Article
Cardiac & Cardiovascular Systems
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, William Wheatley, Jae Min Cho, J. David Symons, Donald E. Kohan
Summary: Loss of sPRR reduces baseline blood pressure, decreases Ang II-induced hypertension and renal injury, and is associated with greater endothelium-dependent vasorelaxation of resistance-sized arteries.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rosemary Wangensteen, Manuel Gomez-Guzman, Inmaculada Banegas, Isabel Rodriguez-Gomez, Rosario Jimenez, Juan Duarte, Joaquin Garcia-Estan, Felix Vargas
Summary: This study investigated the vasoactive effects of DAA-I in rats and found that it increased blood pressure and caused vasoconstriction. These effects were mediated by the activation of AT1 receptors. These findings have potential implications for the treatment of cardiovascular diseases.
Review
Cardiac & Cardiovascular Systems
Sarah M. Nwia, Ana Paula O. Leite, Xiao Chun Li, Jia Long Zhuo
Summary: Cardiovascular disease demonstrates significant biological sex differences, allowing for tailored approaches to prevention and treatment. Hypertension, a major risk factor for various diseases, affects a significant percentage of the American population. Women have lower rates of hypertension during reproductive years, but this protection diminishes after menopause. Treatment-resistant hypertension remains a challenge, suggesting unknown mechanisms in blood pressure regulation. Understanding the genetic and hormonal differences in hypertension can lead to sex-specific treatments and improved outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Transplantation
Carmine Zoccali, Alberto Ortiz, Inga Arune Blumbyte, Sarina Rudolf, Annette G. Beck-Sickinger, Jolanta Malyszko, Goce Spasovski, Sol Carriazo, Davide Viggiano, Justina Kurganaite, Vaiva Sarkeviciene, Daiva Rastenyte, Andreja Figurek, Merita Rroji, Christopher Mayer, Mustapha Arici, Gianvito Martino, Gioacchino Tedeschi, Annette Bruchfeld, Belinda Spoto, Ivan Rychlik, Andrzej Wiecek, Mark Okusa, Giuseppe Remuzzi, Francesca Mallamaci
Summary: NPY, a 36-amino-acid peptide, regulates various biological functions and plays a key role in chronic kidney disease progression, cardiovascular events, and cognitive decline. Interfering with the NPY system has potential for treating diverse diseases, although challenges in drug delivery, cost, and complexity of diseases remain.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Editorial Material
Urology & Nephrology
Sidar Copur, Asiye Kanbay, Mehmet Kanbay
Summary: Patients with chronic kidney disease, chronic heart failure, and hypertension who are infected with COVID-19 may not benefit from discontinuing the use of renin-angiotensin-aldosterone system blockers and it might even have potential harmful effects.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Chantelle Thimm, Lars Erichsen, Wasco Wruck, James Adjaye
Summary: Podocytes, specialized cells in the kidney, play a crucial role in blood filtration and dysfunction of these cells can lead to renal diseases. Studying and utilizing podocytes is important in the field of regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Nisita Chaihongsa, Putcharawipa Maneesai, Weerapon Sangartit, Siwayu Rattanakanokchai, Prapassorn Potue, Juthamas Khamseekaew, Sarawoot Bunbupha, Poungrat Pakdeechote
Summary: This study found that galangin can reduce blood pressure, cardiac dysfunction, and hypertrophy in hypertensive rats. It can also decrease the activity of angiotensin converting enzyme and the concentration of angiotensin II, and reduce the overexpression of certain proteins in cardiac tissue. Furthermore, galangin can attenuate kidney damage and oxidative stress, while increasing antioxidant enzyme activity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Anuson Poasakate, Putcharawipa Maneesai, Prapassorn Potue, Sarawoot Bunbupha, Terdthai Tong-Un, Wannapa Settheetham-Ishida, Juthamas Khamseekaew, Poungrat Pakdeechote
Summary: Genistein can reduce blood pressure and improve vascular and kidney dysfunction in hypertensive rats. It acts through modulation of multiple signaling pathways to attenuate renal atrophy and hypertrophy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Nadin Hoffmann, Joerg Peters
Summary: The (pro)renin receptor (P)RR has important roles in the kidney and brain, independently of prorenin, in activating inflammatory and fibrotic responses in renal dysfunction and being linked to hypertension in the brain. By regulating pH and function of v-ATPase, (P) RR plays crucial roles in cellular homeostasis and autophagy in kidney, brain, and heart.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Moudhi Almutlaq, Fatmah A. Mansour, Jahad Alghamdi, Yassen Alhendi, Abir Abdullah Alamro, Amani Ahmed Alghamdi, Hassan S. Alamri, Fayhan Alroqi, Tlili Barhoumi
Summary: This study demonstrates that angiotensin II (Ang II) exacerbates the T-cell response to SARS-CoV-2 in recovered COVID-19 patients. The presence of Ang II increases the phosphorylation levels of proteins involved in cardiovascular diseases, inflammation, and viral infection. These findings suggest that Ang II may worsen the inflammatory response and alter the immune response to a more inflammatory profile against SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Natalia K. S. Lima, Wilka R. A. Farias, Marry A. S. Cirilo, Angelica G. Oliveira, Juliane S. Farias, Regina S. Aires, Humberto Muzi-Filho, Ana D. O. Paixao, Leucio D. Vieira
Summary: Acute renal injury induced by ischemia-reperfusion may lead to changes in proximal tubule ATPases and RAAS components, which are associated with renal Na+ retention and hypertension. NADPH oxidase plays a key role in these alterations.
Review
Urology & Nephrology
Marieta P. Theodorakopoulou, Maria-Eleni Alexandrou, Afroditi K. Boutou, Charles J. Ferro, Alberto Ortiz, Pantelis Sarafidis
Summary: Hypertension and chronic kidney disease are common comorbidities associated with COVID-19 severity and mortality. Concerns about the use of RAS blockers increasing the risk of COVID-19 infection and severity have been disproven by recent human studies.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Henry Sackin
Summary: Preexisting hypertension is a known risk factor for severe COVID-19. Abnormal activation of RAS upregulates angiotensin II, contributing to severe manifestations of COVID-19. While RAS inhibitors have been associated with an increase in ACE2 receptors that facilitate cellular entry of the SARS-CoV-2 virus, current medical practice does not recommend curtailing RAS inhibitors. Hypotheses suggest that RAS inhibitors reduce the severity of COVID-19 by promoting ACE2-AT1R complex formation and hindering SARS-CoV-2 binding to ACE2, leading to protocols for reducing disease severity.
MEDICAL HYPOTHESES
(2021)
Article
Cell Biology
Jorge F. Giani, Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein
Summary: Renal angiotensin-converting enzyme (ACE) plays a key role in the development of various kidney diseases, particularly hypertension. Studies suggest that ACE may mediate its effects through mechanisms independent of Ang II conversion, involving other substrates.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Peripheral Vascular Disease
Kouichi Tamura, Kengo Azushima, Sho Kinguchi, Hiromichi Wakui, Takahiro Yamaji
Summary: ATRAP is a protein that promotes AT1R internalization to inhibit its pathological activation; ATRAP is abundantly expressed in the kidney and plays a key role in regulating renal sodium handling and blood pressure modulation.
HYPERTENSION RESEARCH
(2022)
Letter
Cardiac & Cardiovascular Systems
Benjamin M. Scirica, Christopher P. Cannon, Naomi D. L. Fisher, Thomas A. Gaziano, David Zelle, Kira Chaney, Angela Miller, Hunter Nichols, Lina Matta, William J. Gordon, Shawn Murphy, Kavi B. Wagholikar, Jorge Plutzky, Calum A. MacRae
Article
Cardiac & Cardiovascular Systems
David E. Kandzari, Raymond R. Townsend, George Bakris, Jan Basile, Michael J. Bloch, Debbie L. Cohen, Cara East, Keith C. Ferdinand, Naomi Fisher, Ajay Kirtane, David P. Lee, Gary Puckrein, Florian Rader, Joseph A. Vassalotti, Michael A. Weber, Kerry Willis, Eric Secemsky
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Peripheral Vascular Disease
Manish Saxena, Roland E. Schmieder, Ajay J. Kirtane, Felix Mahfoud, Joost Daemen, Jan Basile, Philipp Lurz, Philippe Gosse, Kintur Sanghvi, Naomi D. L. Fisher, Lars C. Rump, Atul Pathak, Peter J. Blankestijn, Anthony Mathur, Yale Wang, Michael A. Weber, Andrew S. P. Sharp, Michael J. Bloch, Neil C. Barman, Lisa Claude, Yang Song, Michel Azizi, Melvin D. Lobo
Summary: This post-hoc analysis of the RADIANCE-HTN SOLO study found that predictors of response to renal denervation (RDN) included higher baseline daytime ambulatory diastolic blood pressure and use of antihypertensive medications, with orthostatic hypertension potentially predicting response. Obese females also appeared to have a better response to RDN in an interaction model.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Naomi D. L. Fisher, Ajay J. Kirtane, Joost Daemen, Florian Rader, Melvin D. Lobo, Manish Saxena, Josephine Abraham, Roland E. Schmieder, Andrew S. P. Sharp, Philippe Gosse, Lisa Claude, Yang Song, Michel Azizi
Summary: This study investigated the association between plasma renin and aldosterone concentrations and the blood pressure response to renal denervation. The results showed that renal denervation reduced daytime ambulatory systolic blood pressure, but renin and aldosterone concentrations did not predict the blood pressure response to renal denervation.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
David E. Kandzari, Felix Mahfoud, Michael A. Weber, Raymond Townsend, Gianfranco Parati, Naomi D. L. Fisher, Melvin D. Lobo, Michael Bloch, Michael Bohm, Andrew S. P. Sharp, Roland E. Schmieder, Michel Azizi, Markus P. Schlaich, Vasilios Papademetriou, Ajay J. Kirtane, Joost Daemen, Atul Pathak, Christian Ukena, Philipp Lurz, Guido Grassi, Martin Myers, Aloke Finn, Marie-Claude Morice, Roxana Mehran, Peter Juni, Gregg W. Stone, Mitchell W. Krucoff, Paul K. Whelton, Konstantinos Tsioufis, Donald E. Cutlip, Ernest Spitzer
Summary: The clinical implications of hypertension drive the development of device-based therapies. The HARC document integrates expert consensus and regulatory perspectives to address challenges and unmet needs in treating hypertension.
Editorial Material
Cardiac & Cardiovascular Systems
Naomi D. L. Fisher, Felix Mahfoud
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hunter Nichols, Christopher P. Cannon, Benjamin M. Scirica, Naomi D. L. Fisher
Summary: Hypertension is a major risk factor for death globally, with poor and stagnant control rates. We have developed a remote hypertension management program that uses digitally transmitted home blood pressure measurements, algorithmic care pathways, and patient-navigator communications to help patients achieve guideline-directed blood pressure goals.
CLINICAL CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michel Azizi, Felix Mahfoud, Michael A. Weber, Andrew S. P. Sharp, Roland E. Schmieder, Philipp Lurz, Melvin D. Lobo, Naomi D. L. Fisher, Joost Daemen, Michael J. Bloch, Jan Basile, Kintur Sanghvi, Manish Saxena, Philippe Gosse, J. Stephen Jenkins, Terry Levy, Alexandre Persu, Benjamin Kably, Lisa Claude, Helen Reeve-Stoffer, Candace McClure, Ajay J. Kirtane
Summary: This study aims to evaluate the long-term effects and safety of ultrasound RDN for patients with resistant hypertension. The results show that after 2 months of treatment, both the uRDN group and the sham group had similar antihypertensive effects, but the uRDN group required fewer additional medications.
Article
Cardiac & Cardiovascular Systems
Alexander J. Blood, Christopher P. Cannon, William J. Gordon, Charlotte Mailly, Taylor MacLean, Samantha Subramaniam, Michela Tucci, Jennifer Crossen, Hunter Nichols, Kavishwar B. Wagholikar, David Zelle, Marian McPartlin, Lina S. Matta, Michael Oates, Samuel Aronson, Shawn Murphy, Adam Landman, Naomi D. L. Fisher, Thomas A. Gaziano, Jorge Plutzky, Benjamin M. Scirica
Summary: This study implemented and evaluated a remote hypertension and cholesterol management program in a diverse healthcare network. The program resulted in improved blood pressure and cholesterol control among patients, regardless of their race, ethnicity, or primary language.
Review
Peripheral Vascular Disease
Simin Gharib Lee, Naomi D. L. Fisher
Summary: We are at a critical moment in the delivery of health care for hypertension, as traditional methods are failing and remote management solutions are emerging. With the use of digital technology, home blood pressure measurements, interdisciplinary care teams, and advanced analytics, remote hypertension care is poised to have a significant impact on global cardiovascular health.
Article
Cardiac & Cardiovascular Systems
Simin Gharib Lee, Alexander J. Blood, Christopher P. Cannon, William J. Gordon, Hunter Nichols, David Zelle, Benjamin M. Scirica, Naomi D. L. Fisher
Summary: The COVID-19 pandemic disrupted traditional health care and led to a drastic decrease in blood pressure assessment. This study analyzed the impact of the pandemic on a remote hypertension management program and found that it was successful in improving blood pressure control and increasing home blood pressure monitoring despite the disruption.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Meeting Abstract
Peripheral Vascular Disease
David Perruchoud, Meritxell Cortes, Josep Sola, Melvin D. Lobo, Gregoire Wuerzner, Naomi D. L. Fisher
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Andrew Sharp, Michel Azizi, Felix Mahfoud, Naomi Fisher, Melvin Lobo, Michael Weber, Ajay Kirtane
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Peripheral Vascular Disease
Josep Sola, David Perruchod, Meritxell Cortes, Jay Pandit, Melvin D. Lobo, Gregoire Wuerzner, Naomi D. Fisher, Jay Shah
Article
Engineering, Biomedical
Josep Sola, Meritxell Cortes, David Perruchoud, Bastien De Marco, Melvin D. Lobo, Cyril Pellaton, Gregoire Wuerzner, Naomi D. L. Fisher, Jay Shah
Summary: Hypertension is the leading risk factor for death globally. However, the adoption of cuffless blood pressure monitors in clinical practice has been slow due to differences in technology and reluctance to change established standards. This guidance document provides an overview of cuffless devices, highlights their differences from traditional cuff-based monitors, and presents an interpretation framework using a CE-marked cuffless BP device as an example. The widespread use of cuffless monitors in healthcare will require a collaborative and thoughtful process.
FRONTIERS IN MEDICAL TECHNOLOGY
(2022)