Review
Immunology
Nick Giannoukakis
Summary: Tolerogenic dendritic cells (tDC) have the potential to prevent the progression of autoimmune-driven dysglycemia into insulin-requiring type 1 diabetes (T1D) and preserve β cells. tDC act via multiple layers of immune regulation to suppress effector lymphocytes targeting β cells. It is now appropriate to conduct phase II clinical trials for T1D using well-characterized tDC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Farhan Ullah Khan, Puregmaa Khongorzul, Ahmed Aziz Raki, Ashwini Rajasekaran, Denis Gris, Abdelaziz Amrani
Summary: Type 1 diabetes is caused by the destruction of pancreatic beta cells mediated by T cells. Dendritic cells play a crucial role in the initiation and development of this disease by presenting antigens to activate and regulate the immune response. Recent advancements in understanding dendritic cell function and regulation have led to the development of potential therapeutic strategies for treating type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ranjeny Thomas, Jose M. Carballido, Johnna D. Wesley, Simi T. Ahmed
Summary: Antigen-specific immunotherapy shows promise for treating type 1 diabetes, but faces obstacles in clinical translation. The key to overcoming these challenges lies in collaboration and cooperation among various stakeholders.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
William de Jesus Rios-Rios, Sorely Adelina Sosa-Luis, Honorio Torres-Aguilar
Summary: Type 1 diabetes is an autoimmune disease that involves the destruction of insulin-producing beta-cells by autoreactive T cells. Current treatment strategies include exogenous insulin administration and cellular therapy using dendritic cells (DCs) which have immunoregulatory properties. DCs can be easily obtained from peripheral blood or bone marrow precursors and multiple protocols have been established for manufacturing tolerogenic DCs for therapeutic research in treating T1D.
WORLD JOURNAL OF DIABETES
(2021)
Review
Health Care Sciences & Services
Claire Deligne, Sylvaine You, Roberto Mallone
Summary: Our understanding of the immunopathological features of type 1 diabetes has improved, and personalized treatment based on disease stage and patient characteristics could enhance therapeutic efficacy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Tatjana Nikolic, Jessica S. S. Suwandi, Joris Wesselius, Sandra Laban, Antoinette M. M. Joosten, Petra Sonneveld, Dick Mul, Henk-Jan Aanstoot, John S. S. Kaddis, Jaap Jan Zwaginga, Bart O. O. Roep
Summary: This study demonstrates the safety and efficacy of the tolerogenic dendritic cells (tolDC) vaccine for type 1 diabetes patients. The vaccine not only reduces autoimmune responses but also increases the number of regulatory T cells and memory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Colin J. Raposo, Judith D. Cserny, Gloria Serena, Jonathan N. Chow, Patricia Cho, Hanyang Liu, David Kotler, Armon Sharei, Howard Bernstein, Shinu John
Summary: Antigen-specific therapies using red blood cells as carriers have shown promising results in inducing immunotolerance towards self and foreign antigens, making them a potential treatment option for autoimmune diseases such as type 1 diabetes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Qi Ke, Charles J. Kroger, Matthew Clark, Roland M. Tisch
Summary: Type 1 diabetes (T1D) is an autoimmune disease driven by T cells, and immunotherapies using monoclonal antibodies (mAb) can selectively reestablish beta cell-specific self-tolerance. mAb have varying efficacy in modulating autoimmunity and can alter the function of immune effector cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
S. Alice Long, Jane H. Buckner
Summary: This review examines the current understanding of the etiology of Type 1 diabetes (T1D), focusing on the role of immune cells in the progression of the disease. It also highlights how this knowledge is driving the development of immunotherapies for the prevention and treatment of T1D.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Yimeng Wang, Ying Xia, Yan Chen, Linling Xu, Xiaoxiao Sun, Jiaqi Li, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: The rs352140 polymorphism of the TLR9 gene is associated with the development of type 1 diabetes (T1D) in the Han Chinese population, suggesting a genetic association.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Noemi Anna Nagy, Fernando Lozano Vigario, Rinske Sparrius, Toni M. M. van Capel, Ronald W. van Ree, Sander Tas, I. Jolanda M. de Vries, Teunis B. H. Geijtenbeek, Bram C. Slutter, Esther de Jong
Summary: Nanomedicine offers a promising platform for manipulating dendritic cells (DCs) and the adaptive immune response. Liposomal vitamin D3 can induce the development of regulatory CD4+ T cells and inhibit the proliferation of memory T cells. It can also suppress the development of Th1 and Th17 cells and stimulate the migration of CD14+ skin DCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Radhika R. Gudi, Nicolas Perez, Subha Karumuthil-Melethil, Gongbo Li, Chenthamarakshan Vasu
Summary: Enhancing T cell checkpoint receptor engagement during antigen presentation can modulate T cell function, suppress autoimmunity, and inhibit disease progression in T1D.
Review
Endocrinology & Metabolism
Neslihan Erdem, Enrique Montero, Bart O. Roep
Summary: The research has shown that the dialogue between pancreatic beta cells, islets, immune system, and intestinal microbiome plays a crucial role in the development of Type 1 diabetes. Certain immune therapies can activate the immune system and restore immune tolerance. Understanding the interaction between islets and the immune system is essential for preventing disease progression and designing novel therapeutic strategies.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2021)
Review
Immunology
Susanna Esposito, Elena Mariotti Zani, Lisa Torelli, Sara Scavone, Maddalena Petraroli, Viviana Patianna, Barbara Predieri, Lorenzo Iughetti, Nicola Principi
Summary: Type 1 diabetes is the most common pediatric endocrine disease with an increased infection risk and lower immune response to vaccines; further research is needed to establish the most effective and safe vaccine use in this population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L. Nutt, Axel Kallies, Andrew M. Lew
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Cell Biology
Yifan Zhan, Isabella Kong, Michael Chopin, Christophe Macri, Jian-Guo Zhang, Jiaying Xie, Stephen L. Nutt, Meredith O'Keeffe, Edwin D. Hawkins, Eric F. Morand, Andrew M. Lew
IMMUNOLOGY AND CELL BIOLOGY
(2020)
Letter
Immunology
Ming Liu, Bingtai Lu, Ping Zeng, Bing Huang, Yanhui Xu, Hanquan Liang, Diyuan Yang, Sida Yang, Hai-bin Luo, Andrew M. Lew, Seth L. Masters, Lanlan Geng, Huasong Zeng, Yuxia Zhang
JOURNAL OF CLINICAL IMMUNOLOGY
(2020)
Article
Immunology
Junyun Lai, Sherly Mardiana, Imran G. House, Kevin Sek, Melissa A. Henderson, Lauren Giuffrida, Amanda X. Y. Chen, Kirsten L. Todd, Emma Petley, Jack D. Chan, Emma M. Carrington, Andrew M. Lew, Benjamin J. Solomon, Joseph A. Trapani, Katherine Kedzierska, Maximilien Evrard, Stephin J. Vervoort, Jason Waithman, Phillip K. Darcy, Paul A. Beavis
Article
Pharmacology & Pharmacy
Xiaoyan Liu, Zhe Li, Shuai Liu, Jing Sun, Zhanghua Chen, Min Jiang, Qingling Zhang, Yinghua Wei, Xin Wang, Yi-You Huang, Yinyi Shi, Yanhui Xu, Huifang Xian, Fan Bai, Changxing Ou, Bei Xiong, Andrew M. Lew, Jun Cui, Rongli Fang, Hui Huang, Jincun Zhao, Xuechuan Hong, Yuxia Zhang, Fuling Zhou, Hai-Bin Luo
ACTA PHARMACEUTICA SINICA B
(2020)
Article
Allergy
Lingli Zhou, Tao Liu, Bing Huang, Man Luo, Zhanghua Chen, Zhiyao Zhao, Jun Wang, Daniel Leung, Xingtian Yang, Koon Wing Chan, Yukun Liu, Liya Xiong, Peiyu Chen, Hongli Wang, Liping Ye, Hanquan Liang, Seth L. Masters, Andrew M. Lew, Sitang Gong, Fan Bai, Jing Yang, Pamela Pui-Wah Lee, Wanling Yang, Yan Zhang, Yu-Lung Lau, Lanlan Geng, Yuxia Zhang, Jun Cui
Summary: A rare NLRP3 variant was identified in 3 patients with gastrointestinal symptoms, which increased NLRP3 inflammasome activation and pyroptosis in macrophages. In a dextran sulfate sodium-induced acute colitis model, the variant in hematopoietic cells resulted in more severe colitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Wang, Yanhui Xu, Zhanghua Chen, Jiankun Liang, Zefeng Lin, Huiying Liang, Yiping Xu, Qi Wu, Xuanjie Guo, Junli Nie, Bingtai Lu, Bing Huang, Huifang Xian, Xiaohui Wang, Qiang Wu, Jixiao Zeng, Chengwei Chai, Meixue Zhang, Yuzhen Lin, Li Zhang, Shanmeizi Zhao, Yanlu Tong, Liang Zeng, Xiaoqiong Gu, Zhuang-gui Chen, Shuhong Yi, Tong Zhang, David Delfouneso, Yan Zhang, Stephen L. Nutt, Andrew M. Lew, Liwei Lu, Fan Bai, Huimin Xia, Zhe Wen, Yuxia Zhang
Article
Immunology
Shengbo Zhang, Hannah D. Coughlan, Mitra Ashayeripanah, Simona Seizova, Andrew J. Kueh, Daniel Brown, Wang Cao, Nicolas Jacquelot, Angela D'Amico, Andrew M. Lew, Yifan Zhan, Christopher J. Tonkin, Jose A. Villadangos, Gordon K. Smyth, Michael Chopin, Stephen L. Nutt
Summary: The transcription factor DC-SCRIPT plays a critical role in the development and function of conventional dendritic cells (cDC1), with its deficiency leading to impaired antigen capture and presentation capabilities. This study highlights the importance of DC-SCRIPT in maintaining the identity and functional attributes of cDC1s.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Yifan Zhan, Yuxia Zhang, Shengbo Zhang, Hannah Coughlan, Pedro L. Baldoni, Nicolas Jacquelot, Wang H. J. Cao, Simon Preston, Cynthia Louis, Jai Rautela, Marc Pellegrini, Ian P. Wicks, Warren S. Alexander, Leonard C. Harrison, Andrew M. Lew, Gordon K. Smyth, Stephen L. Nutt, Michael Chopin
Summary: The study found that selectively deleting core components of PRC2, either EZH2 or SUZ12, in CD11c-expressing myeloid cells had different effects on H3K27me3. While EZH2 deficiency did not affect the deposition and maintenance of H3K27me3 in DCs or hinder DC/macrophage homeostasis, SUZ12 deficiency significantly impacted the ability of DCs and macrophages to maintain H3K27me3. This suggests fundamentally different homeostatic mechanisms for tissue-resident myeloid cells versus DCs.
SCIENCE IMMUNOLOGY
(2021)
Article
Hematology
Emma M. Carrington, Cynthia Louis, Tobias Kratina, Manuela Hancock, Christine R. Keenan, Nadia Iannarella, Rhys S. Allan, Ahmad Z. Wardak, Peter E. Czabotar, Marco J. Herold, Robyn L. Schenk, Christine A. White, Damian D'Silva, Yuyan Yang, Wesley Wong, Huon Wong, Vanessa L. Bryant, Nicholas D. Huntington, Jai Rautela, Robyn M. Sutherland, Yifan Zhan, Jacinta Hansen, Duong Nhu, Guillaume Lessene, Ian P. Wicks, Andrew M. Lew
Summary: The study highlights the essential role of BCL-XL in maintaining neutrophils within inflammatory sites and demonstrates the therapeutic potential of BCL-XL inhibition in treating inflammatory diseases. The selective BCL-XL inhibitor reduces inflammatory neutrophil numbers and ameliorates tissue pathology in mouse models, indicating a promising approach for neutrophil-mediated diseases.
Article
Immunology
Li Sun, Wenjie Zhang, Lin Zhao, Yanfang Zhao, Fengge Wang, Andrew M. Lew, Yuekang Xu
Summary: The correlation between infections and vascular autoinflammatory diseases has long been recognized, but the immunological basis of healthy vasculatures that predispose to subsequent vascular autoimmunity during inflammation is not well characterized. This study investigated the immune cells in healthy vascular tissues and found a comprehensive set of immune cells with a higher proportion of innate components. Systemic inflammation eroded the immunotolerant state of vascular tissues, leading to upregulation of proinflammatory cytokines and enhanced antigen presentation by vascular dendritic cells (DCs), ultimately leading to vascular destruction. Different vascular DC subsets had selective effects, with monocyte-derived DCs being potent cytokine producers and B-cell activators, and conventional DCs, particularly cDC1, being efficient at presenting antigens to stimulate T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wayne J. Hawthorne, Evelyn J. Salvaris, Yi Vee Chew, Heather Burns, Joanne Hawkes, Helen Barlow, Min Hu, Andrew M. Lew, Mark B. Nottle, Philip J. O'Connell, Peter J. Cowan
Summary: Genetically modified pig donors, combined with immunosuppression, can provide long-term cure and excellent graft survival in diabetic baboon models.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G. Nelson, Bronte Ennis, Sidonia B. G. Eckle, Michael N. T. Souter, Troi J. Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M. Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M. Lew, Daniel G. Pellicci, James McCluskey, Yifan Zhan, Zhenjun Chen, Kate E. Lawlor, Alexandra J. Corbett
Summary: Cell death mechanisms in T lymphocytes vary depending on their developmental stage, cell subset, and activation status. However, the cell death control mechanisms of mucosal-associated invariant T (MAIT) cells, a specialized T cell population, are not well understood. In this study, it was found that MAIT cells express high levels of key necroptotic machinery, RIPK3 and MLKL proteins. Surprisingly, the loss of RIPK3, but not MLKL or caspase-8, specifically increased the abundance of MAIT cells in various organs, indicating a cell-intrinsic regulation of MAIT cell accumulation by RIPK3 signaling.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Shengbo Zhang, Jai Rautela, Naiara G. Bediaga, Tatiana B. Kolesnik, Yue You, Junli Nie, Laura F. Dagley, Justin Bedo, Hanqing Wang, Li Sun, Robyn Sutherland, Elliot Surgenor, Nadia Iannarella, Rhys Allan, Fernando Souza-Fonseca-Guimaraes, Yi Xie, Qike Wang, Yuxia Zhang, Yuekang Xu, Stephen L. Nutt, Andrew M. Lew, Nicholas D. Huntington, Sandra E. Nicholson, Michael Chopin, Yifan Zhan
Summary: The cytokine GM-CSF can differentiate monocytes into macrophages with opposing functions, proinflammatory M1-like and immunosuppressive M2-like. In this study, it was found that the protein CIS plays a critical role in the GM-CSF signaling pathway, and deficiency of CIS leads to the differentiation of monocytes into immunosuppressive M2-like macrophages, promoting allergic inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Meeting Abstract
Immunology
Annabell Bachem, Christina Makhlouf, Katrina J. Binger, David P. de Souza, Dedreia Tull, Andrew M. Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E. Russ, Ian A. Parish, Axel Kallies, Malcolm McConville, Stephen J. Turner, Thomas Gebhardt, Sammy Bedoui
JOURNAL OF IMMUNOLOGY
(2020)
