Evolution of oncolytic viruses: novel strategies for cancer treatment

Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models

(2015) Wei Zhang et al.   NEOPLASIA

Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8+ T-cell recall responses

(2013) L. Zhang et al.   BLOOD

The histone deacetylase inhibitor valproic acid enhances equine herpesvirus type 1 (EHV-1)-mediated oncolysis of human glioma cells

(2013) M C White et al.   CANCER GENE THERAPY

Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans

(2013) C. J. Breitbach et al.   CANCER RESEARCH

The repertoire of human tumor-associated epitopes — identification and selection of antigens and their application in clinical trials

(2013) Sebastian P Haen et al.   CURRENT OPINION IN IMMUNOLOGY

PEGylation of Vesicular Stomatitis Virus Extends Virus Persistence in Blood Circulation of Passively Immunized Mice

(2013) M. Z. Tesfay et al.   JOURNAL OF VIROLOGY

Prostate-Specific Antigen-Retargeted Recombinant Newcastle Disease Virus for Prostate Cancer Virotherapy

(2013) R. Shobana et al.   JOURNAL OF VIROLOGY

Vesicular Stomatitis Virus Variants Selectively Infect and Kill Human Melanomas but Not Normal Melanocytes

(2013) G. Wollmann et al.   JOURNAL OF VIROLOGY

Regulating Cytokine Function Enhances Safety and Activity of Genetic Cancer Therapies

(2013) Hannah Chen et al.   MOLECULAR THERAPY

HDAC Inhibition Suppresses Primary Immune Responses, Enhances Secondary Immune Responses, and Abrogates Autoimmunity During Tumor Immunotherapy

(2013) Byram W Bridle et al.   MOLECULAR THERAPY

Suppression of Antiviral Innate Immunity by Sunitinib Enhances Oncolytic Virotherapy

(2013) Babal K Jha et al.   MOLECULAR THERAPY

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

(2013) Jeong Heo et al.   NATURE MEDICINE

Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model

(2013) T. A. Cheema et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer models

(2012) B J Passer et al.   CANCER GENE THERAPY

Antitumor efficacy of oncolytic herpes simplex virus adsorbed onto antigen-specific lymphocytes

(2012) A Kanzaki et al.   CANCER GENE THERAPY

Macrophage Delivery of an Oncolytic Virus Abolishes Tumor Regrowth and Metastasis after Chemotherapy or Irradiation

(2012) M. Muthana et al.   CANCER RESEARCH

Oncolytic Virus and Anti-4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer

(2012) L. B. John et al.   CANCER RESEARCH

Systemic Combination Virotherapy for Melanoma with Tumor Antigen-Expressing Vesicular Stomatitis Virus and Adoptive T-cell Transfer

(2012) D. M. Rommelfanger et al.   CANCER RESEARCH

Measles virus selectively blind to signaling lymphocyte activation molecule as a novel oncolytic virus for breast cancer treatment

(2012) T Sugiyama et al.   GENE THERAPY

Oncolytic adenovirus armed with IL-24 Inhibits the growth of breast cancer in vitro and in vivo

(2012) Wei Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Chemovirotherapy of Malignant Melanoma with a Targeted and Armed Oncolytic Measles Virus

(2012) Johanna K. Kaufmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Histone Deacetylase Inhibitor Valproic Acid Lessens NK Cell Action against Oncolytic Virus-Infected Glioblastoma Cells by Inhibition of STAT5/T-BET Signaling and Generation of Gamma Interferon

(2012) Christopher A. Alvarez-Breckenridge et al.   JOURNAL OF VIROLOGY

Harnessing Oncolytic Virus-mediated Antitumor Immunity in an Infected Cell Vaccine

(2012) Chantal G Lemay et al.   MOLECULAR THERAPY

An Oncolytic Adenovirus Enhanced for Toll-like Receptor 9 Stimulation Increases Antitumor Immune Responses and Tumor Clearance

(2012) Vincenzo Cerullo et al.   MOLECULAR THERAPY

Phase II Trial of Intravenous Administration of Reolysin® (Reovirus Serotype-3-dearing Strain) in Patients with Metastatic Melanoma

(2012) Evanthia Galanis et al.   MOLECULAR THERAPY

Multimechanistic Tumor Targeted Oncolytic Virus Overcomes Resistance in Brain Tumors

(2012) Kaoru Tamura et al.   MOLECULAR THERAPY

The Efficacy Versus Toxicity Profile of Combination Virotherapy and TLR Immunotherapy Highlights the Danger of Administering TLR Agonists to Oncolytic Virus-treated Mice

(2012) Diana M Rommelfanger et al.   MOLECULAR THERAPY

Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma

(2012) Jose Pulido et al.   NATURE BIOTECHNOLOGY

Expression of FMS-like Tyrosine Kinase 3 Ligand by Oncolytic Herpes Simplex Virus Type I Prolongs Survival in Mice Bearing Established Syngeneic Intracranial Malignant Glioma

(2012) Zachary Barnard et al.   NEUROSURGERY

Oncolytic Effects of a Novel Influenza A Virus Expressing Interleukin-15 from the NS Reading Frame

(2012) Marijke van Rikxoort et al.   PLoS One

Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation

(2012) Melissa M. Alegre et al.   Journal of Oncology

Expressing human interleukin-15 from oncolytic vesicular stomatitis virus improves survival in a murine metastatic colon adenocarcinoma model through the enhancement of anti-tumor immunity

(2011) K B Stephenson et al.   CANCER GENE THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rβ2 or IL-18Rα

(2011) I-K Choi et al.   GENE THERAPY

Activating Systemic T-Cell Immunity Against Self Tumor Antigens to Support Oncolytic Virotherapy with Vesicular Stomatitis Virus

(2011) Phonphimon Wongthida et al.   HUMAN GENE THERAPY

Oncolytic Virus-Mediated Manipulation of DNA Damage Responses: Synergy With Chemotherapy in Killing Glioblastoma Stem Cells

(2011) Ryuichi Kanai et al.   JNCI-Journal of the National Cancer Institute

Oncolytic Specificity of Newcastle Disease Virus Is Mediated by Selectivity for Apoptosis-Resistant Cells

(2011) M. Mansour et al.   JOURNAL OF VIROLOGY

Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-kappaB mediated and supports innate and adaptive anti-tumour immune priming

(2011) Lynette Steele et al.   Molecular Cancer

Targeting Tumor Vasculature With an Oncolytic Virus

(2011) Caroline J Breitbach et al.   MOLECULAR THERAPY

Chemokine Expression From Oncolytic Vaccinia Virus Enhances Vaccine Therapies of Cancer

(2011) Jun Li et al.   MOLECULAR THERAPY

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

(2011) Caroline J. Breitbach et al.   NATURE

Oncolytic viruses in radiation oncology

(2011) Yann Touchefeu et al.   RADIOTHERAPY AND ONCOLOGY

Cytokines in Cancer Immunotherapy

(2011) Sylvia Lee et al.   Cancers

A phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: Armed oncolytic adenovirus for the treatment of head and neck cancers

(2010) Jianhua Chang et al.   CANCER BIOLOGY & THERAPY

Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

(2010) Vincenzo Cerullo et al.   CANCER RESEARCH

Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

(2010) E. Galanis et al.   CANCER RESEARCH

Translating Tumor Antigens into Cancer Vaccines

(2010) Luigi Buonaguro et al.   Clinical and Vaccine Immunology

Phase I/II Study of Oncolytic HSVGM-CSF in Combination with Radiotherapy and Cisplatin in Untreated Stage III/IV Squamous Cell Cancer of the Head and Neck

(2010) K. J. Harrington et al.   CLINICAL CANCER RESEARCH

Oncolytic parvoviruses as cancer therapeutics

(2010) Jean Rommelaere et al.   CYTOKINE & GROWTH FACTOR REVIEWS

OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma

(2010) Howard L Kaufman et al.   Future Oncology

Current Good Manufacturing Practice Production of an Oncolytic Recombinant Vesicular Stomatitis Viral Vector for Cancer Treatment

(2010) L.J. Ausubel et al.   HUMAN GENE THERAPY

Rapamycin enhances the activity of oncolytic herpes simplex virus against tumor cells that are resistant to virus replication

(2010) Xinping Fu et al.   INTERNATIONAL JOURNAL OF CANCER

Reovirus Virotherapy Overrides Tumor Antigen Presentation Evasion and Promotes Protective Antitumor Immunity

(2010) S. A. Gujar et al.   MOLECULAR CANCER THERAPEUTICS

Oncolytic Adenoviruses for the Treatment of Human Cancer: Focus on Translational and Clinical Data

(2010) Sari Pesonen et al.   MOLECULAR PHARMACEUTICS

Potentiating Cancer Immunotherapy Using an Oncolytic Virus

(2010) Byram W Bridle et al.   MOLECULAR THERAPY

Identification of Genetically Modified Maraba Virus as an Oncolytic Rhabdovirus

(2010) Jan Brun et al.   MOLECULAR THERAPY

“Armed” oncolytic herpes simplex viruses for brain tumor therapy

(2010) Tomoki Todo   Cell Adhesion & Migration

Local and Distant Immunity Induced by Intralesional Vaccination with an Oncolytic Herpes Virus Encoding GM-CSF in Patients with Stage IIIc and IV Melanoma

(2009) Howard L. Kaufman et al.   ANNALS OF SURGICAL ONCOLOGY

Oncolytic and immunostimulatory efficacy of a targeted oncolytic poxvirus expressing human GM-CSF following intravenous administration in a rabbit tumor model

(2009) J-H Lee et al.   CANCER GENE THERAPY

Host Lymphodepletion Enhances the Therapeutic Activity of an Oncolytic Vaccinia Virus Expressing 4-1BB Ligand

(2009) H. S. Kim et al.   CANCER RESEARCH

Antitumoral Immune Response by Recruitment and Expansion of Dendritic Cells in Tumors Infected with Telomerase-Dependent Oncolytic Viruses

(2009) Edukulla Ramakrishna et al.   CANCER RESEARCH

Combination of Viral Oncolysis and Tumor-Specific Immunity to Control Established Tumors

(2009) C.-M. Chuang et al.   CLINICAL CANCER RESEARCH

Immune-Mediated Antitumor Activity of Reovirus Is Required for Therapy and Is Independent of Direct Viral Oncolysis and Replication

(2009) R. J. Prestwich et al.   CLINICAL CANCER RESEARCH

Antitumor Activity of an Oncolytic Adenoviral-CD40 Ligand (CD154) Transgene Construct in Human Breast Cancer Cells

(2009) E. M. Gomes et al.   CLINICAL CANCER RESEARCH

The Case of Oncolytic Viruses Versus the Immune System: Waiting on the Judgment of Solomon

(2009) Robin J. Prestwich et al.   HUMAN GENE THERAPY

Interference of CD40L-Mediated Tumor Immunotherapy by Oncolytic Vesicular Stomatitis Virus

(2009) Feorillo Galivo et al.   HUMAN GENE THERAPY

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

(2009) Neil N. Senzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Oncolytic adenovirus mediated Survivin knockdown by RNA interference suppresses human colorectal carcinoma growth in vitro and in vivo

(2009) Wei Shen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting the Intratumoral Dendritic Cells by the Oncolytic Adenoviral Vaccine Expressing RANTES Elicits Potent Antitumor Immunity

(2009) Natalia Lapteva et al.   JOURNAL OF IMMUNOTHERAPY

In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates

(2009) B. Zheng et al.   MOLECULAR CANCER THERAPEUTICS

Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive Antitumor Immunity

(2009) Jeanette E Boudreau et al.   MOLECULAR THERAPY

Therapeutic and Tumor-specific Immunity Induced by Combination of Dendritic Cells and Oncolytic Adenovirus Expressing IL-12 and 4-1BBL

(2009) Jing-Hua Huang et al.   MOLECULAR THERAPY

An oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid tumors

(2008) N Lei et al.   CANCER GENE THERAPY

Inhibition of renal cancer cell growth in vitro and in vivo with oncolytic adenovirus armed short hairpin RNA targeting Ki-67 encoding mRNA

(2008) J-N Zheng et al.   CANCER GENE THERAPY

Measles Virus Induces Oncolysis of Mesothelioma Cells and Allows Dendritic Cells to Cross-Prime Tumor-Specific CD8 Response

(2008) A. Gauvrit et al.   CANCER RESEARCH

Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity

(2008) R. J. Prestwich et al.   CLINICAL CANCER RESEARCH

Synergy of a Herpes Oncolytic Virus and Paclitaxel for Anaplastic Thyroid Cancer

(2008) S.-F. Lin et al.   CLINICAL CANCER RESEARCH

E2F Promoter-Regulated Oncolytic Adenovirus with p16 Gene Induces Cell Apoptosis and Exerts Antitumor Effect on Gastric Cancer

(2008) J. Ma et al.   DIGESTIVE DISEASES AND SCIENCES

Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma

(2008) F Errington et al.   GENE THERAPY

Loading of oncolytic vesicular stomatitis virus onto antigen-specific T cells enhances the efficacy of adoptive T-cell therapy of tumors

(2008) J Qiao et al.   GENE THERAPY

Arming parvoviruses with CpG motifs to improve their oncosuppressive capacity

(2008) Zahari Raykov et al.   INTERNATIONAL JOURNAL OF CANCER

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

(2008) Byeong-Ho Park et al.   LANCET ONCOLOGY

Recombinant Newcastle Disease Virus as a Vaccine Vector for Cancer Therapy

(2008) Adam Vigil et al.   MOLECULAR THERAPY

Recombinant Newcastle disease virus expressing human interleukin-2 serves as a potential candidate for tumor therapy

(2008) Heng Zhao et al.   VIRUS RESEARCH