CD4+T-cell subsets in intestinal inflammation

IL-10 and IL-10 receptor defects in humans

(2012) Erik-Oliver Glocker et al.   Annals of the New York Academy of Sciences

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Small molecule inhibitors of RORγt: Targeting Th17 cells and other applications

(2012) Jun R. Huh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology

(2012) Aisling O’Hara Hall et al.   IMMUNITY

Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

(2012) Thibault Griseri et al.   IMMUNITY

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

(2012) Jinfang Zhu et al.   IMMUNITY

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine

(2012) Michael H. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A specific role for TLR1 in protective TH17 immunity during mucosal infection

(2012) R. William DePaolo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

(2012) Gary Bloomgren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complete Genome Sequences of Rat and Mouse Segmented Filamentous Bacteria, a Potent Inducer of Th17 Cell Differentiation

(2011) Tulika Prakash et al.   Cell Host & Microbe

The Genome of Th17 Cell-Inducing Segmented Filamentous Bacteria Reveals Extensive Auxotrophy and Adaptations to the Intestinal Environment

(2011) Andrew Sczesnak et al.   Cell Host & Microbe

Blocking Lymphocyte Localization to the Gastrointestinal Mucosa as a Therapeutic Strategy for Inflammatory Bowel Diseases

(2011) Eduardo J. Villablanca et al.   GASTROENTEROLOGY

Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment

(2011) Wei Hu et al.   IMMUNITY

Experimental Inflammatory Bowel Disease: Insights into the Host-Microbiota Dialog

(2011) Maya Saleh et al.   IMMUNITY

Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha

(2011) Jason A. Hall et al.   IMMUNITY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

(2011) Ashutosh Chaudhry et al.   IMMUNITY

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

(2011) Samuel Huber et al.   IMMUNITY

The Role of Retinoic Acid in Tolerance and Immunity

(2011) Jason A. Hall et al.   IMMUNITY

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

(2011) Ilona Gutcher et al.   IMMUNITY

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology

(2011) Masahito Kamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Involvement of interleukin-21 in the regulation of colitis-associated colon cancer

(2011) Carmine Stolfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production

(2011) T. Feng et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Human Regulatory T Cells Require IL-35 To Mediate Suppression and Infectious Tolerance

(2011) V. Chaturvedi et al.   JOURNAL OF IMMUNOLOGY

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

(2011) R. W. DePaolo et al.   NATURE

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Regional and mucosal memory T cells

(2011) Brian S Sheridan et al.   NATURE IMMUNOLOGY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

STAT1Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis

(2011) Frank L. van de Veerdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Mucosal-associated invariant T cells: unconventional development and function

(2011) Lionel Le Bourhis et al.   TRENDS IN IMMUNOLOGY

Gut-associated lymphoid tissue, T cell trafficking, and chronic intestinal inflammation

(2010) Iurii Koboziev et al.   Annals of the New York Academy of Sciences

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut

(2010) Gregory F. Sonnenberg et al.   IMMUNITY

Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development

(2010) Caihong Wang et al.   INFLAMMATORY BOWEL DISEASES

Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases

(2010) Massimiliano Sarra et al.   INFLAMMATORY BOWEL DISEASES

IL-27 promotes T cell–dependent colitis through multiple mechanisms

(2010) Jennifer H. Cox et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

(2010) Anne Puel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

OX40 is required for regulatory T cell–mediated control of colitis

(2010) Thibault Griseri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A

(2010) Gregory F. Sonnenberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restricted Microbiota and Absence of Cognate TCR Antigen Leads to an Unbalanced Generation of Th17 Cells

(2010) M. Lochner et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

IL-35-mediated induction of a potent regulatory T cell population

(2010) Lauren W Collison et al.   NATURE IMMUNOLOGY

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

IL-22+ CD4+ T Cells Are Associated with Therapeutic Trichuris trichiura Infection in an Ulcerative Colitis Patient

(2010) M. J. Broadhurst et al.   Science Translational Medicine

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

Intestinal Effector T Cells in Health and Disease

(2009) Craig L. Maynard et al.   IMMUNITY

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Regulation of immune responses by interleukin-27

(2009) Hiroki Yoshida et al.   IMMUNOLOGICAL REVIEWS

Regulation and pro-inflammatory function of interleukin-17 family cytokines

(2009) Chen Dong   IMMUNOLOGICAL REVIEWS

Fontolizumab in moderate to severe Crohnʼs disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study

(2009) Walter Reinisch et al.   INFLAMMATORY BOWEL DISEASES

Contrasting roles for all-trans retinoic acid in TGF-β–mediated induction ofFoxp3andIl10genes in developing regulatory T cells

(2009) Craig L. Maynard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis

(2009) D. Haribhai et al.   JOURNAL OF IMMUNOLOGY

IL-27 Regulates Homeostasis of the Intestinal CD4+ Effector T Cell Pool and Limits Intestinal Inflammation in a Murine Model of Colitis

(2009) A. E. Troy et al.   JOURNAL OF IMMUNOLOGY

The development of intestinal lymphoid tissues at the interface of self and microbiota

(2009) G Eberl et al.   Mucosal Immunology

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

(2009) Ye Zheng et al.   NATURE

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity

(2009) Santhakumar Manicassamy et al.   NATURE MEDICINE

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE

Innate T cell responses in human gut

(2009) Bertrand Meresse et al.   SEMINARS IN IMMUNOLOGY

Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice

(2008) Reiko Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses

(2008) Jason A. Hall et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD

(2008) Alejandro V. Villarino et al.   INTERNATIONAL IMMUNOLOGY

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

(2008) Colby Zaph et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo

(2008) Swantje I. Hammerschmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo equilibrium of proinflammatory IL-17+and regulatory IL-10+Foxp3+RORγt+T cells

(2008) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen-specific peripheral shaping of the natural regulatory T cell population

(2008) Stephanie K. Lathrop et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Homing imprinting and immunomodulation in the gut: Role of dendritic cells and retinoids

(2007) Rodrigo J. Mora   INFLAMMATORY BOWEL DISEASES

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES