Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Review
Medicine, General & Internal
Mourad Kourie, Darko Bogdanovic, Kamran Mahmutyazicioglu, Sam Ghazi, Nikola Panic, Eva Fjellgren, Laila Hellkvist, Tomas Thiel, Anders Kjellman, Nikolaos Kartalis, Olof Danielsson, Lara Dani, J. -Matthias Lohr, Miroslav Vujasinovic
Summary: Immunoglobulin G4-related disease is an immune-mediated condition that can affect various organs. This article reports a case of autoimmune pancreatitis with involvement of the testicles and nasal cavity, which is a rare occurrence. Creating awareness of this rare clinical condition is important due to the availability of highly effective treatments with corticosteroids and rituximab.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. Delanghe, Marijn M. Speeckaert
Summary: Advanced glycation end products (AGEs) are compounds formed by nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. These AGEs can alter protein structure and activate the receptor for advanced glycation end products (RAGE). RAGE is expressed by various cells and plays a role in chronic inflammatory autoimmune disorders. Soluble RAGE (sRAGE) acts as a decoy and inhibits pro-inflammatory processes mediated by RAGE. AGE overproduction, low sRAGE concentrations, and certain RAGE polymorphisms are associated with rheumatic diseases and cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Qing Yue, Yu Song, Zi Liu, Lin Zhang, Ling Yang, Jinlong Li
Summary: RAGE, as a critical molecule in inflammatory response, binds to various ligands and initiates intracellular signal cascade. It plays a vital role in the occurrence and development of immune-related diseases and has crucial functions in different aspects of life activities. Therefore, targeted intervention in the RAGE signaling pathway may have significant therapeutic potential.
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
M. Vijaykrishnaraj, Kuiwu Wang
Summary: Natural products found in various natural foods have potential biological activities, including plants, fruits, vegetables, and marine life. The biochemical reaction known as advanced glycation end products (AGEs) in the human body contributes to the pathogenesis of diabetic complications. Researchers are exploring the use of food-derived natural products to control AGEs-related disease complications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Endocrinology & Metabolism
Xingyu Zhang, Xiaoyu Chen, Shengjie Li, Mengze Gao, Peipei Han, Liou Cao, Jing Gao, Qiongying Tao, Jiayi Zhai, Dongyu Liang, Li Qin, Qi Guo
Summary: This study found that elevated levels of AGEs are associated with sarcopenia, but not with presarcopenia. Osteoporosis plays a partial mediating role in the association between AGEs and sarcopenia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun, Yu-Bo Fan
Summary: AGEs negatively impact the mechanosensitivity of osteocytes, affecting the bone remodeling process. This study provides a new perspective on exploring the mechanism of osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Patricia Budihartanti Liman, Karina Shasri Anastasya, Nabila Maudy Salma, Yenny Yenny, Meutia Atika Faradilla
Summary: The aim of this study was to analyze scientific articles on advanced glycation end products (AGEs) and obesity using bibliometric methods. The results showed an increase in studies on processed foods and obesity, with the United States making the largest contribution in this field. Open access journals had higher citation numbers and younger publication years compared to closed access journals.
Article
Immunology
Kenta Nagahori, Shuichi Hirai, Naoyuki Hatayama, Miyuki Kuramasu, Takuya Omotehara, Shinichi Kawata, Zhonglian Li, Hidenobu Miyaso, Yuki Ogawa, Ning Qu, Hayato Terayama, Shogo Hayashi, Shuang-Qin Yi, Munekazu Naito, Masahiro Itoh
Summary: By screening a phage display library of TGC peptides, self-antigens that induce EAO have been identified, with GIT1 and HSPA4L emerging as candidate AIAgs. Immunization with HSPA4L in complete Freund's adjuvant resulted in 100% EAO incidence, indicating its potency in inducing EAO. These findings have the potential to improve diagnostic and treatment procedures for immunological infertility in men.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Govigerel Bayarsaikhan, Delger Bayarsaikhan, Pyung Chun Oh, Woong Chol Kang, Bonghee Lee
Summary: Researchers investigated the utility of AGEs as prognostic biomarkers for AMI and found that CUPRAC-reactive AGEs exhibit various patterns of changes in serum samples of AMI patients.
Article
Biochemistry & Molecular Biology
Yongning Lu, Amir Rafiq, Zhengguo Zhang, Ferial Aslani, Monika Fijak, Tao Lei, Ming Wang, Sanjeev Kumar, Joerg Klug, Martin Bergmann, Trinad Chakraborty, Andreas Meinhardt, Sudhanshu Bhushan
Article
Obstetrics & Gynecology
Monika Fijak, Adrian Pilatz, Mark P. Hedger, Nour Nicolas, Sudhanshu Bhushan, Vera Michel, Kenneth S. K. Tung, Hans-Christian Schuppe, Andreas Meinhardt
HUMAN REPRODUCTION UPDATE
(2018)
Article
Cell Biology
Lene N. Nejsum, Adrian Piec, Monika Fijak, Christina Ernstsen, Dania Fischer, Thorsten J. Maier, Ralf Kinscherf, Rainer Hofmann, Anja Urbschat
CELL AND TISSUE RESEARCH
(2019)
Article
Urology & Nephrology
A. Pilatz, M. Fijak, F. Wagenlehner, H-C. Schuppe
Article
Obstetrics & Gynecology
A. Christine Kauerhof, Nour Nicolas, Sudhanshu Bhushan, Eva Wahle, Kate A. Loveland, Daniela Fietz, Martin Bergmann, Nigel P. Groome, Sabine Kliesch, Hans-Christian Schuppe, Adrian Pilatz, Andreas Meinhardt, Mark P. Hedger, Monika Fijak
HUMAN REPRODUCTION
(2019)
Article
Cell Biology
Rukmali Wijayarathna, Alen Pasalic, Nour Nicolas, Sneha Biniwale, Rama Ravinthiran, Rosemary Genovese, Julie A. Muir, Kate L. Loveland, Andreas Meinhardt, Monika Fijak, Mark P. Hedger
CELL AND TISSUE RESEARCH
(2020)
Review
Immunology
Sudhanshu Bhushan, Maria S. Theas, Vanesa A. Guazzone, Patricia Jacobo, Ming Wang, Monika Fijak, Andreas Meinhardt, Livia Lustig
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
Livia Lustig, Vanesa A. Guazzone, Maria S. Theas, Christiane Pleuger, Patricia Jacobo, Cecilia V. Perez, Andreas Meinhardt, Monika Fijak
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Ming Wang, Yalong Yang, Dilay Cansever, Yiming Wang, Crystal Kantores, Sebastien Messiaen, Delphine Moison, Gabriel Livera, Svetoslav Chakarov, Tobias Weinberger, Christopher Stremmel, Monika Fijak, Britta Klein, Christiane Pleuger, Zhexiong Lian, Wentao Ma, Qingzhi Liu, Kathrin Klee, Kristian Handler, Thomas Ulas, Andreas Schlitzer, Joachim L. Schultze, Burkhard Becher, Melanie Greter, Zhaoyuan Liu, Florent Ginhoux, Slava Epelman, Christian Schulz, Andreas Meinhardt, Sudhanshu Bhushan
Summary: Macrophages in the testis and epididymis originate from different stages of cell development and can self-maintain independently of bone marrow hematopoietic cells in a steady state. However, during radiation-induced macrophage ablation or infection, bone marrow-derived cells are recruited to the testis and epididymis, leading to an inflammatory response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Tao Lei, Sandra M. Blois, Nancy Freitag, Martin Bergmann, Sudhanshu Bhushan, Eva Wahle, Annie Chi-Chun Huang, Hung-Lin Chen, Michaela F. Hartmann, Stefan A. Wudy, Fu-Tong Liu, Andreas Meinhardt, Monika Fijak
Summary: Galectin 3 plays a crucial role in testicular physiology by regulating spermatogenesis initiation and testosterone biosynthesis, which ultimately affects testicular weight and reproductive function. Through its involvement in preventing germ cell apoptosis and controlling testosterone production, Galectin 3 serves as a key factor in the development of germ cells and steroidogenesis, offering potential biomarkers for testicular function.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Elena Berg, Petr Houska, Nils Nesheim, Hans-Christian Schuppe, Adrian Pilatz, Monika Fijak, Marc Manthey, Klaus Steger, Florian Wagenlehner, Undraga Schagdarsurengin
Summary: This study compares CP/CPPS patients and healthy volunteers, finding increased sperm DNA fragmentation and abnormal protamine levels in CP/CPPS patients, which have a negative impact on fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fabian Hemm, Monika Fijak, Jan Belikan, Marian Kampschulte, Thaqif El Khassawna, Adrian Pilatz, Christian Heiss, Katrin Susanne Lips
Summary: The study investigated the impact of testicular dysfunction in a rodent model of experimental autoimmune-orchitis on bone status. Results showed altered bone metabolism, loss of bone mass and mineralization, and changes in biomechanical properties mainly caused by the adjuvant rather than the autoimmune-orchitis itself. Therefore, the transfer of laboratory findings to clinical application using the EAO model may be limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Hiba Hasan, Sudhanshu Bhushan, Monika Fijak, Andreas Meinhardt
Summary: Infection and inflammation are relevant factors that can lead to male reproductive disorders, causing damage to the testis and affecting spermatogenesis and steroidogenesis. Increased levels of oxidative stress and pro-inflammatory cytokines negatively impact germ cells. The activation of inflammatory pathways is a common feature in male testicular disorders beyond established infectious/inflammatory cues.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Peng, Artem Kepsch, Till O. Kracht, Hiba Hasan, Rukmali Wijayarathna, Eva Wahle, Christiane Pleuger, Sudhanshu Bhushan, Stefan Guenther, A. Christine Kauerhof, Ana Planinic, Daniela Fietz, Hans-Christian Schuppe, Malgorzata Wygrecka, Kate L. Loveland, Davor Jezek, Andreas Meinhardt, Mark P. Hedger, Monika Fijak
Summary: Experimental autoimmune-orchitis (EAO), a rodent model of chronic testicular inflammation and fibrosis, replicates pathogenic changes seen in some cases of human spermatogenic disturbances. CCR2 and activin A promote fibrosis during testicular inflammation by regulating macrophage function.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biology
Christiane Pleuger, Dingding Ai, Minea L. Hoppe, Laura T. Winter, Daniel Bohnert, Dominik Karl, Stefan Guenther, Slava Epelman, Crystal Kantores, Monika Fijak, Sarina Ravens, Ralf Middendorff, Johannes U. Mayer, Kate L. Loveland, Mark Hedger, Sudhanshu Bhushan, Andreas Meinhardt, Wei Yan
Summary: The epididymis exhibits region-specific immune responses, with inflammation being more pronounced in the distal regions compared to the proximal regions. Through studies using a mouse model and analysis of human cells, it was found that resident immune cells in the epididymis show significant heterogeneity in distribution, potentially providing different immunological environments to address immunological challenges.