Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 57, Issue 10, Pages 2592-2595Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2010.2060337
Keywords
Image classification; image registration; shape analysis and statistics
Categories
Funding
- Michael Smith Foundation for Health Research
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
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We present an automated method for nonrigid registration of the optic nerve head (ONH) surfaces extracted from 3-D optical coherence tomography images to give a one-to-one correspondence between two ONH surfaces. This allows development of population-average ONH surfaces, pooling of morphometric data measured on ONH surfaces from multiple subjects into a single chosen template surface, and statistical analysis (cross sectional, or longitudinal, or both) in a common coordinate system. An application of this coordinate system to construct an average ONH shape across an illustrative dataset is demonstrated, and the impact of template selection is assessed.
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