Article
Immunology
Benjamin Havenga, Brandon Reyneke, Thando Ndlovu, Wesaal Khan
Summary: This study compared the genotypic, phenotypic, and antibiotic resistance profiles of clinical and environmental Acinetobacter baumannii isolates. The clinical isolates showed higher biofilm formation capability and resistance to antibiotics compared to the environmental isolates, which had increased susceptibility to antibiotics. The environmental isolates were assigned to a novel sequence type, indicating their presence in extra-hospital reservoirs.
MICROBIAL PATHOGENESIS
(2022)
Article
Infectious Diseases
Eun-Jeong Yoon, Hyun Soo Kim, Heungjeong Woo, You Jeong Choi, Dongju Won, Jong Rak Choi, Young Ah Kim, Seok Hoon Jeong
Summary: This study analyzed the genetic modifications in colistin-resistant Acinetobacter baumannii isolates, identifying key gene mutations that lead to resistance and observing a reasonable fitness cost incurred in order to maintain drug resistance above a certain level.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Fei-Ju Li, Lora Starrs, Anukriti Mathur, Hikari Ishii, Si Ming Man, Gaetan Burgio
Summary: Acinetobacter baumannii is an emerging nosocomial pathogen with growing clinical significance. Variations in virulence and immune response exist among different strains of A. baumannii.
Article
Medicine, General & Internal
Sang Mee Hwang, Hee Won Cho, Tae Yeul Kim, Jeong Su Park, Jongtak Jung, Kyoung-Ho Song, Hyunju Lee, Eu Suk Kim, Hong Bin Kim, Kyoung Un Park
Summary: This study investigated an outbreak of carbapenem-resistant Acinetobacter baumannii (CRAB) in a hospital setting using whole-genome sequencing and various bioinformatics tools. Three clonal lineages were identified among the 11 isolates analyzed, all of which were found to harbor genes associated with multidrug resistance. Different clones were found within the MLST types through whole-genome MLST and whole-genome SNP analyses, with wgSNP showing the highest discriminatory power.
Article
Immunology
Gathoni Kamuyu, Yat Suen Cheng, Sam Willcocks, Chidchamai Kewcharoenwong, Pattarachai Kiratisin, Peter W. Taylor, Brendan W. Wren, Ganjana Lertmemongkolchai, Richard A. Stabler, Jeremy Brown
Summary: The study suggests that inducing antibody responses to protein antigens can enhance immune recognition and protection against diverse A. baumannii strains, supporting their use as antibody therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Greta Petazzoni, Greta Bellinzona, Cristina Merla, Marta Corbella, Vincenzina Monzillo, Orjan Samuelsen, Jukka Corander, Davide Sassera, Stefano Gaiarsa, Patrizia Cambieri
Summary: This study provides a detailed investigation of a multidrug-resistant Acinetobacter baumannii outbreak that occurred at a hospital in Italy during the COVID-19 pandemic. The outbreak strains were found to be resistant to carbapenems due to the presence of the carbapenemase gene bla(OXA-23). All strains also carried determinants for biofilm formation. The outbreak was caused by two endemic clones of A. baumannii.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Irina Gheorghe-Barbu, Viorica Maria Corbu, Corneliu Ovidiu Vrancianu, Ioana Cristina Marinas, Marcela Popa, Andreea Stefania Dumbrava, Mihai Nita-Lazar, Ionut Pecete, Andrei Alexandru Muntean, Mircea Ioan Popa, Liliana Marinescu, Denisa Ficai, Anton Ficai, Ilda Czobor Barbu
Summary: This study aims to demonstrate the effectiveness of silver nanoparticles on multidrug-resistant Acinetobacter baumannii strains isolated from hospitals and water sources. The results show that silver nanoparticles have inhibitory effects on bacterial growth, biofilm formation, and the production of soluble virulence factors. This is the first description of an antibacterial agent against MDR AB strains in Romania's hospitals and anthropically polluted water.
Article
Immunology
Steven M. Smoke, Alison Brophy, Samuel Reveron, Alina Iovleva, Ellen G. Kline, Michael Marano, Lincoln P. Miller, Ryan K. Shields
Summary: This study reports on the treatment outcomes of 11 critically ill burn patients using cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. The clinical success rate was 36%, but was complicated by the emergence of treatment-resistant A. baumannii and its transmission among patients. The resistant strains harbored disrupted pirA and piuA genes, which were not disrupted in susceptible strains.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Wang Zhang, Yue Yao, Hua Zhou, Jintao He, Jingfen Wang, Li Li, Minsong Gao, Xiaochen Liu, Ya Shi, Jinzhong Lin, Jianzhao Liu, Huan Chen, Yu Feng, Zhihui Zhou, Yunsong Yu, Xiaoting Hua
Summary: This study investigated the pathoadaptation mechanism of Acinetobacter baumannii in response to selective pressure exerted by pulmonary epithelial cells. Through experimental evolution, phenotypic characterization, and multi-omics analysis, the study revealed that A. baumannii exhibited mutations that altered its adhesion ability, anti-phagocytic ability, ribosome translation efficiency, and outer membrane permeability. These mutations also affected the susceptibility of A. baumannii to various antimicrobial agents.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Infectious Diseases
Zhaoyinqian Li, Zixuan Ding, Yao Liu, Xinrui Jin, Jingling Xie, Tingting Li, Zhangrui Zeng, Zhibin Wang, Jinbo Liu
Summary: The study revealed a negative correlation between antimicrobial resistance and biofilm formation in Acinetobacter baumannii, as well as phenotypic and genotypic characteristics of biofilm formation.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biochemistry & Molecular Biology
Seok-Hyeon Na, Hyejin Jeon, Man-Hwan Oh, Yoo-Jeong Kim, Mingi Chu, Ill-Young Lee, Je-Chul Lee
Summary: The study evaluated the therapeutic potential of compound 62520 against CRAB isolates, demonstrating its ability to inhibit ompA expression and biofilm formation in A. baumannii. Compound 62520 also showed bacteriostatic activity against CRAB isolates and increased survival rates in infected mice, suggesting it as a promising agent for CRAB infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Mohammad Hamidian, Stephanie J. Ambrose, Grace A. Blackwell, Steven J. Nigro, Ruth M. Hall
Summary: An early carbapenem-susceptible Acinetobacter baumannii outbreak in Australia was caused by an unusual strain that had acquired plasmids carrying antibiotic resistance genes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Genetics & Heredity
Irene Artuso, Massimiliano Lucidi, Daniela Visaggio, Giulia Capecchi, Gabriele Andrea Lugli, Marco Ventura, Paolo Visca
Summary: Acinetobacter baumannii ATCC 19606(T) is an important opportunistic pathogen widely used in laboratories. This study compared strains from different laboratories and found differences in the genome sequences, including SNPs, deletions, and the presence of phages. Additionally, two plasmids were consistently detected, and one of them was further analyzed for its potential functions.
MICROBIAL GENOMICS
(2022)
Article
Infectious Diseases
Alyona Lavrinenko, Eugene Sheck, Svetlana Kolesnichenko, Ilya Azizov, Anar Turmukhambetova
Summary: The study aimed to determine the prevalence of A. baumannii antibiotic-resistant strains in Kazakhstan and identified high-risk clones associated with carbapenem resistance. The majority of resistant strains belonged to the CG208(92)(OXF)/CG2(PAS) clonal group, indicating a significant spread of carbapenem resistance in the region.
Article
Microbiology
Lei Han, Yiyuan Gao, Yuqing Liu, Siyu Yao, Shuyan Zhong, Sirui Zhang, Jingdan Wang, Peng Mi, Yurong Wen, Zhenlin Ouyang, Jing Zhang, Mona Mohamed Al-Shamiri, Pu Li, Shaoshan Han
Summary: This study investigated the transition of outer membrane proteins (OMPs) in Acinetobacter baumannii under antibiotic stress and identified YiaD as an important marker involved in the development of adaptive resistance to meropenem (MEM) in A. baumannii. The downregulation of YiaD was observed not only in clinically sensitive strains but also in carbapenem-resistant isolates that produced the β-lactamases TEM and OXA-23. Lack of YiaD resulted in increased MIC to MEM, enlarged and irregular colonies, and decreased biofilm formation ability. These findings suggest that YiaD plays a role in the evolution of MEM resistance in both carbapenem-sensitive and -resistant strains.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Scott R. Evans, Andrea M. Hujer, Hongyu Jiang, Kristine M. Hujer, Thomas Hall, Christine Marzan, Michael R. Jacobs, Rangarajan Sampath, David J. Ecker, Claudia Manca, Kalyan Chavda, Pan Zhang, Helen Fernandez, Liang Chen, Jose R. Mediavilla, Carol B. Hill, Federico Perez, Angela M. Caliendo, Vance G. Fowler, Henry F. Chambers, Barry N. Kreiswirth, Robert A. Bonomo
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Critical Care Medicine
Jean-Louis Vincent, David Brealey, Nicolas Libert, Nour Elhouda Abidi, Michael O'Dwyer, Kai Zacharowski, Malgorzata Mikaszewska-Sokolewicz, Jacques Schrenzel, Francois Simon, Mark Wilks, Marcus Picard-Maureau, Donald B. Chalfin, David J. Ecker, Rangarajan Sampath, Mervyn Singer
CRITICAL CARE MEDICINE
(2015)
Correction
Agriculture, Dairy & Animal Science
Vincent Perreten, Andrea Endimiani, Andreas Thomann, Juliette R. K. Wipf, Alexandra Rossando, Michele Bodmer, Andreas Raemy, Kristin A. Sannes-Lowery, David J. Ecker, Rangarajan Sampath, Robert A. Bonomo, Cicely Washington
JOURNAL OF DAIRY SCIENCE
(2015)
Article
Multidisciplinary Sciences
Mark W. Eshoo, Heather E. Carolan, Christian Massire, Danny M. Chou, Chris D. Crowder, Megan A. Rounds, Curtis A. Phillipson, Steven E. Schutzer, David J. Ecker
Article
Medicine, General & Internal
Catherine Satzke, Eileen M. Dunne, Barbara D. Porter, Keith P. Klugman, E. Kim Mulholland
Article
Cell Biology
Andrew J. Kennedy, Elizabeth J. Rahn, Brynna S. Paulukaitis, Katherine E. Savell, Holly B. Kordasiewicz, Jing Wang, John W. Lewis, Jessica Posey, Sarah K. Strange, Mikael C. Guzman-Karlsson, Scott E. Phillips, Kyle Decker, S. Timothy Motley, Eric E. Swayze, David J. Ecker, Todd P. Michael, Jeremy J. Day, J. David Sweatt
Article
Microbiology
Andrea Bacconi, Gregory S. Richmond, Michelle A. Baroldi, Thomas G. Laffler, Lawrence B. Blyn, Heather E. Carolan, Mark R. Frinder, Donna M. Toleno, David Metzgar, Jose R. Gutierrez, Christian Massire, Megan Rounds, Natalie J. Kennel, Richard E. Rothman, Stephen Peterson, Karen C. Carroll, Teresa Wakefield, David J. Ecker, Rangarajan Sampath
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Article
Virology
Jiazhen Chen, Yongfeng Fu, Liwen Ju, Xinyu Miao, Yaojie Shen, Lei He, Wenjie Wang, Jialin Jin, Lingyun Shao, Rangarajan Sampath, David J. Ecker, Ying Zhang, Min Li, Xunjia Cheng, Wenhong Zhang
JOURNAL OF CLINICAL VIROLOGY
(2014)
Article
Multidisciplinary Sciences
David Metzgar, Mark W. Frinder, Richard E. Rothman, Stephen Peterson, Karen C. Carroll, Sean X. Zhang, Gideon D. Avornu, Megan A. Rounds, Heather E. Carolan, Donna M. Toleno, David Moore, Thomas A. Hall, Christian Massire, Gregory S. Richmond, Jose R. Gutierrez, Rangarajan Sampath, David J. Ecker, Lawrence B. Blyn
Article
Microbiology
Michael R. Mosel, Heather E. Carolan, Alison W. Rebman, Steven Castro, Christian Massire, David J. Ecker, Mark J. Soloski, John N. Aucott, Mark W. Eshoo
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Medicine, Research & Experimental
Shane G. Poplawski, Krassimira A. Garbett, Rebekah L. McMahan, Holly B. Kordasiewicz, Hien Zhao, Andrew J. Kennedy, Slavina B. Goleva, Teresa H. Sanders, S. Timothy Motley, Eric E. Swayze, David J. Ecker, J. David Sweatt, Todd P. Michael, Celeste B. Greer
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Microbiology
Michael R. Mosel, Alison W. Rebman, Heather E. Carolan, Tristan Montenegro, Robert Lovari, Steven E. Schutzer, David J. Ecker, Ting Yang, Nitya S. Ramadoss, William H. Robinson, Mark J. Soloski, Mark W. Eshoo, John N. Aucott
Summary: The study conducted on Lyme disease patients showed that PCR-based direct detection methods can help differentiate patient subgroups, especially those who are serologically negative in the early stages of infection. This approach could be particularly useful for future vaccine trials and public health surveillance of tick-borne diseases.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Microbiology
Vaclav Honig, Heather E. Carolan, Zuzana Vavruskova, Christian Massire, Michael R. Mosel, Christopher D. Crowder, Megan A. Rounds, David J. Ecker, Daniel Ruzek, Libor Grubhoffer, Benjamin J. Luft, Mark W. Eshoo
FEMS MICROBIOLOGY ECOLOGY
(2017)
Article
Infectious Diseases
M. J. O'Dwyer, M. H. Starczewska, J. Schrenzel, K. Zacharowski, D. J. Ecker, R. Sampath, D. Brealey, M. Singer, N. Libert, M. Wilks, J. -L. Vincent
CLINICAL MICROBIOLOGY AND INFECTION
(2017)
Article
Immunology
Chris D. Crowder, Heather E. Carolan, Megan A. Rounds, Vaclav Honig, Benedikt Mothes, Heike Haag, Oliver Nolte, Ben J. Luft, Libor Grubhoffer, David J. Ecker, Steven E. Schutzer, Mark W. Eshoo
EMERGING INFECTIOUS DISEASES
(2014)
