Neutrophil migration: moving from zebrafish models to human autoimmunity

Rac GTPases in Human Diseases

(2013) Sung-Yun Pai et al.   DISEASE MARKERS

β2 Integrin-mediated Cell-Cell Contact Transfers Active Myeloperoxidase from Neutrophils to Endothelial Cells

(2013) Uwe Jerke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophils Confer T Cell Resistance to Myeloid-Derived Suppressor Cell-Mediated Suppression To Promote Chronic Inflammation

(2013) S. O. Ryan et al.   JOURNAL OF IMMUNOLOGY

Molecular players in neutrophil chemotaxis-focus on PI3K and small GTPases

(2013) Laure Gambardella et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Intraluminal crawling versus interstitial neutrophil migration during inflammation

(2013) Robert Pick et al.   MOLECULAR IMMUNOLOGY

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation

(2012) Chie Miyabe et al.   ARTHRITIS AND RHEUMATISM

How anti-neutrophil cytoplasmic autoantibodies activate neutrophils

(2012) R. Kettritz   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Lupus neutrophils

(2012) Jason S. Knight et al.   CURRENT OPINION IN RHEUMATOLOGY

The role of neutrophils in autoimmune diseases

(2012) Tamás Németh et al.   IMMUNOLOGY LETTERS

Targeting and transport: How microtubules control focal adhesion dynamics

(2012) Samantha Stehbens et al.   JOURNAL OF CELL BIOLOGY

The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish

(2012) P.-y. Lam et al.   JOURNAL OF CELL SCIENCE

The role of microtubules in neutrophil polarity and migration in live zebrafish

(2012) S. K. Yoo et al.   JOURNAL OF CELL SCIENCE

Acquisition of Antigen-Presenting Functions by Neutrophils Isolated from Mice with Chronic Colitis

(2012) D. V. Ostanin et al.   JOURNAL OF IMMUNOLOGY

Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

(2012) Jeremy Sokolove et al.   PLoS One

Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and Fc R signaling

(2012) C. D. Sadik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

Urine VCAM-1 as a marker of renal pathology activity index in lupus nephritis

(2012) Sandeep Singh et al.   ARTHRITIS RESEARCH & THERAPY

Pathogenesis of ANCA-associated vasculitides

(2011) C. G. M. Kallenberg   ANNALS OF THE RHEUMATIC DISEASES

Protein tyrosine kinases in neutrophil activation and recruitment

(2011) Alexander Zarbock et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Resolution of neutrophilic inflammation by H2O2 in antigen-induced arthritis

(2011) Fernando Lopes et al.   ARTHRITIS AND RHEUMATISM

New insights into the pathogenesis of Behçet's disease

(2011) Marc Pineton de Chambrun et al.   AUTOIMMUNITY REVIEWS

Dual Roles for Rac2 in Neutrophil Motility and Active Retention in Zebrafish Hematopoietic Tissue

(2011) Qing Deng et al.   DEVELOPMENTAL CELL

Neutrophil chemotaxis in granulomatosis with polyangiitis (Wegener's) and idiopathic pulmonary fibrosis

(2011) A. G. Richter et al.   EUROPEAN RESPIRATORY JOURNAL

Receptor-like Tyrosine Phosphatases CD45 and CD148 Have Distinct Functions in Chemoattractant-Mediated Neutrophil Migration and Response to S. aureus

(2011) Jing W. Zhu et al.   IMMUNITY

The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge

(2011) Y. He et al.   JOURNAL OF CELL SCIENCE

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish

(2011) S. K. Yoo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil transmigration, focal adhesion kinase and endothelial barrier function

(2011) Sarah Y. Yuan et al.   MICROVASCULAR RESEARCH

An Evolutionary Analysis of RAC2 Identifies Haplotypes Associated with Human Autoimmune Diseases

(2011) M. Sironi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

(2011) Sa Kan Yoo et al.   NATURE

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Neutrophils in the pathogenesis and manifestations of SLE

(2011) Mariana J. Kaplan   Nature Reviews Rheumatology

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

(2011) M. Kurowska-Stolarska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Regulation of cell migration by dynamic microtubules

(2011) Irina Kaverina et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inhibitor and activator: dual functions for SHIP in immunity and cancer

(2010) William G. Kerr   Annals of the New York Academy of Sciences

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

(2010) K. B. Walters et al.   BLOOD

Activation of normal neutrophils by anti-neutrophil cytoplasm antibodies

(2010) M. T. KEOGAN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

(2010) Sa Kan Yoo et al.   DEVELOPMENTAL CELL

Src redox regulation: Again in the front line

(2010) Elisa Giannoni et al.   FREE RADICAL BIOLOGY AND MEDICINE

An arrayed high-content chemotaxis assay for patient diagnosis

(2010) Erwin Berthier et al.   Integrative Biology

Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia

(2010) Deborah Accetta et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of CD147 (EMMPRIN) on neutrophils in rheumatoid arthritis enhances chemotaxis, matrix metalloproteinase production and invasiveness of synoviocytes

(2010) Cong-Hua Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

'Rac'-ing upstream to treat rheumatoid arthritis

(2010) Gary S Firestein   ARTHRITIS RESEARCH & THERAPY

Mechanisms underlying neutrophil-mediated monocyte recruitment

(2009) O. Soehnlein et al.   BLOOD

Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks

(2009) Robert H. Insall et al.   DEVELOPMENTAL CELL

c-ANCA-induced neutrophil-mediated lung injury: a model of acute Wegener's granulomatosis

(2009) K. Hattar et al.   EUROPEAN RESPIRATORY JOURNAL

CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus

(2009) A. Wang et al.   JOURNAL OF IMMUNOLOGY

Phosphoinositol 3-kinase-γ mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis

(2009) Adrian Schreiber et al.   KIDNEY INTERNATIONAL

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

(2009) A. Nishikimi et al.   SCIENCE

Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium

(2008) Emily Smith et al.   ARTHRITIS AND RHEUMATISM

Regulation of phagocyte migration and recruitment by Src-family kinases

(2008) A. Baruzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Moving towards a Better Understanding of Chemotaxis

(2008) Len Stephens et al.   CURRENT BIOLOGY

Role of PI3Kδ and PI3Kγ in inflammatory arthritis and tissue localization of neutrophils

(2008) Tara M. Randis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Parallel Phosphatidylinositol 3-Kinase (PI3K)-dependent and Src-dependent Pathways Lead to CXCL8-mediated Rac2 Activation and Chemotaxis

(2008) Jiqing Sai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha

(2008) Greg Parsonage et al.   ARTHRITIS RESEARCH & THERAPY

Colchicine: Its mechanism of action and efficacy in crystal-induced inflammation

(2008) George Nuki   Current Rheumatology Reports

Src family kinases: Regulation of their activities, levels and identification of new pathways

(2007) Evan Ingley   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS