Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

(2014) J. Pene et al.   JOURNAL OF IMMUNOLOGY

Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease

(2011) K. L. Hippen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Regulatory T cells in stem cell transplantation: strategies and first clinical experiences

(2011) Matthias Edinger et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis

(2011) Ting Feng et al.   GASTROENTEROLOGY

Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF  treatment

(2011) C. Veltkamp et al.   GUT

Experimental Inflammatory Bowel Disease: Insights into the Host-Microbiota Dialog

(2011) Maya Saleh et al.   IMMUNITY

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

(2011) Samuel Huber et al.   IMMUNITY

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game

(2011) S. A. Long et al.   JOURNAL OF IMMUNOLOGY

Coeliac disease and gluten sensitivity

(2011) R. Troncone et al.   JOURNAL OF INTERNAL MEDICINE

Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance

(2011) Barbara Cassani et al.   MOLECULAR ASPECTS OF MEDICINE

Mouse and human intestinal immunity: same ballpark, different players; different rules, same score

(2011) D L Gibbons et al.   Mucosal Immunology

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Ulcerative Colitis

(2011) Silvio Danese et al.   NEW ENGLAND JOURNAL OF MEDICINE

FOXP3 Expression in Duodenal Mucosa in Pediatric Patients with Celiac Disease

(2011) Eli Brazowski et al.   PATHOBIOLOGY

Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients

(2011) Dag Henrik Reikvam et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Environmental influences on T regulatory cells in inflammatory bowel disease

(2011) Gijs Hardenberg et al.   SEMINARS IN IMMUNOLOGY

Moving to tolerance: Clinical application of T regulatory cells

(2011) Alicia N. McMurchy et al.   SEMINARS IN IMMUNOLOGY

Intestinal CD103+ dendritic cells: master regulators of tolerance?

(2011) Charlotte L. Scott et al.   TRENDS IN IMMUNOLOGY

Balancing acts: the role of TGF-β in the mucosal immune system

(2011) Joanne E. Konkel et al.   TRENDS IN MOLECULAR MEDICINE

Intestinal microbiota in inflammatory bowel disease: Friend of foe?

(2011) Francesca Fava   WORLD JOURNAL OF GASTROENTEROLOGY

IL-15 modulates the effect of retinoic acid, promoting inflammation rather than oral tolerance to dietary antigens

(2011) Eduardo Arranz et al.   Expert Review of Gastroenterology & Hepatology

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes

(2010) M. Tiittanen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Infectious tolerance: therapeutic potential

(2010) Adrian R Kendal et al.   CURRENT OPINION IN IMMUNOLOGY

Characterization of Interleukin-17–Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases

(2010) Zaruhi Hovhannisyan et al.   GASTROENTEROLOGY

Immunomodulation by Commensal and Probiotic Bacteria

(2010) Paul Forsythe et al.   IMMUNOLOGICAL INVESTIGATIONS

Therapy with anti-TNFα antibody enhances number and function of Foxp3+ regulatory T cells in inflammatory bowel diseases

(2010) Gilles Boschetti et al.   INFLAMMATORY BOWEL DISEASES

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

(2010) Pervinder Sagoo et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a B cell signature associated with renal transplant tolerance in humans

(2010) Kenneth A. Newell et al.   JOURNAL OF CLINICAL INVESTIGATION

Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis

(2010) Ting Feng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

(2010) Y. K. Lee et al.   SCIENCE

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Plasticity of CD4+ FoxP3+ T cells

(2009) Xuyu Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

(2009) James L. Riley et al.   IMMUNITY

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

TLR5 is not required for flagellin-mediated exacerbation of DSS colitis

(2009) Sabine M. Ivison et al.   INFLAMMATORY BOWEL DISEASES

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Coeliac disease

(2009) Antonio Di Sabatino et al.   LANCET

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

(2009) R. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is FOXP3 a bona fide marker for human regulatory T cells?

(2008) Maria-Grazia Roncarolo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells

(2008) A M Westendorf et al.   GUT

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Special regulatory T-cell review: regulatory T cells and the intestinal tract – patrolling the frontier

(2008) Ana Izcue et al.   IMMUNOLOGY

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type I diabetes mellitus

(2008) Tamara Vorobjova et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Natural and TGF-β–induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other

(2008) David A. Horwitz et al.   TRENDS IN IMMUNOLOGY