Article
Cell Biology
Shiika Hara, Yoshie Nagai-Yoshioka, Ryota Yamasaki, Yoshiyuki Adachi, Yuko Fujita, Kouji Watanabe, Kenshi Maki, Tatsuji Nishihara, Wataru Ariyoshi
Summary: The study shows that beta-glucan from baker's yeast suppresses RANKL-induced osteoclastogenesis by inhibiting the Dectin-1 receptor and related signaling pathways. This finding suggests a potential new treatment strategy for bone-related diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shoutang Wang, Raki Sudan, Vincent Peng, Yingyue Zhou, Siling Du, Carla M. Yuede, Tingting Lei, Jinchao Hou, Zhangying Cai, Marina Cella, Khai Nguyen, Pietro L. Poliani, Wandy L. Beatty, Yun Chen, Siyan Cao, Kent Lin, Cecilia Rodrigues, Ali H. Ellebedy, Susan Gilfillan, Gordon D. Brown, David M. Holtzman, Simone Brioschi, Marco Colonna
Summary: Genetic studies have shown that microglia play a crucial role in Alzheimer's disease (AD). Microglia that attach to Ab plaques have a transcriptional signature called disease-associated microglia (DAM), which mainly comes from the TREM2-DAP12 receptor complex that signals through the protein tyrosine kinase SYK. The human TREM2R47H variant, associated with a high risk of AD, fails to activate microglia via SYK.
Article
Biochemistry & Molecular Biology
Mingyao Wang, Zhe Zhang, Jiangfeng Liu, Meiyue Song, Tiantian Zhang, Yiling Chen, Huiyuan Hu, Peiran Yang, Bolun Li, Xiaomin Song, Junling Pang, Yanjiang Xing, Zhujie Cao, Wenjun Guo, Hao Yang, Jing Wang, Juntao Yang, Chen Wang
Summary: This study constructed a multi-omics atlas to depict the pivotal abnormalities and biological processes in the progression of silicosis. It identified EGFR and SYK as potential therapeutic targets and demonstrated the effectiveness of Fostamatinib and Gefitinib in inhibiting the progression of silicosis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Zhaozhao Wang, Shu Qu, Jiahao Yuan, Wen Tian, Jinglei Xu, Rui Tao, Shilong Sun, Tao Lu, Weifang Tang, Yong Zhu
Summary: This article reviews the biological function of spleen tyrosine kinase (SYK), its relationship with diseases, and therapies targeting SYK. It also proposes the development of new therapeutic approaches for targeting SYK using new technologies.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Shiju Ye, He Huang, Xue Han, Wu Luo, Lili Wu, Yang Ye, Yingchao Gong, Xia Zhao, Weijian Huang, Yi Wang, Xiaohong Long, Guosheng Fu, Guang Liang
Summary: In this study, the researchers discovered that dectin-1, a pattern recognition receptor, plays a crucial role in cardiac remodeling. They found that Ang II can directly bind to dectin-1, activating downstream signaling pathways and inducing inflammatory responses, leading to heart damage and dysfunction. These findings suggest that dectin-1 may be a potential target for treating hypertension-related heart failure.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Na Yang, Minxiu Wang, Ke Lin, Mengyang Wang, Diyun Xu, Xue Han, Xia Zhao, Yi Wang, Gaojun Wu, Wu Luo, Guang Liang, Peiren Shan
Summary: The study demonstrates that Dectin-1 plays a critical role in the pathogenesis of diabetic cardiomyopathy by regulating inflammation. Dectin-1 deficient mice are protected against diabetes-induced cardiac dysfunction, cardiomyocyte hypertrophy, tissue fibrosis, and inflammation. Dectin-1 may be a potential target for the treatment of diabetic cardiomyopathy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Eszter Kaposztas, Lili Balogh, Attila Mocsai, Eva Kemecsei, Zoltan Jakus, Tamas Nemeth
Summary: Autoimmune arthritis, such as rheumatoid arthritis, affects a significant portion of the population and current therapies often fail to provide complete relief. Research suggests that inhibiting Syk tyrosine kinase can effectively reduce joint inflammation, mainly by targeting neutrophil functions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yaqi Zhou, Yaowen Zhang, Wei Yu, Yufen Qin, Heng He, Fengxian Dai, Yibo Wang, Fengqin Zhu, Guangxi Zhou
Summary: This article reviews the important role of spleen tyrosine kinase (SYK) in chronic inflammatory and autoimmune diseases, and suggests that inhibition of SYK expression or blocking its related pathways may provide new ideas for clinical prevention and treatment of inflammatory or autoimmune diseases.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Pharmacology & Pharmacy
Gang Xie, Wenjie Liu, Zhen Lian, Dantao Xie, Guixin Yuan, Jiajie Ye, Zihong Lin, Weidong Wang, Jican Zeng, Huaxing Shen, Xinjia Wang, Haotian Feng, Wei Cong, Guanfeng Yao
Summary: The study demonstrated the inhibitory effects of the SYK inhibitor PRT on osteoclast and breast cancer functionalities in vitro and in vivo. PRT showed inhibition on osteoclastogenesis, bone resorption, and breast cancer cell growth, migration, and invasion, as well as prevention of bone loss post-OVX and cancer-induced bone destruction.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
J. Willem M. Nissink, Sana Bazzaz, Carolyn Blackett, Matthew A. Clark, Olga Collingwood, Jeremy S. Disch, Diana Gikunju, Kristin Goldberg, John P. Guilinger, Elizabeth Hardaker, Edward J. Hennessy, Rachael Jetson, Anthony D. Keefe, William McCoull, Lindsay McMurray, Allison Olszewski, Ross Overman, Alexander Pflug, Marian Preston, Philip B. Rawlins, Emma Rivers, Marianne Schimpl, Paul Smith, Caroline Truman, Elizabeth Underwood, Juli Warwicker, Jon Winter-Holt, Simon Woodcock, Ying Zhang
Summary: This study conducted an extensive screening for Mer inhibitors through data mining, high-throughput (HT), and DNA-encoded chemical library (DECL) screens, resulting in the identification of many potent, selective, and novel starting points for inhibitor development.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Min-xiu Wang, Wu Luo, Lin Ye, Lei-ming Jin, Bin Yang, Qian-hui Zhang, Jian-chang Qian, Yi Wang, Yi Zhang, Guang Liang
Summary: This study investigates the role of Dectin-1 in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The researchers found that Dectin-1 expression was significantly elevated in liver tissues of patients with NAFLD. They also showed that Dectin-1 plays a deleterious role in NAFLD through enhancing macrophage pro-inflammatory responses.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Oncology
Duen-Yi Huang, Shang-Te Lu, Yuan-Shen Chen, Ching-Yuan Cheng, Wan-Wan Lin
Summary: The study investigated the relationship between Syk gene hypermethylation and DNMT and p53, and found that p53 can upregulate the expression of Syk gene by downregulating DNMT1 at the transcriptional level.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Immunology
Ying Jiang, Yongjing Cheng, Shiliang Ma, Tong Li, Zhe Chen, Xiaoxia Zuo, Xuan Zhang
Summary: This article reviews the pathogenesis and treatment of immune thrombocytopenia (ITP) as a common hematological manifestation of systemic lupus erythematosus (SLE). In addition to traditional treatment methods, the article introduces new therapies and highlights the need for further research to confirm their efficacy.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Tufail Ali, Farah Anjum, Arunabh Choudhury, Alaa Shafie, Amal Adnan Ashour, Abdulraheem Almalki, Taj Mohammad, Md. Imtaiyaz Hassan
Summary: Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that plays a crucial role in signal transduction in different cell types. In this study, two natural compounds, Isolysergic acid and Michelanugine, were identified as potential SYK inhibitors with strong affinity and specificity for the SYK binding pocket. These compounds have the potential to be developed into promising SYK inhibitors for the treatment of autoimmune disorders, cancer, and inflammatory diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Pharmacology & Pharmacy
Qian Liu, Lijuan Hua, Chen Bao, Luxia Kong, Jiannan Hu, Chao Liu, Ziling Li, Shuyun Xu, Xiansheng Liu
Summary: The Syk inhibitor R406 improves sensitivity to dexamethasone by modulating GR, providing a reference for the development of drugs to treat severe steroid-resistant asthma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Chien-Yu Huang, Wei-Chi Chiang, Ya-Chin Yeh, Shih-Chen Fan, Wan-Hsien Yang, Ho-Chang Kuo, Ping-Chia Li
Summary: This study aimed to investigate the effects of immersive virtual reality training on inflammation, oxidative stress, neuroplasticity, and upper limb motor function in stroke patients. The results showed that immersive virtual reality training had positive effects on serum inflammation markers and upper limb motor function, supporting its further application in stroke patients.
Article
Pediatrics
Ho-Chang Kuo, Shih-Feng Liu, Pin-Xing Lin, Kuender D. Yang, Bor-Shyh Lin
Summary: This study monitored the dynamic changes in different stages of Kawasaki disease (KD) using near infrared spectroscopy and found that the concentrations of tissue hemoglobin and water showed significant differences. Water content was significantly associated with the formation of coronary artery lesions (CAL). This non-invasive device can help physicians identify KD from fever illness early.
Article
Pediatrics
Zon-Min Lee, Yao-Hsu Yang, Ling-Sai Chang, Chih-Cheng Chen, Hong-Ren Yu, Kuang-Che Kuo
Summary: This retrospective study analyzed the data of neonates born at Chang Gung Memorial Hospital in Taiwan and found that the use of ibuprofen resulted in an apparent increase in total serum bilirubin (TSB) level in neonates with lower birth weight. For extremely low birth weight neonates experiencing severe unconjugated hyperbilirubinemia, intravenous acetaminophen can be a suitable alternative to ibuprofen for the treatment of patent ductus arteriosus (PDA).
Article
Psychology, Developmental
Liang-Jen Wang, Sung-Chou Li, Yuan-Ming Yeh, Sheng-Yu Lee, Ho-Chang Kuo, Chia-Yu Yang
Summary: This study used high-throughput sequencing to explore the dysbiosis of the gut mycobiome in children with ADHD. The results showed that ADHD patients had abnormal fungal community composition and increased abundance of Candida, especially Candida albicans. The in vitro cell assay also demonstrated that C. albicans secretions enhanced intestinal permeability.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Hong-Tai Tzeng, Wei-Chia Lee, Kay L. H. Wu, Hong-Ren Yu, Julie Y. H. Chan, Chien-Ning Hsu
Summary: Maternal nutrition plays a crucial role in adult disease development. Excessive fructose intake by mothers contributes to hypertension in their offspring. New evidence suggests a connection between early-life gut microbiota and later hypertension. This study aimed to investigate if maternal supplementation of butyrate or propionate can prevent hypertension in offspring exposed to a high-fructose diet.
Article
Microbiology
Hong-Ren Yu, Ching-Chang Tsai, Julie Y. H. Chan, Wei-Chia Lee, Kay L. H. Wu, You-Lin Tain, Te-Yao Hsu, Hsin-Hsin Cheng, Hsin-Chun Huang, Cheng-Hsieh Huang, Wen-Harn Pan, Yao-Tsung Yeh
Summary: This study explored the role of the maternal gut microbiome and associated functional pathways in spontaneous preterm birth (sPTB). It found that overweight mothers had lower microbial diversity in their gut and a higher abundance of Actinomyces spp., which was inversely correlated with gestational age in sPTB. The enrichment of Actinomyces spp. was also associated with dysregulated glycan metabolism in sPTB.
Article
Medicine, General & Internal
Kuo-Shu Tang, Chih-Min Tsai, Ming-Chou Cheng, Ying-Hsien Huang, Chih-Hao Chang, Hong-Ren Yu
Summary: Community-acquired pneumonia (CAP) is common and potentially fatal in children. Salivary analysis shows potential as a noninvasive diagnostic tool. A study identified potential salivary biomarkers using proteomics to differentiate Streptococcus pneumoniae and influenza A pneumonia in pediatric patients, with higher levels of salivary alpha 1-antichymotrypsin in the Streptococcus pneumoniae group.
Article
Pediatrics
Ya-Ling Yang, Jung-Chan Chang, Shu-Chen Ho, Chien-Ning Yeh, Ho-Chang Kuo
Summary: This study examines the correlation between exposure to general anesthesia under three years old and the subsequent course of asthma in children. The study found that the incidence of asthma onset was significantly reduced in children with exposure to general anesthesia under three years old. Furthermore, regardless of the timing of asthma onset, patients with general anesthesia exposure had fewer clinical visits than those without exposure.
Article
Pediatrics
Sheng-Yu Lee, Sung-Chou Li, Chia-Yu Yang, Ho-Chang Kuo, Wen-Jiun Chou, Liang-Jen Wang
Summary: This study investigated the role of gut leakage biomarkers in the susceptibility of ADHD. The results showed that DEFA1 levels were significantly lower in ADHD group compared to the healthy control group. There was no significant difference in serum levels of zonulin and occludin. DEFA1 levels were negatively correlated with inattention scores, while occludin levels were positively correlated with detectability subtest scores. This study provides new insights into the relationship between gut leakage markers and cognition, advancing research on the pathophysiology of ADHD.
Review
Pediatrics
Zon-Min Lee, Ling-Sai Chang, Kuang-Che Kuo, Meng-Chiao Lin, Hong-Ren Yu
Summary: Hyperbilirubinemia is a common condition in neonates with potential neurotoxicity. Although free bilirubin is a more accurate indicator, it is not widely monitored in clinical practice. Total serum bilirubin levels are commonly used to guide phototherapy, but they are not well correlated with neurodevelopmental outcomes.
Article
Pediatrics
Ling-Sai Chang, Ying-Hsien Huang, Hsin-Yu Chang, Zon-Min Lee, Wei-Ling Feng, Ho-Chang Kuo
Summary: This study analyzed the specific IgE levels against food and inhalant allergens in patients with Kawasaki disease (KD). The results suggested a correlation between specific IgE and the age at KD diagnosis and the basophils in KD patients. Further prospective studies are needed to clarify the unique profile of specific IgE in KD patients.
Editorial Material
Pediatrics
Ying-Hsien Huang, Ho-Chang Kuo
Review
Chemistry, Medicinal
Ho-Chang Kuo, Kuang-Den Chen, Ping-Chia Li
Summary: Molecular hydrogen is considered a promising treatment option for stroke management, with its antioxidant, anti-inflammatory, and antiapoptotic functions. It can be administered through inhalation of hydrogen gas, intravenous or intraperitoneal injection of hydrogen-enriched solution, or drinking hydrogen-enriched water.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ho-Chang Kuo
Summary: This review article discusses several important aspects of Kawasaki disease (KD) diagnosis and management. It highlights the limitations of current diagnostic methods based on clinical criteria and suggests the need for updates to account for atypical cases. The review also compares KD with Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 and explores the potential role of new diagnostic methods and treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Lin-Yi Huang, Ting- Lin, Chyi-Her Lin, San-Nan Yang, Wan-Ju Chen, Chien-Yi Wu, Hsien-Kuan Liu, Pei-Ling Wu, Jau-Ling Suen, Jung-Sheng Chen, Yung-Ning Yang
Summary: This study identified key risk factors for moderate-to-severe BPD/death in low-birth-weight infants in Taiwan, including male gender, small for gestational age (SGA), and endotracheal intubation or cardiopulmonary cerebral resuscitation (CPCR) in initial resuscitation.
