Article
Environmental Sciences
Yingdie Zhang, Pei Gu, Yujia Xie, Lieyang Fan, Xiaojie You, Shiyu Yang, Yuxin Yao, Weihong Chen, Jixuan Ma
Summary: This study found that m6A methylation plays an important role in the formation of silicosis, and long-term exposure to crystalline silica can lead to silicosis accompanied by increased levels of m6A methylation. Upregulation and downregulation of certain m6A modification-related genes may contribute to aberrant m6A modification. In addition, there are genes showing differential m6A methylation peaks in silicosis, and there are 1091 genes with differential expression in silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Yanhong Li, Hongwu Liang, Bo Ren, Tingting Zhao, Haiyue Chen, Yuexing Zhao, Hanlin Liang
Summary: In this study, the toxicological effects of the chiral fungicide Mefentrifluconazole on aquatic organisms were investigated. The results showed that Mefentrifluconazole induced enantioselective liver toxicity in zebrafish, with different enantiomers exhibiting different effects. This study highlights the importance of distinguishing different enantiomers and provides valuable insights for environmental protection.
Article
Environmental Sciences
Yongqing Lu, Jiaxing Wu, Jiaokun Li
Summary: The study investigates the effect of exogenous Se application on the toxicity of Sb(III) and Sb(V) in rice seedlings. It is found that Se can alleviate the adverse effects of Sb by improving plant growth, antioxidant system, Sb uptake and distribution, and gene expression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Friesen, Susanne Fritsch-Decker, Matthias Hufnagel, Sonja Muelhopt, Dieter Stapf, Carsten Weiss, Andrea Hartwig
Summary: In vitro lung cell models have become valuable tools for toxicological risk assessment, particularly in testing advanced materials such as nanomaterials. This study investigated the cellular responses of lung cells after exposure to alpha-quartz particles using different cell culture models. The results showed dose- and time-dependent induction of genes related to inflammation and oxidative stress, with differences observed between mono-cultures and co-cultures. The findings highlight the importance of considering the cell culture model and exposure scenario in toxicological risk assessment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Ruiyang Ding, Yang Li, Yang Yu, Zhiwei Sun, Junchao Duan
Summary: This review covers the applications of SiNPs in different fields, especially in biomedicine, and their potential pathways into the environment. It also provides a detailed account of the current methods used to assess SiNPs toxicity on model organisms and cell lines, estimating the potential health risks posed by SiNPs exposure. Furthermore, it elaborates on the potential toxic mechanisms of SiNPs based on results from both in vivo and in vitro trials.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Toxicology
Toshio Kobayashi, Yasuhiro Tsubokura, Yutaka Oshima, Takeshi Sasaki, Kenji Kawaguchi, Kenji Koga, Kunio Uchida, Naohide Shinohara, Shozo Ajimi, Takakazu Kayashima, Makoto Nakai, Nobuya Imatanaka
Summary: Crystalline silica's toxic potential is associated with its surface electrical properties, but in vivo data on its long-term effects are insufficient. A rat model study revealed that the physico-chemical property, including surface potential, of nanocrystalline silica contributes to its hazard. The study suggests that the in vivo toxic potential of nanosilica may be influenced by both surface properties and other physico-chemical properties.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Plant Sciences
Munazza Ijaz, Mahmood-ur-Rahman Ansari, Hayat Ali Alafari, Muhammad Iqbal, Dalal S. Alshaya, Sajid Fiaz, Hafiz Muhammad Ahmad, Muhammad Zubair, Pia Muhammad Adnan Ramzani, Javed Iqbal, Asmaa M. Abushady, Kotb Attia
Summary: Citric acid application enhances Ni phytoextraction efficiency and protects sunflower against Ni-induced oxidative stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yng-Tay Chen, Po-Yi Lue, Po-Wei Chen, Pin-Ju Chueh, Fuu-Jen Tsai, Jiunn-Wang Liao
Summary: Surface-modified nano-SiO2 showed good safety in genotoxicity tests, but acute pulmonary toxicity should be cautiously considered, with mSA showing acute toxicity in rats and mSB showing decreased toxicity after modification.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Environmental
Yungeng Wei, Yichuan You, Jiarui Zhang, Jiaqi Ban, Hui Min, Chao Li, Jie Chen
Summary: Environmental exposure to crystalline silica can cause silicosis, and alveolar macrophages play an important role in its development. Previous studies have shown that enhancing mitophagy in these macrophages can protect against silicosis and reduce inflammation. The specific molecular mechanisms, however, remain unclear. Investigating the interaction and balance between pyroptosis and mitophagy in alveolar macrophages may provide new insights for the treatment of silicosis.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Cell Biology
Wen Nie, Tianxia Lan, Xia Yuan, Min Luo, Guobo Shen, Jiayun Yu, Xiawei Wei
Summary: The study revealed that crystalline silica leads to rapid necrosis of lung macrophages through the release of cathepsin B causing mitochondrial membrane dysfunction. It was also found that CS-induced macrophage necrosis triggers the recruitment of lung neutrophils, regulated by the TLR9 signaling pathway. These findings suggest a novel mechanism for pulmonary inflammation induced by CS and have implications for early prevention and treatment of related diseases.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Environmental Sciences
Johannes Pohl, Oksana Golovko, Gunnar Carlsson, Stefan Orn, Monika Schmitz, Ehsan Pashay Ahi
Summary: Exposure to ozonated carbamazepine (CBZ) was found to result in cardiovascular-related malformations and reduced heart rate in zebrafish embryos, along with a lack of swim bladder inflation. Through gene co-expression analysis, two co-expression networks and their upstream transcription regulators were identified, offering mechanistic explanations for the observed toxicity phenotypes. The study presents a novel application of gene co-expression analysis elucidating potential toxicity mechanisms of an ozonated pharmaceutical with environmental relevance.
Article
Biochemistry & Molecular Biology
Ghasem Rashidian, Ramin Mohammadi-Aloucheh, Farnaz Hosseinzadeh-Otaghvari, Latifeh Chupani, Vlastimil Stejskal, Hamidreza Samadikhah, Soheila Zamanlui, Cristiana Roberta Multisanti, Caterina Faggio
Summary: The study found that small-sized silica nanoparticles (SiO2-NPs) had negative effects on the reproductive performance of zebrafish, leading to decreased gonad weight, reduced fecundity, and lower larval survival rate. Additionally, SiO2-NPs significantly impacted the biochemical parameters, hormone levels, and immune function of zebrafish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Toxicology
Caroline Portela Peruzzi, Natalia Brucker, Guilherme Bubols, Larissa Cestonaro, Rafael Moreira, Daiane Domingues, Marcelo Arbo, Pedro Olivo Neto, Marli Maria Knorst, Solange Cristina Garcia
Summary: Peripheral biomarkers are crucial for detecting occupational exposures and early health alterations. Silicosis is a common issue, and studies in this area aim to diagnose or predict it in advance.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Engineering, Environmental
Yichuan You, Haoyang Yuan, Hui Min, Chao Li, Jie Chen
Summary: Exposure to crystalline silica particles leads to upregulation of fibroblast-derived CXCL14, which recruits bone marrow-derived macrophages and promotes alternative macrophage polarization. Mechanistically, GLI2 and p21-mediated cellular senescence are involved in CXCL14 production after silica exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Jie Shen, Peng Liu, Yongqi Sun, Xiaoxiao Xu, Longfei Guo, Qiong Rao, Minlan Chen, Xunyue Liu
Summary: This study found that prothioconazole is toxic to zebrafish embryos, causing malformations and apoptosis. Exposure to high concentrations of prothioconazole up-regulated the expression levels of oxidative stress defense-related genes and p53, leading to apoptosis in the early life stages of zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)