Editorial Material
Biology
L. A. Hawkes, A. Fahlman, K. Sato
Summary: Biologging and physiologging technologies play a crucial role in studying and documenting the physiological mechanisms of free-living animals, with recent advancements providing deeper insights into these mechanisms. These technologies are expected to benefit animal welfare, agriculture, and potentially therapeutic interventions in human health by shedding light on extreme physiological performances in the animal kingdom.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Review
Oncology
Simon Deycmar, Bruno Gomes, Jehad Charo, Maurizio Ceppi, J. Mark Cline
Summary: The complexity of cancer immunotherapy (CIT) requires reliable preclinical models. Non-human primates (NHPs) share similarities with humans and have the potential to bridge the gap between preclinical models and human patients. This review presents the current knowledge of NHP immunology, naturally-occurring cancers in NHPs, and TBM trials investigating CIT.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Clinical Neurology
Rani Ashouri, Madison Fangman, Jordan Brielmaier, Zoe A. Fields, Natalie Campo, Sylvain Dore
Summary: Vitamin D deficiency is associated with bone disorders, cardiovascular damage, and an increased risk of ischemic stroke if left untreated. Research suggests that dietary vitamin D may impact the pathology of hemorrhagic stroke through potential mechanisms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Plant Sciences
Richard Philbrook, Marzieh Jafari, Sydney Gerstenberg, Krista L. Say, Jeremy Warren, Andrew Maxwell Phineas Jones
Summary: Polyploidy is a significant evolutionary process in plants and it has been recognized as a key mechanism driving plant diversification and adaptation. This study reveals that polyploidy is a naturally occurring event in cannabis, with natural triploids present at an average frequency of approximately 0.5%. These findings provide valuable insights into the natural variation in ploidy within cannabis populations and contribute to our understanding of cannabis genetics and breeding practices.
Article
Immunology
Elisabeth M. Larson, Susanna Babasyan, Bettina Wagner
Summary: Equine IL-8 is mainly produced by CD14(+)/MHC class II+/CD16(-) monocytes, including a subset of IgE-binding monocytes which have a higher capacity for IL-8 production in allergic horses. These IgE-binding monocytes are likely to contribute to the recruitment of innate immune cells and promotion of inflammation in IgE-mediated allergy.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
A. Riera-Mestre, P. Cerda, A. Iriarte, M. Graupera, F. Vinals
Summary: Translational Medicine plays a crucial role in bridging the gap between basic and clinical research, providing new tools and treatment methods that have important implications for disease management and future developments.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yanbei Tu, Ying Yang, Yanfang Li, Chengwei He
Summary: This comprehensive review summarizes the chemical structures and diverse pharmacological activities of coumestans isolated from various plant sources, providing important information on their medicinal values and potential for the rational design and development of more effective drugs. The focus on the counteraction of coumestans against bone diseases and organ damages, along with the involved molecular mechanisms, offers insights into the therapeutic potential of these compounds.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Veterinary Sciences
Brian C. Gilger
Summary: This article reviews naturally occurring ocular diseases in animals and emphasizes how understanding these diseases contributes to one health initiatives, particularly in the context of common ocular diseases shared by animals and humans.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2022)
Review
Biochemistry & Molecular Biology
Andrila E. Collins, Tarek M. Saleh, Bettina E. Kalisch
Summary: The prevalence of Alzheimer's disease is estimated to double by 2040. Current treatments do not address the underlying causes of the disease, but research suggests that antioxidants may help mitigate oxidative stress. Recent studies have focused on natural antioxidants as potential preventatives and treatments for neurodegenerative conditions associated with oxidative stress.
Review
Geriatrics & Gerontology
Wanbin Huang, Jiabin Zong, Yu Zhang, Yanjie Zhou, Lily Zhang, Yajuan Wang, Zhengming Shan, Qingfang Xie, Ming Li, Songqing Pan, Zheman Xiao
Summary: Research has shown a bidirectional relationship between the circadian rhythm and several neurological diseases. Disruptions in the circadian rhythm caused by these diseases can increase their severity. Hence, optimizing treatments by considering the circadian rhythm, such as adjusting dosing and intervention strategies, holds promise for improving clinical outcomes in neurological diseases.
Article
Multidisciplinary Sciences
Hao Wang, Jonathan L. Robinson, Pinar Kocabas, Johan Gustafsson, Mihail Anton, Pierre-Etienne Cholley, Shan Huang, Johan Gobom, Thomas Svensson, Mattias Uhlen, Henrik Zetterberg, Jens Nielsen
Summary: Genome-scale metabolic models (GEMs) are extensively used for analyzing mechanisms of human diseases and metabolic disorders. A unified platform of GEMs covering five major model animals was presented, providing comprehensive metabolic network coverage and revealing a potential biomarker for early diagnosis of Alzheimer's disease through integrative analysis of RNA-sequencing and proteomics data.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Jens Magnus Bernth Jensen, Anette Tarp Hansen, Anna Soderstorm, Charlotte Svaerke Jorgensen, Carsten Schade Larsen, Uffe B. Skov Sorensen, Steffen Thiel, Mikkel Steen Petersen
Summary: This study aimed to investigate whether the levels of naturally occurring antibodies against alpha Gal can serve as alternative markers of functional antibody capacity. The study included data from 229 patients with suspected primary immunodeficiency in a retrospective study. The results showed a positive correlation between anti-alpha Gal antibody levels and anti-pneumococcal antibody levels, and the former showed potential for predicting subsequent immunoglobulin treatment.
CLINICAL IMMUNOLOGY
(2022)
Article
Instruments & Instrumentation
Jillian Elizabeth Moffatt, Thomas Bede Payten, Georgios Tsiminis, Thomas Jacob de Prinse, Lewis Da Silva Teixeira, Elizaveta Klantsataya, David John Ottaway, Barnaby Whitmore Smith, Nigel Antony Spooner
Summary: The study explores the potential application of upconversion fluorescence in real-time monitoring of fluorite, achieving a certain research progress by reducing false signals to improve detection thresholds. This technology can detect fluorite at rare earth concentrations as low as one part per million, making it a promising new method for real-time detection.
APPLIED SPECTROSCOPY
(2021)
Article
Food Science & Technology
F. Pinero-Garcia, R. Thomas, J. Mantero, E. Forssell-Aronsson, M. Isaksson
Summary: The study found that some brands of bottled water in the Swedish market exceeded the drinking water standard in terms of radioactive isotope content, primarily due to high activity concentrations of 238U, 234U, 210Po, and 210Pb.
Review
Nutrition & Dietetics
Amir Mohammad Malvandi, Sara Shahba, Jalil Mehrzad, Giovanni Lombardi
Summary: Naturally occurring food/feed contaminants have become a significant global issue due to their impact on animal and human health. Despite risk assessments and legislation, lower levels of exposure to mycotoxins can affect cell homeostasis. The inflammatory consequences of everyday exposure to toxins on the vascular microenvironment and arterial dysfunction have not been studied in detail.
FRONTIERS IN NUTRITION
(2022)
