Improved Sensitivity for Molecular Detection of Bacterial and Candida Infections in Blood

Significant publications on infectious diseases pharmacotherapy in 2012

(2013) D. R. Bowers et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Impact of Rapid Organism Identification via Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Combined With Antimicrobial Stewardship Team Intervention in Adult Patients With Bacteremia and Candidemia

(2013) Angela M. Huang et al.   CLINICAL INFECTIOUS DISEASES

Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Enhanced Diagnostic Yields of Bacteremia and Candidemia in Blood Specimens by PCR-Electrospray Ionization Mass Spectrometry

(2013) Thomas G. Laffler et al.   JOURNAL OF CLINICAL MICROBIOLOGY

PCR and Electrospray Ionization Mass Spectrometry for Detection of Persistent Enterococcus faecalis in Cerebrospinal Fluid following Treatment of Postoperative Ventriculitis

(2013) J. J. Farrell et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Broad-Spectrum Biosensor Capable of Detecting and Identifying Diverse Bacterial and Candida Species in Blood

(2013) D. Metzgar et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Stewardship Approach for Optimizing Antimicrobial Therapy through Use of a Rapid Microarray Assay on Blood Cultures Positive for Enterococcus Species

(2013) A. Sango et al.   JOURNAL OF CLINICAL MICROBIOLOGY

“Salvage Microbiology”: Detection of Bacteria Directly from Clinical Specimens following Initiation of Antimicrobial Treatment

(2013) John J. Farrell et al.   PLoS One

Rapid Diagnosis of Bloodstream Infections with PCR Followed by Mass Spectrometry

(2013) Elena Jordana-Lluch et al.   PLoS One

Comparison of three different commercial PCR assays for the detection of pathogens in critically ill sepsis patients

(2013) J. Schreiber et al.   Medizinische Klinik-Intensivmedizin und Notfallmedizin

Integrating Rapid Pathogen Identification and Antimicrobial Stewardship Significantly Decreases Hospital Costs

(2012) Katherine K. Perez et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka

(2012) S. B. Agampodi et al.   CLINICAL INFECTIOUS DISEASES

Using the rate of bacterial clearance determined by real-time polymerase chain reaction as a timely surrogate marker to evaluate the appropriateness of antibiotic usage in critical patients with Acinetobacter baumannii bacteremia*

(2012) Yu-Chung Chuang et al.   CRITICAL CARE MEDICINE

Impact of Results of a Rapid Staphylococcus aureus Diagnostic Test on Prescribing of Antibiotics for Patients with Clustered Gram-Positive Cocci in Blood Cultures

(2012) Jane Davies et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Comparative Analysis of PCR-Electrospray Ionization/Mass Spectrometry (MS) and MALDI-TOF/MS for the Identification of Bacteria and Yeast from Positive Blood Culture Bottles

(2011) E. J. Kaleta et al.   CLINICAL CHEMISTRY

Why should we measure bacterial load when treating community-acquired pneumonia?

(2011) Grant Waterer et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Quantitative rt-PCR holds promise as a screening tool for patients with severe sepsis

(2011) Shelley Kirkbright et al.   Emergency Medicine Australasia

Multiplex 5′ Nuclease-Quantitative PCR for Diagnosis of Relapsing Fever in a Large Tanzanian Cohort

(2011) Megan E. Reller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Specificity of a Quantitative Real-Time Polymerase Chain Reaction Assay for the Detection of Invasive Pneumococcal Disease

(2010) Cordelia Kee et al.   CHEST

New technology for rapid molecular diagnosis of bloodstream infections

(2010) David J Ecker et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Use of PCR Coupled with Electrospray Ionization Mass Spectrometry for Rapid Identification of Bacterial and Yeast Bloodstream Pathogens from Blood Culture Bottles

(2010) E. J. Kaleta et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Genotypic Variation and Mixtures of Lyme Borrelia in Ixodes Ticks from North America and Europe

(2010) Chris D. Crowder et al.   PLoS One

High and Increasing Oxa-51 DNA Load Predict Mortality in Acinetobacter baumannii Bacteremia: Implication for Pathogenesis and Evaluation of Therapy

(2010) Yu-Chung Chuang et al.   PLoS One

Comparison of broad range 16S rDNA PCR and conventional blood culture for diagnosis of sepsis in the newborn: a case control study

(2009) Tonje Reier-Nilsen et al.   BMC Pediatrics

Severity of Pneumococcal Pneumonia Associated With Genomic Bacterial Load

(2009) Jordi Rello et al.   CHEST

Severity of Meningococcal Disease Associated with Genomic Bacterial Load

(2009) Tom Darton et al.   CLINICAL INFECTIOUS DISEASES

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Potential clinical utility of polymerase chain reaction in microbiological testing for sepsis

(2009) Lutz Eric Lehmann et al.   CRITICAL CARE MEDICINE

Diagnosis of Bacteremia in Whole-Blood Samples by Use of a Commercial Universal 16S rRNA Gene-Based PCR and Sequence Analysis

(2009) N. Wellinghausen et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Detection and Identification of Ehrlichia Species in Blood by Use of PCR and Electrospray Ionization Mass Spectrometry

(2009) M. W. Eshoo et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Truncated Human Cytidylate-Phosphate-Deoxyguanylate-Binding Protein for Improved Nucleic Acid Amplification Technique-Based Detection of Bacterial Species in Human Samples

(2009) S. Sachse et al.   JOURNAL OF CLINICAL MICROBIOLOGY

High Levels of mecA DNA Detected by a Quantitative Real-Time PCR Assay Are Associated with Mortality in Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia

(2009) Y.-C. Ho et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Evaluation of New Preanalysis Sample Treatment Tools and DNA Isolation Protocols To Improve Bacterial Pathogen Detection in Whole Blood

(2009) W. L. J. Hansen et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Streptococcus pneumoniae DNA Load in Blood as a Marker of Infection in Patients with Community-Acquired Pneumonia

(2009) R. P. H. Peters et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Broad‐Spectrum Antimicrobials and the Treatment of Serious Bacterial Infections: Getting It Right Up Front

(2008) Marin H. Kollef   CLINICAL INFECTIOUS DISEASES

Preanalytic removal of human DNA eliminates false signals in general 16S rDNA PCR monitoring of bacterial pathogens in blood

(2008) Michael Handschur et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Feasibility of real-time polymerase chain reaction in whole blood to identify Streptococcus pneumoniae in patients with community-acquired pneumonia

(2008) Cordelia Kee et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Impact of inappropriate antibiotic therapy on mortality in patients with ventilator-associated pneumonia and blood stream infection: A meta-analysis

(2008) Effie L. Kuti et al.   JOURNAL OF CRITICAL CARE

Rapid detection of pathogens in blood culture bottles by real-time PCR in conjunction with the pre-analytic tool MolYsis

(2008) Susanne Gebert et al.   JOURNAL OF INFECTION