Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 56, Issue 2, Pages 462-470Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2008.2003262
Keywords
Analog-to-digital converter (ADC); antiCRP; amplitude-shift-keying (ASK) receiver; ASK transmitter; C-reactive protein (CRP); microcantilever; label-free; microcontrol unit (MCU); poly-dimethyl-siloxane (PDMS)
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Funding
- National Science Council of Taiwan [NSC95-2221-E002-364, NSC93-2752-E-002-002-PAE]
- Ministry of Economic Affairs [MOEA 94EC17A05-SI-017]
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A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200-mu m-long micro-electromechanical systems (MEMS) microcantilever housed in a 7 x 7 mm(2) reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRP-antiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 mu m CMOS process. CRP concentrations from 1 mu g/mL to 500 mu g/mL can be detected. A 0.2-Hz I-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability.
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