Article
Materials Science, Multidisciplinary
Shahryar Hosseini, Niloofar Eslahi, Reza Jahanmardi
Summary: The aim of this research was to prepare self-healing injectable nanocomposite hydrogels based on benzaldehyde-modified polyethylene glycol and chitosan, reinforced with graphene oxide (GO), for the delivery of pomegranate extract (PG) in hard tissue engineering. The incorporation of GO into the hydrogels improved the pore structure, elastic properties, compressive strength, and antibacterial properties. The designed system shows promising potential as a delivery platform for pharmaceuticals in hard tissue engineering.
MATERIALS TODAY COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Zhenyu Zhao, Zhen Wang, Gen Li, Zhengwei Cai, Jiezhou Wu, Lei Wang, Lianfu Deng, Ming Cai, Wenguo Cui
Summary: Microfluidic hydrogel microspheres have been widely studied and used in various industries, with a focus on their applications in the medical field for controlled delivery of cells and drugs. These materials enable efficient encapsulation and control of functionalities, promoting collaboration across disciplines and advancing precision medicine and applied materials.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Medicinal
Michael Flanagan, Qi Gan, Saahil Sheth, Rachel Schafer, Samuel Ruesing, Linda E. Winter, Karoly Toth, Silviya P. Zustiak, Adriana M. Montano
Summary: Morquio A disease is a genetic disorder caused by GALNS deficiency, and patients are treated with enzyme replacement therapy. This study explored PEG hydrogels as a drug delivery system for sustained release of rhGALNS. The optimized hydrogel formulation achieved sustained release of active rhGALNS for up to 28 days in vitro and up to 20 days in vivo, suggesting that PEG hydrogels could be a promising method for improving patient quality of life.
Article
Polymer Science
Andy Chai, Keagan Schmidt, Gregory Brewster, Lu Shi Peng Xiong, Benjamin Church, Timothy Wahl, Hamed Sadabadi, Subha Kumpaty, Wujie Zhang
Summary: This study aimed to develop a pectin-based microsphere system for encapsulating pulmonary drugs and facilitating their delivery to the deep lungs. Pectin-based hydrogel microspheres were produced using electrospray, and the stability and responsiveness of the microspheres were altered through coatings. The microsphere system exhibited high responsiveness and stability in simulated lung fluid.
Article
Chemistry, Multidisciplinary
Jiawei Lin, Liang Chen, Jielai Yang, Xingchen Li, Juan Wang, Yuan Zhu, Xiangyang Xu, Wenguo Cui
Summary: This study presents a functional hydrogel microsphere designed for efficient drug delivery to joints. The microspheres exhibit targeting properties, cartilage penetration, and cellular phagocytosis, addressing the challenges of drug delivery in damaged tissues. The microspheres can be adsorbed onto the cartilage surface and release drugs over an extended period of time, effectively improving drug delivery efficiency and delaying the development of osteoarthritis.
Article
Biochemistry & Molecular Biology
Lidia Gomez-Cid, Maria Luisa Lopez-Donaire, Diego Velasco, Victor Marin, Maria Isabel Gonzalez, Beatriz Salinas, Lorena Cusso, Angel Garcia, Susana Belen Bravo, Maria Eugenia Fernandez-Santos, Carlos Elvira, Johanna Sierra, Ester Arroba, Rafael Banares, Lilian Grigorian-Shamagian, Francisco Fernandez-Aviles
Summary: Stem cell-derived extracellular vesicles (EVs) show beneficial effects in preclinical models of cardiac diseases, but their poor retention at the target site limits their efficacy. A new product combining cardiac extracellular matrix hydrogels (cECMH), polyethylene glycol (PEG), and EVs (EVs-PEG-cECMH) was developed to overcome this limitation. The combined product demonstrated improved physicochemical properties, increased on-site retention, and maintained bioactivity, potentially leading to enhanced therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Young Hwa Lee, Hae In Park, Woo-Suk Chang, Joon Sig Choi
Summary: A vector for mitochondria-targeted drug delivery was developed by synthesizing TPP-modified glycol chitosan polymeric microspheres. The microspheres possess the potential to effectively deliver drugs to mitochondria. Various analysis and experiments confirmed their efficacy as drug delivery carriers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Jiaqi Li, Huangliang Zheng, En-Yu Xu, Michael Moehwald, Linc Chen, Xin Zhang, Shirui Mao
Summary: Polyethylene glycol (PEG) modification is a promising approach to overcome barriers in the deep lung for sustained therapy of pulmonary diseases. PEG-modified microspheres showed enhanced mucus permeability and reduced macrophage uptake, especially the PEG(2000)-DSPE/PLGA 1:1 group. The PEG 2000-based group had significantly prolonged lung retention in vivo and reduced systemic exposure of drugs compared to other groups, making it a promising candidate for sustained lung delivery in pulmonary disease treatment.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Analytical
Yizhao Jian, Shuibo Xie, Yi Duan, Guohua Wang, Chenxu Wang, Yu Guo
Summary: Porous polyvinyl alcohol/carboxylated carbon nanotubes/sodium alginate (PPCS) hydrogel microspheres were prepared using the physical cross-linking method for efficient removal of U(VI) from aqueous solutions. SEM and BET confirmed the successful formation of highly porous PPCS hydrogel microspheres. Moreover, PPCS hydrogel microspheres were easier to recover from aqueous solutions compared to carbon nanotubes. The chelation of hydroxyl and carboxyl groups was identified as the main mechanism for U(VI) removal by PPCS. PPCS may serve as a promising and recyclable adsorbent for uranium extraction.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Chemistry, Applied
Vahid Zeyni, Soheyla Karimi, Hassan Namazi
Summary: In this study, a zinc-based metal-organic framework/magnetic hydroxyapatite nanocomposite was synthesized and coated with a biocompatible layer of polyethylene glycol as a targeting drug delivery system. The nanocomposites were characterized and utilized as carriers to encapsulate the anticancer drug doxorubicin. Both nanocomposites showed pH-dependent drug release and the Korsmeyer-Peppas model was the best fit to describe the release mechanism. The synthesized systems showed no significant toxicity and exhibited higher toxicity against lung cancer cell lines. Additionally, the nanocomposites demonstrated excellent antioxidant activity. These findings suggest that the prepared drug systems have potential for targeted drug delivery applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Materials Science, Ceramics
Mohammad Poorhossein, Fatemehsadat Pishbin, Abolghasem Ataie, Mohammad Akrami
Summary: Magnetic nanoparticles can improve the delivery of anticancer drugs to tumor sites while reducing side effects. This research examined the effects of polyethylene glycol (PEG) on the structure, size, morphology, magnetic properties, and coating of cobalt ferrite nanoparticles (CFO). The results showed that higher molecular weight PEG created a thicker coating on the nanoparticles, resulting in higher drug loading efficiency.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Lingbin Ou, Qiongyu Zhang, Yong Chang, Ning Xia
Summary: A targeted drug delivery system using nanosized hydroxyapatite particles (nHA) as cores and methotrexate (MTX) conjugated to polyethylene glycol (PEG) was developed. The system exhibited pH-dependent release feature and could increase the concentration of calcium ions, inducing mitochondrial apoptosis and improving the efficacy of medical treatment. In vitro studies demonstrated that the system had higher therapeutic efficacy on osteosarcoma cells (143B, MG63, and HOS), suggesting its great potential for osteosarcoma therapy.
Article
Polymer Science
Zijia Wang, Xinyue Zhai, Ming Fan, Huaping Tan, Yong Chen
Summary: In this study, magnetic microspheres based on chitosan derivatives were developed and a thermal-reversible, self-healing hydrogel was prepared by incorporating these microspheres. The hybrid scaffolds synthesized with the magnetic microspheres showed controllable shape and mobility under magnetic force. The scaffolds exhibited good morphology, dispersity, and stability in physical environment.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Engineering, Biomedical
Ying Han, Jielai Yang, Weiwei Zhao, Haimang Wang, Yulong Sun, Yuji Chen, Jing Luo, Lianfu Deng, Xiangyang Xu, Wenguo Cui, Hongyu Zhang
Summary: In this study, injectable hydrogel microspheres with enhanced lubrication and controllable drug release for OA treatment were developed by bioinspired by the super-lubrication property of cartilage and catecholamine chemistry of mussel. The tribological test and drug release test showed the enhanced lubrication and sustained drug release of the microspheres. Intra-articular injection of the functionalized microspheres into rat knee joint with an OA model provided significant therapeutic effect against the development of OA.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Zhishu Bao, Ailing Yu, Hui Shi, Yuhan Hu, Bo Jin, Dan Lin, Mali Dai, Lei Lei, Xingyi Li, Yuqin Wang
Summary: In this study, a glycol chitosan/oxidized hyaluronic acid hydrogel film for dual ophthalmic drug delivery was fabricated successfully. The hydrogel films exhibited a stepwise release of levofloxacin and dexamethasone, demonstrating potent antibacterial and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biotechnology & Applied Microbiology
Parin U. Kadakia, Emily A. Growney Kalaf, Andrew J. Dunn, Laurie P. Shornick, Scott A. Sell
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2018)
Article
Engineering, Biomedical
Emily A. Growney Kalaf, Meghana Pendyala, J. Gary Bledsoe, Scott A. Sell
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2017)
Meeting Abstract
Endocrinology & Metabolism
Era Jain, Saahil Sheth, Shiragi Patel, Michael Flanagan, Qi Gan, Scott A. Sell, Adriana M. Montano, Silviya P. Zustiak
MOLECULAR GENETICS AND METABOLISM
(2017)
Article
Biotechnology & Applied Microbiology
Katherine R. Hixon, Tracy Lu, Sarah H. McBride-Gagyi, Blythe E. Janowiak, Scott A. Sell
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Biochemical Research Methods
Chengpeng Chen, Alexandra D. Townsend, Elizabeth A. Hayter, Hannah M. Birk, Scott A. Sell, R. Scott Martin
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2018)
Article
Biophysics
Jacob M. Laktas, Emily A. Growney Kalaf, Scott A. Sell, Mark W. Mcquilling
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2018)
Article
Optics
Steven H. Huang, Saahil Sheth, Era Jain, Xuefeng Jiang, Silviya P. Zustiak, Lan Yang
Article
Engineering, Biomedical
Gabriel J. Haas, Andrew J. Dunn, Madison Marcinczyk, Muhamed Talovic, Mark Schwartz, Robert Scheidt, Anjali D. Patel, Katherine R. Hixon, Hady Elmashhady, Sarah H. McBride-Gagyi, Scott A. Sell, Koyal Garg
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Article
Engineering, Biomedical
Krishna H. Patel, Andrew J. Dunn, Muhamed Talovic, Gabriel J. Haas, Madison Marcinczyk, Hady Elmashhady, Emily Growney Kalaf, Scott A. Sell, Koyal Garg
BIOMEDICAL MATERIALS
(2019)
Article
Engineering, Biomedical
Genevieve Hilliard, Cory E. DeClue, Benjamin A. Minden-Birkenmaier, Andrew J. Dunn, Scott A. Sell, Laurie P. Shornick
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Article
Orthopedics
Era Jain, Nobuaki Chinzei, Alexandra Blanco, Natasha Case, Linda J. Sandell, Scott Sell, Muhammad Farooq Rai, Silviya P. Zustiak
JOURNAL OF ORTHOPAEDIC RESEARCH
(2019)
Article
Materials Science, Biomaterials
Mohammad Mehdi Kalani, Jhamak Nourmohammadi, Babak Negandari, Abdolrasol Rahimi, Scott A. Sell
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Instruments & Instrumentation
Era Jain, Michael Flanagan, Saahil Sheth, Shiragi Patel, Qi Gan, Birju Patel, Adriana M. Montano, Silviya P. Zustiak
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Paul Nana Kwame Sagoe, Eduardo Jose Machado Velazquez, Yohely Maria Espiritusanto, Amelia Gilbert, Thalma Orado, Qiu Wang, Era Jain
Summary: In this study, we developed a novel method for synthesizing tunable-sized microparticles with improved monodispersity and batch-to-batch reproducibility. We evaluated the effect of various process parameters on particle size, distribution, and morphology. By adjusting key parameters, we achieved microparticles of comparable sizes across different formulations. The study also demonstrated the influence of polymer concentration, stirring rate, and surfactant concentration on microparticle characteristics.
Editorial Material
Chemistry, Medicinal
Silviya Petrova Zustiak, Era Jain
