☆ 4.7 Editorial Material

Angiotensin II Receptor-Induced Cardiac Remodeling in Mice Without Angiotensin II

HYPERTENSION (2012)

Journal

HYPERTENSION

Volume 59, Issue 3, Pages 542-544

Publisher

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1161/HYPERTENSIONAHA.111.189423

Keywords

-

Categories

Peripheral Vascular Disease

Funding

NHLBI NIH HHS [R01 HL083243, HL007914, R01 HL115964, R01 HL57470, R01 HL057470, R01 HL057470-15, T32 HL007914] Funding Source: Medline

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Cardiac & Cardiovascular Systems

Alamandine improves cardiac remodeling induced by transverse aortic constriction in mice

Mario Morais Silva, Fernando Pedro de Souza-Neto, Itamar Couto Guedes de Jesus, Gleisy Kelly Goncalves, Melissa de Carvalho Santuchi, Bruno de Lima Sanches, Thais Cristina de Alcantara-Leonidio, Marcos Barrouin Melo, Maria Aparecida Ribeiro Vieira, Silvia Guatimosim, Robson Augusto Souza Santos, Rafaela Fernandes da Silva

Summary: Alamandine, the newest identified component of the renin-angiotensin system, has protective effects in the cardiovascular system by preventing cardiac remodeling such as myocyte hypertrophy and fibrosis. The study demonstrates that alamandine can improve various aspects of cardiac remodeling induced by pressure overload.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension

Francisco Olivares-Silva, Nicole De Gregorio, Jenaro Espitia-Corredor, Claudio Espinoza, Raul Vivar, David Silva, Jose Miguel Osorio, Sergio Lavandero, Concepcion Peiro, Carlos Sanchez-Ferrer, Guillermo Diaz-Araya

Summary: Resolvin-D1 (RvD1) attenuates cardiac remodeling and hypertension induced by angiotensin II by reducing inflammation, cytokine levels, cardiac hypertrophy, fibrosis, and blood pressure, demonstrating novel cardioprotective effects.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Add to Collection

Article Medicine, Research & Experimental

A novel caffeic acid derivative prevents angiotensin II-induced cardiac remodeling

Shih-Yi Lee, Yueh-Hsiung Kuo, Chen-Xuan Du, Cheng-Wei Huang, Hui-Chun Ku

Summary: Differentiation of cardiac fibroblasts into myofibroblasts is a critical event in the progression of cardiac fibrosis. The study investigated the effect of caffeic acid ethanolamide (CAEA) on cardiac remodeling induced by Angiotensin (Ang) II. CAEA inhibited fibroblast differentiation, protected against cardiac fibrosis and dysfunction, and regulated the TGF-beta/SMAD/NOX4 signaling pathway. The study supports CAEA administration as a viable method to prevent Ang II-induced cardiac remodeling.

BIOMEDICINE & PHARMACOTHERAPY (2023)

Add to Collection

Article Medical Laboratory Technology

Allergic asthma aggravates angiotensin II-induced cardiac remodeling in mice

C. H. Geng, Y. U. F. A. N. Feng, Y. A. N. G. Yang, H. O. N. G. Q. I. N. Yang, Z. H. I. W. E. I. LI, Y. A. Q. I. N. Tang, J. I. N. G. Wang, H. O. N. G. M. E. Zhao

Summary: Cardiovascular disease, including heart failure (HF), is a leading cause of death globally. This study explored the link between asthma and HF, and found a higher prevalence of HF among asthmatic individuals. In animal models, asthma impaired heart function and aggravated cardiac remodeling. The study also identified the involvement of immunoglobulin E (IgE) and its receptor (Fc epsilon R1) in the adverse effects of asthma on the heart. Blockage of IgE-Fc epsilon R1 prevented asthma-induced decline of cardiac function and alleviated cardiac remodeling. These findings suggest the potential use of anti-IgE therapy in treating asthma complicated with heart conditions.

TRANSLATIONAL RESEARCH (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Atrial Electrical Remodeling in Mice With Cardiac-Specific Overexpression of Angiotensin II Type 1 Receptor

Julie Demers, Anh-Tuan Ton, Francois Huynh, Simon Thibault, Anique Ducharme, Pierre Paradis, Mona Nemer, Celine Fiset

Summary: In this study, chronic AT1R activation was found to result in slower atrial conduction, primarily through reduced I-Na density and decreased connexin 40 expression.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Src tyrosine kinase promotes cardiac remodeling induced by chronic sympathetic activation

Wenqi Li, Yuzhong Zhu, Wenjing Wang, Dan He, Lei Feng, Zijian Li

Summary: This study identifies Src tyrosine kinase as a key player in cardiac remodeling triggered by excessive beta-adrenergic receptor activation. Src mediates isoproterenol-induced cardiac hypertrophy, fibrosis, and inflammation in vivo, as well as proliferation and transdifferentiation of cardiac fibroblasts and hypertrophy of cardiomyocytes in vitro. It also mediates the extracellular signal-regulated protein kinase signaling pathway activated by beta-adrenergic receptor. These findings highlight the potential of Src as a therapeutic target for cardiac remodeling.

BIOSCIENCE REPORTS (2023)

Add to Collection

Article Plant Sciences

Tabersonine attenuates Angiotensin II-induced cardiac remodeling and dysfunction through targeting TAK1 and inhibiting TAK1-mediated cardiac inflammation

Chengyi Dai, Wu Luo, Yanghao Chen, Siyuan Shen, Zhe Wang, Ruijie Chen, Jun Wang, Nipon Chattipakorn, Weijian Huang, Guang Liang

Summary: This study found that Tab protects the heart from Ang II-induced injuries by targeting TAK1 and inhibiting TAK1-mediated inflammatory cascade and response. The protective effects of Tab were observed in both mouse models and in vitro experiments, showing reduced cardiac inflammation and fibrosis. These findings suggest that Tab may be a potential therapeutic candidate for hypertensive heart failure.

PHYTOMEDICINE (2022)

Add to Collection

Article Pharmacology & Pharmacy

Macrophage depletion protects against endothelial dysfunction and cardiac remodeling in angiotensin II hypertensive mice

Yuantong Tian, Jun Luo, Qian Xu, Yueyang Liu, Ruiping Cai, Ming-Sheng Zhou

Summary: The study found that the use of LEC significantly reduced Ang II-induced cardiac hypertrophy and fibrosis, as well as cardiac macrophage infiltration, improved endothelium-dependent relaxation, and slightly reduced systolic blood pressure. In addition, LEC also decreased the expression of inflammatory and fibrotic factors in the heart, preventing the phosphorylation of ERK1/2 and c-Jun-N-terminal kinase induced by Ang II.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2021)

Add to Collection

Article Chemistry, Medicinal

Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling

Na Yang, Chunpeng Zou, Wu Luo, Diyun Xu, Mengyang Wang, Yi Wang, Gaojun Wu, Peiren Shan, Guang Liang

Summary: This study demonstrates the potential use of sclareol in preventing hypertensive heart failure by inhibiting the MAPK-mediated inflammation induced by Ang II.

PHYTOTHERAPY RESEARCH (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Cardiomyocyte-specific deletion of TLR4 attenuates angiotensin II-induced hypertension and cardiac remodeling

Drew Theobald, Anand R. Nair, Srinivas Sriramula, Joseph Francis

Summary: Toll-like receptor 4 (TLR4) plays a crucial role in the innate immune response and cardiovascular diseases. This study found that cardiomyocyte-specific deletion of TLR4 provides protection against hypertension, cardiac hypertrophy, and remodeling. The results showed that in mice with cardiomyocyte-specific TLR4 knockdown, angiotensin II-induced hypertension and cardiac hypertrophy were attenuated, myocardial fibrosis was reduced, and cardiac function was improved.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2023)

Add to Collection

Article Peripheral Vascular Disease

Angiotensin II Type 1A Receptor Expressed in Smooth Muscle Cells is Required for Hypertensive Vascular Remodeling in Mice Infused With Angiotensin II

Keisuke Okuno, Keiichi Torimoto, Stephanie M. Cicalese, Kyle Preston, Victor Rizzo, Tomoki Hashimoto, Thomas M. Coffman, Matthew A. Sparks, Satoru Eguchi

Summary: Smooth muscle AT(1A) receptors mediate Ang II-induced vascular remodeling in both hypertensive and non-hypertensive conditions, contributing to medial hypertrophy and perivascular fibrosis. These findings indicate an independent etiology of blood pressure elevation and hypertensive vascular remodeling in response to Ang II.

HYPERTENSION (2023)

Add to Collection

Article Medicine, Research & Experimental

Fibroblast-specific IKK-β deficiency ameliorates angiotensin II-induced adverse cardiac remodeling in mice

Weiwei Lu, Zhaojie Meng, Rebecca Hernandez, Changcheng Zhou

Summary: The study demonstrates the crucial role of IKK-beta in regulating fibroblast functions and cardiac remodeling, showing that fibroblast-specific IKK-beta deficiency can protect mice from hypertension-induced adverse cardiac remodeling, including hypertrophy, fibrosis, and macrophage infiltration. Ablation of fibroblast IKK-beta inhibits proinflammatory and profibrogenic responses, leading to improved cardiac remodeling and function.

JCI INSIGHT (2021)

Add to Collection

Article Plant Sciences

Diacerein alleviates Ang II-induced cardiac inflammation and remodeling by inhibiting the MAPKs/c-Myc pathway

Mengyang Wang, Wu Luo, Tianxiang Yu, Shiqi Liang, Chunpeng Zou, Jinfeng Sun, Gao Li, Guang Liang

Summary: This study demonstrates that diacerein can protect the heart by inhibiting inflammation and myocardial fibrosis, thereby preventing the occurrence of hypertensive heart failure.

PHYTOMEDICINE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Tributyrin Intake Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in LDLR-/- Mice

Chih-Pei Lin, Po-Hsun Huang, Chi-Yu Chen, I-Shiang Tzeng, Meng-Yu Wu, Jia-Shiong Chen, Jaw-Wen Chen, Shing-Jong Lin

Summary: Abdominal aortic aneurysm (AAA) is a cardiovascular disease that causes vascular dilatation in the infrarenal aorta, leading to a high risk of death. The pathogenesis of AAA involves oxidative stress, inflammation, and vascular smooth muscle cell dysregulation. Tributyrin (TB) has a potential protective effect against AAA by inhibiting HDAC activity and attenuating the AngII-induced AT1R signaling cascade. This study provides insights into the potential therapeutic role of TB in the treatment of AAA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Cell Biology

Kruppel-Like Factor 15 Modulates CXCL1/CXCR2 Signaling-Mediated Inflammatory Response Contributing to Angiotensin II-Induced Cardiac Remodeling

Shun He, Yuanyuan Lu, Yuetong Guo, Shijin Li, Xiao Lu, Shuai Shao, Handan Zhou, Ruiqi Wang, Jiguang Wang, Pingjin Gao, Xiaodong Li

Summary: The study revealed that KLF15 in cardiac fibroblasts negatively regulates the CXCL1/CXCR2 axis-mediated inflammatory response and subsequent cardiac remodeling in hypertension.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Chemistry, Medicinal

Divergent Spatiotemporal Interaction of Angiotensin Receptor Blocking Drugs with Angiotensin Type 1 Receptor

Khuraijam Dhanachandra Singh, Hamiyet Unal, Russell Desnoyer, Sadashiva S. Karnik

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2018)

Add to Collection

Review Pharmacology & Pharmacy

Current topics in angiotensin II type 1 receptor research: Focus on inverse agonism, receptor dimerization and biased agonism

Takanobu Takezako, Hamiyet Unal, Sadashiva S. Karnik, Koichi Node

PHARMACOLOGICAL RESEARCH (2017)

Add to Collection

Article Multidisciplinary Sciences

Connective tissue growth factor dependent collagen gene expression induced by MAS agonist AR234960 in human cardiac fibroblasts

Arunachal Chatterjee, John Barnard, Christine Moravec, Russell Desnoyer, Kalyan Tirupuia, Sadashiva S. Karnik

PLOS ONE (2017)

Add to Collection

Article Pharmacology & Pharmacy

The non-biphenyl-tetrazole angiotensin AT1 receptor antagonist eprosartan is a unique and robust inverse agonist of the active state of the AT1 receptor

Takanobu Takezako, Hamiyet Unal, Sadashiva S. Karnik, Koichi Node

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Angiotensin II increases angiogenesis by NF-κB-mediated transcriptional activation of angiogenic factor AGGF1

Wenxia Si, Wen Xie, Wenbing Deng, Yi Xiao, Sadashiva S. Karnik, Chengqi Xu, Qiuyun Chen, Qing Kenneth Wang

FASEB JOURNAL (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Na(v)1.5

Zhijie Wang, Gang Yu, Yinan Liu, Shiyong Liu, Meir Aridor, Yuan Huang, Yushuang Hu, Longfei Wang, Sisi Li, Hongbo Xiong, Bo Tang, Xia Li, Chen Cheng, Susmita Chakrabarti, Fan Wang, Qingyu Wu, Sadashiva S. Karnik, Chengqi Xu, Qiuyun Chen, Qing K. Wang

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Add to Collection

Article Peripheral Vascular Disease

Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril

Preenie deS Senanayake, Vera L. Bonilha, John W. Peterson, Yoshiro Yamada, Sadashiva S. Karnik, Firouz Daneshgari, K. Bridget Brosnihan, Joe G. Hollyfield

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2018)

Add to Collection

Article Multidisciplinary Sciences

A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks

Sathyamangla V. Naga Prasad, Manveen K. Gupta, Zhong-Hui Duan, Venkata Suresh K. Surampudi, Chang-Gong Liu, Ashwin Kotwal, Christine S. Moravec, Randall C. Starling, Dianne M. Perez, Subha Sen, Qingyu Wu, Edward F. Plow, Sadashiva Karnik

PLOS ONE (2017)

Add to Collection

Article Chemistry, Medicinal

Mechanism of Hormone Peptide Activation of a GPCR: Angiotensin II Activated State of AT(1)R Initiated by van der Waals Attraction

Khuraijam Dhanachandra Singh, Hamiyet Unal, Russell Desnoyer, Sadashiva S. Karnik

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)

Add to Collection

Letter Cardiac & Cardiovascular Systems

Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin II Receptor Blockers A Comparison of Outcomes in Patients With COVID-19

Ankur Kalra, Edward S. Hawkins, Amy S. Nowacki, Vardhmaan Jain, Alex Milinovich, Joshua Saef, George Thomas, Surafel K. Gebreselassie, Sadashiva S. Karnik, Lara Jehi, James B. Young, Lars G. Svensson, Mina K. Chung, Neil Mehta

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Current Trends in GPCR Allostery

Khuraijam Dhanachandra Singh, Sadashiva S. Karnik

Summary: GPCRs are a crucial drug target, with novel approaches like allosteric drugs showing promise in modulating receptor signaling. Classic drugs may lead to severe side effects, while allosteric drugs offer a way to maintain beneficial receptor signaling without blocking endogenous ligand binding.

JOURNAL OF MEMBRANE BIOLOGY (2021)

Add to Collection

Article Peripheral Vascular Disease

β-Arrestin-Biased Agonist Targeting the Brain AT1R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension

Mario Zanaty, Fernando A. C. Seara, Pablo Nakagawa, Guorui Deng, Natalia M. Mathieu, Kirthikaa Balapattabi, Sadashiva S. Karnik, Justin L. Grobe, Curt D. Sigmund

Summary: The study found that intracerebroventricular administration of TRV027 can increase aversion to saline and lower blood pressure in a model of salt-sensitive hypertension. Both TRV027 and losartan increased aversion to saline, with a more pronounced effect on highly aversive saline solutions.

HYPERTENSION (2021)

Add to Collection

Article Pharmacology & Pharmacy

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Stephen P. H. Alexander, Eamonn Kelly, Neil V. Marrion, John A. Peters, Elena Faccenda, Simon D. Harding, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, O. Peter Buneman, John A. Cidlowski, Arthur Christopoulos, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jorg Striessnig, Jamie A. Davies, M. P. Abbracchio, R. Aldrich, K. Al-Hosaini, T. Arumugam, B. Attali, M. Back, N. M. Barnes, R. Bathgate, P. M. Beart, E. Becirovic, B. Bettler, M. Biel, N. J. Birdsall, V Blaho, D. Boison, H. Brauner-Osborne, S. Broer, C. Bryant, G. Burnstock, G. Calo, W. A. Catterall, S. Ceruti, S. L. Chan, K. G. Chandy, P. Chazot, N. Chiang, J. J. Chun, J. J. Chung, D. E. Clapham, L. Clapp, M. A. Connor, H. M. Cox, P. Davies, P. A. Dawson, P. Decaen, G. Dent, P. Doherty, S. D. Douglas, M. L. Dubocovich, T. M. Fong, C. J. Fowler, A. Frantz, P. Fuller, M. Fumagalli, A. H. Futerman, R. R. Gainetdinov, M. A. Gershengorn, A. Goldin, S. Goldstein, C. Goudet, K. Gregory, S. Grissmer, A. L. Gundlach, B. Hagenbuch, J. Hamann, J. R. Hammond, J. C. Hancox, J. Hanson, I Hanukoglu, D. L. Hay, A. J. Hobbs, A. N. Hollenberg, N. D. Holliday, D. Hoyer, A. P. Ijzerman, K. I. Inui, A. J. Irving, S. Ishii, K. A. Jacobson, L. Y. Jan, M. F. Jarvis, R. Jensen, R. Jockers, L. K. Kaczmarek, Y. Kanai, S. Karnik, S. Kellenberger, S. Kemp, C. Kennedy, I. D. Kerr, Y. Kihara, J. Kukkonen, D. Larhammar, K. Leach, D. Lecca, S. Leeman, J. Leprince, S. J. Lolait, D. Macewan, J. J. Maguire, F. Marshall, J. Mazella, C. A. Mcardle, M. C. Michel, L. J. Miller, L. J. Miller, H. Mizuno, P. N. Monk, B. Mouillac, P. M. Murphy, J. L. Nahon, J. Nerbonne, C. G. Nichols, X. Norel, S. Offermanns, L. G. Palmer, M. A. Panaro, A. Papapetropoulos, E. Perez-Reyes, R. G. Pertwee, R. G. Pertwee, J. R. Pisegna, L. D. Plant, D. R. Poyner, E. R. Prossnitz, S. Pyne, R. Ramachandran, D. Ren, P. Rondard, C. Ruzza, H. Sackin, G. Sanger, M. C. Sanguinetti, L. Schild, H. Schioth, G. Schulte, S. Schulz, D. L. Segaloff, C. N. Serhan, K. D. Singh, P. A. Slesinger, T. P. Snutch, C. G. Sobey, G. Stewart, L. A. Stoddart, R. J. Summers, C. Szabo, D. Thwaites, L. Toll, J. S. Trimmer, S. Tucker, H. Vaudry, T. Verri, J. P. Vilargada, S. A. Waldman, D. T. Ward, S. G. Waxman, A. D. Wei, G. B. Willars, S. S. Wong, T. M. Woodruff, H. Wulff, R. D. Ye, Y. Yung, J. M. Zajac

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

A filamin phosphorylation gateway to GPCR function

Sujay Subbayya Ithychanda, Kevin Dou, Sadashiva Karnik, Jun Qin

FASEB JOURNAL (2017)

Add to Collection

Review Pharmacology & Pharmacy

Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22

Sadashiva S. Karnik, Khuraijam Dhanachandra Singh, Kalyan Tirupula, Hamiyet Unal

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.