Article
Medicine, General & Internal
Minjie Chen, Bilian Ke, Jun Zou, Lan Gong, Yan Wang, Chaoran Zhang, Jianjiang Xu, Anji Wei, Jiaxu Hong
Summary: Both the isolated use of fluorometholone and combined use of azelastine and fluorometholone are effective in alleviating the signs and symptoms of severe ACD, but optimal response can be achieved with adjunctive treatment including azelastine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Allergy
Dai Miyazaki, Atsuki Fukushima, Eiichi Uchio, Jun Shoji, Kenichi Namba, Nobuyuki Ebihara, Etsuko Takamura, Ken Fukuda, Akira Matsuda, Shigeki Okamoto, Kazumi Fukagawa, Hiroshi Fujishima, Shigeaki Ohno, Yuichi Ohashi
Summary: This article summarizes the third edition of the Japanese guidelines for allergic conjunctival diseases, outlining the diagnosis, pathogenesis, and treatment of ACD, with a focus on the use of steroids and immunosuppressive drugs. This knowledge will assist healthcare providers and patients in making informed decisions regarding treatment.
ALLERGOLOGY INTERNATIONAL
(2022)
Review
Allergy
Ken Fukuda, Tatsuma Kishimoto, Tamaki Sumi, Kenji Yamashiro, Nobuyuki Ebihara
Summary: The use of biologics targeting specific antibodies and receptors has significantly improved the treatment outcomes in allergic diseases. However, these drugs have not been approved for ocular allergic diseases. While some studies have reported beneficial effects, adverse ocular symptoms have also been observed. Different biologics may have specific effects on different ocular allergies, and allergists must fully understand the effects of each drug on the eye. This review outlines the potential therapeutic and adverse effects of various biologics on allergic diseases of the eye.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Allergy
Stephen D. Anesi, Joseph Tauber, Quan Dong Nguyen, Peter Chang, Gregg J. Berdy, Charles C. Lin, David S. Chu, H. Terry Levine, Andrew D. Fernandez, Neeta Roy, Penny A. Asbell, Andrea M. Kantor, Alan T. Chang, Bhupinder Singh, Bradford A. Youngblood, Bennie H. Jeng, Vishal Jhanji, Henrik S. Rasmussen, C. Stephen Foster
Summary: Lirentelimab demonstrates good tolerability and effectively improves severe symptoms in patients with allergic conjunctivitis, while also reducing concomitant atopic symptoms and inflammatory mediators in patient tears.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Cell Biology
Ken Fukuda, Waka Ishida, Tatsuma Kishimoto, Isana Nakajima, Yusaku Miura, Tamaki Sumi, Kenji Yamashiro
Summary: Severe ocular allergic diseases can cause damage to ocular tissues and inflammation, leading to visual impairments. Research has shown that damage-associated molecular patterns (DAMPs/alarmins) play a critical role in the pathogenesis of these diseases and may be a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Zahra Tajbakhsh, Blanka Golebiowski, Fiona Stapleton, Ramin Salouti, M. Hosein Nowroozzadeh, Mohammad Zamani, Nancy Briggs, Isabelle Jalbert
Summary: This study aimed to compare the distribution of dendritic cells (DCs) in vernal keratoconjunctivitis (VKC), allergic conjunctivitis (AC), and non-allergic controls. The study found that DC density was higher in VKC and AC patients compared to non-allergic controls, with VKC patients showing significantly higher DC density at the limbus. The study also found that DCs in AC and VKC patients had larger cell bodies and a higher proportion of long dendrites than non-allergic controls.
Article
Ophthalmology
Shefali Mazumdar, Saran Kumar Satsangi, Mahak Garg, Payal Goel Rajan
Summary: This study assessed the prevalence of dry eye in different subsets of allergic conjunctivitis (AC) patients and found that the prevalence ranged between 31% and 36%. The study concluded that perennial allergic conjunctivitis (PAC) had the highest percentage of dry eye, followed by seasonal allergic conjunctivitis (SAC), and VKC had the lowest percentage.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Roberto Caputo, Elisa Marziali, Cinzia de Libero, Laura Di Grande, Gioia Danti, Gianni Virgili, Edoardo Villani, Francesca Mori, Giacomo M. Bacci, Ersilia Lucenteforte, Neri Pucci
Summary: This study aimed to evaluate the safety and efficacy of tacrolimus 0.1% eye drops in a large population of pediatric patients with severe VKC. Results showed positive relevance from baseline to all other visits, with no local or systemic complications recorded. Tacrolimus 0.1% eye drops were confirmed to be safe and effective for severe VKC patients who did not respond well to cyclosporine.
Review
Biology
Marta Sacchetti, Rocco Plateroti, Alice Bruscolini, Rosalia Giustolisi, Marco Marenco
Summary: Studies on the pathogenesis of VKC suggest that genetic, endocrine, neuronal factors, and an imbalance of innate immunity may be involved in the development of VKC.
Review
Allergy
Neera Singh, Yolanda Diebold, Srikant K. Sahu, Andrea Leonardi
Summary: Epithelial barrier dysfunction plays a significant role in the development of ocular allergies, leading to chronic inflammation. Abnormal expression of tight junction proteins is reported in ocular allergies, but data is limited in chronic atopic keratoconjunctivitis and vernal keratoconjunctivitis.
Article
Immunology
Yongquan Zhang, Jian Shui, Lu Wang, Fengjun Wang
Summary: This study identifies serum S100A11 and MMP9 as potential biomarkers for early prediction and monitoring of the effectiveness of sublingual immunotherapy (SLIT) in patients with allergic rhinitis (AR). These findings contribute to guiding treatment and understanding the mechanism of SLIT in AR patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Ophthalmology
Yogita Gupta, Namrata Sharma, Prafulla K. Maharana, Rohit Saxena, Rajesh Sinha, Tushar Agarwal, Vishal Jhanji, Jeewan S. Titiyal
Summary: This study found that pediatric keratoconus is commonly associated with vernal keratoconjunctivitis (VKC), and patients with VKC have more severe disease. Corneal biomechanical changes are closely correlated with the stage of keratoconus in this pediatric age group.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Ishith Seth, Gabriella Bulloch, Michael Vine, Joseph Outmezguine, Nimish Seth, James Every, Mark Daniell
Summary: This study investigated the association between keratoconus and allergic eye diseases, eye rubbing, and atopy. The results showed no significant association between keratoconus and allergic eye diseases, eye rubbing, or atopy. Further prospective studies are needed to validate these findings.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Allergy
Artesani Maria Cristina, Esposito Mariacristina, Sacchetti Marta, Mennini Maurizio, Romanzo Antonino, Buzzonetti Luca, Fiocchi Alessandro Giovanni, Sansone Andrea
Summary: This study aimed to evaluate the impact of reduced sunlight exposure during the SARS-CoV-2 pandemic emergency on patients with VKC. The results showed that about one third of the patients benefited from reduced sunlight exposure, while increased use of bright screens was associated with worsening of VKC symptoms.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Ophthalmology
Stefano Bonini, Andrea Leonardi
Summary: Ocular allergy is a common eye disease with multiple factors influencing its development. Treatment should be holistic, dynamic, and personalized.
Article
Plant Sciences
I. Sriram Sandeep, Suryasnata Das, Noohi Nasim, Antaryami Mishra, Laxmikanta Acharya, Raj Kumar Joshi, Sanghamitra Nayak, Sujata Mohanty
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
D. K. Behera, P. M. Behera, L. Acharya, A. Dixit
SAR AND QSAR IN ENVIRONMENTAL RESEARCH
(2017)
Article
Biotechnology & Applied Microbiology
Ambika Sahoo, Sudipta Jena, Basudeba Kar, Suprava Sahoo, Asit Ray, Subhashree Singh, Raj Kumar Joshi, Laxmikanta Acharya, Sanghamitra Nayak
Article
Forestry
Tirthabrata Sahoo, Pratap Chandra Panda, Laxmikanta Acharya
JOURNAL OF FORESTRY RESEARCH
(2017)
Article
Biotechnology & Applied Microbiology
Ambika Sahoo, Sudipta Jena, Basudeba Kar, Suprava Sahoo, Asit Ray, Subhashree Singh, Raj Kumar Joshi, Laxmikanta Acharya, Sanghamitra Nayak
Article
Plant Sciences
Dattatreya Kar, Pratap Keshari Pattanaik, Laxmikanta Acharya, Manoj Kumar Panda, Kamalakanta Sathapathy, Ananya Kuanar, Budhadeva Mishra
BRAZILIAN JOURNAL OF BOTANY
(2014)
Article
Biotechnology & Applied Microbiology
Sujata Mohanty, Manoj Kumar Panda, Laxmikanta Acharya, Sanghamitra Nayak
Article
Agricultural Engineering
Noohi Nasim, I. Sriram Sandeep, Ambika Sahoo, Suryasnata Das, Manoj Kumar Panda, Laxmikanta Acharya, V. V. RamaRao, Sanghamitra Nayak, Sujata Mohanty
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Multidisciplinary Sciences
Bhagyashree Biswal, Biswajit Jena, Alok Kumar Giri, Laxmikanta Acharya
Summary: This study reported the first de novo transcriptome analysis of Operculina turpethum, revealing significant upregulation of DEGs involved in secondary metabolite biosynthesis in stem tissues and validation through qRT-PCR. The study presents a valuable genetic information repository for effective conservation efforts.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Bhagyashree Biswal, Biswajit Jena, Alok Kumar Giri, Laxmikanta Acharya
Summary: The study found that blue light in LEDs can increase biomass accumulation, pigment concentration, and production of bioactive metabolites in Operculina turpethum callus culture. Blue light also enhances in vitro antioxidant activity in callus culture. However, callus culture grown under dark conditions showed higher expression of superoxide dismutase and catalase enzymes. Quantification of phytochemicals revealed highest production under blue light treatment.
PLANT CELL TISSUE AND ORGAN CULTURE
(2022)
Article
Multidisciplinary Sciences
Alok Kumar Giri, Biswajit Jena, Bhagyashree Biswal, Arun Kumar Pradhan, Manoranjan Arakha, Saumyaprava Acharya, Laxmikanta Acharya
Summary: The study successfully synthesized silver nanoparticles using a green synthesis approach and demonstrated their effectiveness in inhibiting biofilm formation. This could be a significant breakthrough in combating various dynamic pathogens.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Alok Kumar Giri, Bhagyashree Biswal, Biswajit Jena, Laxmikanta Acharya
Summary: Eugenia roxburghii, a wild edible plant, possesses pharmacological and nutritional properties. It contains abundant polyphenols and flavonoids, showing significant scavenging activity against reactive oxygen species. Nutritionally, E. roxburghii is rich in vitamin C and provides a substantial amount of calories, carbohydrates, protein, and dietary fiber.
Article
Biochemistry & Molecular Biology
Biswajit Jena, Bhagyashree Biswal, Ashirbad Sarangi, Alok Kumar Giri, Debapriya Bhattacharya, Laxmikanta Acharya
Summary: Plectranthus amboinicus, also known as Indian borage or Mexican mint, is a highly documented species in the Lamiaceae family known for its medicinal properties. The leaf essential oil extracted from this plant has various therapeutic benefits and shows efficient bactericidal effects against both gram positive and gram negative bacteria. The study conducted in Odisha, India, found that the germplasm from this region is preferable for obtaining high-quality leaf oil with potential pharmaceutical use.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Genetics & Heredity
Biswajit Jena, Alok Kumar Giri, Bhagyashree Biswal, Laxmikanta Acharya, Manoj Kumar Panda
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
