Article
Pediatrics
Alon Haim, Sharon Daniel, Eli Hershkovitz, Aviv D. Goldbart, Ariel Tarasiuk
Summary: The prevalence of obstructive sleep apnea (OSA) and its association with comorbid factors in morbid obese adolescents are largely unknown. Moderate/severe OSA in morbidly obese adolescents is linked to higher levels of metabolic complications, such as ferritin. Management of OSA should be considered in addition to weight loss in these adolescents.
PEDIATRIC PULMONOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Piotr Fiedorczuk, Ewa Olszewska, Agnieszka Polecka, Marzena Walasek, Barbara Mroczko, Agnieszka Kulczynska-Przybik
Summary: In this single-center, case-control study, the concentrations of CRP, S100B, IL-6, TNF-α, and IL-8 were found to be elevated in patients with Obstructive Sleep Apnea (OSA), and positively correlated with disease severity, age, and BMI. These results support the potential role of these biomarkers in diagnosing OSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mayra A. Tellez Corral, Eddy Herrera Daza, Natalia Arango Jimenez, Darena Z. Morales Vera, Juliana Velosa Porras, Catalina Latorre Uriza, Francina M. Escobar Arregoces, Patricia Hidalgo Martinez, Maria E. Cortes, Liliana Otero, Claudia M. Parra Giraldo, Nelly S. Roa Molina
Summary: This study compares the concentrations of five cytokines in saliva and gingival crevicular fluid (GCF) in patients with OSA and investigates their association with periodontitis. Samples were obtained from 84 patients classified into four groups. The results show that severe OSA patients have the highest proportion of stage III periodontitis. The cytokine profile in saliva and GCF differs between different groups, suggesting an increased risk of developing periodontitis in patients with OSA. These cytokines could serve as biomarkers for OSA and periodontitis.
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Swayanka Biswas, Katja Bieber, Rudolf Armin Manz
Summary: IL-10 is a cytokine that has pleiotropic effects on immune cells, including both suppressive and activating functions. It plays a dual role in Systemic lupus Erythematosus (SLE), inhibiting pro-inflammatory effector functions while also promoting extrafollicular antibody response. IL-10 is produced by B cells, myeloid cells, and certain T cell subsets, and it drives B cell responses, proliferation, class switching, and plasma cell formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Frederic Schlemmer, Maeva Zysman, Bruno Ribeiro Baptista, Etienne Audureau, Ala Covali Noroc, Audrey Ridoux, Genevieve Derumeaux, Serge Adnot, Bernard Maitre, Philippe le Corvoisier, Sophie Lanone, Jorge Boczkowski, Laurent Boyer
Summary: Obstructive sleep apnea leads to chronic intermittent hypoxia, which may induce adaptative cardiovascular pathways. Activation of autophagy plays a significant role in protecting against cardiovascular events in patients with OSA.
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Christopher M. Cielo, Brendan T. Keenan, Andrew Wiemken, Ignacio E. Tapia, Andrea Kelly, Richard J. Schwab
Summary: The study found that neck fat is associated with obesity and neck circumference in adolescents, with females having significantly greater neck fat than males. However, neck fat does not appear to correlate with the presence and severity of OSAS.
Article
Clinical Neurology
Christopher M. Cielo, Brendan T. Keenan, Andrew Wiemken, Ignacio E. Tapia, Andrea Kelly, Richard J. Schwab
Summary: Neck fat is associated with obesity and neck circumference in adolescents, with females having more neck fat than males. However, it does not appear to correlate with the presence and severity of obstructive sleep apnea syndrome (OSAS).
Article
Endocrinology & Metabolism
A. Cignarelli, A. Ciavarella, M. Barbaro, S. Kounaki, A. Di Trani, V. A. Falcone, V. N. Quaranta, A. Natalicchio, L. Laviola, O. Resta, F. Giorgino, S. Perrini
Summary: OSA is often underdiagnosed in patients with type 2 diabetes, and this study found a significant relationship between OSA and glycometabolic parameters in obese non-diabetic subjects. High values of 2 h-PG and HbA1c may indicate the presence of OSA in obese individuals, beyond traditional clinical parameters.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Milina Tancic-Gajic, Miodrag Vukcevic, Miomira Ivovic, Ljiljana V. Marina, Zorana Arizanovic, Ivan Soldatovic, Milos Stojanovic, Aleksandar Dogo, Aleksandra Kendereski, Svetlana Vujovic
Summary: The study suggests that obstructive sleep apnea is associated with lower total and free testosterone levels in severely obese men. This finding indicates a potential impact of sleep disorders on sex hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Dandan-Zong, Chong Shen, Xiangming Liu, Ting Liu, Yanru Ou, Ruoyun Ouyang
Summary: The IL-33/ST2 signaling pathway is involved in the cognitive impairment of OSA patients by promoting neuroinflammation via activating NF-KB signaling. CPAP treatment can decrease the expression of IL-33, ST2, p65NF-KB, IL-6 and IL-8, and improve cognitive function in OSA patients. IL-33/ST2 signaling is closely related to sleep respiratory parameters and cognitive dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Christopher Seifen, Johannes Pordzik, Katharina Bahr, Lisa Grosse-Brueggemann, Katharina Ludwig, Berit Hackenberg, Christoph Matthias, Perikles Simon, Haralampos Gouveris
Summary: Evidence suggests that the apnea-hypopnea index (AHI) increases with aging, especially in males. However, the impact of aging on sleep-related metrics, specifically AHI, has been less studied in different gender-specific subpopulations while considering confounding factors such as obstructive sleep apnea-related comorbidities and body mass index (BMI). A retrospective analysis of 186 first-time polysomnographic recordings and medical files was conducted, forming six groups based on age and gender. The older mixed-gender and female cohorts showed significantly higher AHI, apnea-index, and hypopnea-index values. Within the older male cohort, AHI and apnea-index were also significantly higher. No significant differences in BMI were found. The older male cohort had significantly more patients with arterial hypertension, diabetes mellitus, cardiovascular diseases, and chronic mental health disorders. Conversely, the female subpopulation showed no significant differences in these comorbidities. In conclusion, sleep PSG-parameters increased in older subpopulations, possibly due to the accumulation of comorbidities in older males but not in females.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Critical Care Medicine
Samuel T. Kuna, David M. Reboussin, Elsa S. Strotmeyer, Richard P. Millman, Gary Zammit, Michael P. Walkup, Thomas A. Wadden, Rena R. Wing, F. Xavier Pi-Sunyer, Adam P. Spira, Gary D. Foster
Summary: Intensive lifestyle intervention for weight loss can lead to reduced severity of obstructive sleep apnea in individuals with type 2 diabetes mellitus, and this improvement can be sustained over a 10-year period. The amount of weight loss is related to the improvement in OSA severity, and ILI may play a significant role in this improvement.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Amene Raouf-Rahmati, Amir-Reza Ansar, Seyed Abdolrahim Rezaee, Seyedeh Maryam Hosseini, Justus G. Garweg, Sanaz Ahmadi Ghezeldasht, Soheila Vaghei, Mehdi Zarean, Seyed Aliakbar Shamsian, Elham Moghaddas
Summary: In patients with ocular toxoplasmosis, IL-10 and IL-17 expression in the aqueous humor is upregulated while TGF-beta is downregulated. This local immunoregulatory process may be an attempt to prevent tissue damage. The cytokine expression pattern in ocular tissues differs from that in peripheral blood mononuclear cells, indicating intraocular immune deviation.
Article
Computer Science, Interdisciplinary Applications
Eduardo J. Arista Romeu, Josue D. Rivera Fernandez, Karen Roa Tort, Alma Valor, Galileo Escobedo, Diego A. Fabila Bustos, Suren Stolik, Jose Manuel de la Rosa, Carolina Guzman
Summary: The combination of spectrometric techniques with statistical processing shows promise in improving the classification of steatosis through a label-free approach. However, the statistical schemes applied may be too complex for everyday medical practice. The designed software, including machine learning algorithms, is capable of automatically classifying samples based on their steatosis grade with low error rates.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yael Delgado-Ramirez, Angel Ocana-Soriano, Yadira Ledesma-Soto, Jonadab E. Olguin, Joselin Hernandez-Ruiz, Luis I. Terrazas, Sonia Leon-Cabrera
Summary: In the context of colitis-associated colorectal cancer (CAC), the absence of STAT6 led to reduced tumor growth and increased Treg cell numbers, thus inhibiting tumorigenesis. The involvement of STAT6 in regulating Treg cells may offer potential for modulating immune responses in colitis and CAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yael Delgado-Ramirez, Itzel Baltazar-Perez, Yamileth Martinez, Blanca E. Callejas, Itzel Medina-Andrade, Jonadab E. Olguin, Norma L. Delgado-Buenrostro, Yolanda Chirino, Luis Terrazas, Sonia Leon-Cabrera
Summary: The study demonstrates that the lack of STAT1 leads to increased tumorigenicity in colitis-associated colorectal cancer and this can be suppressed by neutralizing IL-17. The findings suggest that targeting IL-17 could potentially prevent tumor formation associated with STAT1 deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Hector Gonzalez-Pacheco, Julian Ramirez-Bello, Rosalinda Posadas-Sanchez, Galileo Escobedo, Jose Manuel Fragoso
Summary: Genetic variants of the PCSK7 gene are significantly associated with the development of ACS and dyslipidemia, potentially increasing the risk of ACS.
Article
Biochemistry & Molecular Biology
Aaron N. Manjarrez-Reyna, Camilo P. Martinez-Reyes, Jose A. Aguayo-Guerrero, Lucia A. Mendez-Garcia, Marcela Esquivel-Velazquez, Sonia Leon-Cabrera, Gilberto Vargas-Alarcon, Jose M. Fragoso, Elizabeth Carreon-Torres, Oscar Perez-Mendez, Jessica L. Prieto-Chavez, Galileo Escobedo
Summary: This study demonstrates that native LDL (nLDL) synergizes with LPS to alter the balance of human monocyte subsets and their ability to produce inflammatory cytokines and chemokine receptors. Patients with serum LDL-cholesterol (LDL-C) >100 mg/dL showed increased levels of NCM, IL-1 beta, LPS-binding protein (LBP), and Castelli's atherogenic risk index compared to controls with optimal LDL-C concentrations (<= 100 mg/dL).
Article
Microbiology
Salma A. Rizo-Tellez, Lucia A. Mendez-Garcia, Ana C. Rivera-Rugeles, Marcela Miranda-Garcia, Aaron N. Manjarrez-Reyna, Rebeca Viurcos-Sanabria, Helena Solleiro-Villavicencio, Enrique Becerril-Villanueva, Jose D. Carrillo-Ruiz, Julian M. Cota-Arce, Angelica alvarez-Lee, Marco A. De Leon-Nava, Galileo Escobedo
Summary: This study found that combining IL-15 and albumin values can improve mortality prediction accuracy in COVID-19 patients, with non-survivors showing a significant increase in the IL-15-to-albumin ratio.
Article
Microbiology
Lucia A. Mendez-Garcia, Nallely Bueno-Hernandez, Miguel A. Cid-Soto, Karen L. De Leon, Viridiana M. Mendoza-Martinez, Aranza J. Espinosa-Flores, Miguel Carrero-Aguirre, Marcela Esquivel-Velazquez, Mireya Leon-Hernandez, Rebeca Viurcos-Sanabria, Alejandra Ruiz-Barranco, Julian M. Cota-Arce, Angelica Alvarez-Lee, Marco A. De Leon-Nava, Guillermo Melendez, Galileo Escobedo
Summary: Sucralose consumption alters microbiome and carbohydrate metabolism in mouse models, but there are no conclusive studies in humans. In this open-label clinical trial, volunteers drinking sucralose for ten weeks showed changes in gut microbiota abundance and insulin and glucose levels.
Article
Nutrition & Dietetics
Viridiana Montsserrat Mendoza-Martinez, Monica Rocio Zavala-Solares, Aranza Jhosadara Espinosa-Flores, Karen Lorena Leon-Barrera, Raul Alcantara-Suarez, Jose Damian Carrillo-Ruiz, Galileo Escobedo, Ernesto Roldan-Valadez, Marcela Esquivel-Velazquez, Guillermo Melendez-Mier, Nallely Bueno-Hernandez
Summary: The study found that a diet containing non-caloric sweeteners was associated with an increase in functional gastrointestinal disorders, such as diarrhea, post-prandial discomfort, constipation, and burning. On the other hand, a diet free of non-caloric sweeteners showed a decrease in these symptoms, as well as abdominal pain, post-prandial discomfort, burning, early satiety, and epigastric pain.
Review
Biochemistry & Molecular Biology
Antonio Andrade-Meza, Luis E. Arias-Romero, Leonel Armas-Lopez, Federico Avila-Moreno, Yolanda I. Chirino, Norma L. Delgado-Buenrostro, Veronica Garcia-Castillo, Emma B. Gutierrez-Cirlos, Imelda Juarez-Avelar, Sonia Leon-Cabrera, Monica G. Mendoza-Rodriguez, Jonadab E. Olguin, Araceli Perez-Lopez, Carlos Perez-Plasencia, Jose L. Reyes, Yesennia Sanchez-Perez, Luis I. Terrazas, Felipe Vaca-Paniagua, Olga Villamar-Cruz, Miriam Rodriguez-Sosa
Summary: In 2013, the Mexican Colorectal Cancer Research Consortium was established by researchers at UNAM to tackle the increasing problem of colorectal cancer in Mexico. The Consortium consists of a multidisciplinary team working towards understanding the pathology of this disease and achieving short- and long-term goals. The article highlights the achievements of the consortium and discusses strategies for prevention and treatment of colorectal cancer in Mexico.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ruben D. Arroyo-Olarte, Ana Rivera-Rugeles, Eduardo Nava-Lira, Angel Sanchez-Barrera, Yadira Ledesma-Soto, Rafael Saavedra, Leonel Armas-Lopez, Luis Terrazas, Federico Avila-Moreno, Sonia Leon-Cabrera
Summary: Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis in colitis-associated cancer (CAC) by decreasing the frequency of Foxp3+ cells and allowing for the infiltration of inflammatory cells. The study found that STAT6 plays a crucial role in the generation of inducible in vitro regulatory T cells (iTregs) and peripheral in vivo Tregs (pTregs) under inflammatory conditions. STAT6 deficiency led to stable iTregs phenotype, increased suppressive ability, and overexpression of PD-1, CTLA-4, and Foxp3, as well as decreased IFN-gamma expression. In a mouse model of CAC, STAT6-/- pTregs exhibited an activated phenotype, higher suppressive capacity, and increased expression of PD-1 and LAP, contributing to the attenuation of tumor development.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jose Alfredo Aguayo-Guerrero, Lucia Angelica Mendez-Garcia, Aaron Noe Manjarrez-Reyna, Marcela Esquivel-Velazquez, Sonia Leon-Cabrera, Guillermo Melendez, Elena Zambrano, Espiridion Ramos-Martinez, Jose Manuel Fragoso, Juan Carlos Briones-Garduno, Galileo Escobedo
Summary: Robust animal data indicate that sucralose intake during pregnancy can lead to weight gain, metabolic disturbances, and low-grade systemic inflammation in offspring, but information in humans is still limited. A cross-sectional, prospective study was conducted to examine the effects of light sucralose ingestion (LSI) or heavy sucralose intake (HSI) during pregnancy on neonatal anthropometric, metabolic, and inflammatory features. Infants from HSI mothers had higher birth weight, insulin levels, and percentage of inflammatory nonclassical monocytes compared to those from LSI mothers. Furthermore, umbilical cord tissue of infants from HSI mothers showed higher levels of IL-1 beta and TNF-alpha with lower IL-10 expression. These results suggest that heavy sucralose ingestion during pregnancy can impact neonatal health.
Article
Medicine, Research & Experimental
Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Rosalinda Posadas-Sanchez, Hector Gonzalez-Pacheco, Alexandra Arias -Mendoza, Galileo Escobedo, Teresa Juarez-Cedillo, Marva Arellano-Gonzalez, Jose Manuel Fragoso
Summary: This study found that ABO gene polymorphisms are associated with a lower risk of ACS, lower systolic blood pressure, and plasma lipid levels.
BIOMOLECULES AND BIOMEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Jose Garces-Hernandez, Karen Pedraza-Escudero, Nayely Garibay-Nieto, Joselin Hernandez-Ruiz, Jessica Lakshmi Prieto-Chavez, Lourdes Andrea Arriaga-Pizano, Erendira Villanueva-Ortega, Galileo Escobedo, Aaron Noe Manjarrez-Reyna, Juan Carlos Lopez-Alvarenga, Jose Luis Perez-Hernandez, Gloria Queipo-Garcia
Summary: The expression of CCR2(+) monocyte subsets is significantly associated with subclinical atherosclerosis risk in boys, while in girls, no such association is observed.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Health Care Sciences & Services
Nallely Bueno-Hernandez, Jose Damian Carrillo-Ruiz, Lucia A. Mendez-Garcia, Salma A. Rizo-Tellez, Rebeca Viurcos-Sanabria, Alisson Santoyo-Chavez, Rene Marquez-Franco, Alejandro Aguado-Garcia, Neyla Baltazar-Lopez, Yoshio Tomita-Cruz, Eira Valeria Barron, Ana Laura Sanchez, Edna Marquez, Ruben Fossion, Ana Leonor Rivera, Luis Ruelas, Octavio A. Lecona, Gustavo Martinez-Mekler, Markus Mueller, America G. Arroyo-Valerio, Galileo Escobedo
Summary: This study investigated the incidence of SARS-CoV-2 infection among healthcare workers (HCW) in a dedicated COVID-19 hospital during a six-month follow-up period. The results showed a high infection rate among the HCW cohort, with a majority being asymptomatic carriers. No baseline risk factors contributed to the infection rate. Therefore, it is necessary to enhance hospital safety measures to prevent virus transmission from HCW to relatives and non-COVID-19 patients during future waves of contagion.
