Editorial Material
Genetics & Heredity
Changuk Chung, Xiaoxu Yang, Joseph G. Gleeson
Summary: Brain somatic mosaicism, which is linked to several neurological disorders, may be caused by pre-zygotic aneuploidy followed by post-zygotic partial reversion. This study suggests a recurrent form of epilepsy related to brain mosaicism.
Review
Cell Biology
Mingyue Zheng, Guoxiang Jin, Zhongjun Zhou
Summary: Lamins, ancient intermediate filament proteins, are functionally regulated by post-translational modifications, contributing to various biological functions. Deregulation of lamins is associated with abnormal nuclear morphology and chromatin disorganization, leading to diseases. Understanding these modifications provides new insights into the molecular mechanisms underlying diseases and potential therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Dimitrios Tsikas
Summary: Lysine residues in proteins undergo various chemical modifications, including carbonylation by glyoxal (GO) and methylglyoxal (MGO). Malondialdehyde (MDA) is another carbonyl species formed enzymatically and nonenzymatically. These carbonyl species can occur in free forms or be adducted to proteins, particularly lysine residues. MDA is commonly used as a biomarker of lipid peroxidation, with plasma and serum being the most frequently analyzed samples. However, preanalytical factors, such as artificial MDA formation in lipid-rich samples, can greatly affect MDA concentrations.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dan Wu, Tao Liu
Summary: Understanding post-translational modifications is crucial for manipulating physiological processes in eukaryotes. Genetic code expansion technology has been used to investigate the roles of these modifications, and can be combined with synthetic biology to create genetically modified organisms. This article discusses the applications, limitations, and future perspectives of genetic code expansion technology for studying post-translational modifications, as well as the implications for genetically modified organisms.
Article
Biochemistry & Molecular Biology
Sharon L. Campbell, Mark R. Philips
Summary: Mutations in RAS genes are the most common driving force behind cancer development. RAS proteins, acting as binary molecular switches, control cellular growth through a complex signaling pathway. In addition to nucleotide-binding properties, RAS proteins are also regulated by numerous post-translational modifications, which are currently a high priority for drug discovery research in the field of RAS biology.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Qibin Wu, Zhenxiang Li, Jingtao Yang, Fu Xu, Xueqin Fu, Liping Xu, Chuihuai You, Dongjiao Wang, Yachun Su, Youxiong Que
Summary: This study reports the first comprehensive analysis of protein lysine acetylation, 2-hydroxyisobutyrylation, and lysine lactylation in sugarcane. These post-translational modifications were found to be involved in energy metabolism and stress response. The results provide new insights into the molecular mechanisms of protein PTMs in sugarcane.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Oncology
Ana Gonzalez-Garcia, Antonio Garrido, Ana C. Carrera
Summary: Genetic alterations in the PI3-kinase/PTEN pathway are common in cancer cells. Current efforts to treat PTEN-dependent tumors mainly focus on PI3-kinase inhibition, but modulating PTEN post-translational modifications could provide alternative therapeutic strategies.
Review
Biochemistry & Molecular Biology
Lynsay Blake, Martin J. Cann
Summary: Carbon dioxide plays a crucial role in various life processes, regulating cellular reactions, transport, maintenance, and behavior. Protein carbamate modification, mediated by carbon dioxide, is a mechanism that may alter protein function and participate in sensing and signaling.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Min-Seon Hwang, Jingyeong Park, Yunha Ham, In Hye Lee, Kyung-Hee Chun
Summary: Adipocyte senescence, caused by factors like DNA damage, oxidative stress, telomere dysfunction, and chronic lipid accumulation, can disrupt metabolic homeostasis and lead to various diseases and aging. Understanding the role of post-translational modifications (PTMs) in the regulation of adipocyte senescence is crucial for developing effective strategies to combat metabolic diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Veterinary Sciences
Tong Zhou, Mingshu Wang, Anchun Cheng, Qiao Yang, Bin Tian, Ying Wu, Renyong Jia, Shun Chen, Mafeng Liu, Xin-Xin Zhao, Xuming Ou, Sai Mao, Di Sun, Shaqiu Zhang, Dekang Zhu, Juan Huang, Qun Gao, Yanling Yu, Ling Zhang
Summary: This article mainly describes the viral protein kinases and their mechanisms of regulating viral protein function through phosphorylation. The study of post-translational modification of viral proteins is of great significance for understanding viral infection mechanisms and developing antiviral treatment.
VETERINARY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jing Xia, Songhong Jiang, Shiqi Dong, Yonghong Liao, Yang Zhou
Summary: Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) activate the NLRP3 inflammasome, leading to the production of active caspase-1, interleukin-1 beta (IL-1 beta), and gasdermin D (GSDMD), resulting in pyroptosis and inflammation. Dysregulated NLRP3 inflammasome activation is implicated in various diseases, making it a potential target for disease prevention and treatment. Recent studies have demonstrated that post-translational modifications (PTMs) play a crucial role in regulating NLRP3 inflammasome activity. This review focuses on PTMs of NLRP3 inflammasome components and their impact on its activity regulation, providing insights into the mechanisms underlying NLRP3 inflammasome activation and control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Sony Shrestha, Amuza Byaruhanga Lucky, Awtum Marie Brashear, Xiaolian Li, Liwang Cui, Jun Miao
Summary: This study profiled the histone post-translational modifications (PTMs) in the development of Plasmodium falciparum gametocytes, revealing novel PTM sites and distinct patterns from asexual stages. The results suggest that these PTMs play critical roles in gametocyte development and provide insights into the epigenetic regulation in the life cycle of the malaria parasite.
JOURNAL OF PROTEOME RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Mabel Buelna-Chontal, Wylly R. Garcia-Nino, Alejandro Silva-Palacios, Cristina Enriquez-Cortina, Cecilia Zazueta
Summary: Post-translational modifications based on redox reactions play a crucial role in regulating signaling pathways in physiological and pathological conditions. These modifications are dependent on the generation of redox components, such as reactive oxygen species and nitric oxide, and can impact protective signaling in reperfused hearts. Cardioprotective conditioning strategies have been shown to influence these changes at various subcellular levels, particularly in mitochondria. Additionally, potential redox-based therapeutic strategies against reperfusion damage are discussed.
Article
Biochemistry & Molecular Biology
Filippo Mori, Letizia Natali, Romano Danesi, Silvia Nannizzi, Claudio Farina
Summary: The study examined seven commercially available HSA preparations for clinical use and found differences in PTMs among different commercial albumins. Additionally, an increase in HSA-DA isoform and new oxidative modifications were observed in these samples at the end of the stability time.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Li Cao, Moshe Beiser, Joseph D. Koos, Margarita Orlova, Hader E. Elashal, Hendrik V. Schroder, A. James Link
Summary: Lasso peptides are a family of ribosomally synthesized and post-translationally modified peptides with a threaded structure. PIMT enzymes play a new role in the post-translational modification of lasso peptides, methylating and converting L-aspartate residues to provide rigidity to the lasso peptide ring.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Gen Kaneko, Tatsuki Yoshinaga, Kristin E. Gribble, David M. Welch, Hideki Ushio
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Article
Cell Biology
Vladimir B. Teif, Jan-Philipp Mallm, Tanvi Sharma, David B. Mark Welch, Karsten Rippe, Roland Eils, Joerg Langowski, Ada L. Olins, Donald E. Olins
Article
Cell Biology
Vladimir B. Teif, Jan-Philipp Mallm, Tanvi Sharma, David B. Mark Welch, Karsten Rippe, Roland Eils, Joerg Langowski, Ada L. Olins, Donald E. Olins
Article
Cell Biology
Kristin E. Gribble, George Jarvis, Martha Bock, David B. Mark Welch
Article
Geriatrics & Gerontology
Kristin E. Gribble, Oksana Kaido, George Jarvis, David B. Mark Welch
EXPERIMENTAL GERONTOLOGY
(2014)
Article
Reproductive Biology
Terry W. Snell, Rachel K. Johnston, Kristin E. Gribble, David B. Mark Welch
INVERTEBRATE REPRODUCTION & DEVELOPMENT
(2015)
Article
Multidisciplinary Sciences
Jean-Francois Flot, Boris Hespeels, Xiang Li, Benjamin Noel, Irina Arkhipova, Etienne G. J. Danchin, Andreas Hejnol, Bernard Henrissat, Romain Koszul, Jean-Marc Aury, Valerie Barbe, Roxane-Marie Barthelemy, Jens Bast, Georgii A. Bazykin, Olivier Chabrol, Arnaud Couloux, Martine Da Rocha, Corinne Da Silva, Eugene Gladyshev, Philippe Gouret, Oskar Hallatschek, Bette Hecox-Lea, Karine Labadie, Benjamin Lejeune, Oliver Piskurek, Julie Poulain, Fernando Rodriguez, Joseph F. Ryan, Olga A. Vakhrusheva, Eric Wajnberg, Benedicte Wirth, Irina Yushenova, Manolis Kellis, Alexey S. Kondrashov, David B. Mark Welch, Pierre Pontarotti, Jean Weissenbach, Patrick Wincker, Olivier Jaillon, Karine Van Doninck
Article
Evolutionary Biology
Bette J. Hecox-Lea, David B. Mark Welch
BMC EVOLUTIONARY BIOLOGY
(2018)
Article
Geriatrics & Gerontology
Kristin E. Gribble, Benjamin M. Moran, Shannon Jones, Emily L. Corey, David B. Mark Welch
EXPERIMENTAL GERONTOLOGY
(2018)
Article
Plant Sciences
Pieter R. Gurdebeke, Kenneth N. Mertens, Vera Pospelova, Kazumi Matsuoka, Zhen Li, Kristin E. Gribble, Haifeng Gu, Kara Bogus, Henk Vrielinck, Stephen Louwye
Article
Multidisciplinary Sciences
Martha J. Bock, George C. Jarvis, Emily L. Corey, Emily E. Stoner, Kristin E. Gribble
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Evgeny Ivashkin, Victoria Melnikova, Anastasia Kurtova, Nadja R. Brun, Alexandra Obukhova, Marina Yu Khabarova, Alexander Yakusheff, Igor Adameyko, Kristin E. Gribble, Elena E. Voronezhskaya
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Christina M. Hernandez, Silke F. van Daalen, Hal Caswell, Michael G. Neubert, Kristin E. Gribble
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biotechnology & Applied Microbiology
Kristin E. Gribble, David B. Mark Welch