Could a Swimming Creature Inform Us on Intestinal Diseases? Lessons from Zebrafish

MyD88 Signaling Is Not Essential for Induction of Antigen-Specific B Cell Responses but Is Indispensable for Protection against Streptococcus pneumoniae Infection following Oral Vaccination with Attenuated Salmonella Expressing PspA Antigen

(2014) S.-M. Park et al.   JOURNAL OF IMMUNOLOGY

IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling

(2013) Maria M. Costa et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system

(2013) M. van der Vaart et al.   Disease Models & Mechanisms

Evolution and function of chemokine receptors in the immune system of lower vertebrates

(2013) Baubak Bajoghli   EUROPEAN JOURNAL OF IMMUNOLOGY

Implications of the human microbiome in inflammatory bowel diseases

(2013) Syeda M. Bakhtiar et al.   FEMS MICROBIOLOGY LETTERS

Effects of probiotic administration on zebrafish development and reproduction

(2013) O. Carnevali et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Increasing Incidence and Lifetime Risk of Inflammatory Bowel Disease in Taiwan

(2013) Chiao-Hsiung Chuang et al.   INFLAMMATORY BOWEL DISEASES

Inflammatory Bowel Disease in Chinese Children

(2013) Xin-qiong Wang et al.   INFLAMMATORY BOWEL DISEASES

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

The gut microbiota — masters of host development and physiology

(2013) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Colonizing the Embryonic Zebrafish Gut with Anaerobic Bacteria Derived from the Human Gastrointestinal Tract

(2013) Michael C. Toh et al.   Zebrafish

Emerging inflammatory bowel disease in saudi outpatients: A report of 693 cases

(2013) IbrahimA Al-Mofleh et al.   Saudi Journal of Gastroenterology

Microbiota Regulate Intestinal Absorption and Metabolism of Fatty Acids in the Zebrafish

(2012) Ivana Semova et al.   Cell Host & Microbe

RETRACTED: Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid

(2012) James W. Walters et al.   CHEMISTRY & BIOLOGY

Nutrition and diet in inflammatory bowel disease

(2012) Takayuki Yamamoto   CURRENT OPINION IN GASTROENTEROLOGY

Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish

(2012) Xubo Niu et al.   DEVELOPMENTAL BIOLOGY

A model 450 million years in the making: zebrafish and vertebrate immunity

(2012) S. A. Renshaw et al.   Disease Models & Mechanisms

Glafenine-induced intestinal injury in zebrafish is ameliorated by  -opioid signaling via enhancement of Atf6-dependent cellular stress responses

(2012) J. R. Goldsmith et al.   Disease Models & Mechanisms

Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis

(2012) S. H. Oehlers et al.   Disease Models & Mechanisms

Brain-Gut Interactions in Inflammatory Bowel Disease

(2012) Bruno L. Bonaz et al.   GASTROENTEROLOGY

Differential outcome of infection with attenuated Salmonella in MyD88-deficient mice is dependent on the route of administration

(2012) Jincy M. Issac et al.   IMMUNOBIOLOGY

Immune system and immune responses in fish and their role in comparative immunity study: A model for higher organisms

(2012) Pradipta R. Rauta et al.   IMMUNOLOGY LETTERS

Healing of intestinal inflammation by IL-22

(2012) Atsushi Mizoguchi   INFLAMMATORY BOWEL DISEASES

Loss of Phosphoinositide 3-Kinase p110γ is Protective in the Acute Phase but Detrimental in the Resolution Phase of Hapten-Induced Colitis

(2012) David Prescott et al.   INFLAMMATORY BOWEL DISEASES

IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis

(2012) Christopher J. Moran et al.   INFLAMMATORY BOWEL DISEASES

Think Small: Zebrafish as a Model System of Human Pathology

(2012) J. R. Goldsmith et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

(2012) Martina Perše et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Inflammatory bowel disease in Asia: A systematic review

(2012) Lani Prideaux et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Myelopoiesis during Zebrafish Early Development

(2012) Jin Xu et al.   Journal of Genetics and Genomics

Reverse Genetic Approaches in Zebrafish

(2012) Peng Huang et al.   Journal of Genetics and Genomics

Environmental and ecological factors that shape the gut bacterial communities of fish: a meta-analysis

(2012) KAREN E. SULLAM et al.   MOLECULAR ECOLOGY

Intestinal microbiota composition in fishes is influenced by host ecology and environment

(2012) SANDI WONG et al.   MOLECULAR ECOLOGY

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

IBD—what role do Proteobacteria play?

(2012) Indrani Mukhopadhya et al.   Nature Reviews Gastroenterology & Hepatology

Bacterial Community Assembly and Turnover within the Intestines of Developing Zebrafish

(2012) Qingyun Yan et al.   PLoS One

Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development

(2012) J. Galindo-Villegas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling in Vertebrate Axis Specification

(2012) H. Hikasa et al.   Cold Spring Harbor Perspectives in Biology

A New Zebrafish Model of Oro-Intestinal Pathogen Colonization Reveals a Key Role for Adhesion in Protection by Probiotic Bacteria

(2012) Olaya Rendueles et al.   PLoS Pathogens

Dynamic Evolution of the LPS-Detoxifying Enzyme Intestinal Alkaline Phosphatase in Zebrafish and Other Vertebrates

(2012) Ye Yang et al.   Frontiers in Immunology

Mu Opioid Signaling Protects Against Acute Murine Intestinal Injury in a Manner Involving Stat3 Signaling

(2011) Jason R. Goldsmith et al.   AMERICAN JOURNAL OF PATHOLOGY

Zebrafish as a model to understand autophagy and its role in neurological disease

(2011) Angeleen Fleming et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Host-Pathogen Interactions Made Transparent with the Zebrafish Model

(2011) Annemarie H. Meijer et al.   CURRENT DRUG TARGETS

Toll-like receptors in bony fish: From genomics to function

(2011) Yniv Palti   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Identification and molecular characterization of the interleukin-10 receptor 1 of the zebrafish (Danio rerio) and the goldfish (Carassius auratus L.)

(2011) Leon Grayfer et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Regulatory mechanisms of thymus and T cell development

(2011) Dongyuan Ma et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Visualizing digestive organ morphology and function using differential fatty acid metabolism in live zebrafish

(2011) Juliana Debrito Carten et al.   DEVELOPMENTAL BIOLOGY

Forward and Reverse Genetic Approaches for the Analysis of Vertebrate Development in the Zebrafish

(2011) Nathan D. Lawson et al.   DEVELOPMENTAL CELL

The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish

(2011) S. H. Oehlers et al.   Disease Models & Mechanisms

Microbial Colonization Induces Dynamic Temporal and Spatial Patterns of NF-κB Activation in the Zebrafish Digestive Tract

(2011) Michelle Kanther et al.   GASTROENTEROLOGY

Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation

(2011) Katie C. Crawford et al.   GENESIS

Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

(2011) Peter De Cruz et al.   INFLAMMATORY BOWEL DISEASES

Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease

(2011) Gheorghe Hundorfean et al.   INFLAMMATORY BOWEL DISEASES

Evidence for a core gut microbiota in the zebrafish

(2011) Guus Roeselers et al.   ISME Journal

Cutting Edge: Crohn's Disease-Associated Nod2 Mutation Limits Production of Proinflammatory Cytokines To Protect the Host from Enterococcus faecalis-Induced Lethality

(2011) Y.-G. Kim et al.   JOURNAL OF IMMUNOLOGY

Nucleotide-Binding Oligomerization Domain 1 Mediates Recognition of Clostridium difficile and Induces Neutrophil Recruitment and Protection against the Pathogen

(2011) M. Hasegawa et al.   JOURNAL OF IMMUNOLOGY

Discovery of zebrafish (Danio rerio) interleukin-23 alpha (IL-23α) chain, a subunit important for the formation of IL-23, a cytokine involved in the development of Th17 cells and inflammation

(2011) Amy Holt et al.   MOLECULAR IMMUNOLOGY

Normal Anatomy and Histology of the Adult Zebrafish

(2011) Aswin L. Menke et al.   TOXICOLOGIC PATHOLOGY

Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine

(2010) Zhengyuan Wang et al.   BMC GENOMICS

Host–microbe interactions in the developing zebrafish

(2010) Michelle Kanther et al.   CURRENT OPINION IN IMMUNOLOGY

HSP-Dependent Protection Against Gastrointestinal Diseases

(2010) Tohru Mizushima   CURRENT PHARMACEUTICAL DESIGN

Topographical distribution of antimicrobial genes in the zebrafish intestine

(2010) Stefan H. Oehlers et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents

(2010) Stefan H. Oehlers et al.   DEVELOPMENTAL DYNAMICS

In vivo analysis of gut function and disease changes in a zebrafish larvae model of inflammatory bowel disease

(2010) Angeleen Fleming et al.   INFLAMMATORY BOWEL DISEASES

Evolution of Recognition of Ligands from Gram-Positive Bacteria: Similarities and Differences in the TLR2-Mediated Response between Mammalian Vertebrates and Teleost Fish

(2010) Carla M. S. Ribeiro et al.   JOURNAL OF IMMUNOLOGY

Epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88

(2010) S. E. Cheesman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fish immunology

(2009) Graham J. Lieschke et al.   CURRENT BIOLOGY

Expression of zebrafish cxcl8 (interleukin-8) and its receptors during development and in response to immune stimulation

(2009) Stefan H.B. Oehlers et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Expression and function of stress (heat shock) proteins in gastrointestinal tract

(2009) Michiro Otaka et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Evolution of Lipopolysaccharide (LPS) Recognition and Signaling: Fish TLR4 Does Not Recognize LPS and Negatively Regulates NF- B Activation

(2009) M. P. Sepulcre et al.   JOURNAL OF IMMUNOLOGY

Innate Immunity Mediated by MyD88 Signal Is Not Essential for Induction of Lipopolysaccharide-Specific B Cell Responses but Is Indispensable for Protection against Salmonella enterica serovar Typhimurium infection

(2009) H.-J. Ko et al.   JOURNAL OF IMMUNOLOGY

Transcriptome Profiling and Functional Analyses of the Zebrafish Embryonic Innate Immune Response to Salmonella Infection

(2009) O. W. Stockhammer et al.   JOURNAL OF IMMUNOLOGY

The Gene History of Zebrafish tlr4a and tlr4b Is Predictive of Their Divergent Functions

(2009) C. Sullivan et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll-like receptor signaling in bony fish

(2009) Alexander Rebl et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Immunology and zebrafish: Spawning new models of human disease

(2008) Nathan D. Meeker et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases

(2008) C. D. Packey et al.   JOURNAL OF INTERNAL MEDICINE

MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis

(2007) D. L. Gibson et al.   CELLULAR MICROBIOLOGY