Review
Pharmacology & Pharmacy
Tao Sheng, Bowen Luo, Wentao Zhang, Xinyang Ge, Jicheng Yu, Yuqi Zhang, Zhen Gu
Summary: The application of microneedles for vaccine delivery has gained widespread interests due to its high compliance, minimal invasiveness, and convenience. Recent advances in the development and application of microneedles for vaccination based on different delivery strategies have been introduced. The prospects for its application including opportunities and challenges are further discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Xue Jiang, Huanhuan Zhao, Wei Li
Summary: This paper discusses the importance of drug-carrying nanoparticles in disease treatments and the advantages of microneedle-mediated delivery of nanoparticles. It provides an overview of several methods for nanoparticle delivery and the potential clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Jin-Oh Jeong, Youn-Mook Lim, Jae Young Lee, Jong-Seok Park
Summary: A smart drug delivery system delivers drugs to specific sites and targets. Microneedle patches are effective in treating pain and preventing skin aging, but have mechanical weaknesses and low drug release efficiency. In this study, conductive stimuli microneedle patches were developed using the gamma-ray crosslinking technique for a smart drug delivery system.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Jitong Wang, Jia Zeng, Zhidan Liu, Qin Zhou, Xin Wang, Fan Zhao, Yu Zhang, Jiamiao Wang, Minchen Liu, Ruofei Du
Summary: Arthritis refers to a group of inflammatory joint diseases that severely limit patients' mobility. Rheumatoid arthritis and osteoarthritis, affecting more than 4% of the global population, are the most common clinical conditions. Conventional medication for arthritis often causes gastrointestinal side effects and inconvenience. In recent years, microneedle technology has provided a new approach for transdermal delivery of arthritis drugs with its painless skin perforation and efficient local delivery advantages. This review summarizes different types of arthritis and current therapeutic agents, highlights the development of microneedles in arthritis drug delivery, and discusses the challenges of translating this technology into clinical practice and the marketplace.
Review
Polymer Science
Sipho Mdanda, Philemon Ubanako, Pierre P. D. Kondiah, Pradeep Kumar, Yahya E. Choonara
Summary: Microneedle technology is a versatile, efficient, and promising drug delivery tool with outstanding characteristics suitable for various biomedical fields. Microneedles can penetrate the skin painlessly, enhance drug delivery efficiency, and are expected to become the preferred route for therapeutic injections in the future.
Article
Polymer Science
Kevin Tobin, Jennifer Fiegel, Nicole K. Brogden
Summary: Transdermal delivery of naltrexone (NTX) can be enhanced by using thermosensitive polymer Poloxamer 407 (P407) gel, which may provide more sustained drug release. Microneedle treatment can enhance NTX permeation, and P407 gels show better permeability and more sustained release compared to aqueous solutions.
Article
Engineering, Biomedical
Jeongyun You, Seorin Juhng, Jieun Song, Jihyun Park, Mingyu Jang, Geonwoo Kang, Huisuk Yang, Hye Su Min, Jiwoo Shin, Seri Lee, Hyuk Wan Ko, Hyungil Jung
Summary: Liraglutide is a promising option for the treatment of type 2 diabetes mellitus (T2DM), as it reduces the risk of hypoglycemia compared to insulin. However, concerns related to injection prevent regular use. Dissolving microneedles (DMNs) are a potential substitute for injection, but have limitations in drug delivery and maintaining drug activity. This study introduces egg microneedles (EMNs) with functional layered structures that successfully deliver liraglutide with maximum drug activity, making it a good alternative to injections in T2DM treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Deepak Kulkarni, Fouad Damiri, Satish Rojekar, Mehrukh Zehravi, Sarker Ramproshad, Dipali Dhoke, Shubham Musale, Ashiya A. Mulani, Pranav Modak, Roshani Paradhi, Jyotsna Vitore, Md Habibur Rahman, Mohammed Berrada, Prabhanjan S. Giram, Simona Cavalu
Summary: Microneedle (MNs) technology is a recent advancement in biomedical science that has gained popularity worldwide due to its multifaceted and broad-spectrum applications in drug delivery. The limitations of conventional drug delivery, such as poor absorption and bioavailability, can be overcome by MN-based drug delivery. Nanotechnology has played a significant role in the fabrication techniques and design of microneedles.
Review
Instruments & Instrumentation
Krishanu Aich, Tanya Singh, Shweta Dang
Summary: Microneedles have been shown to enhance drug delivery and overcome the drawbacks of traditional injections, offering a significant opportunity for better clinical outcomes. Various types of microneedle designs, including solid, coated, hollow, and polymer microneedles, have been developed to improve drug delivery efficiency. Multiple studies are currently focusing on advancing formulation and microfabrication techniques for the delivery of protein drugs via microneedles.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
Jian Chen, Hui Ren, Pan Zhou, Shuai Zheng, Bin Du, Xiaowen Liu, Fei Xiao
Summary: Microneedles have gained significant interest as a transdermal drug delivery route, offering advantages such as nonselective loading capacity, minimal invasiveness, simplicity, and biocompatibility. They can be used to deliver various therapeutics for the treatment of cutaneous diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Suliman Khan, Anwarul Hasan, Farnoosh Attar, Mohammad Mahdi Nejadi Babadaei, Hojjat Alizadeh Zeinabad, Majid Salehi, Morteza Alizadeh, Mahbub Hassan, Hossein Derakhshankhah, Michael R. Hamblin, Qian Bai, Majid Sharifi, Mojtaba Falahati, Timo L. M. ten Hagen
Summary: Microneedle arrays have attracted attention as cancer detection and treatment platforms, delivering active molecules through the skin and improving patient health. They enable controlled release of multiple drugs, optimizing treatment and preventing drug interactions.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Engineering, Biomedical
Dan Yang, Minglong Chen, Ying Sun, Yunpan Jin, Chao Lu, Xin Pan, Guilan Quan, Chuanbin Wu
Summary: This review discusses the emergence of versatile microneedles for transdermal delivery of various drugs, especially focusing on their application in treating different skin diseases such as superficial tumors, scars, psoriasis, herpes, acne, and alopecia. It also summarizes the promises and challenges of widespread translation of microneedles for transdermal drug delivery in dermatology.
ACTA BIOMATERIALIA
(2021)
Article
Biophysics
Xiaoli Guo, Tingting Zhu, Xixi Yu, Xin Yi, Longhao Li, Xiaoying Qu, Zhe Zhang, Yuanping Hao, Wanchun Wang
Summary: Oral inflammatory disease (OID), particularly oral ulcers, is a common oral lesion that affects quality of life and can lead to oral cancer. Traditional treatment methods for oral ulcers, such as localized hormone injections, can cause pain and fear. To address this, a soluble hyaluronic acid (HA) microneedle patch containing betamethasone 21-phosphate sodium (BSP) and betamethasone 17,21-dipropionate (BDP) was developed. The patch showed mechanical strength to penetrate the mucosa and released BSP and BDP into the ulcer base rapidly. It exhibited wound healing-promoting and anti-inflammatory effects, providing a new prospect for oral ulcer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Pharmacology & Pharmacy
Lalitkumar K. Vora, Akmal H. Sabri, Yara Naser, Achmad Himawan, Aaron R. J. Hutton, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Deepakkumar Mishra, Mingshan Li, Aoife M. Rodgers, Alejandro J. Paredes, Eneko Larran, Raghu Raj Singh Thakur, Ryan F. Donnelly
Summary: The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into the dermal and ocular space, but they can also control the release profile of the active compound over a desired period. This review discusses various MN formulations loaded with different therapeutics, the design aspects such as polymer selection and MN geometry, as well as manufacturing and regulatory hurdles that need to be overcome to bring MN technology to the market.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Polymer Science
Qida Zong, Rong Zhou, Zhining Zhao, Yan Wang, Cheng Liu, Peng Zhang
Summary: In this study, a simplified method for the preparation of insulin microneedle patch with rapid and controlled drug release was developed using phenylboronic acid modified methacrylate hyaluronic acid as the drug carrier. This approach offers a direction for simplifying the concept of controlled-release insulin microneedle patch and facilitating production.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Instruments & Instrumentation
Yu Wu, Lalitkumar K. Vora, Ryan F. Donnelly, Thakur Raghu Raj Singh
Summary: In this study, dissolving bilayer microneedles were developed as a safe and effective intraocular protein delivery system for the treatment of retinal vascular disorders.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Kurtis Moffatt, Ismaiel A. Tekko, Lalitkumar Vora, Fabiana Volpe-Zanutto, Aaron R. J. Hutton, Jessica Mistilis, Courtney Jarrahian, Nima Akhavein, Andrew D. Weber, Helen O. McCarthy, Ryan F. Donnelly
Summary: This study evaluates the intradermal delivery of long-acting injectable nanosuspensions of RPV LA and CAB LA using self-disabling dissolving microarray patches. The results show that these patches can maintain therapeutically relevant plasma concentrations for an extended period, making them a potential option to improve adherence in the paediatric population.
PHARMACEUTICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Camila J. Picco, Emilia Utomo, Andrea McClean, Juan Dominguez-Robles, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Peter E. McKenna, Jonathan G. Acheson, Dessislava Malinova, Ryan F. Donnelly, Eneko Larraneta
Summary: Implantable drug-eluting devices have the potential to improve treatment of chronic conditions by providing sustained therapeutic effects and reducing pill burden for patients. The use of modern technologies like 3D printing allows for the production of customizable devices. In this study, subcutaneous implants loaded with olanzapine were formulated using the robocasting technique and demonstrated sustained drug release over a period of 200 days.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Correction
Pharmacology & Pharmacy
Emilia Utomo, Juan Dominguez-Robles, Natalia Moreno-Castellanos, Sarah A. Stewart, Camila J. Picco, Qonita Kurnia Anjani, Jon Ander Simon, Ivan Penuelas, Ryan F. Donnelly, Eneko Larraneta
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Engineering, Biomedical
Achmad Himawan, Lalitkumar K. Vora, Andi Dian Permana, Sumarheni Sudir, Airin R. Nurdin, Ririn Nislawati, Rafikah Hasyim, Christopher J. Scott, Ryan F. Donnelly
Summary: Extracellular tissue fluids contain important biomarkers, but their accessibility has been a challenge in clinical diagnosis and monitoring. Microneedle technology provides a minimally invasive solution to collect tissue fluid samples and utilize them for disease diagnosis and monitoring.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Masoud Adhami, Niamh K. Martin, Ciara Maguire, Aaron J. Courtenay, Ryan F. Donnelly, Juan Dominguez-Robles, Eneko Larraneta
Summary: Cardiovascular diseases are the leading cause of death globally. Drug eluting implants, that provide accurate drug release and minimize adverse side effects, have the potential for significant advancements in the treatment of these diseases.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Chemistry, Multidisciplinary
Li Zhao, Lalitkumar K. Vora, Stephen A. Kelly, Linlin Li, Eneko Larraneta, Helen O. McCarthy, Ryan F. Donnelly
Summary: Antibiotic resistance is a serious health problem and is expected to worsen in the future. Researchers have developed a hydrogel-forming microarray patch system that can deliver antibiotics in a sustained manner.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Ahlam Zaid Alkilani, Hadeel Abo-Zour, Haneen A. Basheer, Hana Abu-Zour, Ryan F. Donnelly
Summary: This study aimed to design and evaluate a dermal delivery system of dual antioxidants, ascorbic acid (AA) and caffeine (CAFF), using microneedles (MNs) loaded with niosomes. The results showed that AA and CAFF exhibited excellent antioxidant properties in the niosomal formulation, protecting skin cells from UV radiation and slowing down the process of photoaging. These findings are important for the development of new skincare products.
Review
Pharmacology & Pharmacy
Katie Glover, Deepakkumar Mishra, Shilpkala Gade, Lalitkumar K. Vora, Yu Wu, Alejandro J. Paredes, Ryan F. Donnelly, Thakur Raghu Raj Singh
Summary: Topical eye drops and intraocular injections are common treatment options in ocular drug delivery, but they have limitations in terms of bioavailability and patient acceptability. Microneedle systems have the potential to overcome these limitations by enabling localized drug delivery and improving drug penetration, thus enhancing therapeutic outcomes.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Lalitkumar K. Vora, Akmal H. Sabri, Yara Naser, Achmad Himawan, Aaron R. J. Hutton, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Deepakkumar Mishra, Mingshan Li, Aoife M. Rodgers, Alejandro J. Paredes, Eneko Larran, Raghu Raj Singh Thakur, Ryan F. Donnelly
Summary: The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into the dermal and ocular space, but they can also control the release profile of the active compound over a desired period. This review discusses various MN formulations loaded with different therapeutics, the design aspects such as polymer selection and MN geometry, as well as manufacturing and regulatory hurdles that need to be overcome to bring MN technology to the market.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Analytical
Ana-Maria Dragan, Marc Parrilla, Sofie Cambre, Juan Dominguez-Robles, Usanee Detamornrat, Ryan F. Donnelly, Radu Oprean, Cecilia Cristea, Karolien De Wael
Summary: Illicit drug consumption is a significant global concern, with MDMA being one of the commonly abused drugs. This study presents the development of a wearable electrochemical platform using a hollow microneedle array sensor for the monitoring of MDMA in interstitial fluid. The sensor exhibited excellent analytical performance, making it a promising tool for forensic toxicology and therapeutic management of patients.
MICROCHEMICAL JOURNAL
(2023)
Article
Instruments & Instrumentation
Ryan F. Donnelly, Mark R. Prausnitz
Summary: Microneedle (MN) technologies offer the opportunity to improve drug delivery and treatment by targeting specific tissues. Hollow MNs have been FDA-approved for targeted drug delivery to skin-resident immune cells and specific parts of the eye. MN technology also has applications in cosmetic products. With further research and approved products, MN technology shows promising growth potential.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Juan Dominguez-Robles, Elias Cuartas-Gomez, Sean Dynes, Emilia Utomo, Qonita Kurnia Anjani, Usanee Detamornrat, Ryan F. Donnelly, Natalia Moreno-Castellanos, Eneko Larraneta
Summary: Curcumin and lignin were combined with poly(caprolactone) to create 3D-printed wound dressings with antioxidant and antimicrobial properties. The dressings showed sustained release of DPA and CUR and demonstrated significant improvements in wound healing in animal studies. Histological examination also showed positive outcomes in terms of epithelization, inflammatory reaction, fibroblast proliferation, and neoangiogenesis.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Article
Pharmacology & Pharmacy
Emilia Utomo, Juan Dominguez-Robles, Qonita Kurnia Anjani, Camila J. Picco, Anna Korelidou, Erin Magee, Ryan F. Donnelly, Eneko Larraneta
Summary: Bacterial vaginosis (BV) is an abnormal condition caused by changes in the vaginal microbiota. Current treatment involves the use of antibiotics, but frequent application is needed. This research proposes a prolonged release of metronidazole (MTZ) using biodegradable and biocompatible polymers in the form of intravaginal devices, which can reduce the frequency of administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Instruments & Instrumentation
Masoud Adhami, Camila J. Picco, Usanee Detamornrat, Qonita K. Anjani, Victoria A. Cornelius, Pamela Robles-Martinez, Andriana Margariti, Ryan F. Donnelly, Juan Dominguez-Robles, Eneko Larraneta
Summary: Cardiovascular diseases are a leading cause of death worldwide and significantly impact quality of life. 3D-printed biodegradable vascular grafts loaded with a drug called clopidogrel were developed using digital light processing technology. These grafts provide sustained drug release, reduce platelet deposition, and create a supportive environment for cellular attachment, viability, and growth.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)