tien-Jyun Chang, Yi-Cheng Chang, Meng-Lun Hsieh, Wan-Chen Wu, Hung-Yuan Li, Ye-Fong Du, Ching-Han Lin, Hao-Chang Hung, Kai-Jen Tien, Nai-Cheng Yeh, Shang-Yu Lee, Hui- Yu, Lee-Ming Chuang
Summary: TENS has been shown to have benefits in glycemic control in animal models, but its application in humans is not well-studied. A randomized trial on 160 patients with type 2 diabetes showed that while TENS did not significantly reduce HbA(1c), it was effective in improving glycemic variability.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Joud S. Almutairi, Turky H. Almigbal, Hiba Y. Alruhaim, Muhammad H. Mujammami, Turki A. AlMogbel, Abdullah M. Alshahrani, Abdullah M. Al Zahrani, Mohammed A. Batais, Shaffi A. Shaik
Summary: The aim of this study was to investigate the self-awareness of HbA1c among type 2 diabetic patients in Saudi Arabia and its association with glycemic control. The results showed that the self-awareness rate of HbA1c was approximately 44.5%. Factors such as glycemic control, education level, monthly income, and number of follow-up visits were found to be associated with HbA1c awareness. Furthermore, the type of treatment, duration of diabetes, and self-awareness of HbA1c were independently associated with better glycemic control.
SAUDI MEDICAL JOURNAL
(2022)
Article
Endocrinology & Metabolism
Deep Dutta, Ritin Mohindra, Kunal Mahajan, Meha Sharma
Summary: This study analyzed data from four randomized controlled trials and found that the use of fast-acting aspart insulin (FIAsp) in insulin pumps can effectively lower postprandial blood glucose levels compared to controls, with no increased risk of hypoglycemia or glycemic variability.
DIABETES & METABOLISM JOURNAL
(2023)
Review
Oncology
Hiroki Nishikawa, Shinya Fukunishi, Akira Asai, Keisuke Yokohama, Hideko Ohama, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in energy metabolism and glucose uptake. Conditions like type 2 diabetes, frailty, and aging can impact muscle health. Exercise and proper nutrition interventions are key in maintaining muscle health and preventing various diseases.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Endocrinology & Metabolism
Afif Nakhleh, Naim Shehadeh
Summary: Hypoglycemia is a common complication in diabetes patients, with impairments in counterregulatory responses and hypoglycemia unawareness as main risk factors for severe episodes. Hypoglycemia is associated with physical and psychological morbidity, and fear of hypoglycemia can hinder glycemic control in patients.
WORLD JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Janet B. McGill, Daniel Weiss, Marshall Grant, Marisa C. Jones, David M. Kendall, Byron J. Hoogwerf
Summary: Comparing inhaled insulin with short-acting insulin analogues showed that inhaled insulin can improve post-meal glucose levels and reduce the risk of hypoglycemia.
JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
T. Idrees, Z. E. Zabala, E. M. Moreno, A. Gerges, M. A. Urrutia, J. G. Ruiz, C. Vaughan, P. Vellanki, F. J. Pasquel, L. Peng, G. E. Umpierrez
Summary: This study found that older adults with type 2 diabetes have better glycemic control than younger adults prior to admission and during hospital stay. It also suggested that frailty may affect glucose control among hospitalized patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Siddarth Agrawal, Sebastian Makuch, Mateusz Drozdz, Tomasz Dudzik, Igor Domanski, Rafal Poreba, Grzegorz Mazur
Summary: The increasing mortality and morbidity in patients with diabetes mellitus are recognized as a cause of impaired quality of life, high costs, and diminished productivity. This study found that risk factors such as smoking, drinking alcohol, low BMI, inappropriate diet, low physical activity, lack of vaccination against influenza and pneumococci, and co-existent comorbidities increase the risk of hypoglycemia in diabetic patients. Furthermore, hypoglycemic patients were more likely to experience malnutrition, depression, irritability, and stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Naushira Pandya, Molly Jung, Aaron Norfolk, Claudia Goldblatt, Alyssa Trenery, Ray Sieradzan
Summary: This study investigates the prescribing patterns and frequency of hypoglycemia among residents with type 2 diabetes in long-term care facilities. Findings suggest room for improvement in diabetes management for these patients.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Review
Endocrinology & Metabolism
Gurunanthan Palani, Ethan Stortz, Amir Moheet
Summary: The objective of this study is to review clinical presentation, causes, and diagnostic approach to spontaneous hypoglycemia in adults without diabetes mellitus. The literature review reveals that hypoglycemia is rare in individuals without diabetes, but it can be caused by conditions such as endogenous hyperinsulinism, critical illness, hepatic or renal dysfunction, hormonal deficiency, non-diabetes-related medications, and non-islet cell tumors. Diagnostic approach involves evaluating the patient's symptoms, medication history, underlying comorbid conditions, and acute illness, as well as conducting laboratory assessments.
ENDOCRINE PRACTICE
(2023)
Article
Critical Care Medicine
Yasmine Ali Abdelhamid, Alan Bernjak, Liza K. Phillips, Matthew J. Summers, Luke M. Weinel, Kylie Lange, Elaine Chow, Palash Kar, Michael Horowitz, Simon Heller, Adam M. Deane
Summary: Hypoglycemia is common in ICU survivors with type-2 diabetes, especially during the night, and is often asymptomatic and prolonged. While hypoglycemia was associated with an increased risk of bradycardia, it did not impact atrial or ventricular ectopics, heart rate variability, or cardiac repolarization.
CRITICAL CARE MEDICINE
(2021)
Article
Environmental Sciences
Szymon Rzepczyk, Klaudia Dolinska-Kaczmarek, Aleksandra Uruska, Czeslaw Zaba
Summary: Insulin, as an effective glycemic-lowering drug, carries a higher risk of overdose when self-dosed by patients. The presence of chronic diseases, such as diabetes, increases the risk of intentional overdose. Developing an effective system to detect predisposition to overdose, including assessing symptoms of depression, is crucial. A risk-conscious therapeutic team and education play a key role in preventing and detecting intentional overdose.
Article
Endocrinology & Metabolism
R. Dhaliwal, S. Islam, M. Mikhail, L. Ragolia, J. F. Aloia
OSTEOPOROSIS INTERNATIONAL
(2020)
Letter
Endocrinology & Metabolism
Ruban Dhaliwal, Sanjay K. Bhadada, Sudhaker D. Rao
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Praveer Sihota, Ram Naresh Yadav, Ruban Dhaliwal, Jagadeesh Chandra Bose, Vandana Dhiman, Deepak Neradi, Shailesh Karn, Sidhartha Sharma, Sameer Aggarwal, Vijay G. Goni, Vishwajeet Mehandia, Deepak Vashishth, Sanjay Kumar Bhadada, Navin Kumar
Summary: This study investigated alterations in bone tissue properties in individuals with type 2 diabetes following fragility hip fracture. The findings provide evidence of hyperglycemia's detrimental effects on trabecular bone quality at multiple scales, leading to reduced energy absorption and toughness, indicative of increased propensity to bone fragility.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Meghna Shah, Anusha Veeravanallur Appuswamy, Sudhaker D. Rao, Ruban Dhaliwal
Summary: The pathogenesis of bone fragility in diabetes is not well understood, and the efficacy of current therapies in diabetic patients remains unproven. Anabolic therapies have shown faster and larger benefits to bone mineral density in patients with osteoporosis, suggesting a potential benefit in diabetic bone fragility. However, more research is needed in this area to establish specific guidelines for treatment in patients with diabetes.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2021)
Article
Endocrinology & Metabolism
Ruban Dhaliwal, Susan K. Ewing, Deepak Vashishth, Richard D. Semba, Ann Schwartz
Summary: Higher levels of CML are associated with increased risk of incident clinical fractures in individuals with type 2 diabetes, independent of bone mineral density. These results suggest a role for CML in the pathogenesis of bone fragility in diabetic patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ruban Dhaliwal, Rocio Pereira, Alicia M. Diaz-Thomas, Camille E. Powe, Licy L. Yanes Cardozo, Joshua J. Joseph
Summary: The Endocrine Society identifies racism as the underlying cause of health disparities affecting racial/ethnic minority communities worldwide. Their policy aims to address this issue by educating and engaging healthcare professionals, researchers, educators, policymakers, and leaders to promote an equitable and diverse healthcare system.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Kathryn Dahir, Ruban Dhaliwal, Jill Simmons, Erik A. Imel, Gary S. Gottesman, John D. Mahan, Gnanagurudasan Prakasam, Allison Hoch, Prameela Ramesan, Maria Diaz-Gonzalez de Ferris
Summary: XLH patients require psychosocial and access-related resources for disease education, genetic counseling, family planning, and emancipation from caregiver-directed care. Effective communication through familiar channels and teaching patients to advocate for their health care/access to specialists are essential for successful transition from pediatric- to adult-focused health care.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Rachana D. Shah, Barbara H. Braffett, Jeanie B. Tryggestad, Kara S. Hughan, Ruban Dhaliwal, Kristen J. Nadeau, Lorraine E. Levitt Katz, Samuel S. Gidding
Summary: The incidence and prevalence of cardiovascular risk factors in young adults with youth-onset type 2 diabetes (T2D) were found to be high over a decade of follow-up. Factors such as male sex, non-Hispanic white race/ethnicity, obesity, poor glycemic control, lower insulin sensitivity, and reduced beta-cell function were significantly associated with an unfavorable risk profile. It is crucial to control glucose levels and manage cardiovascular risk factors in youth with T2D to prevent cardiovascular morbidity and mortality.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Meeting Abstract
Rheumatology
Ruban Dhaliwal, David Kendler, Kenneth Saag, Steven Ing, Andrea Singer, Robert Adler, Leny Pearman, Yamei Wang, Bruce Mitlak
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Endocrinology & Metabolism
Srujana Annavarapu, Ruban Dhaliwal, Sanjay Kumar Bhadada, Sudhaker Rao
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Kathryn Dahir, Maria Belen Zanchetta, Irinel Stanciu, Cemre Robinson, Janet Y. Lee, Ruban Dhaliwal, Julia Charles, Roberto Civitelli, Mary Scott Roberts, Stan Krolczyk, Thomas Weber
Summary: TIO is a rare paraneoplastic syndrome caused by small endocrine tumors secreting FGF23, leading to musculoskeletal pain, fatigue, muscle weakness, and fractures. Prompt diagnosis of TIO requires laboratory tests, imaging, and surgical resection for cure. Awareness and education among healthcare professionals are crucial to improve management of this debilitating disease.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Meeting Abstract
Nursing
Marian Hart, Margo Black, Kathryn Dahir, Ruban Dhaliwal, Jill Simmons, Erik A. Imel, Gary S. Gottesman, John D. Mahan, Gnanagurudasan Prakasam, Allison I. Hoch, Prameela Ramesan, Maria Diaz-Gonzalez de Ferris
JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
(2021)
Meeting Abstract
Endocrinology & Metabolism
Praveer Sihota, Ram Naresh Yadav, Ruban Dhaliwal, Jagadeesh Boss, Vandana Dhiman, Deepak Neradi, Shailesh Karn, Sidhartha Sharma, Sameer Aggrawal, Vijay Goni, Vishwajeet Mehandia, Deepak Vashishth, Sanjay Bhadada, Navin Kumar
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Correction
Endocrinology & Metabolism
Ruban Dhaliwal, Didier Hans, Gary Hattersley, Bruce Mitlak, Lorraine A. Fitzpatrick, Yamei Wang, Ann V. Schwartz, Paul D. Miller, Robert G. Josse
Article
Endocrinology & Metabolism
Ruban Dhaliwal, Didier Hans, Gary Hattersley, Bruce Mitlak, Lorraine A. Fitzpatrick, Yamei Wang, Ann V. Schwartz, Paul D. Miller, Robert G. Josse
Article
Medicine, General & Internal
Jeanne E. Conner, Joshua A. Steinberg
Summary: Diagnosis of anaphylaxis should involve comprehensive consideration, including detailed history and objective findings. Using diagnostic criteria and considering rare triggers, as well as evaluating for mast cell disorders, can aid in the diagnosis. Referral to specialists may be necessary.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Alejandra Escobar Vasco, Julie -Ann Talano, Larisa Broglie
Summary: HLH is a rare but fatal disease, and maintaining a high level of suspicion is crucial for patients with evidence of hyperinflammation. Adolescents with HLH should undergo genetic evaluation for familial HLH, and primary immune deficiencies and dysregulation disorders should also be considered. Early diagnosis and treatment are necessary to prevent morbidity and mortality related to HLH's hyperinflammation.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Kathleen Ryan
Summary: Fevers of unknown origin (FUO) present a diagnostic challenge, with a wide range of potential causes including infectious, autoimmune, and malignant. Some adolescents with FUO may never have an identifiable etiology, but the prognosis is generally favorable in the absence of red flag symptoms.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Brett J. Bordini, Ryan D. Walsh, Donald Basel, Tejaswini Deshmukh
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Hsi Yen, Leah Lalor
Summary: The article emphasizes the importance of increased awareness among healthcare providers when faced with severe adolescent acne that may not be typical teenage acne. It provides a summary of uncommon causes of severe adolescent acne and a simplified diagnostic approach. Additionally, it discusses rare autoinflammatory syndromic causes of acne and acne associated with excess androgen states.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Bethany Auble, Justin Dey
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Kaitlin V. Kirkpatrick, James J. Nocton
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Louella Amos
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Tracey Thompson, Ashley Phimister, Alexander Raskin
Summary: Heart failure occurs as a result of pressure or volume overload in congenital and acquired heart diseases, and its treatment varies depending on the underlying cause.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Allison Remiker, Kristina Bolling, James Verbsky
Summary: CVID is a heterogeneous group of disorders characterized by abnormal B-cell differentiation and impaired production of specific immunoglobulin. Clinical manifestations vary and include recurrent bacterial infections, lymphoproliferation, autoimmunity, pulmonary disease, gastrointestinal disease, granulomas, and increased cancer risk. The diagnosis of CVID is complex, requiring exclusion of other causes of immunoglobulin deficiency and assessment based on clinical criteria models. Treatment involves regular immunoglobulin replacement therapy, infection prevention, and surveillance for complications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Bridget A. Rafferty, Pooja Thakrar
Summary: CNO/CRMO is an underrecognized autoinflammatory disorder of the skeletal system resulting from immune dysregulation. Diagnosis is often delayed due to vague symptoms and the lack of accepted diagnostic criteria or specific biomarkers. Untreated CRMO can lead to chronic skeletal deformities, arthritis, and chronic pain. Diagnosis requires MRI and WB-MRI. Treatment primarily involves antiinflammatory medications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Vaishali Singh, Scott K. Van Why
Summary: Hypertension in adolescents is rare, and evaluation for identifiable causes beyond primary hypertension is necessary. Common causes of hypertension in this age group are usually acquired or congenital renal or vascular diseases. If these etiologies are not found, exploration for rare causes, including monogenic hypertension, should be pursued.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Dominic O. Co
Summary: Acquired demyelinating syndromes (ADS) are a group of inflammatory demyelinating conditions that include optic neuritis, transverse myelitis, and acute demyelinating encephalomyelitis. Differentiating between subtypes of ADS is important for optimal patient management, and this can be achieved by considering clinical features, laboratory tests (especially autoantibodies), and MRI findings.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Meghan K. Konda, Matthew Harmelink
Summary: Pediatric adolescent muscle weakness can have various causes. A methodical diagnostic evaluation is necessary to determine the specific disease category, which may require specialized care or extensive testing. The ultimate diagnosis is crucial for prognostication.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
