Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA*

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

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Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation

(2010) Andrei I. Ivanov et al.   AMERICAN JOURNAL OF PATHOLOGY

Roflumilast in chronic obstructive pulmonary disease: evidence from large trials

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Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-κB-independent manner

(2010) Lirlândia P. Sousa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis

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Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease

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Disruption of the Cox-1 gene slows repair of microscopic lesions in the mouse gastric epithelium

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