Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Luc Heerkens, Anniek C. van Westing, Trudy Voortman, Isabella Kardys, Eric Boersma, Johanna M. Geleijnse
Summary: NAFLD and CKD are strongly associated in patients with post-myocardial infarction (MI), which is reflected by higher serum uric acid (SUA) concentrations. SUA is a strong predictor of 12-year mortality risk after MI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hidekatsu Yanai, Hisayuki Katsuyama, Mariko Hakoshima, Hiroki Adachi
Summary: Chronic kidney disease (CKD) is a major global health problem, and there are currently no curative drug treatments available. Hyperuricemia is a risk factor for CKD, but the evidence on the effects of uric acid (UA)-lowering treatments on CKD progression is limited. Dotinurad, a selective urate reabsorption inhibitor, was found to be effective in reducing serum UA levels and improving metabolic parameters in CKD patients with hyperuricemia. Furthermore, dotinurad selectively targets URAT1, which may be beneficial for the pathology of CKD.
Article
Neurosciences
Erin L. Richard, Linda K. McEvoy, Eyal Oren, John E. Alcaraz, Gail A. Laughlin, Andrea Z. LaCroix, Rany M. Salem
Summary: In older men, albuminuria and hyperuricemia are associated with cognitive decline. However, no such associations were detected in women. eGFR showed no significant association with cognitive performance in either sex.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Ophthalmology
Wei Liu, Ruru Guo, Dandan Huang, Jian Ji, Ron T. Gansevoort, Harold Snieder, Nomdo M. Jansonius
Summary: This article reviews the relationship between chronic kidney disease (CKD) and various subtypes of glaucoma, discusses their underlying pathogenic mechanisms and common risk factors. However, some associations have yet to be confirmed, and sometimes even opposite observations are reported.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Peripheral Vascular Disease
Mark M. Mitsnefes, Yunwen Xu, Derek K. Ng, Garick Hill, Thomas Kimball, Susan L. Furth, Bradley A. Warady
Summary: Diastolic dysfunction is an early cardiac abnormality in patients with chronic kidney disease, with E/e' ratio being a marker to assess it. Abnormal E/e' ratio is associated with younger age, lower glomerular filtration rate, lower hemoglobin, hypertension, left ventricular hypertrophy, and sustained hypertension. Ambulatory blood pressure may better identify chronic kidney disease in children at risk for subclinical cardiac dysfunction compared to casual blood pressure.
Article
Nutrition & Dietetics
Young Su Joo, Hyung Woo Kim, Sangmi Lee, Ki Heon Nam, Hae-Ryong Yun, Jong Hyun Jhee, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park
Summary: This study used data from the Korean Genome and Epidemiology Study to show that low dietary zinc intake may increase the risk of chronic kidney disease in individuals with normal renal function.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Health Care Sciences & Services
Yingxian Luo, Qiong Wu, Runtang Meng, Fuzhi Lian, Chen Jiang, Meiyu Hu, Yaxin Wang, Haiyan Ma
Summary: This study found a nonlinear association between serum uric acid (SUA) levels and estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). There was an approximately linear relationship in males, while a nonlinear relationship was observed in females. Elevated SUA levels were associated with an increased risk of CKD development and renal function decline, particularly in postmenopausal women. Additionally, there might be a threshold effect of SUA on the risk of CKD.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Review
Food Science & Technology
Lajos Zsom, Marianna Zsom, Sohail Abdul Salim, Tibor Fulop
Summary: Estimated GFR (eGFR) is widely used to predict the progression of chronic kidney disease (CKD) and the need for dialysis, but it has several limitations, including only reflecting one physiological function of the kidney, depending on non-renal factors, being influenced by dietary intake and cardiovascular status, and not correlating with GFR in certain conditions. Many clinicians rely too heavily on eGFR as a valid reflection of renal function and a reliable diagnostic tool for CKD.
Article
Medicine, General & Internal
Yoon Ho Choi, Seongho Jo, Ro Woon Lee, Ji-Eun Kim, Jin Hyuk Paek, Byoungje Kim, Soo-Yong Shin, Seun Deuk Hwang, Seoung Woo Lee, Joon Ho Song, Kipyo Kim
Summary: Chronic kidney disease (CKD) progression is characterized by morphological changes in the kidney, such as decreased length and thickness, and histopathological alterations. The relationship between these morphological changes and glomerular filtration rate (GFR) has not been extensively studied. In this study, we used computed tomography (CT)-derived features to evaluate the three-dimensional size and shape of the kidney in relation to kidney function. We found that these features were significantly correlated with estimated GFR (eGFR), with surface-area-to-volume ratio (SVR) showing the strongest negative correlation. Different features had varying degrees of diagnostic value for different eGFR thresholds, and diabetes patients showed different patterns of correlation and visualization compared to non-diabetes patients. Overall, these findings highlight the potential of three-dimensional shape and size features in diagnosing CKD.
Article
Medicine, General & Internal
Meghann Pasternak, Ping Liu, Robert Quinn, Meghan Elliott, Tyrone Gorden Harrison, Brenda Hemmelgarn, Ngan Lam, Paul Ronksley, Marcello Tonelli, Pietro Ravani
Summary: This study aims to assess the 5-year probability of CKD regression in patients with newly diagnosed CKD, taking into account the competing risks of CKD progression and death, and investigate the association between albuminuria level and CKD regression.
Article
Cardiac & Cardiovascular Systems
Takaaki Koide, Shintaro Mandai, Reo Kitaoka, Hisazumi Matsuki, Motoko Chiga, Kouhei Yamamoto, Kotaro Yoshioka, Yohsuke Yagi, Soichiro Suzuki, Tamami Fujiki, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Takanori Yokota, Shinichi Uchida
Summary: This study investigated the role of circulating small extracellular vesicles (sEVs) and their microRNAs (miRNAs) in vascular calcification in chronic kidney disease (CKD). It was found that sEVs accelerated calcification in vascular smooth muscle cells (VSMCs), and inhibiting sEV biogenesis/release could reduce calcification. The miRNA transcriptome of sEVs revealed a depletion of specific miRNAs in CKD patients, and transfection of VSMCs with these miRNAs mitigated calcification. The study also identified VEGFA as a convergent target of these miRNAs, and inhibiting VEGFA-VEGFR2 signaling could suppress calcification in VSMCs.
CIRCULATION RESEARCH
(2023)
Article
Environmental Sciences
Xu Tang, Lu Xu, Ruo Gu Meng, Yi Qing Du, Shi Jun Liu, Si Yan Zhan, Tao Xu
Summary: This study aimed to evaluate the association between serum uric acid (SUA) and kidney function decline. The results showed a significant dose-response relationship between SUA and kidney function decline, with a 14% increased risk per 1 mg/dL increase in SUA. Subgroup analysis showed that this relationship was only observed among women, those aged < 60 years, and those without hypertension and diabetes.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Li Chen, Zhangxiang Zhu, Shandong Ye, Mao Zheng
Summary: The study suggests that the serum uric acid to serum creatinine ratio (SUA/SCr) can be used as an indicator of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM) and may be helpful for identifying normoalbuminuric DKD.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Editorial Material
Peripheral Vascular Disease
Ernesto L. Schiffrin, David A. Calhoun, John M. Flack, Sadayoshi Ito, R. Clinton Webb
AMERICAN JOURNAL OF HYPERTENSION
(2017)
Review
Gastroenterology & Hepatology
Takefumi Mori, Yusuke Ohsaki, Ikuko Oba-Yabana, Sadayoshi Ito
HEPATOLOGY RESEARCH
(2017)
Article
Endocrinology & Metabolism
Yuto Yamazaki, Yasuhiro Nakamura, Kei Omata, Kazue Ise, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Yukinaga Nozawa, Celso E. Gomez-Sanchez, Scott A. Tomlins, William E. Rainey, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
Article
Urology & Nephrology
Masahiro Nezu, Tomokazu Souma, Lei Yu, Takafumi Suzuki, Daisuke Saigusa, Sadayoshi Ito, Norio Suzuki, Masayuki Yamamoto
KIDNEY INTERNATIONAL
(2017)
Article
Urology & Nephrology
Eikan Mishima, Shinji Fukuda, Chikahisa Mukawa, Akinori Yuri, Yoshitomi Kanemitsu, Yotaro Matsumoto, Yasutoshi Akiyama, Noriko N. Fukuda, Hiroki Tsukamoto, Kei Asaji, Hisato Shima, Koichi Kikuchi, Chitose Suzuki, Takehiro Suzuki, Yoshihisa Tomioka, Tomoyoshi Soga, Sadayoshi Ito, Takaaki Abe
KIDNEY INTERNATIONAL
(2017)
Article
Multidisciplinary Sciences
Masaaki Nakayama, Noritomo Itami, Hodaka Suzuki, Hiromi Hamada, Naoyuki Osaka, Ryo Yamamoto, Kazumasa Tsunoda, Hirofumi Nakano, Kimio Watanabe, Wan-Jun Zhu, Yukio Maruyama, Hiroyuki Terawaki, Shigeru Kabayama, Ryoichi Nakazawa, Mariko Miyazaki, Sadayoshi Ito
Article
Multidisciplinary Sciences
Dai Suzuki, Akiko Saito-Hakoda, Ryo Ito, Kyoko Shimizu, Rehana Parvin, Hiroki Shimada, Erika Noro, Susumu Suzuki, Ikuma Fujiwara, Hiroyuki Kagechika, William E. Rainey, Shigeo Kure, Sadayoshi Ito, Atsushi Yokoyama, Akira Sugawara
Article
Biochemistry & Molecular Biology
Masahiro Nezu, Tomokazu Souma, Lei Yu, Hiroki Sekine, Nobuyuki Takahashi, Andrew Zu-Sern Wei, Sadayoshi Ito, Akiyoshi Fukamizu, Zsuzsanna K. Zsengeller, Tomohiro Nakamura, Atsushi Hozawa, S. Ananth Karumanchi, Norio Suzuki, Masayuki Yamamoto
Article
Urology & Nephrology
Masaaki Nakayama, Wan-Jun Zhu, Kimio Watanabe, Ayano Gibo, Ali M. Sherif, Shigeru Kabayama, Sadayoshi Ito
Article
Biochemistry & Molecular Biology
Emiko Sato, Yukako Tsunokuni, Manami Kaneko, Daisuke Saigusa, Ritsumi Saito, Shuichi Shimma, Akiyo Sekimoto, Yoshiko Kawana, Yuji Oe, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Hidekazu Shirai, Emiko Sato, Akiyo Sekimoto, Taeko Uchida, Yuji Oe, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Medicine, Research & Experimental
Sadayoshi Ito, Yasuyuki Okuda, Kotaro Sugimoto
Summary: This study examined factors associated with the antihypertensive effects of esaxerenone and the incidence of serum potassium elevation in patients with hypertension. Results showed that factors such as sex, weight, hypertension duration, prior antihypertensive treatment, plasma aldosterone concentration, urinary albumin-to-creatinine ratio, and smoking were associated with changes in blood pressure. Factors significantly associated with serum potassium elevation included baseline serum potassium, renal function, urinary albumin-to-creatinine ratio, blood pressure, and hypertension grade. The study concluded that esaxerenone is effective for patients with various backgrounds, but careful management is needed for those at risk of elevated serum potassium.
ADVANCES IN THERAPY
(2023)
Article
Urology & Nephrology
Kaori Narumi, Eikan Mishima, Yukako Akiyama, Tetsuro Matsuhashi, Takashi Nakamichi, Kiyomi Kisu, Shuhei Nishiyama, Hajime Ikenouchi, Akio Kikuchi, Rumiko Izumi, Mariko Miyazaki, Takaaki Abe, Hiroshi Sato, Sadayoshi Ito
Article
Urology & Nephrology
Toshiki Iwai, Mariko Miyazaki, Gen Yamada, Masaaki Nakayama, Tae Yamamoto, Michihiro Satoh, Hiroshi Sato, Sadayoshi Ito
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2018)
Article
Urology & Nephrology
Susumu Ogawa, Junko Takiguchi, Manami Shimizu, Kazuhiro Nako, Masashi Okamura, Yoshitaka Kinouchi, Sadayoshi Ito
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2017)