Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma

Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma

(2014) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

The Glaucoma-Associated Olfactomedin Domain of Myocilin Forms Polymorphic Fibrils That Are Constrained by Partial Unfolding and Peptide Sequence

(2013) Shannon E. Hill et al.   JOURNAL OF MOLECULAR BIOLOGY

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice

(2012) Colleen M. McDowell et al.   EXPERIMENTAL EYE RESEARCH

Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

(2012) Amirthaa Suntharalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a Grp94 inhibitor

(2012) Adam S. Duerfeldt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Stability of Myocilin Olfactomedin Domain Variants Provides New Insight into Glaucoma as a Protein Misfolding Disorder

(2011) J. Nicole Burns et al.   BIOCHEMISTRY

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

(2011) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid Fibril Formation by the Glaucoma-Associated Olfactomedin Domain of Myocilin

(2011) Susan D. Orwig et al.   JOURNAL OF MOLECULAR BIOLOGY

Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis

(2011) Carole J. Proctor et al.   PLoS One

Rescue of Glaucoma-Causing Mutant Myocilin Thermal Stability by Chemical Chaperones

(2010) J. Nicole Burns et al.   ACS Chemical Biology

Inhibition of N-linked glycosylation by tunicamycin induces E-cadherin-mediated cell–cell adhesion and inhibits cell proliferation in undifferentiated human colon cancer cells

(2010) Julio Cesar Madureira de Freitas Junior et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Identifying the amylome, proteins capable of forming amyloid-like fibrils

(2010) Lukasz Goldschmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Poses for Ligand and Chaperone in Inhibitor-Bound Hsp90 and GRP94: Implications for Paralog-Specific Drug Design

(2009) Robert M. Immormino et al.   JOURNAL OF MOLECULAR BIOLOGY