Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation

Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development

(2014) David Newman et al.   Marine Drugs

The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology

(2013) O. D. Abaan et al.   CANCER RESEARCH

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

(2013) Jiancheng Hu et al.   CELL

A Concise Synthesis of (−)-Lasonolide A

(2013) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of Raf Dimerization and Its Inhibition on Normal and Disease-Associated Raf Signaling

(2013) Alyson K. Freeman et al.   MOLECULAR CELL

Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation

(2012) Marcella Salzano et al.   CELL CYCLE

Lasonolide A, a potent and reversible inducer of chromosome condensation

(2012) Yong-Wei Zhang et al.   CELL CYCLE

Stereoselective Synthesis of Both Tetrahydropyran Rings of the Antitumor Macrolide, (−)-Lasonolide A

(2012) Arun K. Ghosh et al.   JOURNAL OF ORGANIC CHEMISTRY

Erratum: Interfacial inhibitors: targeting macromolecular complexes

(2012) Yves Pommier et al.   NATURE REVIEWS DRUG DISCOVERY

Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants

(2011) Ocky K. Radjasa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer

(2011) Marc Schumacher et al.   BIOTECHNOLOGY ADVANCES

A MEK-independent role for CRAF in mitosis and tumor progression

(2011) Ainhoa Mielgo et al.   NATURE MEDICINE

WNK1 is required for mitosis and abscission

(2011) S.-w. Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

50th anniversary of the word “allosteric”

(2011) Jean-Pierre Changeux   PROTEIN SCIENCE

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells

(2010) Q Wu et al.   ONCOGENE

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity

(2009) Théodora Niault et al.   JOURNAL OF CELL BIOLOGY

Early Effects of Lasonolide A on Pancreatic Cancer Cells

(2009) R. A. Isbrucker et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Total Synthesis of Potent Antitumor Agent (−)-Lasonolide A: A Cycloaddition-Based Strategy

(2008) Arun K. Ghosh et al.   Chemistry-An Asian Journal

Characterization of Ser338Phosphorylation for Raf-1 Activation

(2008) Mengwei Zang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Proliferation Gene Discovery Through Functional Genomics

(2008) M. R. Schlabach et al.   SCIENCE