Article
Psychiatry
Ebru Sahan, Eray Metin Guler, Aise Tangilntiz, Ismet Kirpinar
Summary: This study investigated the levels of the proteoglycan endocan, which is secreted from endothelium upon endothelial damage, in patients with depression (bipolar or unipolar) and healthy controls. The results showed significantly higher levels of endocan in patients with bipolar depression compared to patients with major depressive disorder and healthy controls. This finding suggests a higher degree of endothelial dysfunction in patients with bipolar depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Oncology
He Zhang, Yi-Wen Shen, Li-Jun Zhang, Jin-Jiao Chen, Hui-Ting Bian, Wen-Jie Gu, Hong Zhang, Hong-Zhuan Chen, Wei-Dong Zhang, Xin Luan
Summary: ESM-1, also known as endocan, is a soluble dermatan sulfate proteoglycan that serves as a diagnostic and prognostic indicator for various pathological conditions, including cancer. It plays a significant role in promoting cancer progression and metastasis, as well as regulating the tumor microenvironment. This article discusses the molecular and biological characteristics of ESM-1 in cancer, along with potential therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Jingjing Lu, Qin Liu, Lixia Zhu, Yuanyuan Liu, Xiaoren Zhu, Shiqing Peng, Minbin Chen, Ping Li
Summary: The expression, biological functions and underlying molecular mechanisms of ESM1 in human cervical cancer were investigated. ESM1 was found to be significantly upregulated in cervical cancer tissues and cells, and its overexpression promoted cell proliferation, migration, and activated the PI3K-Akt pathway and EMT progression. ESM1 has the potential to be used as a diagnostic marker and therapeutic target for cervical cancer.
CELL DEATH & DISEASE
(2022)
Article
Obstetrics & Gynecology
Ali Ovayolu, Erbil Karaman, Abdulkadir Turgut, Yusuf Cekici, Tulay Ortabag, Agnese Maria Chiara Rapisarda, Marco Noventa, Antonio Cianci
Summary: This study suggests that endocan is not associated with the cardiovascular disease risk linked with endothelial dysfunction in idiopathic POI.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra Klisic, Dimitrios Patoulias
Summary: Discovered twenty years ago, endocan is still an intriguing biomarker associated with inflammation. It is a soluble dermatan sulphate proteoglycan secreted by endothelial cells and expressed in tissues related to enhanced proliferation. Endocan has been extensively studied in various cardiometabolic disorders, such as type 2 diabetes, hypertension, atherosclerosis, kidney disease, obesity, polycystic ovary syndrome, metabolic syndrome, and fatty liver disease. Understanding the role of endocan in these disorders is important for developing potential therapeutic strategies to delay or prevent related complications.
Review
Peripheral Vascular Disease
Amir Hossein Behnoush, Amirmohammad Khalaji, Pegah Bahiraie, Parsa Alehossein, Parnian Shobeiri, Maral Peisepar, Alessandro Cannavo
Summary: Hypertension is a major risk factor for cardiovascular disease and a leading cause of death worldwide. Endothelial dysfunction (ED) is an important manifestation preceding the development of hypertension. Endocan, secreted from endothelial cells, is a novel biomarker for endothelial dysfunction and inflammation. This systematic review and meta-analysis aimed to explore the association between endocan levels and ED in hypertensive patients.
HYPERTENSION RESEARCH
(2023)
Article
Medicine, General & Internal
Nijat Khanmammadov, Mehmet Zorlu, Omer Faruk Ozer, Cumali Karatoprak, Muharrem Kiskac, Mustafa Cakirca
Summary: In this study, there was no significant difference in serum endocan levels between beta-thalassemia minor patients and healthy controls. Various factors may influence endocan levels, necessitating further multicenter studies with more patients to confirm these findings.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2022)
Review
Cardiac & Cardiovascular Systems
Jinzhi Chen, Liping Jiang, Xiao-Hua Yu, Mi Hu, Yang-Kai Zhang, Xin Liu, Pingping He, Xinping Ouyang
Summary: Endocan, also known as endothelial cell specific molecule-1, is a soluble proteoglycan mainly secreted by endothelial cells. Increased plasma levels of endocan may reflect endothelial activation and dysfunction, and are considered a potential immuno-inflammatory marker related to cardiovascular disease. Endocan shows promise as a prognostic biomarker for cardiovascular disease, but further research into its mechanisms of action is needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Peripheral Vascular Disease
Aysin Nalbantoglu, Ozgur Kizilca, Savas Guzel, Hamdi Cihan Emeksiz, Burcin Nalbantoglu
Summary: Childhood obesity is associated with increased risk of cardiovascular and metabolic diseases in adulthood. Measuring cIMT and endocan levels can serve as biological markers for complications caused by endothelial damage, and early preventive measures can significantly reduce morbidity and mortality in adults.
Review
Peripheral Vascular Disease
Amirmohammad Khalaji, Nikan Amirkhani, Sourena Sharifkashani, Soheil Peiman, Amir Hossein Behnoush
Summary: Since the COVID-19 pandemic, several biomarkers have been proposed for diagnosing and predicting the disease. This systematic review evaluated endocan as a potential biomarker for COVID-19. Eight studies were included, showing higher endocan levels in COVID-19 cases compared to controls, and more severe disease was associated with higher endocan levels. Endocan also acted as a diagnostic and prognostic biomarker with different cut-offs. In conclusion, endocan could be a novel biomarker for COVID-19, but further studies are needed.
Article
Veterinary Sciences
Hee-Jeong Hong, Ye-In Oh, Su-Min Park, Ju-Hyun An, Tae-Hee Kim, Hyung-Kyu Chae, Kyoung-won Seo, Hwa-Young Youn
Summary: This study found that the concentration of serum ESM-1 significantly increased when myxomatous mitral valve disease (MMVD) progressed to decompensated heart failure and resulted in death in dogs. Therefore, ESM-1 could be a potential negative prognostic factor for patients with MMVD.
BMC VETERINARY RESEARCH
(2022)
Article
Biochemical Research Methods
Erbu Yarci, Cuneyt Tayman, Ufuk Cakir, Utku Serkant
Summary: The study found that symptomatic polycythemic newborns had higher serum levels of endocan, IMA, and NSE before the PET procedure, but these levels gradually approached those of the control group at 24 hours after PET, with no statistical difference between the two groups at 72 hours after PET.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Editorial Material
Oncology
Werner Held, Sanjiv A. Luther, V. Tatiana Petrova
Summary: Tumor-infiltrated T cells with stem-cell-like properties play a crucial role in determining the response to immunotherapy. The latest research suggests that their entry into tumor tissue relies on specialized tumor-associated endothelial cells that resemble immature and inflamed lymph node vessels. Furthermore, immunotherapy has been found to enhance the recruitment capacity of these endothelial cells.
Review
Biochemistry & Molecular Biology
Ke-Fan Pan, Yi-Chieh Yang, Wei-Jiunn Lee, Kuo-Tai Hua, Ming-Hsien Chien
Summary: This article summarizes the applications of endocan in cancer diagnoses and prognoses, and discusses the aberrant molecular characteristics of endocan in cancer cells may be due to mislocalization. Defining the specific cellular roles of endocan will provide a promising diagnostic factor and therapeutic target for cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Medicine, General & Internal
Yu He, Lu Lin, Yurong Ou, Xiaowen Hu, Chi Xu, Caizhi Wang
Summary: The study revealed that ESM1 is highly expressed in endometrial cancer and promotes the malignant phenotype of EC by binding with SPI1. Silencing ESM1 inhibited biological processes in EC cells, while overexpression of ESM1 had the opposite effect.
