Peptides and peptidomimetics as immunomodulators

Use of Click-Chemistry in the Development of Peptidomimetic Enzyme Inhibitors

(2014) P. Fabbrizzi et al.   CURRENT MEDICINAL CHEMISTRY

Thiopalmitoylation of Altered Peptide Ligands Enhances Their Protective Effects in an Animal Model of Multiple Sclerosis

(2014) N. C. Cloake et al.   JOURNAL OF IMMUNOLOGY

Systemic lupus erythematosus and lupus nephritis

(2014) Toli Koutsokeras et al.   NATURE REVIEWS DRUG DISCOVERY

Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products

(2013) Wataru Nomura et al.   ACS Chemical Biology

A Matrix Metalloproteinase 1-Cleavable Composite Peptide Derived From Transforming Growth Factor β-Inducible Gene h3 Potently Inhibits Collagen-Induced Arthritis

(2013) Eon Jeong Nam et al.   ARTHRITIS AND RHEUMATISM

α-Helix mimetics: Outwards and upwards

(2013) Madura K.P. Jayatunga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cyclotides as grafting frameworks for protein engineering and drug design applications

(2013) Aaron G. Poth et al.   BIOPOLYMERS

Immunosuppression by Co-stimulatory Molecules: Inhibition of CD2-CD48/CD58 Interaction by Peptides from CD2 to Suppress Progression of Collagen-induced Arthritis in Mice

(2013) Ameya Gokhale et al.   Chemical Biology & Drug Design

Cyclization enhances function of linear anti-arthritic peptides

(2013) Marina Ali et al.   CLINICAL IMMUNOLOGY

Small Cationic Antimicrobial Peptidomimetics: Emerging Candidate for the Development of Potential Anti-infective Agents

(2013) Sandeep Lohan et al.   CURRENT PHARMACEUTICAL DESIGN

An Approach to Chemotherapy-Associated Toxicity

(2013) Zhanna Livshits et al.   EMERGENCY MEDICINE CLINICS OF NORTH AMERICA

Monoclonal antibody treatments for rheumatoid arthritis

(2013) Lukas Bossaller et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

IMA901: a peptide vaccine in renal cell carcinoma

(2013) Jens Bedke et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Autoimmune effector memory T cells: the bad and the good

(2013) Priyadharshini Devarajan et al.   IMMUNOLOGIC RESEARCH

Bridging oncology and immunology: expanding horizons with innovative peptide vaccines and peptidomimetics

(2013) Pravin TP Kaumaya   Immunotherapy

Amygdalin Analogues Inhibit IFN-γ Signalling and Reduce the Inflammatory Response in Human Epidermal Keratinocytes

(2013) Iole Paoletti et al.   INFLAMMATION

An Immunomodulating Motif of the HIV-1 Fusion Protein Is Chirality-independent

(2013) Omri Faingold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Castration of Melanoma Patients Does Not Increase the Frequency of Tumor-specific CD4 and CD8 T Cells After Peptide Vaccination

(2013) Luis M. Vence et al.   JOURNAL OF IMMUNOTHERAPY

Suppression of MOG- and PLP-induced experimental autoimmune encephalomyelitis using a novel multivalent bifunctional peptide inhibitor

(2013) Ahmed H. Badawi et al.   JOURNAL OF NEUROIMMUNOLOGY

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

(2013) Ashley L Hilchie et al.   Nature Chemical Biology

Designing immunogenic peptides

(2013) Darren R Flower   Nature Chemical Biology

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

(2013) Paul F Robbins et al.   NATURE MEDICINE

Challenges and approaches for the development of safer immunomodulatory biologics

(2013) Jean G. Sathish et al.   NATURE REVIEWS DRUG DISCOVERY

Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism

(2013) Carsten Gründemann et al.   PLoS One

Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer

(2013) Ramon Arens et al.   SEMINARS IN IMMUNOLOGY

Transdermal Application of Myelin Peptides in Multiple Sclerosis Treatment

(2013) Agata Walczak et al.   JAMA Neurology

Mimicking Protein–Protein Interactions through Peptide–Peptide Interactions: HIV-1 gp120 and CXCR4

(2013) Andrea Groß et al.   Frontiers in Immunology

Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial

(2012) Robert Zimmer et al.   ANNALS OF THE RHEUMATIC DISEASES

A comparative study of backbone versus side chain peptide cyclization: Application for HIV-1 integrase inhibitors

(2012) Zvi Hayouka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Psoriasis: rationale for targeting interleukin-17

(2012) G. Girolomoni et al.   BRITISH JOURNAL OF DERMATOLOGY

Immune modulating peptides for the treatment and suppression of multiple sclerosis

(2012) Ahmed H. Badawi et al.   CLINICAL IMMUNOLOGY

Peptide vaccines and peptidomimetics targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy

(2012) Pravin TP Kaumaya et al.   Future Oncology

Targeting TNF receptors in rheumatoid arthritis

(2012) S. Bluml et al.   INTERNATIONAL IMMUNOLOGY

Design of a Novel Cyclotide-Based CXCR4 Antagonist with Anti-Human Immunodeficiency Virus (HIV)-1 Activity

(2012) Teshome L. Aboye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Do Plant Cyclotides Have Potential As Immunosuppressant Peptides?

(2012) Carsten Gründemann et al.   JOURNAL OF NATURAL PRODUCTS

Inhibition of the Interaction between HIV-1 Integrase and its Cofactor LEDGF/p75: A Promising Approach in Anti-Retroviral Therapy

(2012) L. De Luca et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Vaccine-like Controlled-Release Delivery of an Immunomodulating Peptide To Treat Experimental Autoimmune Encephalomyelitis

(2012) Barlas Büyüktimkin et al.   MOLECULAR PHARMACEUTICS

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

Drugmaker reaps what it sows with first plant-made biologic

(2012) Sarah C P Williams   NATURE MEDICINE

A General Preparation of Protected Phosphoamino Acids

(2012) Daniel E. Petrillo et al.   ORGANIC LETTERS

Heterobivalent ligands target cell-surface receptor combinations in vivo

(2012) L. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunotherapy with HER-2 and VEGF peptide mimics plus metronomic paclitaxel causes superior antineoplastic effects in transplantable and transgenic mouse models of human breast cancer

(2012) Kevin C. Foy et al.   OncoImmunology

Design of Peptide and Peptidomimetic Ligands with Novel Pharmacological Activity Profiles

(2011) Victor J. Hruby et al.   Annual Review of Pharmacology and Toxicology

Minimalist and universal peptidomimetics

(2011) Eunhwa Ko et al.   CHEMICAL SOCIETY REVIEWS

A phase I pilot trial of MUC1-peptide-pulsed dendritic cells in the treatment of advanced pancreatic cancer

(2011) Yefei Rong et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Engineered Conformation-dependent VEGF Peptide Mimics Are Effective in Inhibiting VEGF Signaling Pathways

(2011) Daniele Vicari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel p65 Binding Glucocorticoid-induced Leucine Zipper Peptide Suppresses Experimental Autoimmune Encephalomyelitis

(2011) Mythily Srinivasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformationally Constrained Peptides from CD2 To Modulate Protein–Protein Interactions between CD2 and CD58

(2011) Ameya Gokhale et al.   JOURNAL OF MEDICINAL CHEMISTRY

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

Suppression of EAE and prevention of blood–brain barrier breakdown after vaccination with novel bifunctional peptide inhibitor

(2011) Ahmed H. Badawi et al.   NEUROPHARMACOLOGY

Generation of a unique small molecule peptidomimetic that neutralizes lupus autoantibody activity

(2011) O. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Strategies in Immunosuppression: Issues in Perspective

(2011) Allison Webber et al.   TRANSPLANTATION

(Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis

(2011) Debby den Uyl et al.   ARTHRITIS RESEARCH & THERAPY

Therapeutic opportunities in systemic lupus erythematosus: state of the art and prospects for the new decade

(2010) G. K. Bertsias et al.   ANNALS OF THE RHEUMATIC DISEASES

HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

(2010) N. Page et al.   ANNALS OF THE RHEUMATIC DISEASES

Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein

(2010) Zvi Hayouka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemical Modifications Designed to Improve Peptide Stability: Incorporation of Non-Natural Amino Acids, Pseudo-Peptide Bonds, and Cyclization

(2010) Luca Gentilucci et al.   CURRENT PHARMACEUTICAL DESIGN

Using peptides to study protein–protein interactions

(2010) Hadar Benyamini et al.   Future Medicinal Chemistry

Universal Peptidomimetics

(2010) Eunhwa Ko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus

(2010) Cynthia Aranow et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Strategies to prolong the plasma residence time of peptide drugs

(2010) Lisa Pollaro et al.   MedChemComm

The β-d-Glucose Scaffold as a β-Turn Mimetic

(2009) Ralph F. Hirschmann et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and Evaluation of Multivalent Branched HPMA Copolymer−Fab′ Conjugates Targeted to the B-Cell Antigen CD20

(2009) Russell N. Johnson et al.   BIOCONJUGATE CHEMISTRY

Long-term efficacy of biologics in the treatment of psoriasis: what do we really know?

(2009) Eihab A. Alwawi et al.   Dermatologic Therapy

Understanding autoimmune disease: new targets for drug discovery

(2009) Cristina Balagué et al.   DRUG DISCOVERY TODAY

Rationalizing the chemical space of protein–protein interaction inhibitors

(2009) Olivier Sperandio et al.   DRUG DISCOVERY TODAY

Enhanced targeting with heterobivalent ligands

(2009) L. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Potential of immunomodulatory host defense peptides as novel anti-infectives

(2009) Donna M. Easton et al.   TRENDS IN BIOTECHNOLOGY

Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: Results of an early phase II clinical trial

(2008) Sylviane Muller et al.   ARTHRITIS AND RHEUMATISM

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

(2008) M. J.P. Welters et al.   CLINICAL CANCER RESEARCH

Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity

(2008) G. G. Kenter et al.   CLINICAL CANCER RESEARCH

Peptidomimetics, a synthetic tool of drug discovery

(2008) Josef Vagner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Discovering and improving novel peptide therapeutics

(2008) D MCGREGOR   CURRENT OPINION IN PHARMACOLOGY

Therapeutic peptide vaccines for treatment of autoimmune diseases

(2008) David C. Wraith   IMMUNOLOGY LETTERS

Serum and Cerebrospinal Fluid Autoantibodies in Patients with Neuropsychiatric Lupus Erythematosus. Implications for Diagnosis and Pathogenesis

(2008) Hilda Fragoso-Loyo et al.   PLoS One