When and how NK cell-induced programmed cell death benefits immunological protection against intracellular pathogen infection

Natural killer cells target and differentiate cancer stem-like cells/undifferentiated tumors: strategies to optimize their growth and expansion for effective cancer immunotherapy

(2018) Kawaljit Kaur et al.   CURRENT OPINION IN IMMUNOLOGY

Antibody-dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells

(2017) Maria Carmen Ochoa et al.   IMMUNOLOGY AND CELL BIOLOGY

Natural Killer Cells: Angels and Devils for Immunotherapy

(2017) Beatriz Martín-Antonio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

(2017) Silvia Pesce et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

NK Cell Exhaustion

(2017) Jiacheng Bi et al.   Frontiers in Immunology

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

The clearance of dying cells: table for two

(2016) D R Green et al.   CELL DEATH AND DIFFERENTIATION

NK Cell Recognition of Candida glabrata through Binding of NKp46 and NCR1 to Fungal Ligands Epa1, Epa6, and Epa7

(2016) Alon Vitenshtein et al.   Cell Host & Microbe

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Hepatitis C Virus–Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1

(2016) Celeste C. Goh et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

(2016) Marian C Okondo et al.   Nature Chemical Biology

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites

(2016) Farokh Dotiwala et al.   NATURE MEDICINE

Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin

(2016) Hung-Mu Wei et al.   PLoS One

The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways

(2016) Xiaoliang Yu et al.   Virology Journal

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma

(2016) Asma Beldi-Ferchiou et al.   Oncotarget

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium

(2015) Youssef Aachoui et al.   Cell Host & Microbe

Herpes Simplex Virus Suppresses Necroptosis in Human Cells

(2015) Hongyan Guo et al.   Cell Host & Microbe

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Granzymes Regulate Proinflammatory Cytokine Responses

(2015) Annette C. Wensink et al.   JOURNAL OF IMMUNOLOGY

Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice

(2015) José Belizário et al.   MEDIATORS OF INFLAMMATION

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Antigen-specific NK cell memory in rhesus macaques

(2015) R Keith Reeves et al.   NATURE IMMUNOLOGY

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

(2015) Michelle L Robinette et al.   NATURE IMMUNOLOGY

Inhibitory Receptors Beyond T Cell Exhaustion

(2015) Silvia A. Fuertes Marraco et al.   Frontiers in Immunology

Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes

(2014) Michael Walch et al.   CELL

IL-17 Regulates Systemic Fungal Immunity by Controlling the Functional Competence of NK Cells

(2014) Eva Bär et al.   IMMUNITY

Cutting Edge: Viral Infection Breaks NK Cell Tolerance to "Missing Self"

(2014) J. C. Sun et al.   JOURNAL OF IMMUNOLOGY

Natural killer cells as effectors of selection and differentiation of stem cells: Role in resolution of inflammation

(2014) Anahid Jewett et al.   Journal of Immunotoxicology

Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control

(2014) Beatriz Sangiuliano et al.   MEDIATORS OF INFLAMMATION

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK cell self tolerance, responsiveness and missing self recognition

(2014) Nataliya Shifrin et al.   SEMINARS IN IMMUNOLOGY

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

(2013) V. Beziat et al.   BLOOD

Danger signalling during cancer cell death: origins, plasticity and regulation

(2013) A D Garg et al.   CELL DEATH AND DIFFERENTIATION

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Macrophages clean up: efferocytosis and microbial control

(2013) Constance J Martin et al.   CURRENT OPINION IN MICROBIOLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Tissue-specific effector functions of innate lymphoid cells

(2013) Niklas K. Björkström et al.   IMMUNOLOGY

Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

(2013) A. Horowitz et al.   Science Translational Medicine

Natural Killer Cell Mediated Antibody-Dependent Cellular Cytotoxicity in Tumor Immunotherapy with Therapeutic Antibodies

(2013) Ursula J. E. Seidel et al.   Frontiers in Immunology

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation

(2012) Scott M. Gordon et al.   IMMUNITY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Proinflammatory cytokine signaling required for the generation of natural killer cell memory

(2012) Joseph C. Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Perspective on Mammalian Caspases as Positive and Negative Regulators of Inflammation

(2012) Seamus J. Martin et al.   MOLECULAR CELL

Genome guardian p53 and viral infections

(2012) Yoshitaka Sato et al.   REVIEWS IN MEDICAL VIROLOGY

PD-1 Expression on Natural Killer Cells and CD8+ T Cells During Chronic HIV-1 Infection

(2012) Sonia Norris et al.   VIRAL IMMUNOLOGY

Human NK cell lytic granules and regulation of their exocytosis

(2012) Konrad Krzewski et al.   Frontiers in Immunology

Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands

(2011) Beatriz Sanchez-Correa et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans

(2011) Shigeru Tsuboi et al.   EMBO JOURNAL

Activation of NK Cells by ADCC Antibodies and HIV Disease Progression

(2011) Amy W Chung et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Granulysin Delivered by Cytotoxic Cells Damages Endoplasmic Reticulum and Activates Caspase-7 in Target Cells

(2011) R. V. Saini et al.   JOURNAL OF IMMUNOLOGY

Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens

(2011) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

(2011) Inna S. Afonina et al.   MOLECULAR CELL

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin

(2010) P. Tewary et al.   BLOOD

Natural Killer Cell Education and Tolerance

(2010) Mark T. Orr et al.   CELL

Granzymes in cancer and immunity

(2010) S P Cullen et al.   CELL DEATH AND DIFFERENTIATION

Inflammasomes as microbial sensors

(2010) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

CD56 negative NK cells: origin, function, and role in chronic viral disease

(2010) Niklas K. Björkström et al.   TRENDS IN IMMUNOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Biology and clinical relevance of granulysin

(2009) A. M. Krensky et al.   TISSUE ANTIGENS

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

(2008) Denis Martinvalet et al.   CELL

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS