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Biology
Nicole Aaron, Michael J. Kraakman, Qiuzhong Zhou, Qiongming Liu, Samantha Costa, Jing Yang, Longhua Liu, Lexiang Yu, Liheng Wang, Ying He, Lihong Fan, Hiroyuki Hirakawa, Lei Ding, James Lo, Weidong Wang, Baohong Zhao, Edward Guo, Lei Sun, Cliff J. Rosen, Li Qiang
Summary: Adipsin is the most upregulated adipokine during MAT expansion in mice and humans in a PPAR gamma acetylation-dependent manner. Genetic ablation of Adipsin in mice specifically inhibited MAT expansion but not peripheral adipose depots, and improved bone mass during calorie restriction, thiazolidinedione treatment, and aging. The effects were mediated through its downstream effector, complement component C3, to prime common progenitor cells toward adipogenesis rather than osteoblastogenesis through inhibiting Wnt/beta-catenin signaling.
Article
Immunology
Min Liu, Xiaolei Luo, Qin Xu, Hongbiao Yu, Linbo Gao, Rong Zhou, Tao Wang
Summary: The study found that levels of adipsin, C5a, and sENG were significantly increased in the plasma of pregnant women with preeclampsia before delivery. In healthy pregnant women, levels of adipsin, C5a, and sENG increased from the third trimester and remained stable postpartum, but C3a levels increased in the second trimester and remained stable afterward.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Longhua Liu, Michelle Chan, Lexiang Yu, Weidong Wang, Li Qiang
Summary: Studies have shown that adipsin deficiency does not impact the development of atherosclerosis in Ldlr(-/-) mice, indicating that it does not play a significant role in mediating the risk of atherosclerotic complications in obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Fernando Corvillo, Laura Gonzalez-Sanchez, Alberto Lopez-Lera, Emilia Arjona, Giovanni Ceccarini, Ferruccio Santini, David Araujo-Vilar, Rebecca J. Brown, Joan Villarroya, Francesc Villarroya, Santiago Rodriguez de Cordoba, Teresa Caballero, Pilar Nozal, Margarita Lopez-Trascasa
Summary: The study found significantly elevated FD levels in BSS patients, with a strong positive correlation between FD and age in BSS. While a positive correlation between FD and C3 was seen in C3G patients, no correlation was detected in BSS. Gene expression studies in BSS adipose tissue showed decreased CFD and C3 levels but elevated C5 transcript levels. This suggests that FD may serve as a reliable diagnostic biomarker for the pathophysiology of BSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
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Veterinary Sciences
Jie Pei, Shoubao Zhao, Mancai Yin, Fude Wu, Jiye Li, Guomo Zhang, Xiaoyun Wu, Pengjia Bao, Lin Xiong, Weiru Song, Yang Ba, Ping Yan, Rende Song, Xian Guo
Summary: In this study, placental protein markers for yak spontaneous miscarriage were identified using proteomic technology and bioinformatics. Abnormalities in biomacromolecule metabolism and oxidative damage were found to be responsible for the high spontaneous miscarriage rate in yak.
BMC VETERINARY RESEARCH
(2022)
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Nutrition & Dietetics
Zunhan Shi, Lihui Wang, Jinwen Luan, Liqin Yin, Xiaohui Ji, Wenqian Zhang, Bingxiang Xu, Linshan Chen, Ying He, Ru Wang, Longhua Liu
Summary: Obesity is a global epidemic associated with various diseases, and exercise has been shown to improve bone density and decrease excess bone marrow adipose tissue. This study investigated the mechanism by which exercise remodels the bone marrow microenvironment in diet-induced obese mice. The data revealed that exercise could slow down obesity progression, improve trabecular bone density, and inhibit the adipsin-Spp1 signaling pathway, thereby preventing the activation of osteoclasts in obese mice.
Editorial Material
Neurosciences
Lisa Johann, Ari Waisman
Summary: The study reveals a novel mechanism by which astrocytes maintain an anti-inflammatory state in the CNS. This mechanism involves IFNg-induced TRAIL expression on astrocytes, leading to effector T cell apoptosis and suppression of inflammation.
Article
Cell & Tissue Engineering
Mou Gao, Qin Dong, Wenjia Wang, Zhijun Yang, Lili Guo, Yingzhou Lu, Boyun Ding, Lihua Chen, Jianning Zhang, Ruxiang Xu
Summary: The study revealed that INSCs receiving CR2-Crry pre-treatment increased the levels of Crry expression in iNSCs and iNSC-derived astrocytes and neurons, attenuating complement-mediated injury following CHI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Manjunath Ramanjaneya, Ilhame Diboun, Najeha Rizwana, Yaser Dajani, Lina Ahmed, Alexandra E. Butler, Thoraya Ali Almarzooqi, Mohammed Shahata, Moza Khalaf Al Bader, Einas Elgassim, Hasan Burjaq, Stephen L. Atkin, Abdul-Badi Abou-Samra, Mohamed A. Elrayess
Summary: The study found that higher adipsin and lower C5a levels in the maternal serum may be potential markers of successful IVF outcomes in obese women.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Xi-Chen Zhu, Lu Liu, Wen-Zhuo Dai, Tao Ma
Summary: CR1 is involved in the phosphorylation of tau protein and its silencing reduces tau phosphorylation and improves cognitive function by regulating neuroinflammation and complement component levels.
NEURAL REGENERATION RESEARCH
(2022)
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Oncology
Ellise M. Johnson, Chandana K. Uppalapati, Agnes S. Pascual, Sarah I. Estrada, Richard L. Averitte, Kathryn J. Leyva, Elizabeth E. Hull
Summary: Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer that may be influenced by immune modulation. Sun exposure has been found to increase the levels of complement factor H (CFH), and CFH levels are higher in cSCC samples compared to normal tissue. Additionally, cSCC is associated with a higher prevalence of regulatory T cells, indicating a potential inhibitory immune response.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Masahiro Nakashima, Manabu Kinoshita, Hiroyuki Nakashima, Azusa Kato, Kazuma Mori, Kazuki Koiwai, Nariyoshi Shinomiya, Shuhji Seki
Summary: Recent studies have shown that mammalian B cells can play a role in acquired immune responses by presenting derivative peptides to CD4(+) T cells without their own somatic hypermutation or isotype switching.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Long Yu, Yang Zhang, Jinfeng Xiong, Jianjun Liu, Ying Zha, Qi Kang, Pan Zhi, Qiang Wang, Hui Wang, Wanjiang Zeng, Yafei Huang
Summary: The frequency and subpopulations of peripheral gamma delta T cells in RSA patients were comparable to healthy subjects, however, RSA pregnant patients had increased expression of PD1 on V delta 2(+) cells. Additionally, RSA-P patients showed significantly higher expression of CD107a and IL-17A-secreting V delta 2(+) cells, indicating increased activation and inflammatory potential of gamma delta T cells in RSA pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Andrea Gottlieb, Inga Flor, Rolf Nimzyk, Lars Burchardt, Burkhard Helmke, Marc Langenbuch, Meike Spiekermann, Susanne Feidicker, Joern Bullerdiek
Summary: The study focuses on the analysis of expression differences of miRNAs from two different gene clusters at different stages of pregnancy, revealing that miRNA-517a-3p and miR-520c-3p increase with gestational age while miR-371-3 shows strong interindividual differences in full-term placental tissue. Individual variations were noted in both placental tissue and serum samples, with differences not related to the site of placental sampling or spontaneous/induced abortion. Differences do not appear to be specifically related to first trimester abortion, and further research is needed to determine their impact on other prenatal processes.
Article
Multidisciplinary Sciences
Mikhael Haruo Fernandes de Lima, Caio Cavalcante Machado, Daniele Carvalho Nascimento, Camila Meirelles S. Silva, Juliana Escher Toller-Kawahisa, Tamara Silva Rodrigues, Flavio Protassio Veras, Marjorie Cornejo Pontelli, Italo A. Castro, Dario Simoes Zamboni, Jose-Carlos A. Filho, Thiago M. Cunha, Eurico Arruda, Larissa Dias da Cunha, Rene D. R. Oliveira, Fernando Q. Cunha, Paulo Louzada-Junior
Summary: Expansion of TIGIT(+)Tregs in COVID-19 patients is associated with inflammation, lung dysfunction, bacteremia, and fatal outcome.
SCIENTIFIC REPORTS
(2023)
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Pediatrics
Tomohiro Kondo, Yoko Kitano-Amahori, Hiroaki Nagai, Masaki Mino, Ai Takeshita, Ken Takeshi Kusakabe, Toshiya Okada
CONGENITAL ANOMALIES
(2015)
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Pediatrics
Tomohiro Kondo, Yoko Kitano-Amahori, Hiroaki Nagai, Masaki Mino, Ai Takeshita, Ken Takeshi Kusakabe, Toshiya Okada
CONGENITAL ANOMALIES
(2015)
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Pediatrics
Ko Yuasa, Tomohiro Kondo, Hiroaki Nagai, Masaki Mino, Ai Takeshita, Toshiya Okada
CONGENITAL ANOMALIES
(2016)
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Biochemistry & Molecular Biology
Tomohiro Kondo, Taketo Nakamori, Hiroaki Nagai, Ai Takeshita, Ken-Takeshi Kusakabe, Toshiya Okada
Article
Pediatrics
Ko Yuasa, Tomohiro Kondo, Hiroaki Nagai, Masaki Mino, Ai Takeshita, Toshiya Okada
CONGENITAL ANOMALIES
(2016)
Article
Biochemistry & Molecular Biology
Hideshi Ihara, Hideyuki Yamamoto, Tomoaki Ida, Hiroyasu Tsutsuki, Tatsuji Sakamoto, Tomoyuki Fujita, Toshiya Okada, Shunji Kzaki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2012)
Article
Pediatrics
Tomohiro Kondo, Naoko Ishiga-Hashimoto, Hiroaki Nagai, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Ken Takeshi Kusakabe, Toshiya Okada
CONGENITAL ANOMALIES
(2014)
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Veterinary Sciences
Tomohiro Kondo, Suguru Yoshida, Hiroaki Nagai, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Takayuki Nakajima, Ken Takeshi Kusakabe, Toshiya Okada
JOURNAL OF VETERINARY SCIENCE
(2018)
Article
Biology
Tomohiro Kondo, Naoko Ishiga-Hashimoto, Hiroaki Nagai, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Ken Takeshi Kusakabe, Toshiya Okada
MEDICAL MOLECULAR MORPHOLOGY
(2011)
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Zoology
Toshiya Okada, Yusuke Kataoka, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Ken Takeshi Kusakabe, Tomohiro Kondo
ZOOLOGICAL SCIENCE
(2013)
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Neurosciences
Paitoon Srimontri, Haruna Hirota, Hiroki Kanno, Toshiya Okada, Yoshio Hirabayashi, Keiko Kato
EXPERIMENTAL BRAIN RESEARCH
(2014)
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Cell Biology
Kazuhiro Nishiyama, Kimiya Aono, Yasuyuki Fujimoto, Mitsuru Kuwamura, Toshiya Okada, Hayato Tokumoto, Takeshi Izawa, Ryoichi Okano, Hidemitsu Nakajima, Tadayoshi Takeuchi, Yasu-Taka Azuma
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
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Veterinary Sciences
Shoji Ogawa, Tamaki Yana, Tomohiro Kondo, Toshiya Okada
Summary: Maternal 5/6 nephrectomy results in low-birth-weight neonates, but catch-up growth leads to increased systolic blood pressure and renin-positive cells in the kidney.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Tomohiro Kondo, Hiroaki Nagai, Takamune Kawashima, Yusuke Taniguchi, Nozomu Koyabu, Ai Takeshita, Ken-Takeshi Kusakabe, Toshiya Okada
COMPARATIVE MEDICINE
(2014)