Article
Biochemistry & Molecular Biology
Amani M. Batarseh, Fatemeh Vafaee, Elham Hosseini-Beheshti, Azadeh Safarchi, Alex Chen, Amy Cohen, Annette Juillard, Nicholas Henry Hunt, Michael Mariani, Todd Mitchell, Georges Emile Raymond Grau
Summary: It is found that the pathogenesis of cerebral malaria can be understood by studying the specific lipid composition in the plasma. There are significant changes in lipid components in the plasma of cerebral malaria patients compared to non-cerebral malaria patients. This study provides important evidence for studying the pathophysiology of cerebral malaria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Sayuri Nakamae, Satoshi Miyagawa, Koki Ogawa, Mariko Kamiya, Mayumi Taniguchi, Akari Ono, Maho Kawaguchi, Awet Alem Teklemichael, Jiun-Yu Jian, Tamasa Araki, Yukimi Katagami, Hidefumi Mukai, Takeshi Annoura, Katsuyuki Yui, Kenji Hirayama, Shigeru Kawakami, Shusaku Mizukami
Summary: Recent studies have shown that CD8+ liver-resident memory T (TRM) cells are essential for protection against liver-stage malaria. In this study, liver TRM cells were induced using liver-directed mRNA-containing lipid nanoparticles (mRNA-LNPs) in mice. The mRNA-LNPs effectively induced antigen-specific cytotoxic T lymphocytes and TRM cells, providing protection against sporozoites during liver-stage malaria and potential for vaccine development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Daniel Fernandez-Ruiz, Maria N. de Menezes, Lauren E. Holz, Sonia Ghilas, William R. Heath, Lynette Beattie
Summary: Tissue-resident memory T cells (T-RM cells) play a critical role in adaptive immunity to infection, particularly in immunity against Plasmodium spp. vaccination with T-RM cells shows promise for efficient protection against malaria, with ongoing research focusing on understanding T-RM formation and identifying suitable target epitopes for human vaccination.
EXPERT REVIEW OF VACCINES
(2021)
Editorial Material
Gastroenterology & Hepatology
Debashree Goswami, Nana K. Minkah, Stefan H. I. Kappe
Summary: Malaria caused by Plasmodium parasite species is a significant global health burden, with the majority of cases reported in sub-Saharan Africa. The infection begins with a mosquito bite, where sporozoites enter the liver cells and develop into liver stages. Recent advancements in research have provided insights into the liver stage biology and immunology, particularly for the two most important human malaria parasites, P. falciparum and P. vivax.
JOURNAL OF HEPATOLOGY
(2022)
Article
Cell Biology
Mitchell N. Lefebvre, Fionna A. Surette, Scott M. Anthony, Rahul Vijay, Isaac J. Jensen, Lecia L. Pewe, Lisa S. Hancox, Natalija Van Braeckel-Budimir, Stephanie van de Wall, Stina L. Urban, Madison R. Mix, Samarchith P. Kurup, Vladimir P. Badovinac, Noah S. Butler, John T. Harty
Summary: The study shows that effector memory CD8 T cells rapidly infiltrate the liver after malarial infection, mediating pathogen clearance through upregulation of inflammatory genes. This highlights the crucial role of Tem in protecting against malaria infection.
Article
Immunology
Saskia C. van der Boor, Geert-Jan van Gemert, Alex E. J. Hanssen, Youri M. van Waardenburg, Matthew B. B. McCall, Teun Bousema, Johannes H. W. de Wilt, Robert W. Sauerwein, Annie S. P. Yang
Summary: The study discovered that while Plasmodium falciparum sporozoites can invade porcine hepatocytes, their development arrests at the mid-stage possibly due to the inability to mobilize critical nutrients across the parasitophorous vacuolar membrane.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lucas Freire-Antunes, Uyla Ornellas-Garcia, Marcos Vinicius Rangel-Ferreira, Monica Lucas Ribeiro-Almeida, Carina Heusner Goncalves de Sousa, Leonardo Jose de Moura Carvalho, Claudio Tadeu Daniel-Ribeiro, Flavia Lima Ribeiro-Gomes
Summary: New data suggests that neutrophils may both aggravate and protect against malaria. The balance of these cells in the body could impact the development of the disease. This study examined the response of neutrophils and T cells in mice infected with Plasmodium berghei ANKA, and found increased levels of neutrophils and neutrophil-T cell ratios before the onset of cerebral malaria. These findings could help predict the development of cerebral malaria and advance our understanding of its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Andres Noe, Mehreen S. Datoo, Amy Flaxman, Mohammad Ali Husainy, Daniel Jenkin, Duncan Bellamy, Rebecca A. Makinson, Richard Morter, Fernando Ramos Lopez, Jonathan Sheridan, Dimitrios Voukantsis, Naveen Prasad, Adrian V. S. Hill, Katie J. Ewer, Alexandra J. Spencer
Summary: This study provides valuable insights into the characteristics and potential of liver CD8+ tissue-resident memory (TRM) cells for protection against liver-stage malaria. It also suggests the possibility of using TRM-like cells as a correlate of protection in malaria vaccine trials. The findings contribute to the development and evaluation of liver-stage malaria vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Damian A. Oyong, Jessica R. Loughland, Megan S. F. Soon, Jo-Anne Chan, Dean Andrew, Bruce D. Wines, P. Mark Hogarth, Stuart D. Olver, Alika D. Collinge, Antiopi Varelias, James G. Beeson, Enny Kenangalem, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Michelle J. Boyle
Summary: The study found that during acute malaria, adults had higher levels of cTfh cell activation compared to children, with adults showing higher levels of parasite-specific cTfh cells and cTfh cells producing more Th2-Tfh associated cytokine IL-4. This higher Tfh cell activation in adults was associated with higher activation of B cells during infection and higher induction of antibodies after 7 and 28 days compared to children.
Article
Immunology
Johanna F. Scheunemann, Julia J. Reichwald, Patricia Jebett Korir, Janina M. Kuehlwein, Lea-Marie Jenster, Christiane Hammerschmidt-Kamper, Matthew D. Lewis, Katrin Klocke, Max Borsche, Kim E. Schwendt, Camille Soun, Stephanie Thiebes, Andreas Limmer, Daniel R. Engel, Ann-Kristin Mueller, Achim Hoerauf, Marc P. Huebner, Beatrix Schumak
Summary: The study demonstrates that mice lacking type I interferon receptor are protected from experimental cerebral malaria when infected with a transgenic parasite. The increase in CD8(+) T cells in the spleen and elevated levels of CCL5 produced by eosinophils are associated with this protection, indicating that eosinophils impact T cell migration and proliferation during infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yikang Li, Zhengrui You, Ruqi Tang, Xiong Ma
Summary: Tissue-resident memory (T-RM) T cells are critical for the defense against pathogens in peripheral non-lymphoid tissues. Hepatic T-RM cells play a vital role in chronic liver diseases and may offer novel strategies for precision immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Maria Lourdes Macalinao, Shin-Ichi Inoue, Sanjaadorj Tsogtsaikhan, Hirotaka Matsumoto, Ganchimeg Bayarsaikhan, Jiun-Yu Jian, Kazumi Kimura, Yoshiaki Yasumizu, Tsuyoshi Inoue, Hiroki Yoshida, Julius Hafalla, Daisuke Kimura, Katsuyuki Yui
Summary: This study reveals that IL-27 plays a critical role in inhibiting the development of unique Th1 memory precursor CD4(+) T cells during malaria infection, and neutralization of IL-27 enhances immune responses and protection.
EMBO MOLECULAR MEDICINE
(2023)
Article
Immunology
Kayla Sylvester, Steven P. Maher, Dora Posfai, Michael K. Tran, McKenna C. Crawford, Amelie Vantaux, Benoit Witkowski, Dennis E. Kyle, Emily R. Derbyshire
Summary: This study utilizes high-resolution microscopy to characterize temporal changes of the TVN in Plasmodium vivax liver stage, revealing its presence in dormant hypnozoites and association with host nuclei. The unexpected association of the host water channel protein AQP3 with TVN-derived vesicles is demonstrated, suggesting a potential function of AQP3 during this stage. These findings enhance understanding of host-parasite interactions in both dormant and replicating P. vivax liver stage forms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
Carola Schafer, Gigliola Zanghi, Ashley M. Vaughan, Stefan H. I. Kappe
Summary: Plasmodium vivax, the most widespread human malaria parasite, can form latent liver stages known as hypnozoites which can activate weeks, months, or even years after the primary infection, causing relapses of blood stage infection. Eliminating hypnozoites is a major obstacle for malaria treatment and eradication as they are undetectable and unaffected by most antimalarial drugs.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Article
Microbiology
Amelie Vantaux, Julie Peneau, Caitlin A. Cooper, Dennis E. Kyle, Benoit Witkowski, Steven P. Maher
Summary: Plasmodium vivax, a parasite causing human malaria, forms dormant liver stage known as hypnozoite, which can be activated weeks, months, or years after the initial infection, resulting in relapse episodes. Relapses contribute significantly to the burden of vivax malaria. However, the molecular processes underlying hypnozoite formation, persistence, and activation, as well as the factors determining relapse periodicity, remain largely unknown.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Alexander Pichugin, Nick Steers, Patricia De la Vega, Stasya Zarling, Isaac Chalom, Urszula Krzych
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Article
Pathology
Alexander V. Pichugin, Bo-Shiun Yan, Alex Sloutsky, Lester Kobzik, Igor Kramnik
AMERICAN JOURNAL OF PATHOLOGY
(2009)
Article
Genetics & Heredity
J. Sissons, B-S Yan, A. V. Pichugin, A. Kirby, M. J. Daly, I. Kramnik
GENES AND IMMUNITY
(2009)
Article
Immunology
Susanna Commandeur, Krista E. van Meijgaarden, Corine Prins, Alexander V. Pichugin, Karin Dijkman, Susan J. F. van den Eeden, Annemieke H. Friggen, Kees L. M. C. Franken, Gregory Dolganov, Igor Kramnik, Gary K. Schoolnik, Fredrik Oftung, Gro Ellen Korsvold, Annemieke Geluk, Tom H. M. Ottenhoff
JOURNAL OF IMMUNOLOGY
(2013)
Article
Immunology
Anjali Yadava, Saule Nurmukhambetova, Alexander V. Pichugin, Joanne M. Lumsden
JOURNAL OF INFECTIOUS DISEASES
(2012)
Article
Biochemistry & Molecular Biology
A. Nalbandian, B-S Yan, A. Pichugin, R. T. Bronson, I. Kramnik
Review
Immunology
Urszula Krzych, Sarat Dalai, Stasya Zarling, Alexander Pichugin
FRONTIERS IN IMMUNOLOGY
(2012)
Article
Immunology
Bo-Shiun Yan, Alexander V. Pichugin, Ousman Jobe, Laura Helming, Evgeniy B. Eruslanov, Jose A. Gutirrez-Pabello, Mauricio Rojas, Yuriy V. Shebzukhov, Lester Kobzik, Igor Kramnik
JOURNAL OF IMMUNOLOGY
(2007)
Article
Immunology
E. V. Kondratieva, V. V. Evstifeev, T. K. Kondratieva, S. N. Petrovskaya, A. V. Pichugin, E. I. Rubakova, M. M. Averbakh, A. S. Apt
INFECTION AND IMMUNITY
(2007)
Article
Immunology
Elvira Rubakova, Svetlana Petrovskaya, Alexander Pichugin, Valentine Khlebnikov, David McMurray, Elena Kondratieva, Irina Baturina, Tatiana Kondratieva, Alexander Apt
Article
Immunology
L. N. Nesterenko, D. V. Balunets, A. S. Tomova, J. M. Romanova, J. S. Alyapkina, N. A. Zigangirova, M. A. Kapina, E. V. Kondratieva, A. V. Pichugin, K. B. Majorov, A. S. Apt
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2006)
Article
Cell Biology
Alexander V. Pichugin, Svetlana N. Petrovskaya, Alexander S. Apt
JOURNAL OF LEUKOCYTE BIOLOGY
(2006)
Article
Immunology
IV Lyadova, EB Eruslanov, SV Khaidukov, VV Yeremeev, KB Majorov, AV Pichugin, BV Nikonenko, TK Kondratieva, AS Apt
JOURNAL OF IMMUNOLOGY
(2000)