Article
Biochemistry & Molecular Biology
Ning Li, Bohao Liu, Rui Xiong, Guorui Li, Bo Wang, Qing Geng
Summary: This study investigated the effects of HDAC3 in AT2 cells on LPS-induced ALI and identified the potential mechanisms involved. The findings revealed that HDAC3 deficiency in AT2 cells not only reduced inflammation, apoptosis, and oxidative stress, but also maintained epithelial barrier integrity. Furthermore, HDAC3 promoted ROCK1 transcription, leading to MQC disruption and ALI. Additionally, HDAC3 inhibitor RGFP966 alleviated epithelial damage and improved MQC in LPS-treated AT2 cells.
Article
Environmental Sciences
Tae Hong Kang, Kyung Soo Kang, Sang In Lee
Summary: Research has found that DON can induce apoptosis in intestinal epithelial cells through the FOXO3a-signaling pathway, leading to the translocation of FOXO3a into the nucleus. Inhibiting FOXO3a can alleviate apoptosis and the expression of apoptosis-related genes. Additionally, treatment with an ERK1/2 inhibitor can suppress the translocation of FOXO3a into the nucleus.
Review
Oncology
Shaojie Yang, Liwei Pang, Wanlin Dai, Shuodong Wu, Tengqi Ren, Yunlong Duan, Yuting Zheng, Shiyuan Bi, Xiaolin Zhang, Jing Kong
Summary: Hepatocellular carcinoma (HCC) is associated with high morbidity and mortality, with surgical resection being the main treatment. Foxo proteins play crucial roles in HCC and are considered multifunctional targets for cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Jung Yeon Hong, Mi Na Kim, Eun Gyul Kim, Jae Woo Lee, Hye Rin Kim, Soo Yeon Kim, Soon Min Lee, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn
Summary: Exposure to high oxygen concentrations leads to excessive generation of reactive oxygen species, causing cellular injury and multiple organ dysfunctions. Clusterin (CLU) expression is increased during prolonged hyperoxia-induced lung injury, and replenishment of CLU can alleviate hyperoxia-induced cell death.
Review
Oncology
Peyman Tabnak, Aysa Hasanzade Bashkandi, Mohammad Ebrahimnezhad, Mahdieh Soleimani
Summary: This review discusses the roles of transcription factors FOXOs and FOXM1 in gliomas, including their interactions with other proteins and microRNAs in regulatory networks, as well as their significance in glioma progression.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Wenfang Xia, Zhou Pan, Huanming Zhang, Qingshan Zhou, Yu Liu
Summary: This study investigates the role of estrogen-related receptor alpha (ERRα) in sepsis-induced acute lung injury (ALI). The results show that overexpression of ERRα can ameliorate LPS-induced endothelial hyperpermeability, apoptosis, and inhibit autophagy, while knockdown of ERRα exacerbates these effects. Administration of an ERRα agonist can alleviate pathological damage, increase the levels of junctional proteins, and decrease apoptosis-related protein expression. Promoting ERRα expression enhances autophagy and reduces sepsis-induced ALI. ERRα is essential for maintaining the integrity of adherens junctions by regulating the balance between autophagy and apoptosis.
MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Binghua He, Fan Yang, Yingxia Ning, Yalan Li
Summary: This study investigated the protective effects of sevoflurane (Sevo) in hepatic ischemia/reperfusion (I/R) injury. It was found that Sevo alleviated liver injury and reduced cell apoptosis in a mouse I/R model by promoting miR-96 expression and inhibiting FOXO4 expression. These findings highlight the molecular mechanism by which Sevo mitigates hepatic I/R injury.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xin Lv, Tingting Yao, Rongling He, Yijun He, Mengyu Li, Yuanyuan Han, Yan Zhang, Lingzhi Long, Guoliang Jiang, Xiaoyun Cheng, Yanyun Xie, Ling Huang, Zhangzhe Peng, Gaoyun Hu, Qianbin Li, Lijian Tao, Jie Meng
Summary: Fluorofenidone demonstrates protective effects against LPS-induced ALI by alleviating lung tissue injury, reducing inflammation, and inhibiting the activation of the MAPK/NF-κB signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Ruolin Wang, Siheng Shen, Luyong Jian, Shuhua Liu, Qi Yuan, Huahui Guo, Jiasheng Huang, Penghui Chen, Renfa Huang
Summary: This study investigated the role of autophagy in AKI-induced ALI and found that autophagy can effectively ameliorate the injury by suppressing inflammation and oxidative stress.
Article
Oncology
Weiyun Wu, Yongze Chen, Shicai Ye, Hui Yang, Jianyun Yang, Juanhua Quan
Summary: The study revealed that FOXK1 regulates miR-32 expression in colorectal cancer by binding directly to the miR-32 promoter, leading to activation of TMEM245 and suppression of PTEN, thereby promoting cell proliferation and invasion while inhibiting apoptosis.
Article
Biotechnology & Applied Microbiology
Feng Yun Yang, Lu Zhang, Yan Zheng, He Dong
Summary: Dexmedetomidine (DEX) attenuates ischemia and reperfusion (I/R)-induced cardiomyocyte apoptosis by blocking p53 expression and FOXO3a/PUMA signaling.
Article
Chemistry, Multidisciplinary
Hamadi Madhi, Jeon-Soo Lee, Young Eun Choi, Yan Li, Myoung Hee Kim, Yongdoo Choi, Sung-Ho Goh
Summary: The focus of this study is FOXM1, which is identified as a potential therapeutic target for cancer immunotherapy and associated with the modulation of PD-L1 expression. The study found that selective knockdown of FOXM1 or treatment with TST significantly reduces PD-L1 expression in NSCLC cells and inhibits proliferation. Animal studies showed that TST treatment downregulates PD-L1 expression in NSCLC tumors and reduces tumor size without side effects. Combined treatment with TST and anti-4-1BB antibody induces synergistic therapeutic outcomes against immune resistant lung tumors and increases the number of CD3(+) T cells in tumor tissues.
Article
Immunology
Lei Li, Yanping Zhan, Haimei Xia, Yunkun Wu, Xiongzhi Wu, Shibiao Chen
Summary: This study identified the role of Sevoflurane (Sev) in intracerebral hemorrhage (ICH). Sev treatment attenuated ICH and hippocampal neuronal apoptosis in mice by upregulating miR-133b, which targeted FOXO4 expression and increased BCL2 expression. These findings highlight the protective effect of Sev on ICH mice through the regulation of miR-133b-mediated FOXO4 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jiayao Zhao, Qun Liang, Chenfei Fu, Didi Cong, Long Wang, Xiaoxin Xu
Summary: Sepsis-induced acute lung injury (ALI) is a severe syndrome with a heavy burden on family and society. Autophagy, as a key factor in cellular homeostasis, plays an important role in the pathophysiological process of sepsis-induced ALI. Regulating autophagy may be beneficial for this disease, although its role in the etiology and treatment is not well characterized.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Rundong Jiang, Jiaqi Xu, Yuezhong Zhang, Xuanmeng Zhu, Jiachen Liu, Yurong Tan
Summary: Ligustrazine has been shown to inhibit the occurrence and development of ALI through multiple pathways, including reducing inflammatory cell infiltration, inhibiting the secretion of inflammatory factors, and decreasing cell pyroptosis and apoptosis. This provides a theoretical basis for the future use of ligustrazine in the treatment of ALI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Chi Zhang, Shunlin Qu, Xing Wei, Yansheng Feng, Honglin Zhu, Jia Deng, Kangkai Wang, Ke Liu, Meidong Liu, Huali Zhang, Xianzhong Xiao
CELL STRESS & CHAPERONES
(2016)
Article
Biochemistry & Molecular Biology
Yansheng Feng, Jia Zhao, Huifang Hou, Hui Zhang, Yunjuan Jiao, Jiangang Wang, Yongling Wang, Yinping Sun
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2016)
Article
Cell Biology
Ngonidzashe B. Madungwe, Yansheng Feng, Mihaela Lie, Nathalie Tombo, Li Liu, Ferdinand Kaya, Jean C. Bopassa
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Lei Jiang, Hao Wang, Guangbin Chen, Yansheng Feng, Jiang Zou, Meidong Liu, Ke Liu, Nian Wang, Huali Zhang, Kangkai Wang, Xianzhong Xiao
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Review
Cell Biology
Yansheng Feng, Ngonidzashe B. Madungwe, Jean C. Bopassa
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Chemistry, Medicinal
Bingxuan Niu, Hui Zhang, Chunyan Li, Fulin Yan, Yu Song, Guangfan Hai, Yunjuan Jiao, Yansheng Feng
DRUG DESIGN DEVELOPMENT AND THERAPY
(2019)
Article
Medicine, Research & Experimental
Devasena Ponnalagu, Ahmed Tafsirul Hussain, Rushi Thanawala, Jahnavi Meka, Piotr Bednarczyk, Yansheng Feng, Adam Szewczyk, Shubha GururajaRao, Jean C. Bopassa, Mahmood Khan, Harpreet Singh
Article
Biochemistry & Molecular Biology
Yansheng Feng, Ngonidzashe B. Madungwe, Abdulhafiz D. Imam Aliagan, Nathalie Tombo, Jean C. Bopassa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Nathalie Tombo, Abdulhafiz D. Imam Aliagan, Yansheng Feng, Harpreet Singh, Jean C. Bopassa
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Endocrinology & Metabolism
Abdulhafiz Imam Aliagan, Ngonidzashe B. Madungwe, Nathalie Tombo, Yansheng Feng, Jean C. Bopassa
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Cell Biology
Yansheng Feng, Abdulhafiz Imam Aliagan, Nathalie Tombo, Derrick Draeger, Jean C. Bopassa
Summary: This study reveals the crucial role of the RIP3-Mitofilin axis in the initiation and development of renal ischemia-reperfusion injury, involving the release of mtDNA and activation of the cGAS-STING pathway, which leads to increased transcription of pro-inflammatory markers and exacerbation of renal injury.
Article
Biochemistry & Molecular Biology
Yansheng Feng, Abdulhafiz Imam Aliagan, Nathalie Tombo, Jean C. C. Bopassa
Summary: Mitofilin, a mitochondrial inner membrane protein, plays a critical role in maintaining mitochondrial architecture and function. Knockout or reduction of Mitofilin expression in mice enhances myocardial injury and inflammation after ischemia/reperfusion (I/R) injury. Understanding the role of Mitofilin in I/R injury could provide insights into potential therapeutic targets for mitigating cardiac damage.
Article
Oncology
Ngonidzashe B. Madungwe, Yansheng Feng, Abdulhafiz Imam Aliagan, Nathalie Tombo, Ferdinand Kaya, Jean C. Bopassa
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Yansheng Feng, Ngonidzashe B. Madungwe, Carolina Victoria da Cruz Junho, Jean C. Bopassa
BRITISH JOURNAL OF PHARMACOLOGY
(2017)
Article
Oncology
Abdulhafiz D. Imam Aliagan, Mina D. Ahwazi, Nathalie Tombo, Yansheng Feng, Jean C. Bopassa
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2020)