Article
Biochemistry & Molecular Biology
Guangyi Cao
Summary: The correct assembly and regulation of the spindle apparatus are crucial for the precise separation of chromosomes in mouse oocytes. NUSAP1 is a spindle-associated protein that plays an important role in oocyte meiosis maturation. Its depletion leads to chromosome misalignment, aneuploidy, and abnormal spindle assembly.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Hao Qin, Yi Qu, Yi-Feng Yuan, Yang-Yang Li, Jie Qiao
Summary: This study revealed that RBM14 is down-regulated in oocytes from old mice and shows overlapped localization patterns with alpha-tubulin in different stages of meiosis. Knockdown of RBM14 may result in symmetric division of oocytes, spindle defects, and chromosome abnormalities. Additionally, RBM14 interacts with endogenous alpha-tubulin and modulates oocyte meiotic maturation by affecting alpha-tubulin acetylation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Danni Wang, Hongzheng Sun, Jiaqi Zhang, Zhenyue Huang, Congyang Li, Longsen Han, Yongan Xin, Shoubin Tang, Juan Ge, Qiang Wang
Summary: FKBP25 plays a crucial role in oocyte maturation by affecting spindle assembly, chromosome alignment, and kinetochore-microtubule attachment. Depletion of FKBP25 results in elevated aneuploidy incidence in oocytes. Reduced levels of FKBP25 protein in old oocytes can be partly rescued by ectopic expression of FKBP25, which is also found to have phosphorylation at serine 163 affecting its action on meiotic maturation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Peng, Yijing He, Weihan Wang, Yajie Chu, Qixin Lin, Rong Rui, Qiao Li, Shiqiang Ju
Summary: In this study, the importance of PAK1 in regulating spindle assembly and cell cycle progression during the first meiotic division of porcine oocytes was highlighted. The activated PAK1 showed dynamic expression and its subcellular localization was closely associated with spindle dynamics. Inhibition of PAK1 activity by IPA-3 led to impaired extrusion of PB1 and failure of bipolar spindle formation, which could be restored by reducing disulfide bonds between PAK1 and IPA-3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Jessica A. Ferrarezi, Alistair R. McTaggart, Peri A. Tobias, Carolina A. A. Hayashibara, Rebecca M. Degnan, Louise S. Shuey, Livia M. Franceschini, Mariana S. Lopes, Maria C. Quecine
Summary: The study revealed the potential of a fungal pathogen, Austropuccinia psidii, to undergo sexual reproduction on different hosts. Additionally, comparative genomics showed the conservation of meiotic genes in rust fungi.
FUNGAL GENETICS AND BIOLOGY
(2022)
Article
Cell Biology
Anna Frappaolo, Roberto Piergentili, Maria Grazia Giansanti
Summary: Drosophila dividing spermatocytes provide a suitable cell system to study the reorganization of microtubule and actin cytoskeleton systems during cell division. The unique characteristics of Drosophila male meiotic cells make them amenable to investigate the molecular pathways regulating spindle microtubules and cytokinesis, with important implications for cancer and other diseases.
Article
Biochemistry & Molecular Biology
Wei Yue, Yue Wang, Tie-Gang Meng, Hong-Yong Zhang, Xin-Ran Zhang, Ying-Chun Ouyang, Yi Hou, Heide Schatten, Zhen-Bo Wang, Qing-Yuan Sun
Summary: This study investigates the role of outer kinetochore protein KNL1 in mouse oocytes and reveals its critical function in ensuring timely and accurate chromosome segregation during oocyte meiotic maturation.
Article
Cell Biology
Hong Yin, Teng Zhang, Hao Wang, Xin Hu, Xuan Hou, Xianbao Fang, Yaoxue Yin, Hui Li, Lanying Shi, You-Qiang Su
Summary: The research reveals that EML1 plays a crucial role in controlling oocyte meiotic progression in mice, and its loss leads to abnormal oocytes unable to progress to the second meiotic division.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Qingqing Cai, Keying Wen, Miao Ma, Wei Chen, Delin Mo, Zuyong He, Yaosheng Chen, Peiqing Cong
Summary: EZH2 plays a crucial role in porcine oocyte meiotic maturation by regulating spindle organization, maintaining chromosomal integrity, and mitochondrial function.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Wilber Escorcia, Vishnu P. Tripathi, Ji-Ping Yuan, Susan L. Forsburg
Summary: Meiosis is a complex process that utilizes proteins from somatic cell division to carry out differentiation and recombination in sexually reproducing eukaryotes. This study in fission yeast cells provides an atlas of dynamic protein behavior during normal meiosis, establishing common landmarks for comparison and suggesting S phase initiation before nuclear fusion.
Article
Cell Biology
Xingzhu Du, Jun Li, Qingrui Zhuan, Luyao Zhang, Lin Meng, Panyu Ren, Xiaohan Huang, Jiachen Bai, Pengcheng Wan, Wenquan Sun, Yunpeng Hou, Shien Zhu, Xiangwei Fu
Summary: Oocyte cryopreservation has significant benefits in conserving animal germplasm resources and assisting reproductive technology. However, this technique can cause damage to oocytes, leading to a decrease in oocyte quality and post-fertilization embryonic development. This study examined oocyte cortical tension and found that vitrified oocytes had decreased cortical tension. Increasing cortical tension improved oocyte polar body extrusion, embryo development, spindle positioning, KT-MT attachment, SAC activity, and reduced aneuploidy in vitrified oocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Genetics & Heredity
Lea Lingg, Sven Rottenberg, Paola Francica
Summary: Tumor cells often have genetic alterations that affect tumor progression and DNA repair. Reactivation of germ cell-specific genes in tumors influences DNA repair and response to treatment. Targeting aberrantly expressed meiotic genes may provide a unique opportunity to kill cancer cells specifically.
FRONTIERS IN GENETICS
(2022)
Article
Plant Sciences
Adam J. Lukaszewski
Summary: This study analyzed the packaging of sister centromeres in FDR-type meiosis and found that sister centromere separation was only visible in univalents placed on the metaphase plate in FDR.
Article
Materials Science, Multidisciplinary
Dongjie Zhou, Zheng-Wen Nie, Xiang-Shun Cui
Summary: The study revealed that EB1 remains stable during mouse oocyte meiosis, and its knockdown results in spindle disorganization, chromosome misalignment, and missegregation, affecting the number of mature oocytes and reducing the binding of beta-catenin to actin, ultimately influencing chromosomal arrangement.
MICROSCOPY AND MICROANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Fen Yang, Nadia Fernandez-Jimenez, Martina Tuckova, Jan Vrana, Petr Capal, Mariana Diaz, Monica Pradillo, Ales Pecinka
Summary: Mutants of the Arabidopsis SMC5/6 complex subunits result in triploid offspring due to a meiotic defect, leading to the production of unreduced male gametes. The mutants show chromosome segregation absence and a disorganized microtubule network during meiotic division, with a high rate of ovule abortion observed. The SMC5/6 complex is partly required for repairing SPO11-induced DNA double-strand breaks, but the nonreduction phenomenon is SPO11-independent.
Article
Obstetrics & Gynecology
Tom Tanbo, Gareth Greggains, Ritsa Storeng, Bjorn Busund, Anton Langebrekke, Peter Fedorcsak
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2015)
Letter
Obstetrics & Gynecology
Heidi Tiller, Peter Fedorcsak, Bjorn R. Skogen
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2016)
Article
Obstetrics & Gynecology
Miriam Landfors, Sigve Nakken, Markus Fusser, John-Arne Dahl, Arne Klungland, Peter Fedorcsak
FERTILITY AND STERILITY
(2016)
Article
Multidisciplinary Sciences
John Arne Dahl, Inkyung Jung, Havard Aanes, Gareth D. Greggains, Adeel Manaf, Mads Lerdrup, Guoqiang Li, Samantha Kuan, Bin Li, Ah Young Lee, Sebastian Preissl, Ingunn Jermstad, Mads Haugland Haugen, Rajikala Suganthan, Magnar Bjoras, Klaus Hansen, Knut Tomas Dalen, Peter Fedorcsak, Bing Ren, Arne Klungland
Article
Obstetrics & Gynecology
Hilde Jorgensen, Abby S. Hill, Michael T. Beste, Manu P. Kumar, Evan Chiswick, Peter Fedorcsak, Keith B. Isaacson, Douglas A. Lauffenburger, Linda G. Griffith, Erik Qvigstad
FERTILITY AND STERILITY
(2017)
Article
Obstetrics & Gynecology
Rasa Pelanis, Jan Roar Mellembakken, Inger Sundstr MPoromaa, Pernille Ravn, Laure Morin-Papunen, Juha S. Tapanainen, Terhi Piltonen, Johanna Puurunen, Angelica Linden Hirschberg, Peter Fedorcsak, Marianne Andersen, Dorte Glintborg
HUMAN REPRODUCTION
(2017)
Article
Biochemical Research Methods
Arne Klungland, John Arne Dahl, Gareth Greggains, Peter Fedorcsak, Adam Filipczyk
Article
Cell Biology
Miriam Landfors, Jostein Johansen, Jan Magnus Aronsen, Cathrine Broberg Vagbo, Louis C. Dore, Chuan He, Ivar Sjaastad, Pal Saetrom, Peter Fedorcsak, John Arne Dahl, Havard Aanes, Markus Fusser, Arne Klungland
Review
Obstetrics & Gynecology
Tom G. Tanbo, Peter Z. Fedorcsak
Summary: Despite the increase in mean menopausal age over the last century, there is significant individual variation in natural menopause age. Women are now able to choose when to have children due to efficient contraception methods, leading to a significant increase in age at first birth. Fertility declines long before menopause, making it important but difficult to predict when a woman will enter menopause.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Obstetrics & Gynecology
M. A. Riegler, M. H. Stensen, O. Witczak, J. M. Andersen, S. A. Hicks, H. L. Hammer, E. Delbarre, P. Halvorsen, A. Yazidi, N. Holst, T. B. Haugen
Summary: In recent years, there has been an exponential increase in data generated in the field of ART, with a diverse range from videos to tabular data. Artificial intelligence (AI) is progressively being used in medical practice, especially in fertility clinics, to potentially improve success rates. AI models are being developed to address the lack of objectivity in critical procedures, such as embryo and sperm assessments, but there are still challenges to overcome in order to fully utilize AI in ART.
HUMAN REPRODUCTION
(2021)
Article
Andrology
Mario Iliceto, Mette Stensen, Jorunn Andersen, Trine Haugen, Oliwia Witczak
Summary: This study found that free seminal L-carnitine levels are associated with sperm fatty acid composition and semen quality, but not with BMI.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Correction
Obstetrics & Gynecology
A. Sharma, T. Haugen, H. Hammer, M. Riegler, M. Stensen
HUMAN REPRODUCTION
(2021)
Review
Obstetrics & Gynecology
Tom Tanbo, Peter Fedorcsak
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2017)