Article
Immunology
Ritu Sarin, Ran Gu, Zahra Jalali, Emanual Maverakis, Maria G. Tsokos, Iannis E. Adamopoulos
Summary: Interleukin 27 has both pro-inflammatory and anti-inflammatory properties in autoimmunity. The anti-inflammatory effects of IL-27 are linked with inhibition of Th17 differentiation and IL-27 also inhibits IL-23-induced inflammation associated with myeloid cell infiltration in the joints and spleen. The IL-27 anti-inflammatory response is associated with reduced levels of myeloid cells in the spleen and bone marrow.
CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Rachel M. Kratofil, Hanjoo B. Shim, Raymond Shim, Woo Yong Lee, Elodie Labit, Sarthak Sinha, Catherine M. Keenan, Bas G. J. Surewaard, Ji Yeon Noh, Yuxiang Sun, Keith A. Sharkey, Matthias Mack, Jeff Biernaskie, Justin F. Deniset, Paul Kubes
Summary: During infection, monocytes and neutrophils are recruited to the infected tissue, but they have different functions. Monocytes can convert to macrophages and regulate adipocyte expansion and leptin production, while neutrophils infiltrate the infection site. Monocytes play a role in wound repair by regulating leptin levels and revascularization.
Article
Cell Biology
Weiyang Li, Yuanru Yang, Lin Yang, Na Chang, Liying Li
Summary: This study reveals that bone marrow monocyte-derived Kupffer cells (MoKCs) dominate in injured livers. MoKCs exhibit enhanced proliferative and anti-apoptotic properties compared to embryonic KCs (EmKCs), promoting repair and attenuating fibrosis while reducing functional damage, necrosis, and fibrosis.
Article
Cell Biology
Erika S. Guimaraes, Fabio V. Marinho, Nina M. G. P. de Queiroz, Maisa M. Antunes, Sergio C. Oliveira
Summary: STING, as an immune sensor, plays a crucial role in the early detection of bacterial pathogens. It activates immune responses by detecting bacterial DNA or cyclic dinucleotides, leading to the production of interferons and proinflammatory cytokines and participating in the metabolic reprogramming of macrophages. However, STING-mediated immune responses during bacterial infections can also be detrimental to the host.
Article
Immunology
Debby Reuveni, Miriam R. Brezis, Eli Brazowski, Philip Vinestock, Patrick S. C. Leung, Paresh Thakker, M. Eric Gershwin, Ehud Zigmond
Summary: IL-23 plays a crucial role in the pathogenesis of PBC, with IL-23 derived from hepatic monocyte-derived macrophages being particularly significant. Studies using a murine model showed that IL-23 produced by specific MNPs contributes to the severity of PBC, suggesting potential for new immune-based therapies for PBC patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Tianyang Li, Yang Yang, Yongqi Li, Zhengmin Wang, Faxiang Ma, Runqi Luo, Xiaoming Xu, Guo Zhou, Jianhua Wang, Junqi Niu, Guoyue Lv, Ian N. Crispe, Zhengkun Tu
Summary: Infection with SARS-CoV-2 can lead to COVID-19, which ranges from mild to moderate disease but carries the risk of morbidity and mortality. Severe cases of COVID-19 are associated with hemostasis disorders, monocyte activation, and a cytokine storm, but the connection between these manifestations is not fully understood. This study reveals that the spike protein of SARS-CoV-2 interacts with P-selectin/PGSL-1 and CD40L/CD40, leading to proinflammatory cytokine production by monocytes. These findings provide an explanation for the correlation between hypercoagulation, monocyte activation, and a cytokine storm in severely affected COVID-19 patients, and suggest a potential target for therapeutic intervention.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Hangkai Huang, Qinqiu Wang, Xiaoying Shi, Yishu Chen, Chao Shen, Juanwen Zhang, Chengfu Xu
Summary: The study found a significant positive association between MHR and the risk of NAFLD, with individuals with higher MHR being more likely to develop NAFLD.
MEDIATORS OF INFLAMMATION
(2021)
Article
Health Care Sciences & Services
Malgorzata Galecka, Katarzyna Blizniewska-Kowalska, Agata Orzechowska, Janusz Szemraj, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki
Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Evelyn Kelemen, Eva Adam, Stella Marta Sagi, Aniko Goblos, Lajos Kemeny, Zsuzsanna Bata-Csorgo, Marta Szell, Judit Danis
Summary: Psoriasis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Increased levels of free nucleic acids in psoriatic skin are associated with IL-23 expression. The study reveals that free nucleic acids regulate IL-23 mRNA expression in epithelial keratinocytes through TLR3 receptor and specific signaling pathways, contributing to the development of an inflammatory milieu favorable for psoriatic symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Gavin W. Sewell, Arthur Kaser
Summary: The cytokine interleukin-23 (IL-23), mainly produced by macrophages and dendritic cells in response to microbial stimulation, plays a critical role in chronic intestinal inflammation. IL-23 has been found to be associated with disease protection through genetic variations, and therapeutic targeting of the shared p40 subunit of IL-12/IL-23 has shown success in treating inflammatory bowel disease (IBD). Recent phase 2 studies have shown promise in targeting the specific p19 subunit of IL-23. However, the exact pathways downstream of IL-23 in mucosal inflammation in the gut are still debated.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Medicine, General & Internal
Katarzyna Pawlak-Bus, Wiktor Schmidt, Piotr Leszczynski
Summary: The study aimed to investigate the associations between serum IL-27 and IL-23 levels and disease activity in Polish patients with different manifestations of SLE, but no significant correlations were found. However, patients with NPSLE and LN showed the highest median scores of SLEDAI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
He-Zhou Guo, Zi-Hua Guo, Shan-He Yu, Li-Ting Niu, Wan-Ting Qiang, Meng-Meng Huang, Yuan-Yuan Tian, Juan Chen, Hui Yang, Xiang-Qin Weng, Yi Zhang, Wu Zhang, Shao-Yan Hu, Jun Shi, Jiang Zhu
Summary: Abnormal IL-36 production in leukemic progenitor cells is a key feature of AML, promoting inflammation and preventing leukemia clearance by CD8(+) T cells. Chemotherapy-induced IL-36 production from residual leukemic cells allows for the persistence of an immunosuppressive axis post-treatment. Depletion of inflammatory monocytes, in combination with chemotherapy and PD-1 blockade, shows promise in restricting AML progression and relapse.
Article
Medicine, Research & Experimental
Ju-Hee Kang, Hwa-Yeong Lee, Na-Young Kim, Dong-seok Lee, Mijung Yim
Summary: The role of extracellular Prdx1 in bacterial infections and inflammatory bone disease has been investigated. The lack of Prdx1 increased susceptibility to infections, while blockade of extracellular Prdx1 provided protection against bacterial infections. These findings suggest that extracellular Prdx1 may be a potential therapeutic target for bacterial infections or inflammatory osteolytic diseases.
Article
Fisheries
Xing Li, Baijian Jiang, Zhiqiang Zhang, Meiling Huang, Jiamin Feng, Yongxiong Huang, Kwaku Amoah, Yu Huang, Jichang Jian
Summary: This study discovered an IL8 gene from Nile tilapia and found that it plays a crucial role in acute bacterial infections. The gene codes for 94 amino acids and is highly expressed in the head-kidney tissue and induced by Streptococcus agalactiae and Aeromonas hydrophila. In vitro experiments showed that IL8 regulates various immune processes and promotes inflammation. These findings are significant for further understanding the protective effects of IL8 in bony fish against bacterial infections.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Adi Biram, Jingjing Liu, Hadas Hezroni, Natalia Davidzohn, Dominik Schmiedel, Eman Khatib-Massalha, Montaser Haddad, Amalie Grenov, Sacha Lebon, Tomer Meir Salame, Nili Dezorella, Dotan Hoffman, Paula Abou Karam, Moshe Biton, Tsvee Lapidot, Mats Bemark, Roi Avraham, Steffen Jung, Ziv Shulman
Summary: Consecutive exposures to different pathogens can alter the host immune response. This study found that bacterial infection disrupts pre-existing immune responses and recruits Sca-1+ monocytes into lymphoid organs. This disruption is associated with impaired cellular respiration and is dependent on TNF alpha and IFN gamma. This phenomenon is observed in both vaccine supplementation and infection with Listeria monocytogenes.
Review
Biochemistry & Molecular Biology
Muthulekha Swamydas, Timothy J. Break, Michail S. Lionakis
CELLULAR AND MOLECULAR LIFE SCIENCES
(2015)
Article
Immunology
Timothy J. Break, Alexandra R. Witter, Mohanalaxmi Indramohan, Mark E. Mummert, Ladislav Dory, Rance E. Berg
INFECTION AND IMMUNITY
(2016)
Article
Cell Biology
Ian A. Myles, Ming Zhao, Glenn Nardone, Lisa R. Olano, Jensen D. Reckhow, Danial Saleem, Timothy J. Break, Michail S. Lionakis, Timothy G. Myers, Paul J. Gardina, Charles H. Kirkpatrick, Steven M. Holland, Sandip K. Datta
JOURNAL OF LEUKOCYTE BIOLOGY
(2017)
Article
Cell Biology
Muthulekha Swamydas, Ji-Liang Gao, Timothy J. Break, Melissa D. Johnson, Martin Jaeger, Carlos A. Rodriguez, Jean K. Lim, Nathaniel M. Green, Amanda L. Collar, Brett G. Fischer, Chyi-Chia Richard Lee, John R. Perfect, Barbara D. Alexander, Bart-Jan Kullberg, Mihai G. Netea, Philip M. Murphy, Michail S. Lionakis
SCIENCE TRANSLATIONAL MEDICINE
(2016)
Article
Immunology
Timothy J. Break, Kevin W. Hoffman, Muthulekha Swamydas, Chyi-Chia Richard Lee, Jean K. Lim, Michail S. Lionakis
Article
Immunology
Nicolas Dutzan, Loreto Abusleme, Hayley Bridgeman, Teresa Greenwell-Wild, Tamsin Zangerle-Murray, Mark E. Fife, Nicolas Bouladoux, Holly Linley, Laurie Brenchley, Kelly Wemyss, Gloria Calderon, Bo-Young Hong, Timothy J. Break, Dawn M. E. Bowdish, Michail S. Lionakis, Simon A. Jones, Giorgio Trinchieri, Patricia I. Diaz, Yasmine Belkaid, Joanne E. Konkel, Niki M. Moutsopoulos
Article
Infectious Diseases
Timothy J. Break, Jigar V. Desai, Mukil Natarajan, Elise M. N. Ferre, Christina Henderson, Adrian M. Zelazny, Ulrich Siebenlist, William J. Hoekstra, Robert J. Schotzinger, Edward P. Garvey, Michail S. Lionakis
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Immunology
Yuan Zhang, Chi A. Ma, Monica G. Lawrence, Timothy J. Break, Michael P. O'Connell, Jonathan J. Lyons, Diego B. Lopez, John S. Barber, Yongge Zhao, Daniel L. Barber, Alexandra F. Freeman, Steven M. Holland, Michail S. Lionakis, Joshua D. Milner
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Infectious Diseases
Timothy J. Break, Jigar V. Desai, Kelley R. Healey, Mukil Natarajan, Elise M. N. Ferre, Christina Henderson, Adrian Zelazny, Ulrich Siebenlist, Christopher M. Yates, Oren J. Cohen, Robert J. Schotzinger, David S. Perlin, Edward P. Garvey, Michail S. Lionakis
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Immunology
Caroline M. Percopo, Michelle Ma, Todd A. Brenner, Julia O. Krumholz, Timothy J. Break, Karen Laky, Helene F. Rosenberg
JOURNAL OF IMMUNOLOGY
(2019)
Article
Cell Biology
Elise M. N. Ferre, Timothy J. Break, Peter D. Burbelo, Michael Allgaeuer, David E. Kleiner, Dakai Jin, Ziyue Xu, Les R. Folio, Daniel J. Mollura, Muthulekha Swamydas, Wenjuan Gu, Sally Hunsberger, Chyi-Chia R. Lee, Anamaria Bondici, Kevin W. Hoffman, Jean K. Lim, Kerry Dobbs, Julie E. Niemela, Thomas A. Fleisher, Amy P. Hsu, Laquita N. Snow, Dirk N. Darnell, Samar Ojaimi, Megan A. Cooper, Martin Bozzola, Gary I. Kleiner, Juan C. Martinez, Robin R. Deterding, Douglas B. Kuhns, Theo Heller, Karen K. Winer, Arun Rajan, Steven M. Holland, Luigi D. Notarangelo, Kevin P. Fennelly, Kenneth N. Olivier, Michail S. Lionakis
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Immunology
Felix E. Y. Aggor, Timothy J. Break, Giraldina Trevejo-Nunez, Natasha Whibley, Bianca M. Coleman, Rachel D. Bailey, Daniel H. Kaplan, Julian R. Naglik, Wei Shan, Amol C. Shetty, Carrie McCracken, Scott K. Durum, Partha S. Biswas, Vincent M. Bruno, Jay K. Kolls, Michail S. Lionakis, Sarah L. Gaffen
SCIENCE IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Timothy J. Break, Vasileios Oikonomou, Nicolas Dutzan, Jigar Desai, Marc Swidergall, Tilo Freiwald, Daniel Chauss, Oliver J. Harrison, Julie Alejo, Drake W. Williams, Stefania Pittaluga, Chyi-Chia R. Lee, Nicolas Bouladoux, Muthulekha Swamydas, Kevin W. Hoffman, Teresa Greenwell-Wild, Vincent M. Bruno, Lindsey B. Rosen, Wint Lwin, Andy Renteria, Sergio M. Pontejo, John P. Shannon, Ian A. Myles, Peter Olbrich, Elise M. N. Ferre, Monica Schmitt, Daniel Martin, Daniel L. Barber, Norma Solis, Luigi D. Notarangelo, David Serreze, Mitsuru Matsumoto, Heather D. Hickman, Philip M. Murphy, Mark S. Anderson, Jean K. Lim, Steven M. Holland, Scott G. Filler, Behdad Afzali, Yasmine Belkaid, Niki M. Moutsopoulos, Michail S. Lionakis
Summary: Research has shown that enhanced type 1 immunity rather than defective type 17 responses can promote mucosal fungal infection susceptibility in certain cases. AIRE deficiency in mice and humans leads to intact mucosal type 17 responses and exacerbated type 1 responses, increasing susceptibility to mucosal fungal infections.
Review
Immunology
Vasileios Oikonomou, Timothy J. Break, Sarah L. Gaffen, Niki M. Moutsopoulos, Michail S. Lionakis
Summary: APECED is caused by mutations in the AIRE gene leading to autoimmune attacks on multiple tissues and increased susceptibility to specific infections such as CMC and COVID-19.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Elise M. N. Ferre, Stacey R. Rose, Sergio D. Rosenzweig, Peter D. Burbelo, Kimberly R. Romito, Julie E. Niemela, Lindsey B. Rosen, Timothy J. Break, Wenjuan Gu, Sally Hunsberger, Sarah K. Browne, Amy P. Hsu, Shakuntala Rampertaap, Muthulekha Swamydas, Amanda L. Collar, Heidi H. Kong, Chyi-Chia Richard Lee, David Chascsa, Thomas Simcox, Angela Pham, Anamaria Bondici, Mukil Natarajan, Joseph Monsale, David E. Kleiner, Martha Quezado, Ilias Alevizos, Niki M. Moutsopoulos, Lynne Yockey, Cathleen Frein, Ariane Soldatos, Katherine R. Calvo, Jennifer Adjemian, Morgan N. Similuk, David M. Lang, Kelly D. Stone, Gulbu Uzel, Jeffrey B. Kopp, Rachel J. Bishop, Steven M. Holland, Kenneth N. Olivier, Thomas A. Fleisher, Theo Heller, Karen K. Winer, Michail S. Lionakis