Article
Biochemistry & Molecular Biology
I. Patlan, M. P. Jeffrey, D. Lewis, J. Green-Johnson, S. Dogra
Summary: This study compared the effects of exercise in cold-dry and normal conditions on salivary cytokine levels and airway response in young healthy males. The results showed that IL-8 levels increased in normal conditions but not in cold-dry conditions, while the opposite trend was observed for IL-1RA.
Article
Immunology
Grzegorz Majka, Henryk Mazurek, Magdalena Strus, Marta Ciszek-Lenda, Rafal Szatanek, Agnieszka Pac, Edyta Golinska, Janusz Marcinkiewicz
Summary: The high concentration of sputum bacteria in cystic fibrosis patients with advanced lung disease is associated with increased levels of inflammatory markers and low levels of certain cytokines. Specific inflammatory biomarkers including blood CRP, NLR, and sputum elastase, IL-6, IL-8, and IL-10 are recommended for monitoring the disease.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dan Mao, Hiroshi Inoue, Takuya Notomi, Seiji Goda
Summary: The p38a isoform is crucial for TNF-a-induced IL-8 production in Ca9-22 cells, and its activation is associated with the phosphorylation of threonine 180 and tyrosine 182. This study highlights p38a as a potential therapeutic target for preventing and treating periodontal disease.
Review
Immunology
Lauren A. Zenewicz
Summary: Cytokines, including IL-22, play crucial roles in inflammation, with their activity regulated by factors like IL-22BP. IL-22BP, a soluble receptor homolog, binds to IL-22 with greater affinity, impacting the biological functions of IL-22, yet further research is needed to fully understand its role and regulation mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michal Tomaszewski, Paulina Mertowska, Martyna Janczewska, Agnieszka Styczen, Sebastian Mertowski, Kamil Jonas, Ewelina Grywalska, Grzegorz Kopec
Summary: Pulmonary arterial hypertension (PAH) is a complex disorder where cytokines play a crucial role in deregulation of the immune system. This study found that PAH patients have abnormal immune function with decreased percentages of immune cell subpopulations and changes in cytokine concentration. Furthermore, significant differences were observed between PAH subtypes and immunological parameters, suggesting the important role of the immune system in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiaofei Xu, Errol Prens, Edwin Florencia, Pieter Leenen, Luis Boon, Patrick Asmawidjaja, Anne-Marie Mus, Erik Lubberts
Summary: The up-regulation of IL-19 and IL-24 induced by IL-17A in skin stromal cells contributes to keratinocyte proliferation. Depletion of IL-10 leads to increased expression of IL-23/IL-17 pathway related cytokines followed by significant up-regulation of IL-19 and IL-24.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Huy Quang Quach, Christina Johnson, Karin Ekholt, Rakibul Islam, Tom Eirik Mollnes, Per H. Nilsson
Summary: In this study, we investigated the role of thrombin and platelets in interleukin 8 (IL-8) release. Our findings suggest that IL-8 release is mediated by leukocytes, mainly monocytes, but is potentiated by thrombin-dependent activation of platelets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Gang Liu, Xiang-Ting Chen, Hao Zhang, Xin Chen
Summary: This study investigated the relationship between changes in peripheral blood VEGF, IL-5, IL-6, IL-8, and IL-17 concentrations in breast cancer patients and their significance in breast cancer staging and invasive metastasis. The results showed that IL-6, IL-17, and VEGF were strongly associated with breast cancer development and could be used as reference indicators for diagnosis and postoperative follow-up.
FRONTIERS IN ONCOLOGY
(2022)
Article
Microbiology
Zane Vitenberga-Verza, Mara Pilmane, Ksenija Serstnova, Ivars Melderis, Lukasz Gontar, Maksymilian Kochanski, Andzelika Drutowska, Gergely Maroti, Beatriz Prieto-Simon
Summary: This study aimed to investigate the inflammatory and regulatory cytokines in the milk of dairy cows with subclinical and clinical mastitis. The results showed that IL-1 alpha, IL-4, and IL-17A drive the inflammatory responses in mastitis cases. Furthermore, the host defense response in mastitis is characterized by the continuation or resolution of the initial inflammation.
Article
Clinical Neurology
Xiao Liu, Jingjing Huang, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Peng Yu, Jianyong Ma, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: This study investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that levels of IL-6 and IL-8 were positively correlated with symptoms of depression, suggesting they may play a role in the pathogenesis of psychological disorders. However, these associations were not significant after multiple testing. Larger and longitudinal studies are needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Vilotic, Mirjana Nacka-Aleksic, Andrea Pirkovic, Zanka Bojic-Trbojevic, Dragana Dekanski, Milica Jovanovic Krivokuca
Summary: This review summarizes the role of interleukin-6 (IL-6) and interleukin-8 (IL-8) in healthy and pathological pregnancies. The authors provide an overview of the expression of these cytokines during pregnancy and discuss their involvement in pregnancy establishment, parturition, and various pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xiaoli Ren, Yuying Fan, Dongmei Shi, Yun Liu
Summary: Mammary gland tumors are a common malignant disease that poses a serious threat to women and female dogs. The lack of an effective tumor marker hinders the early diagnosis and prognosis of these tumors in veterinary clinical medicine. This study investigated the expression of IL-6, IL-8, and IL-10 in canine mammary gland tumors to determine their association with tumor progression. The results suggest that IL-6 and IL-8 could potentially serve as diagnostic or biomarkers for canine mammary gland tumors.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Aurelie Najm, Iain B. McInnes
Summary: IL-23, a pro-inflammatory cytokine secreted by dendritic cells and macrophages, plays a key role in the pathogenesis of rheumatic diseases by promoting T cell differentiation into Th17 cells. Therapeutic strategies targeting IL-23 have shown efficiency in PsA but not yet in RA.
Article
Oncology
Paul Katongole, Obondo J. Sande, Sheilla Nabweyambo, Moses Joloba, Henry Kajumbula, Samuel Kalungi, Steven J. Reynolds, Kenneth Ssebambulidde, Maxine Atuheirwe, Jackson Orem, Nixon Niyonzima
Summary: The study found that plasma levels of proinflammatory cytokines IL-6 and IL-8 were elevated in prostate cancer patients, potentially related to disease progression and levels of prostate-specific antigen.
Article
Immunology
Elisa Toppi, Laura Sireno, Micaela Lembo, Nerisa Banaj, Beatrice Messina, Sedigheh Golesorkhtafti, Gianfranco Spalletta, Paola Bossu
Summary: Homotaurine is a potential therapeutic compound for Alzheimer's disease (AD) and has anti-inflammatory properties. This study suggests that supplementation of homotaurine in patients with mild cognitive impairment (MCI) increases the levels of anti-inflammatory cytokines IL-10 and IL-33, while decreasing the levels of pro-inflammatory cytokine IL-18. The elevation of IL-10 and IL-33 is associated with improved episodic memory in treated patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Tom Tanbo, Gareth Greggains, Ritsa Storeng, Bjorn Busund, Anton Langebrekke, Peter Fedorcsak
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2015)
Article
Obstetrics & Gynecology
Mette Haug Stensen, Tom Gunnar Tanbo, Ritsa Storeng, Thomas Abyholm, Peter Fedorcsak
FERTILITY AND STERILITY
(2015)
Letter
Obstetrics & Gynecology
Heidi Tiller, Peter Fedorcsak, Bjorn R. Skogen
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2016)
Article
Obstetrics & Gynecology
Miriam Landfors, Sigve Nakken, Markus Fusser, John-Arne Dahl, Arne Klungland, Peter Fedorcsak
FERTILITY AND STERILITY
(2016)
Article
Multidisciplinary Sciences
John Arne Dahl, Inkyung Jung, Havard Aanes, Gareth D. Greggains, Adeel Manaf, Mads Lerdrup, Guoqiang Li, Samantha Kuan, Bin Li, Ah Young Lee, Sebastian Preissl, Ingunn Jermstad, Mads Haugland Haugen, Rajikala Suganthan, Magnar Bjoras, Klaus Hansen, Knut Tomas Dalen, Peter Fedorcsak, Bing Ren, Arne Klungland
Article
Obstetrics & Gynecology
Hilde Jorgensen, Abby S. Hill, Michael T. Beste, Manu P. Kumar, Evan Chiswick, Peter Fedorcsak, Keith B. Isaacson, Douglas A. Lauffenburger, Linda G. Griffith, Erik Qvigstad
FERTILITY AND STERILITY
(2017)
Article
Obstetrics & Gynecology
Rasa Pelanis, Jan Roar Mellembakken, Inger Sundstr MPoromaa, Pernille Ravn, Laure Morin-Papunen, Juha S. Tapanainen, Terhi Piltonen, Johanna Puurunen, Angelica Linden Hirschberg, Peter Fedorcsak, Marianne Andersen, Dorte Glintborg
HUMAN REPRODUCTION
(2017)
Article
Biochemical Research Methods
Arne Klungland, John Arne Dahl, Gareth Greggains, Peter Fedorcsak, Adam Filipczyk
Article
Cell Biology
Miriam Landfors, Jostein Johansen, Jan Magnus Aronsen, Cathrine Broberg Vagbo, Louis C. Dore, Chuan He, Ivar Sjaastad, Pal Saetrom, Peter Fedorcsak, John Arne Dahl, Havard Aanes, Markus Fusser, Arne Klungland
Review
Obstetrics & Gynecology
Tom G. Tanbo, Peter Z. Fedorcsak
Summary: Despite the increase in mean menopausal age over the last century, there is significant individual variation in natural menopause age. Women are now able to choose when to have children due to efficient contraception methods, leading to a significant increase in age at first birth. Fertility declines long before menopause, making it important but difficult to predict when a woman will enter menopause.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Obstetrics & Gynecology
M. A. Riegler, M. H. Stensen, O. Witczak, J. M. Andersen, S. A. Hicks, H. L. Hammer, E. Delbarre, P. Halvorsen, A. Yazidi, N. Holst, T. B. Haugen
Summary: In recent years, there has been an exponential increase in data generated in the field of ART, with a diverse range from videos to tabular data. Artificial intelligence (AI) is progressively being used in medical practice, especially in fertility clinics, to potentially improve success rates. AI models are being developed to address the lack of objectivity in critical procedures, such as embryo and sperm assessments, but there are still challenges to overcome in order to fully utilize AI in ART.
HUMAN REPRODUCTION
(2021)
Article
Andrology
Mario Iliceto, Mette Stensen, Jorunn Andersen, Trine Haugen, Oliwia Witczak
Summary: This study found that free seminal L-carnitine levels are associated with sperm fatty acid composition and semen quality, but not with BMI.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Correction
Obstetrics & Gynecology
A. Sharma, T. Haugen, H. Hammer, M. Riegler, M. Stensen
HUMAN REPRODUCTION
(2021)
Review
Obstetrics & Gynecology
Tom Tanbo, Peter Fedorcsak
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2017)