Journal
MATERIALS LETTERS
Volume 152, Issue -, Pages 185-188Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2015.03.120
Keywords
Polymers; Micelles; Superparamagnetic nanoparticles; MRI contrast agent; Tumor imaging
Funding
- National High Technology Research and Development Program of China (863 Program) [2013AA032202]
- National Natural Science Foundation of China [51203118]
- Fundamental Research Funds for the Central Universities
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Superparamagnetic nanoparticles can be used as contrast agents for magnetic resonance imaging (Mm), which improve sensitivity and enhance biological information imaging at tissue, cellular or even molecular levels. In this study, manganese and zinc-doped superparamagnetic ferrite nanoparticles were used to form MRI contrast agent for tumor imaging. Hydrophobic Mn0.6Zn0.4Fe2O4 (MZF) nanocrystals with mean diameter of about 8 nm were synthesized in organic phase and then transferred into water to self-assemble into small clusters inside micelles with the help of biocompatible and amphiphilic star-block copolymers. The MU-loaded micellar nanocomposites are superparamagnetic and could serve as a new T-2 MRI contrast agent in cancer diagnosis. The new MRI contrast agent shows a low cytotoxicity in human hepatoma cell line, HepG2, and a high r(2) relaxivity value. Thus, it could improve sensitivity of tumor imaging and be promising MRI contrast agent for tumor theranostic applications. (C) 2015 Elsevier B.V. All rights reserved.
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