Article
Respiratory System
Michael G. Crooks, Albertus C. den Brinker, Susannah Thackray-Nocera, Ralph van Dinther, Caroline E. Wright, Alyn H. Morice
Summary: This study compared the effectiveness of cough monitoring and questionnaire surveys in identifying prodromal symptoms of AE-COPD, with results showing that the alert system based on cough monitoring is more effective in predicting AE-COPD in advance, while the utility of questionnaire-based symptom monitoring is limited by frequent false alerts.
Review
Medicine, General & Internal
Jing-wen Lu, Yu Wang, Yue Sun, Qin Zhang, Li-ming Yan, Ying-xi Wang, Jing-han Gao, Yan Yin, Qiu-yue Wang, Xue-lian Li, Gang Hou
Summary: This study found that telemonitoring can reduce emergency room visits, exacerbation-related readmissions, exacerbation-related hospital days, mortality, and improve quality of life for COPD patients. Longer telemonitoring periods may be more effective in reducing readmissions.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Yun Su Sim, Jin Hwa Lee, Eung Gu Lee, Joon Young Choi, Chang-Hoon Lee, Tai Joon An, Yeonhee Park, Young Soon Yoon, Joo Hun Park, Kwang Ha Yoo
Summary: We evaluated the association between COPD medications used in the 6 months before acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the pathogens identified during AE-COPD. Medical records of 1177 patients diagnosed with AE-COPD were analyzed retrospectively. The use of inhaled corticosteroid (ICS) and systemic steroid was analyzed in relation to the microorganisms identified during AE-COPD. Bacteria were more frequently identified in patients using ICS and systemic steroids, and the risk of Pseudomonas aeruginosa infection increased in patients who used systemic steroids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
A. C. den Brinker, R. van Dinther, M. G. Crooks, S. Thackray-Nocera, A. H. Morice
Summary: An observational study was conducted in the homes of 30 patients with Chronic Obstructive Pulmonary Disease (COPD) using an unobtrusive cough count monitor for long-term monitoring. The study illustrated patient-specific cough count parameters obtained through a personalized cough classifier, as well as introduced a novel cough count scale for constructing an alert mechanism to detect worsening respiratory conditions. Additionally, the paper outlined various specific patterns identified in the clinical study and highlighted the basic components in the design of an alert system compatible with the experimental findings.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Respiratory System
Peter S. P. Cho, Hannah Fletcher, Irem S. Patel, Richard D. Turner, Caroline J. Jolley, Surinder S. Birring
Summary: Patients with COPD-chronic cough and CRC both exhibited heightened cough reflex sensitivity, but only those with CRC were unable to suppress capsaicin-evoked cough. This indicates differing mechanisms of cough between patients with COPD and CRC, highlighting the need for disease-specific approaches to management.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Health Care Sciences & Services
Linzy Houchen-Wolloff, Mark Orme, Amy Barradell, Lisa Clinch, Emma Chaplin, Nikki Gardiner, Sally J. Singh
Summary: This study aimed to assess the feasibility and acceptability of a web-based self-management program for patients with AECOPD. Results showed that only 18% of the 100 participants completed the web program within 6 months. The main challenge identified was the lack of web literacy among patients.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Multidisciplinary Sciences
Ewert Ralf, Alexander Heine, Anne Obst, Karoline Koerner, Veit Hustig-Kittler, Michael Boesche, Mohamed Elhadad, Beate Stubbe, Michael Westhoff
Summary: The establishment of guidelines for long-term noninvasive ventilation treatment in acute hypercapnic exacerbations of chronic obstructive pulmonary disease (AECOPD) has been elusive. Most studies have shown no mortality benefit of this treatment. However, our retrospective analysis of patient data from 2012 to 2019 demonstrated higher survival rates in the group receiving long-term noninvasive ventilation compared to those who didn't. This study provides evidence of the mortality benefit of long-term NIV therapy for AECOPD patients in real-world conditions.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Rod Hughes, Eleni Rapsomaniki, Christer Janson, Christina Keen, Barry J. Make, Pierre-Regis Burgel, Erin L. Tomaszewski, Hana Mullerova, Helen K. Reddel
Summary: Frequent productive cough is a common clinical trait in patients with chronic obstructive pulmonary disease (COPD), and it is associated with severity, smoking, and exposure to pollutants. It is also related to adverse clinical outcomes and exacerbations.
RESPIRATORY MEDICINE
(2022)
Article
Biology
Thomas Kronborg, Stine Hangaard, Simon L. Cichosz, Ole Hejlesen
Summary: This study demonstrates that a two-layer probabilistic model can improve classification rates for predicting COPD exacerbations compared to a one-layer model. The comparison across nine different classification algorithms showed a significant increase in the area under the receiver operating characteristics curve and sensitivity at a specificity of 0.95.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Esha Singla, Gayatri Puri, Vivek Dharwal, Amarjit S. Naura
Summary: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease that can be effectively modulated by timely administration of Gallic acid (GA), which can reduce inflammation and restore redox balance in the lungs, thereby alleviating exacerbation manifestations of COPD.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Respiratory System
Chi-Tai Lee, Ping-Huai Wang
Summary: The study found that low handgrip strength in patients with COPD upon admission to the hospital is associated with an increased risk of exacerbation after discharge.
BMC PULMONARY MEDICINE
(2021)
Review
Medicine, General & Internal
Irene Prediletto, Gilda Giancotti, Stefano Nava
Summary: Chronic obstructive pulmonary disease (COPD) is a major global cause of morbidity and mortality. Acute exacerbations of COPD (AECOPD) leading to hospitalization are a significant health issue with implications for disease outcomes and healthcare resources. Severe AECOPD can result in acute respiratory failure (ARF) requiring admission to the intensive care unit (ICU) for invasive mechanical ventilation. AECOPD also poses comorbidity risks in critically ill patients, which are associated with poorer prognoses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Jessica A. Walsh, Ruth E. Barker, Samantha S. C. Kon, Sarah E. Jones, Winston Banya, Claire M. Nolan, Suhani Patel, Oliver Polgar, Brigitte M. Haselden, Michael I. Polkey, Paul Cullinan, William D-C. Man
Summary: The 4-m gait speed (4MGS) test is a simple and effective tool to predict prognosis in patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (AECOPD), with higher predictive value for all-cause readmission and mortality compared to traditional factors such as age and FEV1. Identifying at-risk patients with COPD using 4MGS at hospital discharge can help in planning post-discharge care and support.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Critical Care Medicine
Kasper M. Sorensen, Rebecca Leicht, Christian J. Carlsson, Mikkel Elvekjaer, Celeste Porsbjerg, Eske K. Aasvang, Christian S. Meyhoff
Summary: Transcutaneous measurements of CO2 and O2 did not accurately reflect arterial blood gas analysis results in COPD patients, but the agreement in changes of CO2 during monitoring was acceptable.
Article
Computer Science, Interdisciplinary Applications
Sezer Ulukaya, Ahmet Alp Sarica, Oguzhan Erdem, Ali Karaali
Summary: The coronavirus has had a significant impact on millions of lives, making it one of the important pandemics that continue to affect people with its variants. Due to its respiratory transmission, it has greatly affected public health and social relations. Isolating COVID-positive individuals can minimize transmission, leading to the proposal of various virus detection methods such as RT-PCR, chest X-Ray, and CT. However, these methods have limitations in detection rate, radiation dosage, and cost.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Review
Public, Environmental & Occupational Health
Judith Dyson, Malvika Bhatnagar, James Skinner, Michael Crooks
Summary: This study aims to investigate the barriers and facilitators to e-cigarette cessation and the support needed. Through systematic searches and paper selection, it was found that barriers to e-cigarette cessation include fear of returning to tobacco, dependency, and stress reduction. Additionally, health and hazard beliefs, degree of enjoyment, social influences, and environmental factors are identified as barriers or facilitators. Several support measures for e-cigarette cessation were suggested. Therefore, addressing these specific barriers to e-cigarette cessation should be considered in intervention design.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Medicine, General & Internal
Gavin D. Perkins, Chen Ji, Bronwen A. Connolly, Keith Couper, Ranjit Lall, J. Kenneth Baillie, Judy M. Bradley, Paul Dark, Chirag Dave, Anthony De Soyza, Anna Dennis, Anne Devrell, Sara Fairbairn, Hakim Ghani, Ellen A. Gorman, Christopher A. Green, Nicholas Hart, Siew Wan Hee, Zoe Kimbley, Shyam Madathil, Nicola McGowan, Benjamin Messer, Jay Naisbitt, Chloe Norman, Dhruv Parekh, Emma M. Parkin, Jaimin Patel, Scott E. Regan, Clare Ross, Anthony J. Rostron, Mohammad Saim, Anita K. Simonds, Emma Skilton, Nigel Stallard, Michael Steiner, Rama Vancheeswaran, Joyce Yeung, Daniel F. McAuley
Summary: Among patients with acute hypoxemic respiratory failure due to COVID-19, an initial strategy of CPAP significantly reduced the risk of tracheal intubation or mortality compared with conventional oxygen therapy, but there was no significant difference between an initial strategy of HFNO compared with conventional oxygen therapy. The study may have been underpowered for the comparison of HFNO vs conventional oxygen therapy, and early study termination and crossover among the groups should be considered when interpreting the findings.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Respiratory System
Lucia Crowther, Mark Pearson, Helena Cummings, Michael George Crooks
Summary: This article describes an experience-based codesign process for developing an implementation-ready intervention to reduce the overuse of short-acting beta agonist (SABA) and optimize asthma treatment.
BMJ OPEN RESPIRATORY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Alex Wilkinson, Ekaterina Maslova, Christer Janson, Yang Xu, John Haughney, Jennifer K. Quint, Nigel Budgen, Andrew Menzies-Gow, John Bell, Michael G. Crooks
Summary: The CARBON program aims to assess the carbon footprint of respiratory care and identify strategies for reducing greenhouse gas emissions. It will quantify the carbon footprint of medications and healthcare resource utilization and explore the impact of different treatment approaches on greenhouse gas emissions in patients with respiratory diseases.
ADVANCES IN THERAPY
(2022)
Editorial Material
Critical Care Medicine
Alyn H. Morice
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Christian Friedrich, Klaus Francke, Isabella Gashaw, Christian Scheerans, Stefan Klein, Lueder Fels, Jaclyn A. Smith, Thomas Hummel, Alyn Morice
Summary: This study investigated the safety and tolerability of repeated ascending oral doses of eliapixant in healthy volunteers. The results showed that eliapixant at doses of 200 mg and 750 mg achieved plasma concentrations that cover the predicted therapeutic threshold and demonstrated good safety and tolerability. These findings suggest that eliapixant has potential for use in clinical trials for refractory chronic cough.
CLINICAL PHARMACOKINETICS
(2022)
Article
Biochemistry & Molecular Biology
Farhad Jahanfar, Laura Sadofsky, Alyn Morice, Massimo D'Amico
Summary: TRPM8 is an important ion channel involved in various diseases. This study identified two potential TRPM8 inhibitors through high-throughput screening, providing candidate drugs for further development.
Letter
Critical Care Medicine
Surinder S. Birring, Peter V. Dicpinigaitis, Jaclyn A. Smith, Alyn H. Morice, Lorcan P. McGarvey, Ian D. Pavord, Allison Martin Nguyen, Jonathan Schelfhout, Qing Li, Beata Iskold, Stuart A. Green, George Philip, David R. Muccino, Carmen La Rosa
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Surinder S. Birring, Alyn H. Morice, Peter V. Dicpinigaitis, Lorcan P. McGarvey, Ian D. Pavord, Stuart A. Green, George Philip, Jaclyn A. Smith
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Respiratory System
Kayleigh Brindle, Alyn Morice, Natalie Carter, Dominic Sykes, Mengru Zhang, Andrea Hilton
Summary: The aim of this study was to systematically search and synthesise findings from peer-reviewed qualitative studies describing the experiences of those living with chronic cough. The thematic synthesis generated three analytical themes: 1) It's just a cough; 2) Constant cough and constant worry; and 3) No light at the end of the tunnel, highlighting the biopsychosocial nature of chronic cough. The study emphasizes the need for more qualitative research on the experiences of those living with chronic cough.
Article
Respiratory System
Michael G. Crooks, Lucia Crowther, Helena Cummings, Judith Cohen, Chao Huang, Lukas Pitel, Mark Pearson, Alyn Morice, John Turgoose, Shoaib Faruqi, Michael Watt, Tamsin Morris, Yang Xu
Summary: The SENTINEL programme aimed to reduce SABA overuse and promote MART as a preferred treatment for asthma. The implementation of the programme led to decreased SABA prescribing, increased uptake of inhaled corticosteroids, and fewer asthma exacerbations.
Letter
Respiratory System
Kayleigh Brindle, Mengru Zhang, Natalie Carter, Alyn H. Morice
Review
Oncology
Matthew G. Drake, Lorcan P. McGarvey, Alyn H. Morice
Summary: Chronic cough is a burdensome condition that significantly affects quality of life and lacks effective therapies. Recent studies have focused on targeting ion channels and receptors involved in cough activation and processing, providing new insights and treatment options for chronic cough.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Respiratory System
Lorcan McGarvey, Alyn H. Morice, Ashley Martin, Vicky W. Li, Michael J. Doane, Eduardo Urdaneta, Jonathan Schelfhout, Helen Ding, Eileen Fonseca
Summary: Chronic cough is highly prevalent in the UK and has a significant impact on quality of life, work productivity, and healthcare resource utilization.
Letter
Respiratory System
Mengru Zhang, Kayleigh Brindle, Melanie Robinson, Debbie Ingram, Tanya Cavany, Alyn Morice
