Nanobody; an Old Concept and New Vehicle for Immunotargeting

A llama-derived gelsolin single-domain antibody blocks gelsolin–G-actin interaction

(2010) Anske Van den Abbeele et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A bispecific nanobody to provide full protection against lethal scorpion envenoming

(2010) Issam Hmila et al.   FASEB JOURNAL

An Intrabody Based on a Llama Single-domain Antibody Targeting the N-terminal α-Helical Multimerization Domain of HIV-1 Rev Prevents Viral Production

(2010) Thomas Vercruysse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of EGFR by a novel multivalent nanobody-liposome platform

(2010) Sabrina Oliveira et al.   JOURNAL OF CONTROLLED RELEASE

PrP-specific camel antibodies with the ability to immunodetect intracellular prion protein

(2010) M. Tayebi et al.   JOURNAL OF GENERAL VIROLOGY

A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding Region

(2010) Jianbo Dong et al.   JOURNAL OF MOLECULAR BIOLOGY

Nanobodies as Tools for In Vivo Imaging of Specific Immune Cell Types

(2010) K. De Groeve et al.   JOURNAL OF NUCLEAR MEDICINE

In Vitro Analysis and In Vivo Tumor Targeting of a Humanized, Grafted Nanobody in Mice Using Pinhole SPECT/Micro-CT

(2010) I. Vaneycken et al.   JOURNAL OF NUCLEAR MEDICINE

Isolation of a Novel Nanobody Against HER-2/neuUsing Phage Displays Technology

(2010) Farzaneh Sheikholeslami et al.   Labmedicine

Llama Single Domain Antibodies Specific for the 7 Botulinum Neurotoxin Serotypes as Heptaplex Immunoreagents

(2010) Jerry O. Conway et al.   PLoS One

Llama VHH antibody fragments against GFAP: better diffusion in fixed tissues than classical monoclonal antibodies

(2009) Claire Perruchini et al.   ACTA NEUROPATHOLOGICA

Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by N-glycosylation

(2009) M. M. Harmsen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

1H, 13C and 15N assignments of a camelid nanobody directed against human α-synuclein

(2009) Anneleen Vuchelen et al.   Biomolecular NMR Assignments

Applications of single-chain variable fragment antibodies in therapeutics and diagnostics

(2009) Nina E. Weisser et al.   BIOTECHNOLOGY ADVANCES

Specific immuno capturing of the Staphylococcal superantigen toxic-shock syndrome toxin-1 in plasma

(2009) Hendrik Adams et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1

(2009) Jian-Wei Wang et al.   CANCER LETTERS

The promise and potential pitfalls of chimeric antigen receptors

(2009) Michel Sadelain et al.   CURRENT OPINION IN IMMUNOLOGY

An alpaca single-domain antibody blocks filopodia formation by obstructing L-plastin-mediated F-actin bundling

(2009) Veerle Delanote et al.   FASEB JOURNAL

Anti-MUC1 Nanobody Can Redirect T-Body Cytotoxic Effector Function

(2009) Seyed Hamid Aghaee Bakhtiari et al.   HYBRIDOMA

Single Domain Antibodies Are Specially Suited for Quantitative Determination of Gliadins under Denaturing Conditions

(2009) Vanina Doña et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isolation of antigen-binding camelid heavy chain antibody fragments (nanobodies) from an immune library displayed on the surface of Pichia pastoris

(2009) Stefan Ryckaert et al.   JOURNAL OF BIOTECHNOLOGY

A single-step procedure of recombinant library construction for the selection of efficiently produced llama VH binders directed against cancer markers

(2009) Damjana Kastelic et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Antidotes against venomous animals: State of the art and prospectives

(2009) G.P. Espino-Solis et al.   Journal of Proteomics

Use of tumour-responsive T cells as cancer treatment

(2009) Mary L Disis et al.   LANCET

Cell selection and characterization of a novel human endothelial cell specific nanobody

(2009) Davoud Ahmadvand et al.   MOLECULAR IMMUNOLOGY

Pentabody-mediated antigen delivery induces antigen-specific mucosal immune response

(2009) Shenghua Li et al.   MOLECULAR IMMUNOLOGY

Reverse proteomic antibody screening identifies anti adhesive VHH targeting VLA-3

(2009) Arjan J. Groot et al.   MOLECULAR IMMUNOLOGY

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

(2009) Konstantin V. Korotkov et al.   STRUCTURE

High-level expression of Camelid nanobodies in Nicotiana benthamiana

(2009) Yi-Hui Audrey Teh et al.   TRANSGENIC RESEARCH

A llama single domain anti-idiotypic antibody mimicking HER2 as a vaccine: Immunogenicity and efficacy

(2009) Nidia Alvarez-Rueda et al.   VACCINE

Thermostable Llama Single Domain Antibodies for Detection of Botulinum A Neurotoxin Complex

(2008) Ellen R. Goldman et al.   ANALYTICAL CHEMISTRY

Engineering a Camelid Antibody Fragment That Binds to the Active Site of Human Lysozyme and Inhibits Its Conversion into Amyloid Fibrils†

(2008) Pak-Ho Chan et al.   BIOCHEMISTRY

Single-domain antibodies as building blocks for novel therapeutics

(2008) D SAERENS et al.   CURRENT OPINION IN PHARMACOLOGY

Monoclonal Antibodies as Innovative Therapeutics

(2008) Janice Reichert   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice

(2008) Benedikte Serruys et al.   HEPATOLOGY

Production and Characterization of a High-Affinity Nanobody Against Human Endoglin

(2008) Davoud Ahmadvand et al.   HYBRIDOMA

Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis

(2008) N. Deckers et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

TNT detection using llama antibodies and a two-step competitive fluid array immunoassay

(2008) George P. Anderson et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Comparison of the Biodistribution and Tumor Targeting of Two 99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT

(2008) L. O. T. Gainkam et al.   JOURNAL OF NUCLEAR MEDICINE

Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

(2008) Anita Y. Lam et al.   JOURNAL OF STRUCTURAL BIOLOGY

Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120

(2008) A. Forsman et al.   JOURNAL OF VIROLOGY

Llama-Derived Single-Chain Antibody Fragments Directed to Rotavirus VP6 Protein Possess Broad Neutralizing Activity In Vitro and Confer Protection against Diarrhea in Mice

(2008) L. Garaicoechea et al.   JOURNAL OF VIROLOGY

Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

(2008) B. M. Tijink et al.   MOLECULAR CANCER THERAPEUTICS

VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI′

(2008) Issam Hmila et al.   MOLECULAR IMMUNOLOGY

Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol

(2008) Patrick J. Doyle et al.   MOLECULAR IMMUNOLOGY

Single-domain antibodies recognize selectively small oligomeric forms of amyloid β, prevent Aβ-induced neurotoxicity and inhibit fibril formation

(2008) Pierre Lafaye et al.   MOLECULAR IMMUNOLOGY

Relevance of the Diversity among Members of the Trypanosoma Cruzi Trans-Sialidase Family Analyzed with Camelids Single-Domain Antibodies

(2008) Laura Ratier et al.   PLoS One

Development of ELISAs for the measurement of IgM and IgG subclasses in sera from llamas (Lama glama) and assessment of the humoral immune response against different antigens

(2008) Emilio A. De Simone et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Camelid immunoglobulins and nanobody technology

(2008) S. Muyldermans et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Single-domain antibody fragments with high conformational stability

(2002) Mireille Dumoulin et al.   PROTEIN SCIENCE