Article
Cell Biology
Jia Li, Chenghui Yan, Yilong Wang, Can Chen, Haibo Yu, Dan Liu, Kai Huang, Yaling Han
Summary: Pathological cardiac hypertrophy is a major risk factor for heart failure, characterized by abnormal remodeling of cardiomyocytes in response to pressure overload or other stress stimuli. The study reveals that GCN5 plays a significant role in promoting cardiac hypertrophy through excessive activation of the TAK1-JNK/p38 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Xi Chen, Ying Zhao, Xu Wang, Yimin Lin, Weixin Zhao, Di Wu, Jingye Pan, Wu Luo, Yi Wang, Guang Liang
Summary: The activation of focal adhesion kinase (FAK) by endotoxin lipopolysaccharide (LPS) can induce inflammatory responses in macrophages. In this study, inhibition of FAK suppressed LPS-induced inflammatory cytokine production, as well as the activation of MAPKs and NF kappa B in macrophages. FAK was found to interact with transforming growth factor-beta-activated kinase-1 (TAK1) and phosphorylate it at Ser412. Pharmacological inhibition of FAK in a mouse model of LPS-induced acute lung injury (ALI) resulted in the preservation of lung tissues and increased survival during LPS-induced septic shock.
CELL DEATH & DISEASE
(2022)
Article
Virology
Zhili Qu, Yuqin Sun, Xuefeng Zhou, Xiaolong Yan, Tianjun Xu
Summary: This study found that overexpression of Smyd3 facilitates the replication of Siniperca chuatsi rhabdovirus (SCRV) and promotes the degradation of TAK1 protein, thus exerting a negative regulatory effect on the NF-kappa B and IRF3 signaling pathways.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
Xiaohe Li, Qing Liang, Shaoyan Gao, Qiuyan Jiang, Fangxia Zhang, Ruiqin Zhang, Hao Ruan, Shuangling Li, Jiaoyan Luan, Ruxia Deng, Honggang Zhou, Hui Huang, Cheng Yang
Summary: Lenalidomide has potential anti-fibrotic effects by suppressing inflammation-related signaling pathways, thereby reducing pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Bozhi Ye, Xudong Chen, Yanghao Chen, Wante Lin, Diyun Xu, Zimin Fang, Nipon Chattipakorn, Weijian Huang, Xu Wang, Gaojun Wu, Guang Liang
Summary: This study demonstrates that Costunolide (Cos) can improve obesity cardiomyopathy by inhibiting inflammation. Through molecular docking, we confirmed that Cos targets TAK1 and inhibits NF-kappa B pathway activation by blocking the formation of the TAK1/TAB2 complex, thereby reducing inflammatory cytokine release and improving myocardial inflammation. Moreover, Cos effectively reduces cardiac hypertrophy and fibrosis caused by obesity, leading to improved cardiac function against obesity cardiomyopathy.
Review
Immunology
Yan-Ran Xu, Cao-Qi Lei
Summary: TAK1, a member of the MAPKKK family, functions by assembling with TAB1, TAB2, and TAB3 and can be activated by various stimuli. Post-translational modifications play important roles in controlling the activity, stability, and assembly of the TAK1-TABs complex.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Ying Fu, Yu Xiang, Ying Wang, Zhiwen Liu, Danyi Yang, Jie Zha, Chengyuan Tang, Juan Cai, Guochun Chen, Zheng Dong
Summary: This study uncovers the role of the STAT1/HMGB1/NF-?B pathway in chronic kidney problems after long-term use of cisplatin, providing new therapeutic targets for kidney protection in cancer patients receiving cisplatin chemotherapy.
Article
Chemistry, Multidisciplinary
Li Xiang, Juan Nie, Li Wang, Yu Wang, Jingchun Shi, Juntong Wei, Chi-Wai Lau, Zongwei Cai, Yu Huang
Summary: The study showed that PPAR delta agonist GW501516 significantly altered the metabolic profile in type 2 diabetic mice, helping to alleviate insulin resistance and providing valuable insights into the therapeutic potential of PPAR delta agonists in correcting metabolic dysfunction in diabetes.
CHINESE CHEMICAL LETTERS
(2021)
Article
Cell Biology
Shuai Jiang, Yandan Wu, Shunjie Wu, Suhui Ye, Renyi Kong, Jie Chang, Mingjie Xia, Junping Bao, Xin Peng, Xin Hong, Zhanyang Qian, Haijun Li
Summary: The study demonstrated that inhibition of TAK1 could alleviate neuroinflammation and tissue damage post SCI, leading to better locomotor recovery and suppression of microglia pro-inflammatory activities.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Hongdian Zhang, Youming Han, Wanyi Xiao, Yongyin Gao, Zhilin Sui, Peng Ren, Fanbiao Meng, Peng Tang, Zhentao Yu
Summary: This study reveals that USP4 plays a crucial role in the progression of esophageal squamous cell carcinoma (ESCC) by modulating proliferation, migration, and invasion. USP4 interacts with TAK1 and stabilizes its protein levels in ESCC cells. Additionally, USP4 promotes ESCC progression through the activation of the MEK/ERK signaling pathway.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Long Cui, Yu-Jing Tan, Shi-Qi Xu, Bo-Feng Qin, Meng-Xue Xiu, Xue Zhang, Li-Qiang Shi, Hai-Ming Sun, Jian Song
Summary: Ginsenoside Rd has the potential to inhibit hepatic fibrosis and reduce liver inflammation through the activation of the ERR alpha-P2X7r signaling pathway.
Article
Cell Biology
Hao Sheng, Fang Zheng, Tian Lan, Hang-fei Chen, Chun-yi Xu, Si-wei Wang, Yuan-yuan Weng, Li-feng Xu, Feng Zhang
Summary: YEATS2 promotes NF-kappa B transcriptional activity by modulating TAK1 activation and interacting with NF-kappa B.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sha Tu, Yanzhi Jiang, Haihua Cheng, Xiangning Yuan, Ying He, Yu Peng, Xiongqun Peng, Zhangzhe Peng, Lijian Tao, Huixiang Yang
Summary: Despite the limited therapies available for combatting hepatic fibrosis, the novel pyridone agent Fluorofenidone (AKF-PD) shows promising effects in ameliorating liver fibrosis by inhibiting the NF-kappa B pathway. AKF-PD treatment reduces inflammatory cytokines, suppresses inflammatory cell infiltration in the liver, and attenuates liver injury and fibrosis in experimental models induced by CCL4 and PS. The mechanism of action involves the downregulation of proinflammatory mediators and suppression of NF-kappa B signaling pathway activation.
Article
Nutrition & Dietetics
Xuejiao Zhang, Bowei Zhang, Bo Peng, Jin Wang, Yaozhong Hu, Ruican Wang, Shuo Wang
Summary: The study demonstrates that sucrose has differential effects on colitis at different doses. Low-dose sucrose intervention alleviates colitis by reducing inflammation and repairing mucosal damages while high-dose sucrose intervention exacerbates colitis. Additionally, the three doses of sucrose administration significantly alter gut microbiota composition, with low-dose sucrose restoring microbial dysfunction and enhancing the production of short chain fatty acids.
Article
Cell Biology
Qin He, Yiting Cai, Jiani Huang, Xiaoying He, Wei Han, Wei Chen
Summary: This study found that autophagic activity was decreased in human pterygium tissues, and activating autophagy can slow down the fibrotic process of pterygium, while blocking autophagy exacerbates this process.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)