Article
Clinical Neurology
Haipeng Liu, Yu Liu, Bonaventure Y. M. Ip, Sze Ho Ma, Jill Abrigo, Yannie O. Y. Soo, Thomas W. Leung, Xinyi Leng
Summary: The geometry of stent in ICAS might influence focal WSS and LDL filtration rate, while having a negligible effect on pressure. Further studies are needed to confirm the relevance of these hemodynamic parameters in plaque growth and in-stent restenosis in ICAS.
FRONTIERS IN NEUROLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Ali Rostamian, Keivan Fallah, Yasser Rostamiyan, Javad Alinejad
Summary: This paper conducts numerical studies to investigate the hemodynamic effects on the rupture of the middle cerebral artery (MCA) under different working conditions. The findings show that the increase in blood viscosity and velocity leads to higher wall shear stress and increases the risk of aneurysm rupture. The flow pattern inside the aneurysm and the angle of the incoming bloodstream also play important roles in the formation of high-risk regions.
INTERNATIONAL JOURNAL OF MODERN PHYSICS C
(2023)
Article
Chemistry, Multidisciplinary
Bang-Sia Chen, Rong-Ching Wu, Pao-Hsin Liu
Summary: The purpose of this study was to investigate the restenosis effect in patients with coronary bifurcation stenting, and the relationship between the bifurcation angles and three types of stenting techniques. The study used computational fluid dynamics analysis to compare the two types of arterial shapes, and found that the bifurcation angle was directly proportional to the risk of restenosis.
APPLIED SCIENCES-BASEL
(2023)
Article
Biology
Peshala T. Gamage, Pengfei Dong, Juhwan Lee, Yazan Gharaibeh, Vladislav N. Zimin, Luis A. P. Dallan, Hiram G. Bezerra, David L. Wilson, Linxia Gu
Summary: In this study, hemodynamic alterations in heavily calcified coronary arteries following stent deployment and post-dilations were quantified using in silico and ex-vivo approaches. Results showed that post-dilations are necessary for lumen gain and hemodynamic restoration towards hemostasis, mitigating risks associated with in-stent restenosis and stent thrombosis. Additionally, computational fluid dynamics simulations indicated that areas near malapposed stent struts are more prone to in-stent restenosis.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Edward Ferdian, David J. Dubowitz, Charlene A. Mauger, Alan Wang, Alistair A. Young
Summary: Wall shear stress (WSS) is an important factor in vessel wall remodeling and atherosclerosis. The accuracy of WSS estimation from 4D Flow MRI is limited by spatial resolution. To address this, researchers have developed a deep learning algorithm (WSSNet) trained on aortic computational fluid dynamics (CFD) simulations. The results show that WSSNet accurately estimates WSS and performs better than existing methods.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
M. Yousuf Salmasi, Selene Pirola, Sumesh Sasidharan, Serena M. Fisichella, Alberto Redaelli, Omar A. Jarral, Declan P. O'Regan, Aung Ye Oo, James E. Moore, Xiao Yun Xu, Thanos Athanasiou
Summary: The study found that elevated values of WSS in ATAA patients were associated with aortic wall degradation, indicating a potential relationship between WSS and the progression of ATAA disease. Further research may help in identifying threshold values to predict acute aortic events.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sricharan S. S. Veeturi, Tatsat R. R. Patel, Ammad A. A. Baig, Aichi Chien, Andre Monteiro, Muhammad Waqas, Kenneth V. V. Snyder, Adnan H. H. Siddiqui, Vincent M. M. Tutino
Summary: The study shows that there is a correlation between hemodynamic simulation results and the wall type of intracranial aneurysm. High wall shear stress and normalized wall shear stress are associated with thin regions of the aneurysm wall rather than thick and normal regions.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Engineering, Multidisciplinary
Hyunwoo Jung, Taehak Kang, Chul-Hyung Lee, Shin-Young Woo, Shin-Seok Yang, Debanjan Mukherjee, Dong-Ik Kim, Jaiyoung Ryu
Summary: This study investigated the differences in haemodynamic forces between carotid arteries that underwent primary closure or patch angioplasty using computational fluid dynamics. The study found that carotid arteries in the primary closure group were exposed to abnormal haemodynamic forces related to atherosclerosis, while the patch angioplasty group had smaller exposure to abnormal haemodynamic forces.
ENGINEERING APPLICATIONS OF COMPUTATIONAL FLUID MECHANICS
(2022)
Article
Engineering, Mechanical
Marzieh Rezazadeh, Ramin Ostadi
Summary: This study numerically investigates the effect of stenosis on carotid artery bifurcation with elastic and rigid walls. The results show that the maximum wall shear stress in the stenosed artery is three times higher than that of a healthy artery, and the shear stress gradient in elastic arteries is lower than in rigid arteries.
JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Xiao-Yong Shen, M. Barzegar Gerdroodbary, Amin Poozesh, Amir Musa Abazari, S. Misagh Imani
Summary: Cardiovascular disease and stroke have been identified as the leading causes of high death rates in recent decades, with irregular blood flow being a major factor. The study reveals that blood viscosity and velocity have a significant impact on the blood flow inside an aneurysm, with high velocity and viscosity increasing the risk of aneurysm rupture.
INTERNATIONAL JOURNAL OF MODERN PHYSICS C
(2021)
Article
Engineering, Multidisciplinary
Jie-min Zhan, Tian-dong Lu, Zhi-yun Yang, Wen-qing Hu, Wei Su
Summary: This study conducted numerical simulations and experiments on patient-specific normal abdominal aorta and abdominal aortic aneurysm (AAA) models with intraluminal thrombus (ILT), which were reconstructed from CT angiography (CTA) images published online. The distribution of wall shear stress (WSS), oscillatory shear index (OSI), and relative residence time (RRT) were compared between the normal abdominal aorta and AAA under rest and exercise conditions. The results indicated that ILT deposition positions were associated with low WSS, high OSI, and high RRT regions, and the distribution of AAA wall parameters correlated with nearby vortex structures and influenced ILT formation and development. Additionally, high WSS, low OSI, and low RRT regions in the middle and lower aneurysm walls under exercise condition reduced the risk of ILT formation and development.
ENGINEERING APPLICATIONS OF COMPUTATIONAL FLUID MECHANICS
(2022)
Article
Multidisciplinary Sciences
Ioanna Samara, Christos S. Katsouras, Arsen Semertzioglou, Athanassios Vratimos, Amalia I. Moula, Constantinos A. Dimitriou, Michail Theofanis, Triantafyllia Papadimitropoulou, Vasileios Bouratzis, Georgia Karanasiou, Dimitrios Fotiadis, Lampros K. Michalis, Anargyros N. Moulas
Summary: This study evaluated the safety and efficacy of innovative retinoic acid (RA) eluting stents with bioabsorbable polymer. The results showed that RA eluting stents did not lead to thrombus formation and had an acceptable level of stenosis after 4 weeks of implantation. The dose of RA and type of polymer may play a role in the biocompatibility of the stents.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyan Bai, Mingzhu Fu, Zhiye Li, Peiyi Gao, Haiqing Zhao, Rui Li, Binbin Sui
Summary: This study investigates the distribution and regional variation of wall shear stress (WSS) in the curved middle cerebral artery (MCA) using 4D-flow MRI. The results show that there are distribution variations of WSS and oscillatory shear index (OSI) parameters in the curved M1 section of the curved MCA. The inner curvature of the curved M1 section has the lowest WSS and highest OSI distribution, which may be related to the development of atherosclerotic plaque.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Acoustics
Adrian J. Y. Chee, Chung Kit Ho, Billy Y. S. Yiu, Alfred C. H. Yu
Summary: In atherosclerosis, monitoring wall shear stress (WSS) is crucial for plaque diagnostics. This study proposes wall shear imaging (WASHI), a noninvasive framework that uses high-frame-rate ultrasound to map the wall shear rate (WSR). WASHI can track arterial wall motion and provide spatiotemporal dynamics of WSR, facilitating investigations on the relationship between WSS and atherosclerosis.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Engineering, Biomedical
Ryan Pewowaruk, Luke Lamers, Alejandro Roldan-Alzate
Summary: Branch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease. The study found that large-proximal PAs may maintain WSS homeostasis in branch PAS, but WSS of mid-sized PA segments may vary. Results suggest that achieving WSS homeostasis may require long-term remodeling response rather than short-term vasodilation response.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Ingrid S. Lan, Ju Liu, Weiguang Yang, Judith Zimmermann, Daniel B. Ennis, Alison L. Marsden
Summary: This study validates the accuracy and reliability of the cardiovascular FSI formulation in an in vitro flow circuit, which is important for simulating vascular hemodynamics in patients.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Jonathan Pham, Sofia Wyetzner, Martin R. R. Pfaller, David W. W. Parker, Doug L. L. James, Alison L. L. Marsden
Summary: We propose svMorph, a framework for interactive virtual sculpting of patient-specific vascular anatomic models. Our tools allow the creation of tortuosity, aneurysms, and stenoses in tubular vascular geometries via geometric operations on the surface mesh and vessel centerline curves. The tortuosity tool uses the physics-based Oriented Particles method and linear blend skinning for smooth, elastic-like deformations.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Engineering, Biomedical
Victoria Yuan, Francesco De Gaetano, Kasra Osouli, Alison L. Marsden, Maria Laura Costantino
Summary: This study developed a computational model to simulate Norwood patients and evaluate the effects of Berlin Heart support on patient hemodynamics. The results showed that increasing device volume and rate can increase cardiac output, but have minimal impact on arterial oxygen content. Specific BH settings are recommended for patients with pulmonary hypertension and those treated with milrinone post-operatively. The findings emphasize that oxygen delivery does not increase with BH rate or volume and highlight the adaptability of the model to analyze BH support in different clinical situations.
Article
Computer Science, Interdisciplinary Applications
O. Z. Tikenogullari, M. Peirlinck, H. Chubb, A. M. Dubin, E. Kuhl, A. L. Marsden
Summary: Single ventricle patients, including those with hypoplastic left heart syndrome (HLHS), may develop arrhythmias, electrical dyssynchrony, and ventricular failure. The relationship between ventricular enlargement and electrical dysfunction in HLHS physiology is poorly understood. Computational modeling was used to characterize this relationship and found that right ventricle enlargement negatively affects QRS duration and interventricular dyssynchrony, while left ventricle enlargement can partially compensate for this dyssynchrony.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Letter
Public, Environmental & Occupational Health
Alison Marsden
JOURNAL OF PUBLIC HEALTH
(2023)
Letter
Public, Environmental & Occupational Health
Premila Webster, Keith Neal, Alison Marsden
JOURNAL OF PUBLIC HEALTH
(2023)
Letter
Public, Environmental & Occupational Health
Alison Marsden
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Karthik Menon, Jongmin Seo, Ryuji Fukazawa, Shunichi Ogawa, Andrew M. Kahn, Jane C. Burns, Alison L. Marsden
Summary: The current treatment for coronary aneurysms caused by Kawasaki disease is primarily based on the size of the aneurysm, overlooking the hemodynamic factors that affect the risk of myocardial ischemia. Computational hemodynamics simulations were performed for 15 KD patients, and ischemic risk was evaluated using parameters such as fractional flow reserve, wall shear stress, and residence time. The study found that the ratio of maximum-to-minimum aneurysmal lumen diameter predicted ischemic risk better than the aneurysm Z-score.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Engineering, Biomedical
Aaron L. Brown, Fannie M. Gerosa, Jing Wang, Tzun Hsiai, Alison L. Marsden
Summary: Mechanical forces play a crucial role in coordinating cardiac morphogenesis, yet much remains unknown about their interactions with mechano-transduction pathways. Due to the complexity of cardiac mechanobiology, multiple experimental and analytical techniques are required for a complete understanding. This review focuses on computational modeling as a tool to investigate mechanobiological pathways in cardiac development. Recent studies show that understanding spatial and temporal patterns of biomechanical forces is crucial, and computational modeling provides an effective and efficient means to obtain such detail. Multidisciplinary studies combining all three tools yield the most compelling results.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Alexander D. Kaiser, Nicole K. Schiavone, Christopher J. Elkins, Doff B. McElhinney, John K. Eaton, Alison L. Marsden
Summary: The immersed boundary (IB) method is used in this study to simulate fluid-structure interaction (FSI) problems around heart valves. Physical experiments and numerical simulations were conducted, and the results showed excellent qualitative and quantitative agreement between the two, providing comparable experimental data for further validation studies of FSI simulations.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Multidisciplinary
Erica L. Schwarz, Martin R. Pfaller, Jason M. Szafron, Marcos Latorre, Stephanie E. Lindsey, Christopher K. Breuer, Jay D. Humphrey, Alison L. Marsden
Summary: This study implements a comprehensive, three-dimensional constrained mixture theory into a finite element fluid-structure interaction solver for simulating vascular growth and remodeling. The resulting solver allows long-term predictions of changing hemodynamics, vessel wall morphology, tissue composition, and material properties, enhancing the understanding of disease progression in complex environments.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Computer Science, Interdisciplinary Applications
Kathrin Baumler, Evan H. Phillips, Noelia Grande Gutierrez, Dominik Fleischmann, Alison L. Marsden, Craig J. Goergen
Summary: This study investigated the progression of false lumen thrombus over 7 days and found that flow stagnation is the predominant factor driving thrombus formation in the false lumen.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Weiguang Yang, Timothy A. Conover, Richard S. Figliola, Guruprasad A. Giridharan, Alison L. Marsden, Mark D. Rodefeld
Summary: Patients with single ventricle defects undergoing the Fontan procedure often face Fontan failure, and long-term cavopulmonary assist devices using rotary pump technologies are being developed to prevent and treat this failure. This study aims to assess the performance of a viscous impeller pump for Fontan patients and validate flow simulations using in-vitro data. The results show that the pump design provides low resistance and minimal pressure loss in the failed condition, making it clinically acceptable for Fontan patients.
SCIENTIFIC REPORTS
(2023)
Review
Biophysics
Erica L. Schwarz, Luca Pegolotti, Martin R. Pfaller, Alison L. Marsden
Summary: Physics-based computational models of the cardiovascular system have wide-ranging applications in studying cardiovascular diseases, allowing for simulations of hemodynamics, tissue mechanics, and physiology. These models are used not only for surgical planning, but also for understanding disease progression, guiding design, and generating testable hypotheses. Recent advances in modeling methodology have improved the accuracy and impact of simulations, benefiting clinical care and medical device design in congenital and acquired cardiovascular diseases.
BIOPHYSICS REVIEWS
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Kathrin Baumler, Judith Zimmermann, Daniel B. Ennis, Alison L. Marsden, Dominik Fleischmann
Summary: This study investigated the impact of tear size on hemodynamics in a Type B aortic dissection using simulation models. The results showed that alterations in tear size significantly affected flow ratios, pressure differences, and systolic pressure drops. Compared to rigid wall simulations, fluid structure interaction simulations resulted in decreased flow ratios, dampening of flow waveforms, smaller negative pressure differences, and decreased pressure drops at entry and exit tears.
COMPUTER METHODS, IMAGING AND VISUALIZATION IN BIOMECHANICS AND BIOMEDICAL ENGINEERING II
(2023)