The actin-driven spatiotemporal organization of T-cell signaling at the system scale

TACTICS, an interactive platform for customized high-content bioimaging analysis

(2013) R. Shimoni et al.   BIOINFORMATICS

Controversy and consensus regarding myosin II function at the immunological synapse

(2013) John A Hammer et al.   CURRENT OPINION IN IMMUNOLOGY

GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development

(2013) W. Paster et al.   JOURNAL OF IMMUNOLOGY

The lymphoid lineage–specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

(2013) Yinming Liang et al.   NATURE IMMUNOLOGY

Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9

(2013) J. L. Gallop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sculpting Organs: Mechanical Regulation of Tissue Development

(2012) Celeste M. Nelson et al.   Annual Review of Biomedical Engineering

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

Dynamic In Situ Cytometry Uncovers T Cell Receptor Signaling during Immunological Synapses and Kinapses In Vivo

(2012) Hélène D. Moreau et al.   IMMUNITY

Divergent lymphocyte signalling revealed by a powerful new tool for analysis of time-lapse microscopy

(2012) Kim Pham et al.   IMMUNOLOGY AND CELL BIOLOGY

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

Mechanism and function of Vav1 localisation in TCR signalling

(2012) Olga Ksionda et al.   JOURNAL OF CELL SCIENCE

Characterization of dynamic actin associations with T-cell receptor microclusters in primary T cells

(2012) A. A. Smoligovets et al.   JOURNAL OF CELL SCIENCE

Self-reactive human CD4 T cell clones form unusual immunological synapses

(2012) David A. Schubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells

(2012) P. T. Sage et al.   JOURNAL OF IMMUNOLOGY

CD2AP Links Cortactin and Capping Protein at the Cell Periphery To Facilitate Formation of Lamellipodia

(2012) J. Zhao et al.   MOLECULAR AND CELLULAR BIOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Integration of the movement of signaling microclusters with cellular motility in immunological synapses

(2012) Peter Beemiller et al.   NATURE IMMUNOLOGY

Biological imaging software tools

(2012) Kevin W Eliceiri et al.   NATURE METHODS

Computational modeling of cellular signaling processes embedded into dynamic spatial contexts

(2012) Bastian R Angermann et al.   NATURE METHODS

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells

(2011) Emily J Quann et al.   NATURE IMMUNOLOGY

Phosphatidylinositol (4,5) Bisphosphate Controls T Cell Activation by Regulating T Cell Rigidity and Organization

(2011) Yi Sun et al.   PLoS One

CD4+ T-cell synapses involve multiple distinct stages

(2011) H. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

(2011) B. N. Manz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Itk Controls the Spatiotemporal Organization of T Cell Activation

(2011) K. L. Singleton et al.   Science Signaling

Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

(2011) Gregory D. Rak et al.   PLOS BIOLOGY

Remodelling of Cortical Actin Where Lytic Granules Dock at Natural Killer Cell Immune Synapses Revealed by Super-Resolution Microscopy

(2011) Alice C. N. Brown et al.   PLOS BIOLOGY

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells

(2010) Guokai Chen et al.   Cell Stem Cell

Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms

(2010) J. Oliaro et al.   JOURNAL OF IMMUNOLOGY

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA–regulated adhesions

(2010) Jordan Jacobelli et al.   NATURE IMMUNOLOGY

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42

(2010) P. Sinai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes

(2010) Georges A. Azar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

(2009) Misty R. Jenkins et al.   IMMUNITY

Dynamic Interaction of Amphiphysin with N-WASP Regulates Actin Assembly

(2009) Hiroshi Yamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Spatiotemporal Patterning During T Cell Activation Is Highly Diverse

(2009) K. L. Singleton et al.   Science Signaling

Fluorescence Proteins, Live-Cell Imaging, and Mechanobiology: Seeing Is Believing

(2008) Yingxiao Wang et al.   Annual Review of Biomedical Engineering

Metastatic Cancer Cell

(2008) Marina Bacac et al.   Annual Review of Pathology-Mechanisms of Disease

Cell Shape and Negative Links in Regulatory Motifs Together Control Spatial Information Flow in Signaling Networks

(2008) Susana R. Neves et al.   CELL

Low Ligand Requirement for Deletion and Lack of Synapses in Positive Selection Enforce the Gauntlet of Thymic T Cell Maturation

(2008) Peter J.R. Ebert et al.   IMMUNITY

How Antigen Quantity and Quality Determine T-Cell Decisions in Lymphoid Tissue

(2008) H. Zheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility

(2008) Aaron J. Tooley et al.   NATURE CELL BIOLOGY

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coronin-1A Links Cytoskeleton Dynamics to TCRαβ-Induced Cell Signaling

(2008) Bénédicte Mugnier et al.   PLoS One

Deformation-based nuclear morphometry: Capturing nuclear shape variation in HeLa cells

(2007) Gustavo K. Rohde et al.   CYTOMETRY PART A