Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Wuyang Zhang, Zhiwei Dong, Dengke Li, Bei Li, Yuan Liu, Xueni Zheng, Hui Liu, Hongzhi Zhou, Kaijin Hu, Yang Xue
Summary: The study revealed that Ctsk knockout or inhibition could promote alveolar bone regeneration by enhancing JBMMSC regeneration via glycolysis. These findings provide new insights into the regulatory mechanism of CTSK on bone regeneration.
CELL PROLIFERATION
(2021)
Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Liang Chen, Ri-Yan Zhang, Jun Xie, Jia-Yi Yang, Kang-Hao Fang, Chen-Xuan Hong, Rong-Bo Yang, Najeeb Bsoul, Lei Yang
Summary: The study found that catalpol can enhance the osteogenic ability of bone marrow mesenchymal stem cells and promote BMSC-mediated angiogenesis by activating the JAK2/STAT3 signaling pathway. This suggests that catalpol may be an ideal therapeutic agent for the clinical treatment of osteoporotic bone fractures.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xiaodong Zhang, Ligang Liu, Danyang Liu, Yongtao Li, Jun He, Lei Shen
Summary: Estrogen plays an important role in angiogenesis and female physical development. This study investigates the effect of 17β-estradiol on bone marrow mesenchymal stem cell (BMSC) angiogenic differentiation and its underlying molecular mechanism, providing a basis for the treatment of microvascular diseases.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Orthopedics
Xiaoxiong Huang, Weikai Chen, Chao Gu, Hao Liu, Mingzhuang Hou, Wanjin Qin, Xuesong Zhu, Xi Chen, Tao Liu, Huilin Yang, Fan He
Summary: This study investigates the regulatory role of melatonin in the differentiation of bone marrow-derived mesenchymal stem cells (BMMSCs) towards osteoblasts or adipocytes. The results show that melatonin activates the SIRT1 signaling pathway and switches the differentiation of BMMSCs from osteogenesis to adipogenesis, preventing bone loss in postmenopausal osteoporosis.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Cell Biology
Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, Sujin Jung, Soyeong Joung, Jihyun Kim, Jin Woo Lee
Summary: The study revealed that overexpression of USP53 can enhance osteogenic differentiation of hBMSCs by promoting the degradation of β-catenin through interaction with FBXO31, potentially promoting bone regeneration. Therefore, USP53 may be a promising target for gene therapy in bone regeneration.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Cui Zhang, Shali Wu, Erman Chen, Luyang Yu, Jinfu Wang, Mengrui Wu
Summary: This study reveals that the lncRNA AC132217.4 plays a critical role in BMSC osteogenesis, promoting the development and function of osteoblasts. AC132217.4 interacts with IGF2 mRNA to regulate its expression and activate the AKT pathway, thereby controlling osteoblast maturation and function. Additionally, the splicing factors SC35 and HNRNPA1 are involved in the biogenesis of AC132217.4, while the transcription factor ALX1 regulates the expression of AC132217.7 to promote osteogenesis. In vivo over-expression of AC132217.4 significantly promotes bone healing in mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biology
Zhaoyi Mai, Jingpeng Liu, Xiao Jiang, Wenli Gu, Wei Wang, Simin Li, Gerhard Schmalz, Hui Xiao, Jianjiang Zhao
Summary: This study reports for the first time that the lncRNA KCNMA1-AS1 plays a vital role in regulating the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). KCNMA1-AS1 overexpression enhances in vitro osteogenic differentiation and in vivo bone formation, while knockdown of KCNMA1-AS1 has the opposite effect. Furthermore, the interaction between KCNMA1-AS1 and SMAD9 regulates the activation of the SMAD9 signaling pathway.
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Materials Science, Ceramics
Jiebing Zhang, Shuang Tang, Ning Ding, Ping Ma, Zutai Zhang
Summary: Bone defects are a common problem that poses a serious threat to human health worldwide. Photothermal therapy, which induces osteogenic differentiation of bone marrow mesenchymal stem cells through mild heat stress, holds promise for addressing this problem. This study developed a new photothermal therapeutic agent, MXene/nanohydroxyapatite nanocomposite, with improved osteogenic activity and photothermal properties. The nanocomposite demonstrated excellent photothermal properties under 808 nm near-infrared irradiation and promoted cell proliferation and adhesion, making it a suitable candidate for photothermal therapy. Overall, this study presents a novel strategy for the application of photothermal therapy in bone regeneration.
CERAMICS INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Hongwei Wang, Xiaotong Qiao, Chao Zhang, Jingyi Hou, Suqing Qi
Summary: This study aimed to explore the role of lncRNA LINC00616 in the regulation of periodontitis. The results showed that the knockdown of LINC00616 promoted cell viability and suppressed ferroptosis in periodontal ligament stem cells (PDLSCs). Additionally, the miR-370/TFRC axis was found to be involved in the regulation of LINC00616.
Article
Chemistry, Medicinal
Zhikang Su, Ding Chen, Jiangyon Huang, Zitian Liang, Wen Ren, Zeyu Zhang, Qianzhou Jiang, Tao Luo, Lvhua Guo
Summary: This study found that isoliquiritin (ISL) can improve osteoporosis by promoting autophagy and regulating the MAPK signaling pathway. The experimental results showed that ISL has a therapeutic effect in promoting bone formation without inducing toxicity to vital organs.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Yuhang Liu, Xudong Zhang, Xiaodong Chen, Bingjun Zhang, Liming Dai, Chenglong Wang, Yang Li, Xiaoling Zhang
Summary: MicroRNAs are crucial in the chondrogenesis of bone marrow mesenchymal stem cells (MSCs) and regulate joint regeneration in osteoarthritis. This study aimed to determine the role of miR146a in the chondrogenic differentiation of MSCs and its underlying mechanisms. The results showed that miR146a inhibits chondrogenesis in MSCs by directly targeting Lsm11.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cell Biology
Bulin Jiang, Liyuan Huang, Tian Tian, Hongling Wu, Hantao Yao, Tyler Marmo, Fangfang Song, Cui Huang
Summary: In this study, we found that IRX5 plays a crucial role in promoting adipogenesis of human bone marrow-derived mesenchymal stem cells (hMSCs) by transcriptionally regulating PGC-1 alpha and inhibiting glycolysis. This study reveals a potential target to control hMSCs fate decision and bone homeostasis.
CELL DEATH DISCOVERY
(2022)
Article
Rheumatology
Ying He, Lihong Fan, Nicole Aaron, Yiping Feng, Qian Fang, Ying Zhang, Dan Zhang, Hui Wang, Tianyou Ma, Jian Sun, Jinghong Chen
Summary: This study found that oxidative stress induces necrosis of hypertrophic chondrocytes by downregulating Smad2 protein, thereby aggravating the pathogenesis of KBD cartilage. This provides a new potential target for the treatment of KBD.
Article
Pharmacology & Pharmacy
Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Chen
Summary: This study found that TGF-beta RI and TGF-beta RII mediate matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes, leading to decreased cell viability.
Review
Endocrinology & Metabolism
Nicole Aaron, Samantha Costa, Clifford J. Rosen, Li Qiang
Summary: BMAT is now recognized as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis, and metabolism. Age-related inflammatory changes associated with BMAT accrual and the downstream effect on endocrine function, energy expenditure, and metabolism are discussed, with potential therapeutic strategies addressed to prevent dysfunction during aging. Further research is needed to fully understand the explicit characterization of BMAT in aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Liora S. Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B. Honig, Nicolas Gomez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A. Stanley, Dirk Homann, Andrew F. Stewart, James C. Lo, Mark A. Herman, Adolfo Garcia-Ocana, Donald K. Scott
Summary: This study discovered that the hyperactive isoform of Carbohydrate Response-Element Binding Protein (ChREBP beta) is a nuclear effector in beta-cells that responds to hyperglycemic stress caused by prolonged glucose exposure, high-fat diet, and diabetes. The transient positive feedback induction of ChREBP beta is necessary for adaptive beta-cell expansion, while chronic overexpression of ChREBP beta leads to loss of beta-cell identity, apoptosis, and diabetes. Deletion of ChREBP beta can prevent beta-cell glucolipotoxicity.
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Liora S. Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B. Honig, Nicolas Gomez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A. Stanley, Dirk Homann, Andrew F. Stewart, James C. Lo, Mark A. Herman, Adolfo Garcia-Ocana, Donald K. Scott
NATURE COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Domenico Accili, Wen Du, Takumi Kitamoto, Taiyi Kuo, Wendy McKimpson, Yasutaka Miyachi, Maria Mukhanova, Jinsook Son, Liheng Wang, Hitoshi Watanabe
Summary: Research on the etiology and treatment of diabetes has made significant progress. However, the number of patients achieving glycemic control targets has not increased, mainly due to the restoration of insulin sensitivity and the reversal of pancreatic beta cell failure. This review aims to integrate research advances in transcriptional regulation of insulin action and the pathophysiology of beta cell dedifferentiation, exploring the potential impact on prospects of a durable cure for patients suffering from type 2 diabetes.
DIABETOLOGY INTERNATIONAL
(2023)
Article
Hematology
Tarik Zahr, Longhua Liu, Michelle Chan, Qiuzhong Zhou, Bishuang Cai, Ying He, Nicole Aaron, Domenico Accili, Lei Sun, Li Qiang
Summary: This study found that PPARγ deacetylation prevents the development of aging-associated atherosclerosis and hypercholesterolemia. This protective effect may be achieved through suppression of inflammation and promotion of macrophage polarization.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Qianfen Wan, Baoding Huang, Tianyu Li, Yang Xiao, Ying He, Wen Du, Branden Z. Wang, Gregory F. Dakin, Michael Rosenbaum, Marcus D. Goncalves, Shuibing Chen, Kam W. Leong, Li Qiang
Summary: This research develops a nanomedicine based on polycation, which targets visceral fat selectively, preventing obesity and alleviating metabolic dysfunctions. By modulating nutrient-sensing signalling pathways, the polycation uncouples lipid synthesis and storage from adipocyte development, resulting in adipocytes with normal functions but deficient in hypertrophic growth. The study suggests the potential of cationic nanomaterials in treating metabolic diseases.
NATURE NANOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Zunhan Shi, Lihui Wang, Jinwen Luan, Liqin Yin, Xiaohui Ji, Wenqian Zhang, Bingxiang Xu, Linshan Chen, Ying He, Ru Wang, Longhua Liu
Summary: Obesity is a global epidemic associated with various diseases, and exercise has been shown to improve bone density and decrease excess bone marrow adipose tissue. This study investigated the mechanism by which exercise remodels the bone marrow microenvironment in diet-induced obese mice. The data revealed that exercise could slow down obesity progression, improve trabecular bone density, and inhibit the adipsin-Spp1 signaling pathway, thereby preventing the activation of osteoclasts in obese mice.
Article
Chemistry, Multidisciplinary
Ying He, Alana B'nai Taub, Lexiang Yu, Yifan Yao, Ruotong Zhang, Tarik Zahr, Nicole Aaron, Joseph LeSauter, Lihong Fan, Longhua Liu, Ruya Tazebay, Jianwen Que, Utpal Pajvani, Liheng Wang, Rae Silver, Li Qiang
Summary: This study reveals that the acetylation of PPAR gamma in adipose tissue orchestrates metabolic oscillation in daily rhythms. The findings suggest that PPAR gamma acetylation is a crucial link between adipose plasticity and metabolic rhythms, which are two determinants of metabolic health.
Article
Pharmacology & Pharmacy
Ying He, Yawen Shi, Ying Zhang, Ruotong Zhang, Li Cao, Yinan Liu, Tianyou Ma, Jinghong Chen
Summary: The study found that T-2 toxin-induced apoptosis of chondrocytes contributes to growth plate damage through the Smad2 and Smad3 signaling pathway, revealing the pathogenesis of endemic osteoarthritis and providing two potential targets for treatment.
Article
Medicine, Research & Experimental
Wen Du, Junqiang Wang, Taiyi Kuo, Liheng Wang, Wendy M. McKimpson, Jinsook Son, Hitoshi Watanabe, Takumi Kitamoto, Yunkyoung Lee, Remi J. Creusot, Lloyd E. Ratner, Kasi McCune, Ya-Wen Chen, Brendan H. Grubbs, Matthew E. Thornton, Jason Fan, Nishat Sultana, Bryan S. Diaz, Iyshwarya Balasubramanian, Nan Gao, Sandro Belvedere, Domenico Accili
Summary: The study demonstrates the potential of using the intestine as a source for cellular reprogramming to replace lost pancreatic beta cells in diabetes. By ablating FoxO1, the Paneth/goblet cell lineage can be converted into insulin-producing cells. Through a combination treatment targeting FOXO1, Notch, and TGF-beta, near normalization of glucose levels can be achieved in diabetic animals, accompanied by the generation of intestinal insulin-producing cells.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Maria Concepcion Izquierdo, Niroshan Shanmugarajah, Samuel X. Lee, Michael J. Kraakman, Marit Westerterp, Takumi Kitamoto, Michael Harris, Joshua R. Cook, Galina A. Gusarova, Kendra Zhong, Elijah Marbuary, Insug O-Sullivan, Nikolaus Rasmus, Stefania Camastra, Terry G. Unterman, Ele Ferrannini, Barry E. Hurwitz, Rebecca A. Haeusler
Summary: This study found that insulin resistance is associated with decreased HDL-associated S1P. Hepatic FoxO transcription factors are regulators of the ApoM/S1P pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Toxicology
Ying Zhang, Zhengzheng Li, Ying He, Yinan Liu, Ge Mi, Jinghong Chen
Summary: The study investigates the key molecules that regulate T-2 toxin-mediated cartilage degradation and potential treatments for Kashin-Beck disease (KBD). The expression of MMP-13 and TGF-beta RI/II was analyzed in rats treated with T-2 toxin. In chondrocytes, the expression of mRNA for TGF-beta RI/II, MMP-13, and proteins for MMP-13 and Smad-2 were analyzed. The findings suggest that inhibiting the expression of TGF-beta Rs is a potential treatment for KBD.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)